Q9FUJ2

PR
Gene name
CKX4 (At4g29740, T16L4.250)
Protein name
Cytokinin dehydrogenase 4
Names
Cytokinin oxidase 4, AtCKX4, CKO 4
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT4G29740
EC number
1.5.99.12: With other acceptors
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

65-141 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9FUJ2

Entry ID Method Resolution Chain Position Source
AF-Q9FUJ2-F1 Predicted AlphaFoldDB

40 variants for Q9FUJ2

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH06799281 11 T>P No 1000Genomes
ENSVATH02941430 14 T>A No 1000Genomes
ENSVATH12303730 15 L>F No 1000Genomes
ENSVATH06799282 36 I>V No 1000Genomes
ENSVATH06799283 62 E>A No 1000Genomes
tmp_4_14566606_G_A 86 G>R No 1000Genomes
ENSVATH12303750 110 S>P No 1000Genomes
ENSVATH14312056 122 V>I No 1000Genomes
ENSVATH06799285 127 C>Y No 1000Genomes
ENSVATH06799286 149 A>T No 1000Genomes
tmp_4_14566819_G_A 157 V>I No 1000Genomes
ENSVATH12303788 162 V>M No 1000Genomes
ENSVATH12303790 177 L>F No 1000Genomes
ENSVATH12303791 204 E>D No 1000Genomes
ENSVATH06799291 218 S>C No 1000Genomes
ENSVATH06799291 218 S>Y No 1000Genomes
ENSVATH06799292 219 P>L No 1000Genomes
ENSVATH00544514 265 A>G No 1000Genomes
tmp_4_14568023_G_A 265 A>T No 1000Genomes
ENSVATH12303854 267 K>R No 1000Genomes
ENSVATH06799299 275 S>L No 1000Genomes
tmp_4_14568062_A_C 278 N>H No 1000Genomes
ENSVATH12303896 282 V>I No 1000Genomes
tmp_4_14568159_C_G 310 A>G No 1000Genomes
ENSVATH00544517 319 I>M No 1000Genomes
tmp_4_14568207_A_C 326 K>T No 1000Genomes
tmp_4_14568488_G_A 341 D>N No 1000Genomes
ENSVATH14312064 347 L>P No 1000Genomes
tmp_4_14568518_C_T 351 P>S No 1000Genomes
tmp_4_14568554_G_C 363 D>H No 1000Genomes
ENSVATH06799303 374 K>E No 1000Genomes
ENSVATH12303929 413 T>P No 1000Genomes
ENSVATH02941465 438 P>S No 1000Genomes
tmp_4_14568948_T_C 464 L>P No 1000Genomes
ENSVATH14312095 470 Q>K No 1000Genomes
ENSVATH06799308 474 N>H No 1000Genomes
ENSVATH06799309 475 S>W No 1000Genomes
tmp_4_14569023_A_G 489 K>R No 1000Genomes
ENSVATH12303978 503 F>V No 1000Genomes
ENSVATH12303979 509 M>L No 1000Genomes

No associated diseases with Q9FUJ2

3 regional properties for Q9FUJ2

Type Name Position InterPro Accession
domain FAD linked oxidase, N-terminal 64 - 218 IPR006094
domain Cytokinin dehydrogenase 1, FAD/cytokinin binding domain 250 - 523 IPR015345
domain FAD-binding domain, PCMH-type 60 - 249 IPR016166

Functions

Description
EC Number 1.5.99.12 With other acceptors
Subcellular Localization
  • Secreted, extracellular space
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

4 GO annotations of molecular function

Name Definition
cytokinin dehydrogenase activity Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor.
FAD binding Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
primary amine oxidase activity Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide.

1 GO annotations of biological process

Name Definition
cytokinin catabolic process The chemical reactions and pathways resulting in the breakdown of cytokinins, a class of adenine-derived compounds that can function in plants as plant growth regulators.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5JLP4 CKX4 Cytokinin dehydrogenase 4 Oryza sativa subsp japonica (Rice) PR
A3AVP1 CKX8 Cytokinin dehydrogenase 8 Oryza sativa subsp japonica (Rice) PR
Q8LNV6 CKX3 Cytokinin dehydrogenase 3 Oryza sativa subsp japonica (Rice) PR
Q6YW51 CKX6 Cytokinin dehydrogenase 6 Oryza sativa subsp japonica (Rice) PR
Q6YW50 CKX7 Cytokinin dehydrogenase 7 Oryza sativa subsp japonica (Rice) PR
Q94AX4 DLD D-lactate dehydrogenase [cytochrome], mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
Q9LTS3 CKX3 Cytokinin dehydrogenase 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LY71 CKX6 Cytokinin dehydrogenase 6 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MTNTLCLSLI TLITLFISLT PTLIKSDEGI DVFLPISLNL TVLTDPFSIS AASHDFGNIT
70 80 90 100 110 120
DENPGAVLCP SSTTEVARLL RFANGGFSYN KGSTSPASTF KVAARGQGHS LRGQASAPGG
130 140 150 160 170 180
VVVNMTCLAM AAKPAAVVIS ADGTYADVAA GTMWVDVLKA AVDRGVSPVT WTDYLYLSVG
190 200 210 220 230 240
GTLSNAGIGG QTFRHGPQIS NVHELDVITG KGEMMTCSPK LNPELFYGVL GGLGQFGIIT
250 260 270 280 290 300
RARIALDHAP TRVKWSRILY SDFSAFKRDQ ERLISMTNDL GVDFLEGQLM MSNGFVDTSF
310 320 330 340 350 360
FPLSDQTRVA SLVNDHRIIY VLEVAKYYDR TTLPIIDQVI DTLSRTLGFA PGFMFVQDVP
370 380 390 400 410 420
YFDFLNRVRN EEDKLRSLGL WEVPHPWLNI FVPGSRIQDF HDGVINGLLL NQTSTSGVTL
430 440 450 460 470 480
FYPTNRNKWN NRMSTMTPDE DVFYVIGLLQ SAGGSQNWQE LENLNDKVIQ FCENSGIKIK
490 500 510 520
EYLMHYTRKE DWVKHFGPKW DDFLRKKIMF DPKRLLSPGQ DIFN