P32454
PR
Gene name |
APE2 (LAP1, YKL157W, YKL158W, YKL611, YKL612) |
Protein name |
Aminopeptidase 2, mitochondrial |
Names |
AP-II, Aminopeptidase II, YscII |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YKL157W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P32454
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P32454-F1 | Predicted | AlphaFoldDB |
12 variants for P32454
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s11-155002 | 3 | I>V | No | SGRP | |
| s11-155028 | 11 | S>R | No | SGRP | |
| s11-155160 | 55 | M>I | No | SGRP | |
| s11-155190 | 65 | R>S | No | SGRP | |
| s11-155672 | 98 | N>K | No | SGRP | |
| s11-155824 | 149 | T>I | No | SGRP | |
| s11-155880 | 168 | E>K | No | SGRP | |
| s11-156735 | 453 | S>G | No | SGRP | |
| s11-156977 | 533 | D>E | No | SGRP | |
| s11-157354 | 659 | L>Q | No | SGRP | |
| s11-158097 | 907 | K>Q | No | SGRP | |
| s11-158234 | 952 | Y>F | No | SGRP |
No associated diseases with P32454
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell wall-bounded periplasmic space | The region between the plasma membrane and the cell wall in organisms lacking an outer cell membrane such as yeast and Gram positive bacteria. The region is thinner than the equivalent in Gram negative bacteria. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| metalloaminopeptidase activity | Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
| peptide binding | Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds. |
| zinc ion binding | Binding to a zinc ion (Zn). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| peptide catabolic process | The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. |
| proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
22 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P40462 | TMA108 | Protein TMA108 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P79171 | ANPEP | Aminopeptidase N | Felis catus (Cat) (Felis silvestris catus) | PR |
| Q9UKU6 | TRHDE | Thyrotropin-releasing hormone-degrading ectoenzyme | Homo sapiens (Human) | PR |
| P15144 | ANPEP | Aminopeptidase N | Homo sapiens (Human) | PR |
| Q9UIQ6 | LNPEP | Leucyl-cystinyl aminopeptidase | Homo sapiens (Human) | PR |
| Q9NZ08 | ERAP1 | Endoplasmic reticulum aminopeptidase 1 | Homo sapiens (Human) | PR |
| P55786 | NPEPPS | Puromycin-sensitive aminopeptidase | Homo sapiens (Human) | PR |
| Q8K093 | Trhde | Thyrotropin-releasing hormone-degrading ectoenzyme | Mus musculus (Mouse) | PR |
| P97449 | Anpep | Aminopeptidase N | Mus musculus (Mouse) | PR |
| Q8C129 | Lnpep | Leucyl-cystinyl aminopeptidase | Mus musculus (Mouse) | PR |
| Q9EQH2 | Erap1 | Endoplasmic reticulum aminopeptidase 1 | Mus musculus (Mouse) | PR |
| Q11011 | Npepps | Puromycin-sensitive aminopeptidase | Mus musculus (Mouse) | PR |
| P15145 | ANPEP | Aminopeptidase N | Sus scrofa (Pig) | PR |
| Q10836 | Trhde | Thyrotropin-releasing hormone-degrading ectoenzyme | Rattus norvegicus (Rat) | PR |
| P15684 | Anpep | Aminopeptidase N | Rattus norvegicus (Rat) | PR |
| P97629 | Lnpep | Leucyl-cystinyl aminopeptidase | Rattus norvegicus (Rat) | PR |
| Q9JJ22 | Erap1 | Endoplasmic reticulum aminopeptidase 1 | Rattus norvegicus (Rat) | PR |
| Q0J5V5 | Os08g0398700 | Aminopeptidase M1-B | Oryza sativa subsp japonica (Rice) | PR |
| Q6Z6L4 | Os02g0218200 | Aminopeptidase M1-A | Oryza sativa subsp japonica (Rice) | PR |
| Q6K4E7 | Os09g0362800 | Aminopeptidase M1-D | Oryza sativa subsp japonica (Rice) | PR |
| Q17405 | AC3.5 | Aminopeptidase-like protein AC3.5 | Caenorhabditis elegans | PR |
| Q8VZH2 | APM1 | Aminopeptidase M1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPIVRWLLLK | SAVRGSSLIG | KAHPCLRSIA | AHPRYLSNVY | SPPAGVSRSL | RINVMWKQSK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LTPPRFVKIM | NRRPLFTETS | HACAKCQKTS | QLLNKTPNRE | ILPDNVVPLH | YDLTVEPDFK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TFKFEGSVKI | ELKINNPAID | TVTLNTVDTD | IHSAKIGDVT | SSEIISEEEQ | QVTTFAFPKG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TMSSFKGNAF | LDIKFTGILN | DNMAGFYRAK | YEDKLTGETK | YMATTQMEPT | DARRAFPCFD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EPNLKASFAI | TLVSDPSLTH | LSNMDVKNEY | VKDGKKVTLF | NTTPKMSTYL | VAFIVAELKY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VESKNFRIPV | RVYATPGNEK | HGQFAADLTA | KTLAFFEKTF | GIQYPLPKMD | NVAVHEFSAG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AMENWGLVTY | RVVDLLLDKD | NSTLDRIQRV | AEVVQHELAH | QWFGNLVTMD | WWEGLWLNEG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FATWMSWYSC | NEFQPEWKVW | EQYVTDTLQH | ALSLDSLRSS | HPIEVPVKKA | DEINQIFDAI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SYSKGASLLR | MISKWLGEET | FIKGVSQYLN | KFKYGNAKTE | DLWDALADAS | GKDVRSVMNI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| WTKKVGFPVI | SVSEDGNGKI | TFRQNRYLST | ADVKPDEDKT | IYPVFLALKT | KNGVDSSVVL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SERSKTIELE | DPTFFKVNSE | QSGIYITSYT | DERWAKLGQQ | ADLLSVEDRV | GLVADVKTLS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ASGYTSTTNF | LNLVSKWNNE | KSFVVWDQII | NSISSMKSTW | LFEPKETQDA | LDNFTKQLIS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GMTHHLGWEF | KSSDSFSTQR | LKVTMFGAAC | AARDADVEKA | ALKMFTDYCS | GNKEAIPALI |
| 790 | 800 | 810 | 820 | 830 | 840 |
| KPIVFNTVAR | VGGAENYEKV | YKIYLDPISN | DEKLAALRSL | GRFKEPKLLE | RTLGYLFDGT |
| 850 | 860 | 870 | 880 | 890 | 900 |
| VLNQDIYIPM | QGMRAHQEGV | EALWNWVKKN | WDELVKRLPP | GLSMLGSVVT | LGTSGFTSMQ |
| 910 | 920 | 930 | 940 | 950 | |
| KIDEIKKFFA | TKSTKGFDQS | LAQSLDTITS | KAQWVNRDRD | VVNKYLKENG | YY |