P32891

PR
Gene name
DLD1
Protein name
D-lactate dehydrogenase [cytochrome] 1, mitochondrial
Names
D-lactate ferricytochrome C oxidoreductase, D-LCR
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YDL174C
EC number
1.1.2.4: With a cytochrome as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-181 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P32891

Entry ID Method Resolution Chain Position Source
AF-P32891-F1 Predicted AlphaFoldDB

3 variants for P32891

Variant ID(s) Position Change Description Diseaes Association Provenance
s04-147277 105 V>A No SGRP
s04-147209 128 A>T No SGRP
s04-146399 398 P>A No SGRP

No associated diseases with P32891

3 regional properties for P32891

Type Name Position InterPro Accession
domain FAD-binding oxidoreductase/transferase, type 4, C-terminal 327 - 574 IPR004113
domain FAD linked oxidase, N-terminal 151 - 290 IPR006094
domain FAD-binding domain, PCMH-type 146 - 327 IPR016166

Functions

Description
EC Number 1.1.2.4 With a cytochrome as acceptor
Subcellular Localization
  • Mitochondrion inner membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial intermembrane space The region between the inner and outer lipid bilayers of the mitochondrial envelope.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

4 GO annotations of molecular function

Name Definition
D-lactate dehydrogenase (cytochrome) activity Catalysis of the reaction: (R)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate.
D-lactate dehydrogenase activity Catalysis of the reaction: (R)-lactate + NAD(+) = H(+) + NADH + pyruvate.
FAD binding Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
flavin adenine dinucleotide binding Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.

1 GO annotations of biological process

Name Definition
lactate catabolic process The chemical reactions and pathways resulting in the breakdown of lactate.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q94AX4 DLD D-lactate dehydrogenase [cytochrome], mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MLWKRTCTRL IKPIAQPRGR LVRRSCYRYA STGTGSTDSS SQWLKYSVIA SSATLFGYLF
70 80 90 100 110 120
AKNLYSRETK EDLIEKLEMV KKIDPVNSTL KLSSLDSPDY LHDPVKIDKV VEDLKQVLGN
130 140 150 160 170 180
KPENYSDAKS DLDAHSDTYF NTHHPSPEQR PRIILFPHTT EEVSKILKIC HDNNMPVVPF
190 200 210 220 230 240
SGGTSLEGHF LPTRIGDTIT VDLSKFMNNV VKFDKLDLDI TVQAGLPWED LNDYLSDHGL
250 260 270 280 290 300
MFGCDPGPGA QIGGCIANSC SGTNAYRYGT MKENIINMTI VLPDGTIVKT KKRPRKSSAG
310 320 330 340 350 360
YNLNGLFVGS EGTLGIVTEA TVKCHVKPKA ETVAVVSFDT IKDAAACASN LTQSGIHLNA
370 380 390 400 410 420
MELLDENMMK LINASESTDR CDWVEKPTMF FKIGGRSPNI VNALVDEVKA VAQLNHCNSF
430 440 450 460 470 480
QFAKDDDEKL ELWEARKVAL WSVLDADKSK DKSAKIWTTD VAVPVSQFDK VIHETKKDMQ
490 500 510 520 530 540
ASKLINAIVG HAGDGNFHAF IVYRTPEEHE TCSQLVDRMV KRALNAEGTC TGEHGVGIGK
550 560 570 580
REYLLEELGE APVDLMRKIK LAIDPKRIMN PDKIFKTDPN EPANDYR