Q6GL72
Gene name |
dpysl3 |
Protein name |
Dihydropyrimidinase-related protein 3 |
Names |
DRP-3, Dihydropyrimidinase-like 3 |
Species |
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
KEGG Pathway |
xtr:448103 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6GL72
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6GL72-F1 | Predicted | AlphaFoldDB |
No variants for Q6GL72
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6GL72 | |||||
No associated diseases with Q6GL72
1 regional properties for Q6GL72
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Amidohydrolase-related | 64 - 453 | IPR006680 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| growth cone | The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| actin crosslink formation | The process in which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes. |
| actin filament bundle assembly | The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. |
| positive regulation of filopodium assembly | Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. |
| regulation of cell migration | Any process that modulates the frequency, rate or extent of cell migration. |
| regulation of neuron projection development | Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
| response to axon injury | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q90635 | DPYSL2 | Dihydropyrimidinase-related protein 2 | Gallus gallus (Chicken) | PR |
| Q16555 | DPYSL2 | Dihydropyrimidinase-related protein 2 | Homo sapiens (Human) | PR |
| Q14194 | CRMP1 | Dihydropyrimidinase-related protein 1 | Homo sapiens (Human) | PR |
| Q14195 | DPYSL3 | Dihydropyrimidinase-related protein 3 | Homo sapiens (Human) | PR |
| O08553 | Dpysl2 | Dihydropyrimidinase-related protein 2 | Mus musculus (Mouse) | PR |
| P97427 | Crmp1 | Dihydropyrimidinase-related protein 1 | Mus musculus (Mouse) | PR |
| Q62188 | Dpysl3 | Dihydropyrimidinase-related protein 3 | Mus musculus (Mouse) | PR |
| P47942 | Dpysl2 | Dihydropyrimidinase-related protein 2 | Rattus norvegicus (Rat) | PR |
| Q62952 | Dpysl3 | Dihydropyrimidinase-related protein 3 | Rattus norvegicus (Rat) | PR |
| Q9FMP3 | PYD2 | Dihydropyrimidinase | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSYQGKKNIP | RITSDRLLIK | GGRIVNDDQS | FYADIYMEDG | LIKQIGDNLI | VPGGVKTIEA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NGKMVIPGGI | DVHTHLQMPY | RGMTTVDDFF | QGTKAALAGG | TTMIVDHVIP | EPEASLTEAF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EKWREWADGK | TCCDYSLHVD | ITHWNDSVKQ | EVEALVKQKG | VNSFMVYMAY | KDLYQMSNTE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LYEVFTFLGG | LGAIAQVHAE | NGDIIAQEQN | RMLELGITGP | EGHVLSRPEE | LEAEAVFRAI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TIASQTNCPL | YVTKVMSKSS | VDLISQARKK | GYVVFGEPIT | ASLGTDGTHY | WSKNWAKAAA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FVTSPPLSPD | PTTPDYINSL | LASGDLQVTG | SAHATFSTAQ | KAIGKDNFTL | IPEGTNGIEE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RMSVIWDKAV | ATGKMDENQF | VAVTSTNAAK | IFNLYPRKGR | IAVGSDSDLV | IWDPDAVKIV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SAKSHHSAAE | YNIFEGMELR | GAPLVVICQG | KIMMEDGTLH | VTQGTGRFIP | CSPFPDYVYK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RIKARTKMAE | LHAVPRGMYD | GPVYDLASTP | KAGTPAGSTK | GSPTKQTAPV | RNLHHSGFSL |
| 550 | 560 | 570 | |||
| AGNQGDESGV | RSASRRIVAP | PGGRSNITSL | S |