Q8VZH2
PR
Gene name |
APM1 (At4g33090, F4I10_20) |
Protein name |
Aminopeptidase M1 |
Names |
Alpha-aminoacylpeptide hydrolase |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G33090 |
EC number |
3.4.11.2: Aminopeptidases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8VZH2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8VZH2-F1 | Predicted | AlphaFoldDB |
53 variants for Q8VZH2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH06816404 | 12 | K>N | No | 1000Genomes | |
| ENSVATH06816403 | 33 | T>I | No | 1000Genomes | |
| tmp_4_15970310_C_T | 37 | A>T | No | 1000Genomes | |
| ENSVATH06816402 | 39 | D>H | No | 1000Genomes | |
| tmp_4_15970303_T_A | 39 | D>V | No | 1000Genomes | |
| tmp_4_15970288_G_T | 44 | A>D | No | 1000Genomes | |
| ENSVATH12363123 | 70 | S>Y | No | 1000Genomes | |
| ENSVATH06816399 | 72 | K>M | No | 1000Genomes | |
| ENSVATH06816399 | 72 | K>T | No | 1000Genomes | |
| tmp_4_15969777_T_A | 108 | N>Y | No | 1000Genomes | |
| ENSVATH14330039 | 109 | G>R | No | 1000Genomes | |
| ENSVATH06816392 | 125 | H>N | No | 1000Genomes | |
| ENSVATH06816391 | 126 | N>H | No | 1000Genomes | |
| ENSVATH06816390 | 131 | N>K | No | 1000Genomes | |
| tmp_4_15969414_T_A | 162 | L>F | No | 1000Genomes | |
| tmp_4_15969368_C_T | 178 | E>K | No | 1000Genomes | |
| ENSVATH06816386 | 180 | K>N | No | 1000Genomes | |
| tmp_4_15969169_C_T | 218 | G>E | No | 1000Genomes | |
| tmp_4_15969152_A_G | 224 | Y>H | No | 1000Genomes | |
| tmp_4_15968715_C_T | 306 | A>T | No | 1000Genomes | |
| ENSVATH12363041 | 344 | L>M | No | 1000Genomes | |
| tmp_4_15968204_A_C | 410 | V>G | No | 1000Genomes | |
| ENSVATH12363035 | 413 | K>N | No | 1000Genomes | |
| tmp_4_15968019_G_A | 425 | S>L | No | 1000Genomes | |
| tmp_4_15967984_C_G | 437 | E>Q | No | 1000Genomes | |
| tmp_4_15967977_C_T | 439 | G>E | No | 1000Genomes | |
| tmp_4_15967902_A_T | 464 | I>K | No | 1000Genomes | |
| ENSVATH06816359 | 527 | S>N | No | 1000Genomes | |
| ENSVATH06816358 | 530 | I>N | No | 1000Genomes | |
| tmp_4_15967530_C_T | 557 | A>T | No | 1000Genomes | |
| ENSVATH06816357 | 564 | E>D | No | 1000Genomes | |
| ENSVATH00549731 | 584 | T>S | No | 1000Genomes | |
| ENSVATH06816353 | 598 | C>F | No | 1000Genomes | |
| ENSVATH06816354 | 598 | C>S | No | 1000Genomes | |
| tmp_4_15967186_T_C | 616 | I>V | No | 1000Genomes | |
| tmp_4_15967175_T_G | 619 | K>N | No | 1000Genomes | |
| ENSVATH12362994 | 630 | E>* | No | 1000Genomes | |
| ENSVATH12362993 | 630 | E>V | No | 1000Genomes | |
| ENSVATH00549727 | 644 | Q>H | No | 1000Genomes | |
| tmp_4_15967101_T_G | 644 | Q>P | No | 1000Genomes | |
| tmp_4_15967096_C_T | 646 | A>T | No | 1000Genomes | |
| tmp_4_15966895_T_C | 681 | T>A | No | 1000Genomes | |
| tmp_4_15966853_C_G | 695 | D>H | No | 1000Genomes | |
| ENSVATH00549725 | 718 | N>K | Number of days following stratification to opening of first flower. the experiment was stopped at 200 d and accessions that had not flowered at that point were assigned a value of 200 [18c with 16 hrs daylight and vernalized (5 wks at 4c)] Plants were checked bi-weekly for presence of first buds and the average flowering time of 4 plants of the same accession were collected [10c and 16 hrs daylight] Number of days following stratification to opening of first flower. the experiment was stopped at 200 d and accessions that had not flowered at that point were assigned a value of 200 [18c and 16 hrs daylight] Number of days following stratification to opening of first flower. the experiment was stopped at 200 d and accessions that had not flowered at that point were assigned a value of 200 [18c and 8 hrs daylight] Plants were checked bi-weekly for presence of first buds and the average flowering time of 4 plants of the same accession were collected [22c and 16 hrs daylight] Plants were checked bi-weekly for presence of first buds and the average flowering time of 4 plants of the same accession were collected [16c and 16 hrs daylight] Number of days required for the bolt height to reach 5cm [23c and 16hrs daylight. vernalized for 8 wks at 5c and 8hrs daylight] Flowering time was scored as the number of days between germination date and appearance of the first flower [growth in field with natural light and started in october] Number of days required for the bolt height to reach 5cm [23c and 16hrs daylight. vernalized for 2 wks at 5c and 8hrs daylight] Flowering time was scored as the number of days for the bolt to reach 5cm [20-22c and natural light from the middle of october 2002 till march 2003] Plants were checked bi-weekly for presence of first buds and the average leaf number at flowering time of 4 plants of the same accession were collected [22c and 16 hrs daylight] [EnsemblGenome] | No | 1000Genomes |
| ENSVATH06816343 | 754 | P>L | No | 1000Genomes | |
| ENSVATH12362959 | 757 | V>D | No | 1000Genomes | |
| tmp_4_15966478_C_A | 759 | D>Y | No | 1000Genomes | |
| tmp_4_15966321_C_A | 777 | G>V | No | 1000Genomes | |
| ENSVATH06816342 | 820 | P>S | No | 1000Genomes | |
| ENSVATH12362927 | 824 | F>Y | No | 1000Genomes | |
| ENSVATH12362926 | 868 | N>T | No | 1000Genomes | |
| ENSVATH12362925 | 875 | Q>K | No | 1000Genomes | |
| tmp_4_15965929_G_A | 876 | L>F | No | 1000Genomes |
No associated diseases with Q8VZH2
Functions
| Description | ||
|---|---|---|
| EC Number | 3.4.11.2 | Aminopeptidases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| aminopeptidase activity | Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain. |
| metalloaminopeptidase activity | Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
| N-1-naphthylphthalamic acid binding | Binding to N-1-naphthylphthalamic acid, an auxin transport inhibitor. |
| peptide binding | Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds. |
| zinc ion binding | Binding to a zinc ion (Zn). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| auxin polar transport | The unidirectional movement of auxin in the stem from tip to base along the vector of gravity or basipetally. |
| peptide catabolic process | The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. |
| proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
23 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P40462 | TMA108 | Protein TMA108 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P32454 | APE2 | Aminopeptidase 2, mitochondrial | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P79171 | ANPEP | Aminopeptidase N | Felis catus (Cat) (Felis silvestris catus) | PR |
| P15144 | ANPEP | Aminopeptidase N | Homo sapiens (Human) | PR |
| Q9UKU6 | TRHDE | Thyrotropin-releasing hormone-degrading ectoenzyme | Homo sapiens (Human) | PR |
| Q9UIQ6 | LNPEP | Leucyl-cystinyl aminopeptidase | Homo sapiens (Human) | PR |
| Q9NZ08 | ERAP1 | Endoplasmic reticulum aminopeptidase 1 | Homo sapiens (Human) | PR |
| P55786 | NPEPPS | Puromycin-sensitive aminopeptidase | Homo sapiens (Human) | PR |
| A6NEC2 | NPEPPSL1 | Puromycin-sensitive aminopeptidase-like protein | Homo sapiens (Human) | PR |
| P97449 | Anpep | Aminopeptidase N | Mus musculus (Mouse) | PR |
| Q11011 | Npepps | Puromycin-sensitive aminopeptidase | Mus musculus (Mouse) | PR |
| Q8C129 | Lnpep | Leucyl-cystinyl aminopeptidase | Mus musculus (Mouse) | PR |
| Q8K093 | Trhde | Thyrotropin-releasing hormone-degrading ectoenzyme | Mus musculus (Mouse) | PR |
| Q9EQH2 | Erap1 | Endoplasmic reticulum aminopeptidase 1 | Mus musculus (Mouse) | PR |
| P15145 | ANPEP | Aminopeptidase N | Sus scrofa (Pig) | PR |
| P15684 | Anpep | Aminopeptidase N | Rattus norvegicus (Rat) | PR |
| P97629 | Lnpep | Leucyl-cystinyl aminopeptidase | Rattus norvegicus (Rat) | PR |
| Q9JJ22 | Erap1 | Endoplasmic reticulum aminopeptidase 1 | Rattus norvegicus (Rat) | PR |
| Q10836 | Trhde | Thyrotropin-releasing hormone-degrading ectoenzyme | Rattus norvegicus (Rat) | PR |
| Q0J5V5 | Os08g0398700 | Aminopeptidase M1-B | Oryza sativa subsp japonica (Rice) | PR |
| Q6Z6L4 | Os02g0218200 | Aminopeptidase M1-A | Oryza sativa subsp japonica (Rice) | PR |
| Q6K4E7 | Os09g0362800 | Aminopeptidase M1-D | Oryza sativa subsp japonica (Rice) | PR |
| Q17405 | AC3.5 | Aminopeptidase-like protein AC3.5 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDQFKGEPRL | PKFAVPKRYD | LRLNPDLIAC | TFTGTVAIDL | DIVADTRFIV | LNAADLSVND |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ASVSFTPPSS | SKALAAPKVV | LFEEDEILVL | EFGEILPHGV | GVLKLGFNGV | LNDKMKGFYR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| STYEHNGEKK | NMAVTQFEPA | DARRCFPCWD | EPACKATFKI | TLEVPTDLVA | LSNMPIMEEK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VNGNLKIVSY | QESPIMSTYL | VAIVVGLFDY | VEDHTSDGIK | VRVYCQVGKA | DQGKFALHVG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AKTLDLFKEY | FAVPYPLPKM | DMIAIPDFAA | GAMENYGLVT | YRETALLYDE | QHSAASNKQR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VATVVAHELA | HQWFGNLVTM | EWWTHLWLNE | GFATWVSYLA | TDSLFPEWKI | WTQFLDESTE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GLRLDGLEES | HPIEVEVNHA | AEIDEIFDAI | SYRKGASVIR | MLQSYLGAEV | FQKSLAAYIK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NHAYSNAKTE | DLWAALEAGS | GEPVNKLMSS | WTKQKGYPVV | SAKIKDGKLE | LEQSRFLSSG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SPGEGQWIVP | VTLCCGSYEK | RKNFLLESKS | GAYDLKELLG | CSIADGSDKI | NGTCSWIKIN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VDQAGFYRVK | YDDSLAAGLR | NATESQSLTS | IDRYGILDDS | FALTMARQQS | LASLLTLCSA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| YKKELDYTVL | SNLIAISYKV | VKIGADANQE | LMSGIKHFFI | GVFQFAAGKL | GWDPKQGESH |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LDAMLRGEVL | TALAVFGHDE | TLKEAVRRFD | AFLADRNTPL | LPPDIRRAAY | VAVMQRANKS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| DKSGYESLLR | VYRETDLSQE | KTRILGSLAS | CPDPTIVQDV | LNFVLSDEVR | NQDALYGLSG |
| 790 | 800 | 810 | 820 | 830 | 840 |
| VSWEGREVAW | KWLQEKWEYI | GNTWGSGFLI | TRFISAVVSP | FASFEKAKEV | EEFFATRSKP |
| 850 | 860 | 870 | |||
| SMARTLKQSI | ERVHINANWV | ESIKKEDNLT | QLVAQLSSN |