P97427
PR
Gene name |
Crmp1 (Dpysl1, Ulip3) |
Protein name |
Dihydropyrimidinase-related protein 1 |
Names |
DRP-1, Collapsin response mediator protein 1, CRMP-1, Inactive dihydropyrimidinase, Unc-33-like phosphoprotein 3, ULIP-3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:12933 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P97427
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1KCX | X-ray | 212 A | A/B | 8-525 | PDB |
| AF-P97427-F1 | Predicted | AlphaFoldDB |
29 variants for P97427
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388742955 | 45 | I>L | No | EVA | |
| rs3388742938 | 53 | G>A | No | EVA | |
| rs3395465237 | 80 | S>C | No | EVA | |
| rs3388754106 | 81 | Q>* | No | EVA | |
| rs3388754106 | 81 | Q>E | No | EVA | |
| rs3395345608 | 83 | M>L | No | EVA | |
| rs3388747379 | 103 | M>I | No | EVA | |
| rs3388758763 | 109 | V>L | No | EVA | |
| rs3395403590 | 116 | L>* | No | EVA | |
| rs3388753892 | 143 | S>I | No | EVA | |
| rs3388759275 | 147 | G>D | No | EVA | |
| rs3388742886 | 282 | S>N | No | EVA | |
| rs3388758755 | 286 | D>E | No | EVA | |
| rs3388757523 | 299 | A>S | No | EVA | |
| rs1133078471 | 358 | I>V | No | EVA | |
| rs3388759279 | 367 | D>Y | No | EVA | |
| rs3388762650 | 377 | E>A | No | EVA | |
| rs3388758043 | 381 | V>E | No | EVA | |
| rs3388752172 | 410 | V>F | No | EVA | |
| rs3388752181 | 417 | M>L | No | EVA | |
| rs3388758791 | 473 | P>T | No | EVA | |
| rs3388758107 | 500 | D>V | No | EVA | |
| rs3388756394 | 503 | V>M | No | EVA | |
| rs3388754116 | 505 | E>D | No | EVA | |
| rs3388758740 | 529 | P>S | No | EVA | |
| rs3388763980 | 531 | I>T | No | EVA | |
| rs3388757445 | 532 | R>P | No | EVA | |
| rs3410870034 | 543 | G>D | No | EVA | |
| rs3388750288 | 546 | I>T | No | EVA |
No associated diseases with P97427
1 regional properties for P97427
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Amidohydrolase-related | 64 - 453 | IPR006680 |
Functions
11 GO annotations of cellular component
| Name | Definition |
|---|---|
| actin cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. |
| centrosome | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| growth cone | The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic. |
| midbody | A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis. |
| neuronal cell body | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| perikaryon | The portion of the cell soma (neuronal cell body) that excludes the nucleus. |
| spindle | The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| filamin binding | Binding to a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain. |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. |
| identical protein binding | Binding to an identical protein or proteins. |
| phosphoprotein binding | Binding to a phosphorylated protein. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| microtubule cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. |
| negative regulation of actin filament binding | Any process that stops, prevents or reduces the frequency, rate or extent of actin filament binding. |
| negative regulation of neuron projection development | Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
| semaphorin-plexin signaling pathway | The series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q90635 | DPYSL2 | Dihydropyrimidinase-related protein 2 | Gallus gallus (Chicken) | PR |
| Q16555 | DPYSL2 | Dihydropyrimidinase-related protein 2 | Homo sapiens (Human) | PR |
| Q14195 | DPYSL3 | Dihydropyrimidinase-related protein 3 | Homo sapiens (Human) | PR |
| Q14194 | CRMP1 | Dihydropyrimidinase-related protein 1 | Homo sapiens (Human) | PR |
| O08553 | Dpysl2 | Dihydropyrimidinase-related protein 2 | Mus musculus (Mouse) | PR |
| Q62188 | Dpysl3 | Dihydropyrimidinase-related protein 3 | Mus musculus (Mouse) | PR |
| P47942 | Dpysl2 | Dihydropyrimidinase-related protein 2 | Rattus norvegicus (Rat) | PR |
| Q62952 | Dpysl3 | Dihydropyrimidinase-related protein 3 | Rattus norvegicus (Rat) | PR |
| Q9FMP3 | PYD2 | Dihydropyrimidinase | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6GL72 | dpysl3 | Dihydropyrimidinase-related protein 3 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSHQGKKSIP | HITSDRLLIR | GGRIINDDQS | FYADVYLEDG | LIKQIGENLI | VPGGVKTIEA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NGRMVIPGGI | DVNTYLQKPS | QGMTSADDFF | QGTKAALAGG | TTMIIDHVVP | EPGSSLLTSF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EKWHEAADTK | SCCDYSLHVD | ITSWYDGVRE | ELEVLVQDKG | VNSFQVYMAY | KDLYQMSDSQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LYEAFTFLKG | LGAVILVHAE | NGDLIAQEQK | RILEMGITGP | EGHALSRPEE | LEAEAVFRAI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AIAGRINCPV | YITKVMSKSA | ADIIALARKK | GPLVFGEPIA | ASLGTDGTHY | WSKNWAKAAA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FVTSPPLSPD | PTTPDYLTSL | LACGDLQVTG | SGHCPYSTAQ | KAVGKDNFTL | IPEGVNGIEE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RMTVVWDKAV | ATGKMDENQF | VAVTSTNAAK | IFNLYPRKGR | IAVGSDADVV | IWDPDKMKTI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TAKSHKSTVE | YNIFEGMECH | GSPLVVISQG | KIVFEDGNIS | VSKGMGRFIP | RKPFPEHLYQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RVRIRSKVFG | LHSVSRGMYD | GPVYEVPATP | KHAAPAPSAK | SSPSKHQPPP | IRNLHQSNFS |
| 550 | 560 | 570 | |||
| LSGAQIDDNN | PRRTGHRIVA | PPGGRSNITS | LG |