AiPD: Autoinhibited Protein Database

Q14194

Gene name	CRMP1 (DPYSL1, ULIP3)
Protein name	Dihydropyrimidinase-related protein 1
Names	DRP-1, Collapsin response mediator protein 1, CRMP-1, Inactive dihydropyrimidinase, Unc-33-like phosphoprotein 3, ULIP-3
Species	Homo sapiens (Human)
KEGG Pathway	hsa:1400
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

472-554 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

472-554 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q14194

Entry ID	Method	Resolution	Chain	Position	Source
4B3Z	X-ray	305 A	A/B/C/D	1-572	PDB
AF-Q14194-F1	Predicted				AlphaFoldDB

423 variants for Q14194

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA356159163 rs1308607005	2	S>T		No	ClinGen TOPMed gnomAD
CA91760355 rs966152617	2	S>W		No	ClinGen gnomAD
rs986093942 CA91760345	4	Q>*		No	ClinGen Ensembl
CA356159145 rs1275676580	4	Q>H		No	ClinGen gnomAD
CA356159146 rs1290791436	4	Q>R		No	ClinGen gnomAD
CA356159118 rs1381451068	8	S>N		No	ClinGen gnomAD
rs866896444 CA91760317	10	P>Q		No	ClinGen Ensembl
rs1182965444 CA356159086	13	T>S		No	ClinGen TOPMed
CA2837429 rs769736612	16	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs934941436 CA91740431	16	R>Q		No	ClinGen TOPMed gnomAD
rs1577820383 CA356157229	20	K>R		No	ClinGen Ensembl
CA2837427 rs770457969	23	R>Q		No	ClinGen ExAC gnomAD
rs745621595 CA2837428	23	R>W		No	ClinGen ExAC TOPMed gnomAD
CA356157143 rs545458583	27	D>N		No	ClinGen ExAC TOPMed gnomAD
CA2837425 rs545458583	27	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs777215799 CA356157098	29	Q>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA356157092 rs1272473241	30	S>Y		No	ClinGen gnomAD
CA2837423 rs771581090	31	L>F		No	ClinGen ExAC gnomAD
rs1370732535 CA356157065	33	A>G		No	ClinGen gnomAD
rs377482181 CA2837420	35	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs377482181 CA356157050	35	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA356157030 rs1440426495	36	Y>C		No	ClinGen TOPMed
CA91740389 rs985902300	37	L>V		No	ClinGen TOPMed
rs1328239238 CA356157000	39	D>N		No	ClinGen gnomAD
rs1410639561 CA356156982	40	G>R		No	ClinGen gnomAD
rs750718997 CA2837419	41	L>H		No	ClinGen ExAC gnomAD
CA2837418 rs781402227	42	I>V		No	ClinGen ExAC gnomAD
CA356155326 rs1186366027	44	Q>E		No	ClinGen gnomAD
rs899968776 CA91734874	46	G>A		No	ClinGen Ensembl
rs1366057255 CA356155240	47	E>D		No	ClinGen gnomAD
rs1232728809 CA356155224	48	N>K		No	ClinGen TOPMed
CA356155223 rs1258872031	49	L>I		No	ClinGen gnomAD
rs1303845719 CA356155211	50	I>V		No	ClinGen gnomAD
CA91734852 rs1038411295	51	V>A		No	ClinGen gnomAD
CA2837397 rs758415603	51	V>I	Variant assessed as Somatic; 4.63e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA356155199 rs758415603	51	V>L		No	ClinGen ExAC gnomAD
CA356155169 rs1553906823	53	G>S		No	ClinGen Ensembl
rs1419888417 CA356155087	58	I>F		No	ClinGen gnomAD
rs1196992053 CA356155077	58	I>T		No	ClinGen TOPMed
rs752770907 CA356155006	61	N>K		No	ClinGen ExAC TOPMed gnomAD
CA356155012 rs1272674453	61	N>S		No	ClinGen TOPMed
rs1352884103 CA356155001	62	G>R		No	ClinGen TOPMed gnomAD
TCGA novel	63	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2837394 rs373508403	63	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs147608754 CA2837395	63	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
TCGA novel	68	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1314742024 CA356154860	70	I>T		No	ClinGen gnomAD
rs766137456 CA2837392	74	T>S		No	ClinGen ExAC gnomAD
rs1402107149 CA356154514	79	P>L		No	ClinGen gnomAD
rs141399602 CA2837389	80	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	81	Q>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs761326053 CA2837388	81	Q>L		No	ClinGen ExAC
CA91734676 rs917433210	82	G>E		No	ClinGen gnomAD
CA91734688 rs62297733	82	G>R		No	ClinGen Ensembl
rs1035732948 CA91734667 CA356154345	83	M>I		No	ClinGen TOPMed
rs768146939 CA2837386	84	T>S		No	ClinGen ExAC TOPMed gnomAD
rs1241930427 CA356154330	85	A>S		No	ClinGen gnomAD
COSM297424 CA2837385 rs201508359	85	A>V	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA356154288 rs1271550334	86	A>D		No	ClinGen gnomAD
TCGA novel	88	D>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2837382 rs747334581	89	F>I		No	ClinGen ExAC gnomAD
CA356154206 rs747334581	89	F>L		No	ClinGen ExAC gnomAD
rs777875354 CA2837381	90	F>Y		No	ClinGen ExAC gnomAD
rs748376145 CA2837379	91	Q>H		No	ClinGen ExAC gnomAD
CA2837380 rs549636760	91	Q>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1033462450 CA91734637	93	T>S		No	ClinGen TOPMed gnomAD
CA2837378 rs779175259 COSM1738975	95	A>V	Variant assessed as Somatic; 0.0 impact. NS prostate [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs755864249 CA2837374	97	L>Q		No	ClinGen ExAC gnomAD
CA2837375 rs766297812	97	L>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	99	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM1430387 CA356153857 rs1560508405	102	T>M	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA356165169 rs1290527173	106	D>G		No	ClinGen Ensembl
CA2837355 rs138323311	108	V>A		No	ClinGen 1000Genomes ExAC gnomAD
CA356165140 rs1480286004	109	V>A		No	ClinGen gnomAD
CA356165134 rs1279374761	110	P>A		No	ClinGen gnomAD
TCGA novel	111	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1430391794 CA356165112	112	P>S		No	ClinGen gnomAD
CA356165091 COSM462148 rs1390300757	114	S>C	cervix Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs757022185 CA2837353	115	S>N		No	ClinGen ExAC gnomAD
CA2837352 rs751232611	115	S>R		No	ClinGen ExAC gnomAD
CA2837351 rs763672490	116	L>I		No	ClinGen ExAC gnomAD
CA2837350 rs762384169	118	T>N		No	ClinGen ExAC gnomAD
rs1157208110 CA356165037	120	F>L		No	ClinGen gnomAD
CA2837348 rs144668952	120	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs773574222 CA2837346	121	E>K		No	ClinGen ExAC TOPMed gnomAD
rs773574222 CA91783637	121	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA2837345 rs371476843	122	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs762231166 CA2837344	123	W>C		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	123	W>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA356164960 rs139688791	124	H>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs376766526 COSM1202305 CA2837341	125	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs376766526 CA2837342	125	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA356164932 rs1227366630	126	A>V		No	ClinGen TOPMed
CA356164918 rs1486563126	127	A>G		No	ClinGen gnomAD
rs1260825471 CA356164884	129	T>I		No	ClinGen TOPMed gnomAD
rs1260825471 CA356164886	129	T>S		No	ClinGen TOPMed gnomAD
rs1237886052 CA356164881	130	K>E		No	ClinGen gnomAD
CA356164876 rs1202824412	130	K>T		No	ClinGen gnomAD
TCGA novel	131	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1316946495 CA356164840	132	C>S		No	ClinGen gnomAD
rs548835481 CA2837338	139	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	140	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA356164712 rs1312866868	141	I>V		No	ClinGen TOPMed gnomAD
rs189022086 CA2837337	142	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2837336 rs757073146	144	W>*		No	ClinGen ExAC gnomAD
TCGA novel	145	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	145	Y>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM1430385 rs777531665 CA2837334	146	D>N	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA91783545 rs386671024	147	G>R		No	ClinGen Ensembl
RCV000962067 rs114376030 CA2837333	147	G>R		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA356164614 COSM179314 rs1417061818	148	V>I	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs754327324 COSM1249130 CA91783499	149	R>L	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
COSM4135414 rs754327324 CA2837330	149	R>Q	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs373503083 CA2837331	149	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs1168953718 CA356164584	150	E>D		No	ClinGen TOPMed
CA91783498 rs868118770 COSM1430384	150	E>K	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA2837329 rs751001437	151	E>A		No	ClinGen ExAC gnomAD
rs762280042 CA2837327	154	V>A		No	ClinGen ExAC gnomAD
rs1470586615 CA356164543 COSM1540666	154	V>M	lung [Cosmic]	No	ClinGen cosmic curated TOPMed
rs1333537242 CA356164526	156	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA356164482 rs1293140351	159	K>N		No	ClinGen gnomAD
rs577913448	160	G>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA356164189 rs1167880099	160	G>D		No	ClinGen TOPMed
rs200972738 CA2837301	161	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2837299 rs746998647	162	N>S		No	ClinGen ExAC
CA356164157 rs1194954213	164	F>V		No	ClinGen gnomAD
CA2837298 rs773088512	168	M>L		No	ClinGen ExAC gnomAD
rs1404891531 CA356164104	169	A>T		No	ClinGen TOPMed
rs1338697490 CA356164098	169	A>V		No	ClinGen gnomAD
rs771936597 CA356164092	170	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs771936597 CA2837297	170	Y>F		No	ClinGen ExAC TOPMed gnomAD
rs1299474362 CA356164084	171	K>E		No	ClinGen TOPMed
CA356164070 rs1277243766	172	D>G		No	ClinGen TOPMed gnomAD
CA356164076 rs1340451216	172	D>N		No	ClinGen gnomAD
rs754642764 CA2837294	174	Y>C		No	ClinGen ExAC gnomAD
rs779747285 CA2837292	175	Q>K		No	ClinGen ExAC gnomAD
rs755662444 CA2837291	176	M>I		No	ClinGen ExAC TOPMed gnomAD
rs764467563 CA2837289 COSM734027	178	D>N	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs758792685 CA2837288	179	S>G		No	ClinGen ExAC gnomAD
CA356163984 rs1171487605	180	Q>R		No	ClinGen gnomAD
rs755287180 CA2837260	182	Y>C		No	ClinGen ExAC gnomAD
rs556396914 CA2837258	183	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2837257 rs200982795	184	A>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs200982795 CA356163811	184	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs750528856 CA2837256	185	F>L		No	ClinGen ExAC gnomAD
CA2837254 rs142860765	187	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA356163791 rs771606012	187	F>L		No	ClinGen ExAC gnomAD
rs1382912703 CA356163778	189	K>N		No	ClinGen gnomAD
rs762796750 CA2837251	190	G>D		No	ClinGen ExAC gnomAD
CA2837249 rs769512358	194	V>M		No	ClinGen ExAC gnomAD
rs745531246 CA2837248	197	V>I		No	ClinGen ExAC gnomAD
CA2837246 rs770452762	199	A>G		No	ClinGen ExAC gnomAD
rs780608958 CA2837247	199	A>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	203	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	204	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2837244 rs148566004	207	Q>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1189462087 CA356163665	207	Q>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1354523900 CA356163367	208	E>K		No	ClinGen gnomAD
CA91768871 rs1040712735	209	Q>R		No	ClinGen TOPMed
CA2837219 rs757287386	210	K>T		No	ClinGen ExAC gnomAD
CA356163342 rs751597431	211	R>L		No	ClinGen ExAC TOPMed gnomAD
rs751597431 CA2837218	211	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs943976253 CA91768847	213	L>V		No	ClinGen Ensembl
COSM587831 CA2837217 rs146352571	215	M>I	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA356163317 rs1173251909	215	M>R		No	ClinGen TOPMed gnomAD
CA356163312 rs1480329725	216	G>S		No	ClinGen TOPMed
COSM1202302 rs142255876 CA2837215	218	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1183227411 CA356163284	221	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1279085177 CA356163232	227	R>G		No	ClinGen gnomAD
TCGA novel	227	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA356163212 rs1313390721	228	P>L		No	ClinGen gnomAD
rs766002544 CA2837211	228	P>S		No	ClinGen ExAC gnomAD
rs1577773980 CA356163188	230	E>G		No	ClinGen Ensembl
rs866170289 CA356163059	235	A>S		No	ClinGen gnomAD
CA91766704 rs866170289	235	A>T		No	ClinGen gnomAD
COSM1202301 CA2837177 rs755012630	238	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs753690772 CA2837176	239	A>T		No	ClinGen ExAC gnomAD
CA356163028 rs1323883316	240	I>T		No	ClinGen gnomAD
CA2837175 rs138991048	241	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA2837173 rs750102720	243	A>G		No	ClinGen ExAC gnomAD
rs200099288 CA2837170	245	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA2837171 rs149255467	245	R>W		No	ClinGen ESP ExAC gnomAD
CA2837169 rs763505249	246	I>T		No	ClinGen ExAC gnomAD
CA91766565 rs895552524	247	N>I		No	ClinGen Ensembl
CA2837168 rs760128691	252	I>L		No	ClinGen ExAC gnomAD
CA2837167 rs776956058	253	T>A		No	ClinGen ExAC TOPMed gnomAD
rs1230574363 CA356162892	253	T>S		No	ClinGen gnomAD
CA91766536 rs377118826	257	S>N		No	ClinGen ESP TOPMed gnomAD
rs372823825 CA2837161 COSM3767925	262	D>N	liver [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs749266226 CA2837159 COSM1158297	263	I>V	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA356162745 rs1450790289 COSM1056405	265	A>T	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA2837157 rs755904586	266	L>V		No	ClinGen ExAC gnomAD
rs150121214 CA2837155	270	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA356162526 rs1442052171	274	V>D		No	ClinGen gnomAD
CA91764430 rs930409854	278	P>S		No	ClinGen gnomAD
rs930409854 CA356162499	278	P>T		No	ClinGen gnomAD
rs983344104 CA91764428	279	I>L		No	ClinGen TOPMed gnomAD
rs202144395 CA2837127	279	I>T		No	ClinGen 1000Genomes ExAC gnomAD
rs983344104 COSM3826040 CA356162494	279	I>V	breast [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA356162488 rs1228951393	280	A>S		No	ClinGen gnomAD
rs756727397 CA2837126	280	A>V		No	ClinGen ExAC gnomAD
CA356162480 rs1447103252	281	A>V		No	ClinGen gnomAD
CA2837124 rs768018968	285	T>N		No	ClinGen ExAC gnomAD
rs376257908 COSM1430381 CA2837122	286	D>N	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA356162447 rs1387322876	287	G>S		No	ClinGen gnomAD
TCGA novel	288	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2837121 rs764161441	288	T>N		No	ClinGen ExAC gnomAD
rs1414916505 CA356162437	289	H>N		No	ClinGen TOPMed gnomAD
CA2837119 rs775497450	289	H>R		No	ClinGen ExAC gnomAD
rs1238198804 CA356162421	291	W>R		No	ClinGen gnomAD
rs939261116 CA91764353	292	S>N		No	ClinGen gnomAD
rs939261116 CA91764352	292	S>T		No	ClinGen gnomAD
rs745855014 CA2837117	296	A>G		No	ClinGen ExAC gnomAD
rs1396151256 CA356162365	298	A>G		No	ClinGen TOPMed
rs1247467022 CA356162369	298	A>S		No	ClinGen TOPMed gnomAD
CA2837116 rs776501083	299	A>V		No	ClinGen ExAC gnomAD
rs746725914 CA2837114	300	A>T		No	ClinGen ExAC gnomAD
CA2837113 rs777612271	301	F>S		No	ClinGen ExAC gnomAD
rs371645916 CA2837111	302	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA2837109 rs754492184	304	S>F		No	ClinGen ExAC
CA356162318 rs1022120190	307	L>M		No	ClinGen TOPMed gnomAD
CA2837105 rs367815553	309	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA91764214 rs367815553	309	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA2837106 rs757651187	309	P>T		No	ClinGen ExAC gnomAD
rs1165412291 CA356162295	310	D>E		No	ClinGen gnomAD
CA91764174 rs956794431	311	P>L		No	ClinGen Ensembl
CA2837103 rs763122399	311	P>S		No	ClinGen ExAC gnomAD
rs775667649 CA2837102	312	T>I		No	ClinGen ExAC gnomAD
CA356162288 rs1189284180	312	T>S		No	ClinGen gnomAD
rs1041659079 CA91764165	313	T>M		No	ClinGen TOPMed gnomAD
rs1553904184 CA356162275	314	P>L		No	ClinGen Ensembl
CA356162278 rs1451922060	314	P>S		No	ClinGen gnomAD
rs1340998808 CA356162269	315	D>E		No	ClinGen gnomAD
rs577291213 CA2837099	315	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA356162263 rs1463723821	316	Y>C		No	ClinGen TOPMed
TCGA novel	317	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs373607371 CA2837098	318	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs771881348 CA2837095	320	L>I		No	ClinGen ExAC TOPMed gnomAD
rs771881348 CA2837096	320	L>V		No	ClinGen ExAC TOPMed gnomAD
CA2837094 rs372231548	322	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA356162227 rs1436361640	323	C>R		No	ClinGen gnomAD
CA356162193 rs1577759576	325	D>N		No	ClinGen Ensembl
CA91760885 rs566109918	327	Q>E		No	ClinGen 1000Genomes
CA2837075 rs768478598	327	Q>H		No	ClinGen ExAC gnomAD
CA356162137 rs1204131300	329	T>I		No	ClinGen TOPMed
CA2837073 rs374326359	332	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs769323304 CA2837072	334	C>S		No	ClinGen ExAC gnomAD
rs183322981 CA2837071	335	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs371310830 CA2837069	342	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA91760836 rs923554051	343	V>M		No	ClinGen TOPMed
CA356161933 rs1184127237	346	D>E		No	ClinGen TOPMed gnomAD
CA2837067 rs779247738	346	D>H		No	ClinGen ExAC
rs1482068781 CA356161899	349	T>I		No	ClinGen TOPMed gnomAD
TCGA novel	350	L>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA91760824 rs904384968	350	L>V		No	ClinGen Ensembl
CA356161882 rs1210139716	351	I>F		No	ClinGen gnomAD
rs1560491682 CA917119947	353	E>*		No	ClinGen Ensembl
rs1299174133 CA356161861	353	E>K		No	ClinGen gnomAD
rs1265502252 CA356161845	354	G>S		No	ClinGen gnomAD
rs750337007 CA2837062	355	V>I		No	ClinGen ExAC gnomAD
CA2837061 rs141437952	356	N>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1292984800 CA356161781	360	E>K		No	ClinGen TOPMed
rs1449890270 CA356161722	364	V>A		No	ClinGen gnomAD
rs370480340 CA2837055	364	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
rs533613606 CA2837053	365	V>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs969134569 CA91760721	365	V>G		No	ClinGen TOPMed
rs533613606 CA2837052	365	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA2837051 COSM215949 rs748624496	367	D>E	NS [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1456611479 CA356161661 COSM1310164	369	A>V	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1475945513 CA356161497	372	T>A		No	ClinGen TOPMed
CA356161425 TCGA novel rs1577757667	375	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen Ensembl
rs968396021 CA91759893	379	Q>H		No	ClinGen Ensembl
CA2837025 rs781379290	383	V>L		No	ClinGen ExAC gnomAD
rs1398712578 CA356161229	386	T>S		No	ClinGen TOPMed
rs757361313 CA2837024	387	N>S		No	ClinGen ExAC TOPMed gnomAD
CA356161090 rs751577654	393	N>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	396	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2837022 rs377414609	400	R>W		No	ClinGen ESP ExAC gnomAD
CA356160931 rs1167603120	402	A>V		No	ClinGen gnomAD
CA91759835 rs752604466	403	V>L		No	ClinGen ExAC TOPMed gnomAD
CA2837020 rs752604466	403	V>M	Variant assessed as Somatic; 0.0001389 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs373011172 CA2837019	404	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1196194107 CA356160905	404	G>S		No	ClinGen gnomAD
rs201899333 CA91759827	406	D>H		No	ClinGen Ensembl
rs1490946697 CA356160852	408	D>N		No	ClinGen gnomAD
rs780275060 CA2837016	409	V>M		No	ClinGen ExAC gnomAD
CA356160754 rs1577757407	413	D>A		No	ClinGen Ensembl
CA2837014 rs774857712	413	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
COSM140477 CA356160737 rs1198872212	414	P>L	skin [Cosmic]	No	ClinGen cosmic curated TOPMed
CA356160740 rs1484267481	414	P>S		No	ClinGen TOPMed
CA2837011 rs190668040 CA356160718	415	D>E		No	ClinGen ExAC TOPMed gnomAD
CA2837012 COSM1202308 rs145169573	415	D>N	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs1229641982 CA356160709	416	K>E		No	ClinGen gnomAD
CA2837009 rs373390925	416	K>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA2837008 rs781523712	416	K>N		No	ClinGen ExAC gnomAD
rs373390925 CA2837010	416	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1464078195 CA356160673	418	K>R		No	ClinGen TOPMed
rs1577757288 CA356160664	419	T>P		No	ClinGen Ensembl
CA356160644 rs1398260336	420	I>M		No	ClinGen gnomAD
CA91759710 rs946483184	420	I>V		No	ClinGen TOPMed gnomAD
CA356160642 rs1170295177	421	T>A		No	ClinGen gnomAD
CA2837005 rs777996781 COSM1056400	422	A>T	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA2837004 COSM447985 rs758401728	427	S>L	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs768870212 COSM1486024 CA2836976	428	A>V	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1577739920 CA356159881	429	V>G		No	ClinGen Ensembl
rs879192554 CA91752779	430	E>G		No	ClinGen Ensembl
rs760073922 CA2836974	430	E>Q		No	ClinGen ExAC gnomAD
CA91752774 rs879187715	431	Y>D		No	ClinGen Ensembl
rs1490054464 CA356159770	436	G>D		No	ClinGen gnomAD
CA356159736 rs1560484043	438	E>G		No	ClinGen Ensembl
rs112079786 CA91752759	439	C>R		No	ClinGen Ensembl
rs139579016 CA2836970	442	S>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA91752730 rs974371024	445	V>L		No	ClinGen Ensembl
CA356159610 rs1386173274	446	V>A		No	ClinGen gnomAD
CA356159519 rs1463611994	451	K>N		No	ClinGen gnomAD
CA356159534 rs1185424448	451	K>Q		No	ClinGen TOPMed gnomAD
CA2836966 rs768538875 COSM1430378	453	V>I	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs146365732 CA2836965	456	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA356159461 rs1287440264	457	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA356159444 rs1377581652	459	I>N		No	ClinGen TOPMed
CA2836963 rs755857404	460	N>D		No	ClinGen ExAC gnomAD
rs745552877 CA2836962	460	N>S		No	ClinGen ExAC gnomAD
rs34611001 CA2836960 VAR_037745	461	V>I		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
TCGA novel	462	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751088487 CA2836959	463	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1024707261 CA91752648	463	K>R		No	ClinGen TOPMed
CA2836956 rs754346969	465	M>I		No	ClinGen ExAC gnomAD
CA2836957 rs755590414	465	M>T		No	ClinGen ExAC gnomAD
rs140124818 CA2836958	465	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs146163071 CA2836955	467	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA356159393 rs1405146741	467	R>H		No	ClinGen gnomAD
rs370759908 CA2836953	470	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs370759908 CA356159375	470	P>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs201976585 COSM239442 CA2836954	470	P>S	Variant assessed as Somatic; 0.0 impact. prostate breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs768763171 CA2836950	471	R>L		No	ClinGen ExAC TOPMed gnomAD
CA2836949 rs768763171	471	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA2836951 COSM3428575 rs762086490	471	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA2836948 rs141992841	473	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs775369390 COSM88528 CA2836947	473	A>V	ovary [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA356159359 rs1392466253	474	F>I		No	ClinGen TOPMed
CA91752572 rs911222014	475	P>L		No	ClinGen TOPMed
CA2836945 rs745605874	476	E>D		No	ClinGen ExAC gnomAD
CA356159328 rs1202554559	478	L>P		No	ClinGen gnomAD
TCGA novel	479	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA91752567 rs757384732 COSM1056397	481	R>C	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA356159308 rs1577739143	481	R>H		No	ClinGen Ensembl
rs149485730 CA2836941	482	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs757940391 CA2836940	484	I>M		No	ClinGen ExAC TOPMed gnomAD
CA2836939 rs754399880	485	R>K		No	ClinGen ExAC gnomAD
rs1346575481 CA356159276	486	N>T		No	ClinGen gnomAD
rs1051203638 CA91752550	487	K>E		No	ClinGen Ensembl
CA356159062 rs1307924337	489	F>L		No	ClinGen TOPMed gnomAD
CA2836902 rs771914486	490	G>E		No	ClinGen ExAC TOPMed gnomAD
rs1453483067 CA356159042	492	Q>K		No	ClinGen gnomAD
rs867650926 CA91749063	493	G>E		No	ClinGen Ensembl
CA91749086 rs369274794 CA2836900	493	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	495	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2836898 rs746396887	497	G>S		No	ClinGen ExAC gnomAD
rs1175997520 CA356159007	498	M>V		No	ClinGen TOPMed
rs1185018252 CA356158981	501	G>R		No	ClinGen TOPMed
rs1185018252 CA356158982	501	G>S		No	ClinGen TOPMed
CA2836896 rs757578843	503	V>M		No	ClinGen ExAC TOPMed gnomAD
rs747466792 CA2836895	505	E>K		No	ClinGen ExAC
CA356158950 rs1445936137	506	V>I		No	ClinGen gnomAD
CA2836894 rs778108731	507	P>L		No	ClinGen ExAC gnomAD
TCGA novel	508	A>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs375021309 CA2836893	508	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs1356077431 CA356158930	509	T>K		No	ClinGen TOPMed
rs1218470184 CA356158924	510	P>L		No	ClinGen gnomAD
CA2836892 rs372770633	510	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1314650407 CA356158902	513	A>V		No	ClinGen gnomAD
CA356158901 rs1246743523	514	T>A		No	ClinGen gnomAD
rs1246743523 CA356158900	514	T>P		No	ClinGen gnomAD
TCGA novel	514	T>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1295548718 CA356158888	516	A>P		No	ClinGen gnomAD
rs1295548718 CA356158889	516	A>T		No	ClinGen gnomAD
rs865879939 CA91749012	518	S>L		No	ClinGen Ensembl
CA2836888 rs766395790	519	A>T		No	ClinGen ExAC gnomAD
rs1456201616 CA356158866	520	K>E		No	ClinGen gnomAD
CA2836886 rs187171314 COSM179306	522	S>L	Variant assessed as Somatic; 4.674e-05 impact. large_intestine breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	523	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA91748959 rs931871133	525	K>Q		No	ClinGen Ensembl
rs761583442 CA356158829	526	H>N		No	ClinGen ExAC TOPMed gnomAD
rs761583442 CA2836884	526	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs182480399 CA2836882	528	P>R		No	ClinGen 1000Genomes ExAC gnomAD
CA356158807 rs1309653303	529	P>S		No	ClinGen TOPMed
CA2836880 rs532397289	530	P>L		No	ClinGen 1000Genomes ExAC gnomAD
rs1487724776 CA356158801	530	P>S		No	ClinGen gnomAD
rs771536060 CA2836879	531	I>V		No	ClinGen ExAC TOPMed gnomAD
CA2836877 rs778160054	540	S>R		No	ClinGen ExAC TOPMed gnomAD
rs758722114 CA2836876	540	S>T		No	ClinGen ExAC gnomAD
CA356158721 COSM1567295 rs1205078406	541	L>F	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA356158699 rs1471137174	543	G>D		No	ClinGen gnomAD
rs1384815460 CA356158713	543	G>R		No	ClinGen gnomAD
TCGA novel	543	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA356158690 rs1158398166	545	Q>*		No	ClinGen gnomAD
CA2836835 rs146955659	546	I>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2836833 rs746005692	546	I>M		No	ClinGen ExAC gnomAD
CA356158679 rs770010840	546	I>R		No	ClinGen ExAC gnomAD
CA2836834 rs770010840	546	I>T		No	ClinGen ExAC gnomAD
CA2836832 rs781419836	548	D>Y		No	ClinGen ExAC gnomAD
CA2836831 rs757302329	549	N>D		No	ClinGen ExAC TOPMed gnomAD
CA2836829 rs777646783	549	N>K		No	ClinGen ExAC gnomAD
CA2836828 rs758089833	550	N>H		No	ClinGen ExAC gnomAD
rs764855735 CA2836825	552	R>G		No	ClinGen ExAC TOPMed gnomAD
CA356158643 rs1282080513	552	R>K		No	ClinGen gnomAD
COSM1056396 rs1244536819 CA356158636	553	R>C	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
CA2836824 rs759182182	553	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA356158631 rs1577708921	554	T>P		No	ClinGen Ensembl
CA2836822 rs765849718	555	G>S		No	ClinGen ExAC TOPMed gnomAD
rs769065864 CA2836819	557	R>C		No	ClinGen ExAC gnomAD
rs910781348 CA91740243 COSM1056395	557	R>H	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs769065864 CA2836820	557	R>S		No	ClinGen ExAC gnomAD
rs1387354245 CA356158571	561	P>A		No	ClinGen gnomAD
CA91740215 rs987501889	563	G>S		No	ClinGen TOPMed
rs1161942169	563	G>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA356158526 rs1243731668	565	R>C		No	ClinGen TOPMed
CA356158524 rs1385918607	565	R>H		No	ClinGen gnomAD
rs770211777 CA2836816	566	S>C		No	ClinGen ExAC gnomAD
rs1577708605 CA356158477	569	T>P		No	ClinGen Ensembl
rs776901530 CA2836814	570	S>G		No	ClinGen ExAC TOPMed gnomAD
CA2836815 rs776901530	570	S>R		No	ClinGen ExAC TOPMed gnomAD
rs771086650 CA2836812	572	G>S		No	ClinGen ExAC gnomAD

No associated diseases with Q14194

1 regional properties for Q14194

Type	Name	Position	InterPro Accession
domain	Amidohydrolase-related	64 - 453	IPR006680

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Cell projection, growth cone Cytoplasm, cytoskeleton Perikaryon	Associated with centrosomes and the mitotic spindle during metaphase (PubMed:11562390) Colocalizes with FLNA and tubulin in the central region of DRG neuron growth cone (By similarity) Following SEMA3A stimulation of DRG neurons, colocalizes with F-actin (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
centrosome	A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
growth cone	The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
midbody	A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
perikaryon	The portion of the cell soma (neuronal cell body) that excludes the nucleus.
spindle	The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

3 GO annotations of molecular function

Name	Definition
filamin binding	Binding to a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain.
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.
identical protein binding	Binding to an identical protein or proteins.

6 GO annotations of biological process

Name	Definition
axon guidance	The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
microtubule cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
negative regulation of actin filament binding	Any process that stops, prevents or reduces the frequency, rate or extent of actin filament binding.
negative regulation of neuron projection development	Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
nervous system development	The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
nucleobase-containing compound metabolic process	Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.

10 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q90635	DPYSL2	Dihydropyrimidinase-related protein 2	Gallus gallus (Chicken)	PR
Q14195	DPYSL3	Dihydropyrimidinase-related protein 3	Homo sapiens (Human)	PR
Q16555	DPYSL2	Dihydropyrimidinase-related protein 2	Homo sapiens (Human)	PR
O08553	Dpysl2	Dihydropyrimidinase-related protein 2	Mus musculus (Mouse)	PR
Q62188	Dpysl3	Dihydropyrimidinase-related protein 3	Mus musculus (Mouse)	PR
P97427	Crmp1	Dihydropyrimidinase-related protein 1	Mus musculus (Mouse)	PR
P47942	Dpysl2	Dihydropyrimidinase-related protein 2	Rattus norvegicus (Rat)	PR
Q62952	Dpysl3	Dihydropyrimidinase-related protein 3	Rattus norvegicus (Rat)	PR
Q9FMP3	PYD2	Dihydropyrimidinase	Arabidopsis thaliana (Mouse-ear cress)	PR
Q6GL72	dpysl3	Dihydropyrimidinase-related protein 3	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR

10	20	30	40	50	60
MSYQGKKSIP	HITSDRLLIK	GGRIINDDQS	LYADVYLEDG	LIKQIGENLI	VPGGVKTIEA
70	80	90	100	110	120
NGRMVIPGGI	DVNTYLQKPS	QGMTAADDFF	QGTRAALVGG	TTMIIDHVVP	EPGSSLLTSF
130	140	150	160	170	180
EKWHEAADTK	SCCDYSLHVD	ITSWYDGVRE	ELEVLVQDKG	VNSFQVYMAY	KDVYQMSDSQ
190	200	210	220	230	240
LYEAFTFLKG	LGAVILVHAE	NGDLIAQEQK	RILEMGITGP	EGHALSRPEE	LEAEAVFRAI
250	260	270	280	290	300
TIAGRINCPV	YITKVMSKSA	ADIIALARKK	GPLVFGEPIA	ASLGTDGTHY	WSKNWAKAAA
310	320	330	340	350	360
FVTSPPLSPD	PTTPDYLTSL	LACGDLQVTG	SGHCPYSTAQ	KAVGKDNFTL	IPEGVNGIEE
370	380	390	400	410	420
RMTVVWDKAV	ATGKMDENQF	VAVTSTNAAK	IFNLYPRKGR	IAVGSDADVV	IWDPDKLKTI
430	440	450	460	470	480
TAKSHKSAVE	YNIFEGMECH	GSPLVVISQG	KIVFEDGNIN	VNKGMGRFIP	RKAFPEHLYQ
490	500	510	520	530	540
RVKIRNKVFG	LQGVSRGMYD	GPVYEVPATP	KYATPAPSAK	SSPSKHQPPP	IRNLHQSNFS
550	560	570
LSGAQIDDNN	PRRTGHRIVA	PPGGRSNITS	LG