AiPD: Autoinhibited Protein Database

P55786

Gene name	NPEPPS (PSA)
Protein name	Puromycin-sensitive aminopeptidase
Names	PSA, Cytosol alanyl aminopeptidase, AAP-S
Species	Homo sapiens (Human)
KEGG Pathway	hsa:9520
EC number	3.4.11.14: Aminopeptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-82 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-82 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for P55786

Entry ID	Method	Resolution	Chain	Position	Source
8SW0	X-ray	230 A	A	46-919	PDB
8SW1	X-ray	365 A	A	46-919	PDB
AF-P55786-F1	Predicted				AlphaFoldDB

480 variants for P55786

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA400036026 rs1342141916	2	W>C		No	ClinGen gnomAD
CA400036040 rs1170436727	5	A>P		No	ClinGen TOPMed gnomAD
CA400036039 rs1170436727	5	A>T		No	ClinGen TOPMed gnomAD
rs774749702 CA8624526	6	A>P		No	ClinGen ExAC gnomAD
CA400036059 rs1443379208	8	P>H		No	ClinGen TOPMed gnomAD
CA400036061 rs1443379208	8	P>L		No	ClinGen TOPMed gnomAD
rs1443379208 CA400036060	8	P>R		No	ClinGen TOPMed gnomAD
rs1390187618 CA400036067	9	S>F		No	ClinGen gnomAD
rs1597803026 CA400036064	9	S>P		No	ClinGen Ensembl
rs1485458781 CA400036072	10	L>P		No	ClinGen TOPMed
rs1486959734 CA400036087	13	R>G		No	ClinGen gnomAD
CA400036096 rs1248006550	14	L>Q		No	ClinGen TOPMed
CA400036093 rs1423527512	14	L>V		No	ClinGen gnomAD
rs1228566823 CA400036113	17	L>F		No	ClinGen TOPMed
CA8624529 rs767758109	18	G>R		No	ClinGen ExAC gnomAD
rs1413728317 CA400036123	19	P>S		No	ClinGen gnomAD
CA291252286 rs914958567	21	P>L		No	ClinGen TOPMed
CA400036143 rs1435341349	22	P>L		No	ClinGen gnomAD
rs1319395474 CA400036145	23	P>T		No	ClinGen gnomAD
rs1362422126 CA400036153	24	L>F		No	ClinGen gnomAD
CA8624531 rs756200893	26	L>F		No	ClinGen ExAC TOPMed gnomAD
CA291252333 rs978902294	30	S>G		No	ClinGen TOPMed
CA400036196 rs1319025173	31	R>G		No	ClinGen TOPMed gnomAD
CA400036203 rs1209603116	32	S>P		No	ClinGen TOPMed gnomAD
rs1463616847 CA400036215	34	R>C		No	ClinGen TOPMed gnomAD
CA400036217 rs1428155053	34	R>L		No	ClinGen TOPMed
rs1428155053 CA400036218	34	R>P		No	ClinGen TOPMed
rs754918918 CA8624534	35	R>G		No	ClinGen ExAC gnomAD
CA400036229 rs1477642683	36	R>H		No	ClinGen gnomAD
CA8624535 rs778878338	37	L>F		No	ClinGen ExAC TOPMed gnomAD
rs778878338 CA400036231	37	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1409878657 CA400036239	38	H>R		No	ClinGen TOPMed gnomAD
rs1157998929 CA400036250	39	S>R		No	ClinGen TOPMed gnomAD
rs1195872902 CA400036243	39	S>R		No	ClinGen TOPMed
CA400036264 rs1462601225	42	L>F		No	ClinGen TOPMed gnomAD
CA400036262 rs1462601225	42	L>I		No	ClinGen TOPMed gnomAD
CA400036271 rs1437832619	43	A>D		No	ClinGen TOPMed gnomAD
TCGA novel	43	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA400036293 rs1436384311	46	P>R		No	ClinGen gnomAD
CA400036317 rs1273518045	49	R>S		No	ClinGen gnomAD
rs746589578 CA8624539	51	F>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	55	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1567830915 CA400036368	57	D>V		No	ClinGen Ensembl
CA400036373 rs1166234355	58	V>F		No	ClinGen TOPMed
rs1430304838 CA400036382	59	S>C		No	ClinGen TOPMed
CA8624543 rs769086867	61	I>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA8624546 rs762187418	62	N>S		No	ClinGen ExAC TOPMed gnomAD
rs762187418 CA8624545	62	N>T		No	ClinGen ExAC TOPMed gnomAD
rs28482949 CA291252381 COSM228197	63	Y>C	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1472815425 CA400036415	64	S>R		No	ClinGen gnomAD
TCGA novel	65	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1181153632 CA400036417	65	L>V		No	ClinGen gnomAD
CA400036426 rs1292264560	66	C>S		No	ClinGen gnomAD
rs201212390 CA400036477	73	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA291252395 rs888505585	80	L>V		No	ClinGen TOPMed gnomAD
rs1264658244 CA400036615	82	A>V		No	ClinGen TOPMed
rs753901730 CA8624550	83	A>V		No	ClinGen ExAC gnomAD
CA400036656 rs1410870274	84	A>T		No	ClinGen gnomAD
rs765284224 CA8624552	85	Q>K		No	ClinGen ExAC gnomAD
CA8624553 rs752623748	85	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1180262323 CA400033464	86	V>A		No	ClinGen TOPMed
rs578177730 CA291235269	87	R>G		No	ClinGen 1000Genomes gnomAD
CA8624564 rs369570255 COSM188552	89	A>V	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs560492787 CA8624567	94	V>M		No	ClinGen 1000Genomes ExAC gnomAD
rs1484124629 CA400033665	100	I>T		No	ClinGen gnomAD
rs1285989519 CA400033712	103	I>V		No	ClinGen TOPMed gnomAD
rs1200778661 CA400033731	104	T>I		No	ClinGen gnomAD
CA400033730 rs1200778661	104	T>R		No	ClinGen gnomAD
TCGA novel	110	E>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1025393835 CA291235301	111	G>R		No	ClinGen TOPMed
CA400033860 rs1194768212	111	G>V		No	ClinGen gnomAD
CA8624570 rs765341357	113	E>D		No	ClinGen ExAC gnomAD
rs750183773 CA8624609	114	E>D		No	ClinGen ExAC gnomAD
CA400035389 rs1229281225	116	H>Y		No	ClinGen gnomAD
CA400035503 rs1164148219	125	E>Q		No	ClinGen gnomAD
rs536898445 CA8624614	135	S>G		No	ClinGen 1000Genomes ExAC gnomAD
CA400035691 rs1238133898	139	T>I		No	ClinGen TOPMed
CA8624628 rs766039929	141	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	145	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1306219340 CA400036619	146	I>V		No	ClinGen gnomAD
TCGA novel	148	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	148	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8624631 rs764868510	157	K>R		No	ClinGen ExAC gnomAD
rs1228138879 CA400036775	159	F>V		No	ClinGen TOPMed
CA400036823 rs1277065947	165	T>I		No	ClinGen gnomAD
rs757830863 CA8624633	168	S>F		No	ClinGen ExAC TOPMed
CA400036843 rs1292872762	169	G>R		No	ClinGen TOPMed
TCGA novel	169	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781519164 COSM1630235 CA8624634	171	V>L	liver [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA400036857 rs781519164	171	V>M		No	ClinGen ExAC TOPMed gnomAD
CA291257376 rs746268471	172	R>H		No	ClinGen ExAC TOPMed gnomAD
rs746268471 CA8624635	172	R>P		No	ClinGen ExAC TOPMed gnomAD
rs780438466 CA8624637	173	Y>C		No	ClinGen ExAC gnomAD
CA291257380 rs902873342	173	Y>H		No	ClinGen TOPMed gnomAD
CA400036935 rs1555609380	181	A>V		No	ClinGen Ensembl
CA400036996 rs1243706174	187	A>G		No	ClinGen TOPMed gnomAD
CA400037030 rs1420308086	190	C>Y		No	ClinGen TOPMed
rs1025542093 CA291259161	195	A>G		No	ClinGen TOPMed
rs1162874219 CA400037103	196	I>V		No	ClinGen TOPMed gnomAD
rs1276634547 CA400037122	197	K>R		No	ClinGen TOPMed gnomAD
TCGA novel	199	T>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA400037184 rs1342654153	201	D>G		No	ClinGen gnomAD
CA400037190 rs1204140097	202	I>V		No	ClinGen gnomAD
CA400037224 rs1187721160	207	P>H		No	ClinGen gnomAD
CA400037221 rs1443775874	207	P>S		No	ClinGen gnomAD
CA400037228 rs1236386989	208	K>E		No	ClinGen TOPMed gnomAD
CA400037540 rs898532030	218	V>I		No	ClinGen TOPMed gnomAD
rs898532030 CA291260557	218	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA400037562 rs1189899043	219	I>T		No	ClinGen gnomAD
CA400037599 rs1450619760	221	R>Q		No	ClinGen gnomAD
CA400037592 rs1250491673	221	R>W		No	ClinGen gnomAD
CA400037630 rs1227583166	223	P>L		No	ClinGen TOPMed gnomAD
rs1227583166 CA400037632	223	P>R		No	ClinGen TOPMed gnomAD
CA291260563 rs1033662405	223	P>S		No	ClinGen TOPMed
rs763445892 CA8624675	225	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA400037730 rs1173410797	229	N>D		No	ClinGen gnomAD
rs370952703 CA8624677	236	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA400037854 rs1455389309	236	A>V		No	ClinGen TOPMed
CA291260586 rs377728785	237	R>C		No	ClinGen ESP TOPMed gnomAD
rs766973996 CA8624678	237	R>H		No	ClinGen ExAC gnomAD
rs1567858647 CA919851993	241	M>T		No	ClinGen Ensembl
rs149179597 CA8624679	243	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1465095273 CA400038325	260	S>L		No	ClinGen TOPMed
CA400038321 rs1182387784	260	S>P		No	ClinGen TOPMed
rs1332630050 CA400038353	264	V>A		No	ClinGen gnomAD
CA291260644 rs3968300	267	R>C		No	ClinGen TOPMed gnomAD
rs1187226796 CA400038373	268	V>I		No	ClinGen gnomAD
rs1268201255 CA400038409	273	G>D		No	ClinGen gnomAD
rs777887981 CA8624684	276	E>Q		No	ClinGen ExAC gnomAD
rs541030331 CA291260701	279	K>R		No	ClinGen 1000Genomes TOPMed gnomAD
rs1435324499 CA400038465	281	A>G		No	ClinGen TOPMed gnomAD
rs1435324499 CA400038466	281	A>V		No	ClinGen TOPMed gnomAD
CA400038507 rs1236219870	286	A>T		No	ClinGen gnomAD
rs571371035 CA8624692 COSM980458	297	N>S	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA400038599 rs1305676820	298	V>A		No	ClinGen TOPMed
CA8624693 rs762579897	308	I>V		No	ClinGen ExAC TOPMed gnomAD
CA400038682 rs1359438215	311	A>S		No	ClinGen TOPMed
TCGA novel	312	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1223777723 CA400038697	313	F>Y		No	ClinGen gnomAD
CA400038705 rs1184637475	314	A>E		No	ClinGen gnomAD
rs1184637475 CA400038706	314	A>V		No	ClinGen gnomAD
CA400038712 rs1408934803	315	A>V		No	ClinGen gnomAD
rs1357778309 CA400038761	320	N>K		No	ClinGen gnomAD
CA291260974 rs866591537	321	W>C		No	ClinGen Ensembl
CA8624704 rs1809279	322	G>D		No	ClinGen ExAC gnomAD
CA291260984 rs867359409	323	L>I		No	ClinGen Ensembl
TCGA novel	324	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1209182656 CA400038797	326	Y>C		No	ClinGen TOPMed
rs866465803 CA291260987	327	R>M		No	ClinGen Ensembl
CA400039054 rs1445192910	328	E>G		No	ClinGen gnomAD
CA8624729 rs763334933 COSM980460	330	A>T	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA400039086 rs1490108407	333	I>T		No	ClinGen gnomAD
CA400039098 rs1196864162	335	P>A		No	ClinGen gnomAD
rs1253473781 CA400039105	336	K>E		No	ClinGen gnomAD
TCGA novel	336	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	337	N>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA400039123 COSM436757 rs751723632	338	S>C	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA8624731 rs751723632	338	S>F		No	ClinGen ExAC gnomAD
rs757336093 CA8624732	340	S>C		No	ClinGen ExAC gnomAD
CA400039135 rs757336093	340	S>F		No	ClinGen ExAC gnomAD
rs1407980672 CA400039139	341	S>A		No	ClinGen gnomAD
CA8624734 rs373998810	343	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA8624735 rs756058723	343	R>H		No	ClinGen ExAC TOPMed gnomAD
rs756058723 CA291261636	343	R>L		No	ClinGen ExAC TOPMed gnomAD
CA8624737 rs749070520	345	W>R		No	ClinGen ExAC gnomAD
rs1233076293 CA400039173	346	V>A		No	ClinGen gnomAD
rs1419229034 CA400039175	347	A>S		No	ClinGen TOPMed
rs1301570877 CA400039186	349	V>I		No	ClinGen gnomAD
TCGA novel	353	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA400039301 rs1229972929	365	M>T		No	ClinGen gnomAD
CA8624750 rs376523771	367	W>*		No	ClinGen ExAC gnomAD
CA8624751 rs762080539	367	W>C		No	ClinGen ExAC gnomAD
CA8624754 rs756183447	372	W>*		No	ClinGen ExAC gnomAD
CA8624753 rs750512524	372	W>R		No	ClinGen ExAC gnomAD
CA8624755 rs766251900	374	N>S		No	ClinGen ExAC gnomAD
CA400039672 rs1175259727	378	A>T		No	ClinGen gnomAD
rs1244354048 CA400039707	383	Y>H		No	ClinGen gnomAD
CA8624762 rs758163229	384	L>Q		No	ClinGen ExAC gnomAD
CA8624761 rs752513715	384	L>V		No	ClinGen ExAC gnomAD
rs1475917633 CA400039720	385	C>Y		No	ClinGen gnomAD
CA8624764 rs746521440	387	D>N		No	ClinGen ExAC gnomAD
rs749861075 CA8624767 COSM706020	391	P>S	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
TCGA novel	392	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8624770 rs762137955	394	D>N		No	ClinGen ExAC gnomAD
rs1268102362 CA400039839	401	S>F		No	ClinGen gnomAD
rs1261967556 CA400039855	404	Y>H		No	ClinGen TOPMed gnomAD
rs1597868200 CA400039863	405	T>P		No	ClinGen Ensembl
rs773439751 CA8624773	406	R>C		No	ClinGen ExAC TOPMed gnomAD
rs773439751 CA8624774	406	R>G		No	ClinGen ExAC TOPMed gnomAD
rs766544766 CA8624775	406	R>H		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	409	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	412	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759593353 CA8624777	414	D>A		No	ClinGen ExAC gnomAD
rs759593353 CA8624778	414	D>G		No	ClinGen ExAC gnomAD
rs759593353 CA400039923	414	D>V		No	ClinGen ExAC gnomAD
rs752570522 CA8624780	415	N>K		No	ClinGen ExAC gnomAD
CA8624782 rs373465833	417	H>R		No	ClinGen 1000Genomes ESP ExAC gnomAD
CA8624783 rs756856093	418	P>H		No	ClinGen ExAC gnomAD
rs780813459 COSM706019 CA8624784	419	I>T	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1374502129 CA400039954	419	I>V		No	ClinGen TOPMed gnomAD
CA8624785 rs745361214	420	E>*		No	ClinGen ExAC gnomAD
rs763006639 CA8624814	421	V>I		No	ClinGen ExAC gnomAD
CA8624816 rs774243796	422	S>I		No	ClinGen ExAC
CA400040031 rs1425120512	424	G>V		No	ClinGen gnomAD
CA400040048 rs1363401900	425	H>L		No	ClinGen gnomAD
rs1420145152 CA400040077	427	S>F		No	ClinGen TOPMed
CA8624823 rs765944100	432	I>M		No	ClinGen ExAC gnomAD
COSM4151647 rs1307782333 CA400040139	432	I>V	kidney [Cosmic]	No	ClinGen cosmic curated gnomAD
CA8624824 rs200616431	433	F>C		No	ClinGen ExAC gnomAD
CA400040162 rs758980195	433	F>L		No	ClinGen ExAC TOPMed gnomAD
rs878860297 CA291264146	434	D>E		No	ClinGen Ensembl
rs564351828 CA8624826	434	D>N		No	ClinGen 1000Genomes ExAC gnomAD
CA8624827 rs747422131	435	A>V		No	ClinGen ExAC TOPMed gnomAD
rs577953048 CA8624828	436	I>R		No	ClinGen 1000Genomes ExAC gnomAD
rs1388937997 CA400040196	436	I>V		No	ClinGen gnomAD
rs1196800708 CA400040246	439	S>N		No	ClinGen gnomAD
CA8624830 rs746157900	440	K>R		No	ClinGen ExAC gnomAD
rs770128195 CA8624831	446	R>*		No	ClinGen ExAC TOPMed gnomAD
rs1242914548 CA400040333	446	R>Q		No	ClinGen TOPMed
CA8624832 rs775761519	449	H>Y		No	ClinGen ExAC gnomAD
CA8624833 rs749299161	450	D>Y		No	ClinGen ExAC gnomAD
CA8624834 rs768671345	452	I>F		No	ClinGen ExAC gnomAD
rs774109901 CA8624835	452	I>T		No	ClinGen ExAC TOPMed gnomAD
CA8624836 rs761684324	453	G>E		No	ClinGen ExAC gnomAD
CA400040447 rs1170079054	454	D>E		No	ClinGen gnomAD
CA291264440 rs1047405858	457	F>L		No	ClinGen TOPMed gnomAD
CA400040528 rs1285385998	458	K>R		No	ClinGen gnomAD
CA291264444 rs909768697	462	N>S		No	ClinGen TOPMed
CA400040588 rs768565275	463	M>L		No	ClinGen ExAC gnomAD
rs1222958652 CA400040593	463	M>T		No	ClinGen gnomAD
CA8624858 rs768565275	463	M>V		No	ClinGen ExAC gnomAD
CA400040644 rs1318655470	466	T>I		No	ClinGen gnomAD
rs1241323214 CA400040649	467	K>E		No	ClinGen gnomAD
CA8624861 rs771988486	470	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA400040693 rs1597870008	470	Q>K		No	ClinGen Ensembl
rs762882775 CA8624862	471	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1469652082 CA400040736	472	N>S		No	ClinGen gnomAD
rs1597870039 CA400040746	473	A>P		No	ClinGen Ensembl
rs1170283254 CA400040782	476	E>K		No	ClinGen gnomAD
rs753943738 CA400041215	477	D>E		No	ClinGen ExAC gnomAD
rs755227467 CA8624878	478	L>F		No	ClinGen ExAC gnomAD
rs755227467 CA8624877	478	L>V		No	ClinGen ExAC gnomAD
rs1356381033 CA400041226	479	W>L		No	ClinGen gnomAD
rs772025328 CA8624880	480	E>D		No	ClinGen ExAC gnomAD
rs748190978 CA8624879	480	E>G		No	ClinGen ExAC TOPMed gnomAD
rs1442976554 CA400041230	480	E>Q		No	ClinGen TOPMed gnomAD
rs777635759 CA8624881	484	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1315475426 CA400041282	487	G>C		No	ClinGen gnomAD
CA400041283 rs1358390170	487	G>D		No	ClinGen TOPMed gnomAD
CA8624883 rs770562706	490	I>T		No	ClinGen ExAC gnomAD
CA8624882 rs200634700	490	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs190795420 CA8624885	501	M>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	506	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8624886 rs200095837	507	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs1161716310 CA400041434	509	E>A		No	ClinGen TOPMed gnomAD
CA291266693 rs919330065	509	E>D		No	ClinGen Ensembl
TCGA novel	510	A>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1421884305 CA400041444	511	E>K		No	ClinGen gnomAD
CA400041449 rs1462350113	511	E>V		No	ClinGen gnomAD
CA8624899 rs370170213	514	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA8624901 rs199810184	519	L>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1463451485 CA400041549	524	K>Q		No	ClinGen gnomAD
CA400041564 rs1325125540	525	K>N		No	ClinGen gnomAD
rs961645229 CA291268565	529	G>A		No	ClinGen Ensembl
rs866067274 CA291268563	529	G>S		No	ClinGen Ensembl
rs1229014394 CA400041655	537	C>F		No	ClinGen TOPMed
CA8624915 rs765389403	542	V>G		No	ClinGen ExAC gnomAD
CA291269621 rs928030160	543	P>R		No	ClinGen Ensembl
rs758613691 CA8624917	545	T>K		No	ClinGen ExAC gnomAD
CA291269630 rs917855351	546	I>V		No	ClinGen TOPMed gnomAD
rs374390998 CA8624919	548	T>A		No	ClinGen ESP ExAC gnomAD
CA8624920 rs757181102	548	T>I		No	ClinGen ExAC gnomAD
rs1244348186 CA400041730	549	S>G		No	ClinGen TOPMed
CA8624921 rs781144700	552	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1322333615 CA400041764	553	N>K		No	ClinGen TOPMed
CA291269639 rs769548905	553	N>S		No	ClinGen Ensembl
rs1567866288 CA400041767	554	Q>E		No	ClinGen Ensembl
CA400041769 rs1597879969	554	Q>R		No	ClinGen Ensembl
rs868140358 CA291269643	555	A>T		No	ClinGen Ensembl
rs893757112 CA291269644	556	K>E		No	ClinGen Ensembl
CA400041788 rs1367130076	557	L>P		No	ClinGen gnomAD
CA8624923 rs755882812	560	L>V		No	ClinGen ExAC gnomAD
rs779859570 CA400041810 CA8624924	561	M>L		No	ClinGen ExAC gnomAD
rs1011508541 CA291269654	563	K>Q		No	ClinGen Ensembl
CA400041828 rs1392593867	563	K>R		No	ClinGen gnomAD
rs1410240001 CA400041842	565	E>G		No	ClinGen gnomAD
rs1378289577 CA400041854	566	M>I		No	ClinGen gnomAD
TCGA novel	569	V>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1432596669 CA400041870	569	V>L		No	ClinGen TOPMed
rs1042924116 CA291269660	575	P>A		No	ClinGen TOPMed gnomAD
CA400041913 rs1042924116	575	P>S		No	ClinGen TOPMed gnomAD
rs1410996110 CA400041937	578	W>S		No	ClinGen TOPMed
rs889646408 CA291269665	579	V>L		No	ClinGen Ensembl
CA400041985 rs1317324291	583	L>S		No	ClinGen gnomAD
CA8624939 rs751380612	586	V>A		No	ClinGen ExAC gnomAD
TCGA novel	592	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs368712014 CA8624940 COSM365100	594	S>C	lung [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA291270796 rs371661038	595	S>C		No	ClinGen ESP
CA400042071 rs750310068	596	A>G		No	ClinGen ExAC gnomAD
rs750310068 CA8624941	596	A>V		No	ClinGen ExAC gnomAD
CA400042076 rs1429942696	597	M>T		No	ClinGen gnomAD
CA400042073 rs1253735072	597	M>V		No	ClinGen gnomAD
CA8624942 rs756003607 COSM3402962	606	R>C	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs201311692 CA8624943	606	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA400042137 rs201311692	606	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs993407853 CA291270827	611	P>A		No	ClinGen TOPMed
CA8624945 rs148467949	611	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8624946 rs778655999	612	P>A		No	ClinGen ExAC TOPMed gnomAD
CA400042173 rs1384161715	613	V>M		No	ClinGen gnomAD
TCGA novel	615	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA400042223 rs1279033599	620	N>S		No	ClinGen gnomAD
rs1216851791 CA400042237	622	L>F		No	ClinGen gnomAD
CA400042243 rs1259047540	623	F>V		No	ClinGen gnomAD
CA8624955 rs768889388	626	A>G		No	ClinGen ExAC gnomAD
rs768889388 CA8624954	626	A>V		No	ClinGen ExAC gnomAD
rs1042345776 CA291271302	627	R>G		No	ClinGen TOPMed
CA400042281 rs1299086033	627	R>Q		No	ClinGen gnomAD
rs761805395 CA8624956	630	I>M		No	ClinGen ExAC gnomAD
rs902431051 CA291271314	630	I>T		No	ClinGen Ensembl
rs767705802 CA8624957	631	I>V		No	ClinGen ExAC gnomAD
rs760746804 CA8624959	633	T>A		No	ClinGen ExAC gnomAD
CA400042317 rs1218606403	633	T>I		No	ClinGen gnomAD
rs1159636357 CA400042322	634	V>A		No	ClinGen TOPMed gnomAD
rs1318549795 CA400042334	636	V>F		No	ClinGen gnomAD
rs754757916 CA8624962	640	M>T		No	ClinGen ExAC gnomAD
rs753721946 CA8624961	640	M>V		No	ClinGen ExAC gnomAD
rs1224186232 CA400042377	642	A>V		No	ClinGen gnomAD
CA8624963 rs778709375	645	N>Y		No	ClinGen ExAC gnomAD
TCGA novel	646	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA400042414 rs1177199481	648	N>D		No	ClinGen TOPMed
rs1477386735 CA400042417	648	N>S		No	ClinGen TOPMed gnomAD
CA400042434 rs1423658969	650	T>I		No	ClinGen gnomAD
CA291271387 rs976054298	651	V>I		No	ClinGen TOPMed
rs1418122853 CA400042458	654	D>N		No	ClinGen gnomAD
rs1325729233 CA400042466	655	L>V		No	ClinGen gnomAD
rs746468578 CA8624967	657	C>G		No	ClinGen ExAC gnomAD
rs746468578 CA400042478	657	C>S		No	ClinGen ExAC gnomAD
rs1234335494 CA400042480	657	C>Y		No	ClinGen TOPMed
CA400042501 rs1273062229	660	G>E		No	ClinGen gnomAD
rs756644470 CA400042508	661	I>S		No	ClinGen ExAC TOPMed gnomAD
rs756644470 CA8624968	661	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1308282984 CA400042523	664	T>A		No	ClinGen gnomAD
CA400042551 rs1290111773	668	H>R		No	ClinGen gnomAD
rs780489427 CA8624969	669	T>A		No	ClinGen ExAC TOPMed gnomAD
rs369577595 CA291271406	670	D>E		No	ClinGen ESP TOPMed gnomAD
TCGA novel	670	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8624970 rs376975784	672	Y>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA8624971 rs371362770	674	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA291271417 rs374288577	675	I>T		No	ClinGen Ensembl
rs1277474931 CA400042612	677	E>Q		No	ClinGen TOPMed
CA400042616 rs1179758248	677	E>V		No	ClinGen gnomAD
CA400042642 rs1165267378	681	D>Y		No	ClinGen gnomAD
rs1311858358 CA400042668	684	S>L		No	ClinGen TOPMed
CA291271439 rs372571754	685	P>L		No	ClinGen ESP TOPMed
rs200402839 CA8624973	686	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs866093835 CA291271445	686	I>V		No	ClinGen gnomAD
rs772150779 CA8624974	687	G>E		No	ClinGen ExAC gnomAD
CA400042679 rs1447456306	687	G>R		No	ClinGen TOPMed gnomAD
TCGA novel	688	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1597883838 CA400042685	688	E>Q		No	ClinGen Ensembl
CA8624976 rs760783596	691	G>A		No	ClinGen ExAC gnomAD
CA8624975 rs773386794	691	G>S		No	ClinGen ExAC gnomAD
rs776656178 CA8624978	695	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1161261847 CA400042740	696	P>A		No	ClinGen Ensembl
CA8624979 COSM377888 rs759536164	696	P>R	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA8624980 rs765149025	697	G>V		No	ClinGen ExAC gnomAD
TCGA novel	699	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8624996 rs776850173	702	D>N		No	ClinGen ExAC gnomAD
TCGA novel	709	V>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA400044392 rs1442169634	712	K>R		No	ClinGen gnomAD
rs1249237212 CA400044494	720	A>E		No	ClinGen TOPMed gnomAD
CA8624998 rs368658252	720	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA8624999 rs370834075	721	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1193039330 CA400044545	724	E>A		No	ClinGen gnomAD
CA8625000 rs762616490	726	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA291243396 rs967339486	726	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs375012383 CA8625001	727	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA291243398 rs754973654	727	R>H		No	ClinGen Ensembl
CA8625002 rs751154546	728	R>Q		No	ClinGen ExAC gnomAD
rs1173048259 CA400044588	728	R>W		No	ClinGen TOPMed gnomAD
CA8625003 rs756889043	729	F>L		No	ClinGen ExAC TOPMed gnomAD
CA400044618 rs1299715722	730	K>R		No	ClinGen gnomAD
rs1217400856 CA400044695	736	K>E		No	ClinGen TOPMed
rs1398930723 CA400044713	737	Q>R		No	ClinGen TOPMed gnomAD
rs749901711 CA400044722	738	I>M		No	ClinGen ExAC gnomAD
rs1284375523 CA400044717	738	I>V		No	ClinGen TOPMed
rs1395763439 CA400044725	739	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA400044737 rs1236114933	740	S>T		No	ClinGen gnomAD
rs1344813666 CA400044748	741	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1274277810 CA400044775	745	S>C		No	ClinGen TOPMed
CA400044787 rs1288508942	746	P>L		No	ClinGen gnomAD
CA291244338 rs766689858	761	D>G		No	ClinGen TOPMed gnomAD
TCGA novel	761	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760060357 CA8625026	762	I>T		No	ClinGen ExAC TOPMed gnomAD
rs749954965 CA8625025	762	I>V		No	ClinGen ExAC gnomAD
CA400044928 rs1597893911	765	K>N		No	ClinGen Ensembl
rs1186343139 CA400044947	766	L>F		No	ClinGen gnomAD
CA8625040 rs774177913	771	D>E		No	ClinGen ExAC gnomAD
TCGA novel	771	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	771	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM1521326 CA8625041 rs761544720	772	M>T	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
TCGA novel	775	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8625042 rs771739427	778	R>P		No	ClinGen ExAC gnomAD
CA400045049 rs1296819543	780	E>K		No	ClinGen gnomAD
CA400045059 rs1374889598	781	R>K		No	ClinGen gnomAD
CA8625044 rs373373883	782	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	783	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM341750 CA8625046 rs368913646	785	A>T	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs923589103 CA400045087	786	T>A		No	ClinGen TOPMed
CA291248767 rs923589103	786	T>S		No	ClinGen TOPMed
CA8625047 rs763421365	788	L>F		No	ClinGen ExAC gnomAD
CA8625048 rs764648796	789	P>S		No	ClinGen ExAC
CA400045119 rs1286874801	791	L>P		No	ClinGen TOPMed
rs1286874801 CA400045120	791	L>R		No	ClinGen TOPMed
rs767865517 CA8625051	792	I>M		No	ClinGen ExAC TOPMed gnomAD
rs1202286112 CA400045128	793	Q>E		No	ClinGen TOPMed gnomAD
rs1483433089 CA400045159	797	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs756353349 CA8625053	800	L>F		No	ClinGen ExAC gnomAD
rs1336345457 CA400045180	801	S>T		No	ClinGen TOPMed
COSM980467 CA291249212 rs1051959782	805	R>C	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA400045222 rs1218515200	805	R>H		No	ClinGen gnomAD
CA291249230 rs376103009	810	V>A		No	ClinGen ESP
rs1355531614 CA400045254	810	V>L		No	ClinGen gnomAD
CA8625082 rs748154171	811	S>L		No	ClinGen ExAC TOPMed gnomAD
rs777480931 CA8625084	814	G>S		No	ClinGen ExAC gnomAD
CA400045331 rs770523437	822	H>L		No	ClinGen ExAC TOPMed gnomAD
rs770523437 CA8625086	822	H>P		No	ClinGen ExAC TOPMed gnomAD
rs1251556685 CA400045346	824	R>S		No	ClinGen gnomAD
CA400045366 rs1187085561	827	A>V		No	ClinGen gnomAD
CA400045377 rs1159530539	829	K>E		No	ClinGen gnomAD
CA400045385 rs1407523015	830	F>L		No	ClinGen gnomAD
rs745384995 CA8625088	832	K>N		No	ClinGen ExAC gnomAD
rs769487819 CA8625089	838	L>I		No	ClinGen ExAC gnomAD
CA8625090 rs775135339	839	Y>C		No	ClinGen ExAC gnomAD
CA291249336 rs775135339	839	Y>F		No	ClinGen ExAC gnomAD
rs1366987487 CA400045453	839	Y>H		No	ClinGen gnomAD
rs762449893 CA8625091	841	R>Q		No	ClinGen ExAC gnomAD
rs777683276 CA8625093	843	Q>P		No	ClinGen ExAC gnomAD
rs1396433988 CA400045485	844	G>R		No	ClinGen TOPMed
rs766511851 CA8625095	849	S>P		No	ClinGen ExAC gnomAD
CA291249936 rs749564117	854	L>V		No	ClinGen TOPMed gnomAD
CA8625123 rs375636986	856	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA8625125 rs369531389	857	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs781079518 CA8625124	857	E>K		No	ClinGen ExAC gnomAD
TCGA novel	859	F>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8625127 rs755850863	861	V>I		No	ClinGen ExAC gnomAD
CA8625126 rs755850863	861	V>L		No	ClinGen ExAC gnomAD
CA291249963 rs1028690165	862	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA8625128 rs748809162	866	G>E		No	ClinGen ExAC TOPMed gnomAD
rs771324665 CA400045761	867	E>D		No	ClinGen ExAC TOPMed gnomAD
CA8625131 rs747615836	867	E>G		No	ClinGen ExAC gnomAD
CA8625133 rs777006725	868	V>F		No	ClinGen ExAC gnomAD
CA400045767 rs1252188596	868	V>G		No	ClinGen gnomAD
CA400045764 rs777006725	868	V>L		No	ClinGen ExAC gnomAD
rs1259070027 CA400045853	870	A>T		No	ClinGen gnomAD
CA8625142 rs34598464	873	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8625141 rs34598464	873	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1272454413 CA400045957	877	A>S		No	ClinGen gnomAD
CA400045984 rs1467019985	879	S>L		No	ClinGen gnomAD
rs753598374 CA8625145	881	E>G		No	ClinGen ExAC
CA8625144 rs766140719	881	E>K		No	ClinGen ExAC TOPMed gnomAD
rs754579242 CA8625146	882	R>C		No	ClinGen ExAC TOPMed gnomAD
CA400046016 rs1179179896	882	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA291251619 rs747566073	888	C>W		No	ClinGen ExAC gnomAD
CA400046097 rs1457953803	888	C>Y		No	ClinGen gnomAD
rs757816506 CA8625149	890	N>H		No	ClinGen ExAC gnomAD
CA400046186 rs1333810079	895	A>T		No	ClinGen gnomAD
rs1176163312 CA400046206	897	W>C		No	ClinGen TOPMed
CA400046226 rs1454274189	900	R>Q		No	ClinGen gnomAD
rs746245242 CA8625151	903	E>K		No	ClinGen ExAC gnomAD
rs1171430735 CA400046251	904	S>N		No	ClinGen gnomAD
CA400046271 rs1391079111	907	Q>K		No	ClinGen gnomAD
CA400046275 rs1567876509	907	Q>R		No	ClinGen Ensembl
rs1305104459 CA400046283	908	Y>C		No	ClinGen gnomAD
rs1305104459 CA400046282	908	Y>S		No	ClinGen gnomAD
rs1233974124 CA400046288	909	L>F		No	ClinGen gnomAD
CA8625152 rs201842079	912	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs763783960 CA291251654	912	R>W		No	ClinGen gnomAD
CA291251655 rs891961141	913	K>R		No	ClinGen Ensembl
rs1193766333 CA400046347	919	V>M		No	ClinGen gnomAD

No associated diseases with P55786

3 regional properties for P55786

Type	Name	Position	InterPro Accession
domain	Peptidase M1, membrane alanine aminopeptidase	280 - 497	IPR014782
domain	ERAP1-like C-terminal domain	578 - 891	IPR024571
domain	Aminopeptidase N-like, N-terminal domain	60 - 245	IPR045357

Functions

		Description
EC Number	3.4.11.14	Aminopeptidases
Subcellular Localization	Cytoplasm, cytosol Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name	Definition
aminopeptidase activity	Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain.
metalloaminopeptidase activity	Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
peptide binding	Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds.
zinc ion binding	Binding to a zinc ion (Zn).

5 GO annotations of biological process

Name	Definition
cellular response to hypoxia	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
peptide catabolic process	The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.
positive regulation of protein targeting to mitochondrion	Any process that activates or increases the frequency, rate or extent of protein targeting to mitochondrion.
protein polyubiquitination	Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
proteolysis	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

22 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P40462	TMA108	Protein TMA108	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P32454	APE2	Aminopeptidase 2, mitochondrial	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P79171	ANPEP	Aminopeptidase N	Felis catus (Cat) (Felis silvestris catus)	PR
Q9UIQ6	LNPEP	Leucyl-cystinyl aminopeptidase	Homo sapiens (Human)	PR
Q9NZ08	ERAP1	Endoplasmic reticulum aminopeptidase 1	Homo sapiens (Human)	PR
P15144	ANPEP	Aminopeptidase N	Homo sapiens (Human)	PR
Q9UKU6	TRHDE	Thyrotropin-releasing hormone-degrading ectoenzyme	Homo sapiens (Human)	PR
Q8C129	Lnpep	Leucyl-cystinyl aminopeptidase	Mus musculus (Mouse)	PR
Q8K093	Trhde	Thyrotropin-releasing hormone-degrading ectoenzyme	Mus musculus (Mouse)	PR
P97449	Anpep	Aminopeptidase N	Mus musculus (Mouse)	PR
Q9EQH2	Erap1	Endoplasmic reticulum aminopeptidase 1	Mus musculus (Mouse)	PR
Q11011	Npepps	Puromycin-sensitive aminopeptidase	Mus musculus (Mouse)	PR
P15145	ANPEP	Aminopeptidase N	Sus scrofa (Pig)	PR
Q10836	Trhde	Thyrotropin-releasing hormone-degrading ectoenzyme	Rattus norvegicus (Rat)	PR
Q9JJ22	Erap1	Endoplasmic reticulum aminopeptidase 1	Rattus norvegicus (Rat)	PR
P97629	Lnpep	Leucyl-cystinyl aminopeptidase	Rattus norvegicus (Rat)	PR
P15684	Anpep	Aminopeptidase N	Rattus norvegicus (Rat)	PR
Q0J5V5	Os08g0398700	Aminopeptidase M1-B	Oryza sativa subsp japonica (Rice)	PR
Q6Z6L4	Os02g0218200	Aminopeptidase M1-A	Oryza sativa subsp japonica (Rice)	PR
Q6K4E7	Os09g0362800	Aminopeptidase M1-D	Oryza sativa subsp japonica (Rice)	PR
Q17405	AC3.5	Aminopeptidase-like protein AC3.5	Caenorhabditis elegans	PR
Q8VZH2	APM1	Aminopeptidase M1	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MWLAAAAPSL	ARRLLFLGPP	PPPLLLLVFS	RSSRRRLHSL	GLAAMPEKRP	FERLPADVSP
70	80	90	100	110	120
INYSLCLKPD	LLDFTFEGKL	EAAAQVRQAT	NQIVMNCADI	DIITASYAPE	GDEEIHATGF
130	140	150	160	170	180
NYQNEDEKVT	LSFPSTLQTG	TGTLKIDFVG	ELNDKMKGFY	RSKYTTPSGE	VRYAAVTQFE
190	200	210	220	230	240
ATDARRAFPC	WDEPAIKATF	DISLVVPKDR	VALSNMNVID	RKPYPDDENL	VEVKFARTPV
250	260	270	280	290	300
MSTYLVAFVV	GEYDFVETRS	KDGVCVRVYT	PVGKAEQGKF	ALEVAAKTLP	FYKDYFNVPY
310	320	330	340	350	360
PLPKIDLIAI	ADFAAGAMEN	WGLVTYRETA	LLIDPKNSCS	SSRQWVALVV	GHELAHQWFG
370	380	390	400	410	420
NLVTMEWWTH	LWLNEGFASW	IEYLCVDHCF	PEYDIWTQFV	SADYTRAQEL	DALDNSHPIE
430	440	450	460	470	480
VSVGHPSEVD	EIFDAISYSK	GASVIRMLHD	YIGDKDFKKG	MNMYLTKFQQ	KNAATEDLWE
490	500	510	520	530	540
SLENASGKPI	AAVMNTWTKQ	MGFPLIYVEA	EQVEDDRLLR	LSQKKFCAGG	SYVGEDCPQW
550	560	570	580	590	600
MVPITISTSE	DPNQAKLKIL	MDKPEMNVVL	KNVKPDQWVK	LNLGTVGFYR	TQYSSAMLES
610	620	630	640	650	660
LLPGIRDLSL	PPVDRLGLQN	DLFSLARAGI	ISTVEVLKVM	EAFVNEPNYT	VWSDLSCNLG
670	680	690	700	710	720
ILSTLLSHTD	FYEEIQEFVK	DVFSPIGERL	GWDPKPGEGH	LDALLRGLVL	GKLGKAGHKA
730	740	750	760	770	780
TLEEARRRFK	DHVEGKQILS	ADLRSPVYLT	VLKHGDGTTL	DIMLKLHKQA	DMQEEKNRIE
790	800	810	820	830	840
RVLGATLLPD	LIQKVLTFAL	SEEVRPQDTV	SVIGGVAGGS	KHGRKAAWKF	IKDNWEELYN
850	860	870	880	890	900
RYQGGFLISR	LIKLSVEGFA	VDKMAGEVKA	FFESHPAPSA	ERTIQQCCEN	ILLNAAWLKR
910
DAESIHQYLL	QRKASPPTV