Q9LTS3
Gene name |
CKX3 (At5g56970, MHM17.8) |
Protein name |
Cytokinin dehydrogenase 3 |
Names |
Cytokinin oxidase 3, AtCKX3, CKO 3 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G56970 |
EC number |
1.5.99.12: With other acceptors |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9LTS3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9LTS3-F1 | Predicted | AlphaFoldDB |
63 variants for Q9LTS3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_5_23048236_A_T | 4 | Y>N | No | 1000Genomes | |
| tmp_5_23048218_C_T | 10 | V>I | No | 1000Genomes | |
| tmp_5_23048211_A_T | 12 | L>H | No | 1000Genomes | |
| tmp_5_23048205_G_A | 14 | A>V | No | 1000Genomes | |
| tmp_5_23048193_A_C | 18 | V>G | No | 1000Genomes | |
| tmp_5_23048164_T_C | 28 | T>A | No | 1000Genomes | |
| tmp_5_23048114_G_T | 44 | F>L | No | 1000Genomes | |
| tmp_5_23048113_C_G | 45 | A>P | No | 1000Genomes | |
| ENSVATH07436831 | 52 | S>F | No | 1000Genomes | |
| ENSVATH07436830 | 60 | T>I | No | 1000Genomes | |
| tmp_5_23048055_T_A | 64 | H>L | No | 1000Genomes | |
| ENSVATH00738325 | 75 | I>N | No | 1000Genomes | |
| ENSVATH12816789 | 84 | D>N | No | 1000Genomes | |
| ENSVATH03441990 | 97 | P>S | No | 1000Genomes | |
| tmp_5_23047885_T_C | 121 | M>V | No | 1000Genomes | |
| ENSVATH12816788 | 129 | R>Q | No | 1000Genomes | |
| ENSVATH00738324 | 135 | R>G | No | 1000Genomes | |
| ENSVATH00738323 | 137 | C>G | No | 1000Genomes | |
| tmp_5_23047816_C_A | 144 | A>S | No | 1000Genomes | |
| tmp_5_23047813_C_T | 145 | A>T | No | 1000Genomes | |
| ENSVATH07436828 | 155 | T>S | No | 1000Genomes | |
| tmp_5_23047780_A_T | 156 | L>M | No | 1000Genomes | |
| ENSVATH12816784 | 163 | V>A | No | 1000Genomes | |
| ENSVATH12816785 | 163 | V>I | No | 1000Genomes | |
| tmp_5_23046153_T_A | 215 | M>L | No | 1000Genomes | |
| ENSVATH03441938 | 234 | T>I | No | 1000Genomes | |
| ENSVATH07436776 | 241 | E>K | No | 1000Genomes | |
| ENSVATH07436775 | 245 | K>T | No | 1000Genomes | |
| tmp_5_23045912_C_A | 267 | V>L | No | 1000Genomes | |
| ENSVATH00738315 | 281 | I>V | No | 1000Genomes | |
| tmp_5_23045818_G_T | 298 | P>Q | No | 1000Genomes | |
| ENSVATH12816644 | 305 | A>G | No | 1000Genomes | |
| ENSVATH12816643 | 306 | S>A | No | 1000Genomes | |
| tmp_5_23045773_A_G | 313 | V>A | No | 1000Genomes | |
| ENSVATH07436774 | 313 | V>I | No | 1000Genomes | |
| ENSVATH14636628 | 357 | M>I | No | 1000Genomes | |
| tmp_5_23045541_T_A | 357 | M>L | No | 1000Genomes | |
| ENSVATH12816638 | 360 | L>V | No | 1000Genomes | |
| tmp_5_23045519_C_A | 364 | R>L | No | 1000Genomes | |
| tmp_5_23045492_T_C | 373 | K>R | No | 1000Genomes | |
| ENSVATH14636627 | 394 | K>T | No | 1000Genomes | |
| tmp_5_23045412_A_T | 400 | F>I | No | 1000Genomes | |
| ENSVATH12816636 | 400 | F>L | No | 1000Genomes | |
| ENSVATH14636626 | 402 | G>D | No | 1000Genomes | |
| ENSVATH07436770 | 416 | V>I | No | 1000Genomes | |
| ENSVATH12816614 | 425 | N>H | No | 1000Genomes | |
| ENSVATH14636625 | 430 | A>V | No | 1000Genomes | |
| tmp_5_23045209_T_C | 436 | D>G | No | 1000Genomes | |
| ENSVATH07436764 | 447 | A>V | No | 1000Genomes | |
| ENSVATH12816613 | 448 | G>D | No | 1000Genomes | |
| ENSVATH07436763 | 450 | D>G | No | 1000Genomes | |
| tmp_5_23045156_C_G | 454 | A>P | No | 1000Genomes | |
| ENSVATH07436762 | 455 | F>Y | No | 1000Genomes | |
| tmp_5_23045129_G_T | 463 | L>M | No | 1000Genomes | |
| tmp_5_23045125_T_C | 464 | K>R | No | 1000Genomes | |
| ENSVATH07436761 | 471 | M>V | No | 1000Genomes | |
| ENSVATH03441934 | 472 | G>R | No | 1000Genomes | |
| tmp_5_23045062_C_T | 485 | G>E | No | 1000Genomes | |
| ENSVATH07436760 | 485 | G>R | No | 1000Genomes | |
| ENSVATH00738307 | 488 | R>K | Plants were checked bi-weekly for presence of first buds and the average flowering time of 4 plants of the same accession were collected [16c and 16 hrs daylight] [EnsemblGenome] | No | 1000Genomes |
| tmp_5_23045008_T_A | 503 | K>I | No | 1000Genomes | |
| tmp_5_23044991_T_A | 509 | I>L | No | 1000Genomes | |
| ENSVATH07436759 | 523 | S>T | No | 1000Genomes |
1 associated diseases with Q9LTS3
Without disease ID
2 regional properties for Q9LTS3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | CBS domain | 601 - 657 | IPR000644-1 |
| domain | CBS domain | 806 - 868 | IPR000644-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.5.99.12 | With other acceptors |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| vacuole | A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| cytokinin dehydrogenase activity | Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor. |
| FAD binding | Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. |
| oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. |
| primary amine oxidase activity | Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| cytokinin catabolic process | The chemical reactions and pathways resulting in the breakdown of cytokinins, a class of adenine-derived compounds that can function in plants as plant growth regulators. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5JLP4 | CKX4 | Cytokinin dehydrogenase 4 | Oryza sativa subsp japonica (Rice) | PR |
| A3AVP1 | CKX8 | Cytokinin dehydrogenase 8 | Oryza sativa subsp japonica (Rice) | PR |
| Q8LNV6 | CKX3 | Cytokinin dehydrogenase 3 | Oryza sativa subsp japonica (Rice) | PR |
| Q6YW51 | CKX6 | Cytokinin dehydrogenase 6 | Oryza sativa subsp japonica (Rice) | PR |
| Q6YW50 | CKX7 | Cytokinin dehydrogenase 7 | Oryza sativa subsp japonica (Rice) | PR |
| Q94AX4 | DLD | D-lactate dehydrogenase [cytochrome], mitochondrial | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LY71 | CKX6 | Cytokinin dehydrogenase 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FUJ2 | CKX4 | Cytokinin dehydrogenase 4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASYNLRSQV | RLIAITIVII | ITLSTPITTN | TSPQPWNILS | HNEFAGKLTS | SSSSVESAAT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DFGHVTKIFP | SAVLIPSSVE | DITDLIKLSF | DSQLSFPLAA | RGHGHSHRGQ | ASAKDGVVVN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MRSMVNRDRG | IKVSRTCLYV | DVDAAWLWIE | VLNKTLELGL | TPVSWTDYLY | LTVGGTLSNG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GISGQTFRYG | PQITNVLEMD | VITGKGEIAT | CSKDMNSDLF | FAVLGGLGQF | GIITRARIKL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EVAPKRAKWL | RFLYIDFSEF | TRDQERVISK | TDGVDFLEGS | IMVDHGPPDN | WRSTYYPPSD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HLRIASMVKR | HRVIYCLEVV | KYYDETSQYT | VNEEMEELSD | SLNHVRGFMY | EKDVTYMDFL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NRVRTGELNL | KSKGQWDVPH | PWLNLFVPKT | QISKFDDGVF | KGIILRNNIT | SGPVLVYPMN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RNKWNDRMSA | AIPEEDVFYA | VGFLRSAGFD | NWEAFDQENM | EILKFCEDAN | MGVIQYLPYH |
| 490 | 500 | 510 | 520 | ||
| SSQEGWVRHF | GPRWNIFVER | KYKYDPKMIL | SPGQNIFQKI | NSS |