AiPD: Autoinhibited Protein Database

Gene name	DPYSL2
Protein name	Dihydropyrimidinase-related protein 2
Names	DRP-2, Collapsin response mediator protein CRMP-62
Species	Gallus gallus (Chicken)
KEGG Pathway
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

480-558 (Predicted disordered autoinhibitory region) PR

480-558 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q90635-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs732504898	83	M>R	No	Ensembl
rs734402508	123	W>G	No	Ensembl
rs732405822	138	H>P	No	Ensembl
rs741143774	140	D>G	No	Ensembl
rs733674301	142	T>P	No	Ensembl
rs733427643	232	E>G	No	Ensembl
rs737914567	304	S>P	No	Ensembl
rs731760679	310	D>A	No	Ensembl
rs739320792	313	T>P	No	Ensembl
rs740820389	343	V>A	No	Ensembl
rs741481294	383	V>G	No	Ensembl
rs733999772	384	T>A	No	Ensembl
rs314773800	431	Y>D	No	Ensembl
rs732343203	439	C>G	No	Ensembl
rs733776620	445	V>G	No	Ensembl
rs1058346702	451	K>R	No	Ensembl
rs732976231	463	E>G	No	Ensembl
rs741051278	490	E>G	No	Ensembl
rs733082394	511	K>Q	No	Ensembl
rs740448742	522	S>P	No	Ensembl
rs316482402	559	V>G	No	Ensembl
rs312926363	560	A>P	No	Ensembl
rs740118870	569	T>P	No	Ensembl

Type	Name	Position	InterPro Accession
domain	Amidohydrolase-related	64 - 453	IPR006680

		Description
EC Number
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Name	Definition
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.
microtubule binding	Binding to a microtubule, a filament composed of tubulin monomers.

Name	Definition
axon guidance	The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
brain development	The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
regulation of axon extension	Any process that modulates the rate, direction or extent of axon extension.
regulation of neuron differentiation	Any process that modulates the frequency, rate or extent of neuron differentiation.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q14194	CRMP1	Dihydropyrimidinase-related protein 1	Homo sapiens (Human)	PR
Q14195	DPYSL3	Dihydropyrimidinase-related protein 3	Homo sapiens (Human)	PR
Q16555	DPYSL2	Dihydropyrimidinase-related protein 2	Homo sapiens (Human)	PR
Q62188	Dpysl3	Dihydropyrimidinase-related protein 3	Mus musculus (Mouse)	PR
P97427	Crmp1	Dihydropyrimidinase-related protein 1	Mus musculus (Mouse)	PR
O08553	Dpysl2	Dihydropyrimidinase-related protein 2	Mus musculus (Mouse)	PR
Q62952	Dpysl3	Dihydropyrimidinase-related protein 3	Rattus norvegicus (Rat)	PR
P47942	Dpysl2	Dihydropyrimidinase-related protein 2	Rattus norvegicus (Rat)	PR
Q9FMP3	PYD2	Dihydropyrimidinase	Arabidopsis thaliana (Mouse-ear cress)	PR
Q6GL72	dpysl3	Dihydropyrimidinase-related protein 3	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR