P40462
PR
Gene name |
TMA108 (YIL137C) |
Protein name |
Protein TMA108 |
Names |
108 kDa translation machinery-associated protein |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YIL137C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P40462
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P40462-F1 | Predicted | AlphaFoldDB |
22 variants for P40462
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s09-92620 | 57 | T>S | No | SGRP | |
| s09-92563 | 76 | G>R | No | SGRP | |
| s09-92242 | 183 | A>S | No | SGRP | |
| s09-92229 | 187 | A>V | No | SGRP | |
| s09-92103 | 229 | F>Y | No | SGRP | |
| s09-91834 | 319 | T>S | No | SGRP | |
| s09-91756 | 345 | S>A | No | SGRP | |
| s09-91633 | 386 | P>S | No | SGRP | |
| s09-91579 | 404 | A>S | No | SGRP | |
| s09-91444 | 449 | V>I | No | SGRP | |
| s09-91116 | 558 | K>T | No | SGRP | |
| s09-91112 | 559 | F>L | No | SGRP | |
| s09-90988 | 601 | L>F | No | SGRP | |
| s09-90952 | 613 | G>R | No | SGRP | |
| s09-90897 | 631 | N>T | No | SGRP | |
| s09-90765 | 675 | K>I | No | SGRP | |
| s09-90720 | 690 | E>G | No | SGRP | |
| s09-90695 | 698 | H>Q | No | SGRP | |
| s09-90546 | 748 | S>L | No | SGRP | |
| s09-90521 | 756 | Q>H | No | SGRP | |
| s09-90180 | 870 | T>I | No | SGRP | |
| s09-90025 | 922 | D>N | No | SGRP |
No associated diseases with P40462
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nascent polypeptide-associated complex | A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| metalloaminopeptidase activity | Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
| nascent polypeptide-associated complex binding | Binding to nascent polypeptide-associated complex, a heterodimeric protein complex that can reversibly bind to ribosomes and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome. |
| peptide binding | Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds. |
| zinc ion binding | Binding to a zinc ion (Zn). |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| peptide catabolic process | The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. |
| proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
| regulation of cytoplasmic translation | Any process that modulates the frequency, rate or extent of cytoplasmic translation. |
| ribosome biogenesis | A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis. |
22 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32454 | APE2 | Aminopeptidase 2, mitochondrial | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P79171 | ANPEP | Aminopeptidase N | Felis catus (Cat) (Felis silvestris catus) | PR |
| Q9UKU6 | TRHDE | Thyrotropin-releasing hormone-degrading ectoenzyme | Homo sapiens (Human) | PR |
| P15144 | ANPEP | Aminopeptidase N | Homo sapiens (Human) | PR |
| Q9UIQ6 | LNPEP | Leucyl-cystinyl aminopeptidase | Homo sapiens (Human) | PR |
| Q9NZ08 | ERAP1 | Endoplasmic reticulum aminopeptidase 1 | Homo sapiens (Human) | PR |
| P55786 | NPEPPS | Puromycin-sensitive aminopeptidase | Homo sapiens (Human) | PR |
| Q8K093 | Trhde | Thyrotropin-releasing hormone-degrading ectoenzyme | Mus musculus (Mouse) | PR |
| P97449 | Anpep | Aminopeptidase N | Mus musculus (Mouse) | PR |
| Q8C129 | Lnpep | Leucyl-cystinyl aminopeptidase | Mus musculus (Mouse) | PR |
| Q9EQH2 | Erap1 | Endoplasmic reticulum aminopeptidase 1 | Mus musculus (Mouse) | PR |
| Q11011 | Npepps | Puromycin-sensitive aminopeptidase | Mus musculus (Mouse) | PR |
| P15145 | ANPEP | Aminopeptidase N | Sus scrofa (Pig) | PR |
| Q10836 | Trhde | Thyrotropin-releasing hormone-degrading ectoenzyme | Rattus norvegicus (Rat) | PR |
| P15684 | Anpep | Aminopeptidase N | Rattus norvegicus (Rat) | PR |
| P97629 | Lnpep | Leucyl-cystinyl aminopeptidase | Rattus norvegicus (Rat) | PR |
| Q9JJ22 | Erap1 | Endoplasmic reticulum aminopeptidase 1 | Rattus norvegicus (Rat) | PR |
| Q0J5V5 | Os08g0398700 | Aminopeptidase M1-B | Oryza sativa subsp japonica (Rice) | PR |
| Q6Z6L4 | Os02g0218200 | Aminopeptidase M1-A | Oryza sativa subsp japonica (Rice) | PR |
| Q6K4E7 | Os09g0362800 | Aminopeptidase M1-D | Oryza sativa subsp japonica (Rice) | PR |
| Q17405 | AC3.5 | Aminopeptidase-like protein AC3.5 | Caenorhabditis elegans | PR |
| Q8VZH2 | APM1 | Aminopeptidase M1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSDNLLSLEN | PVVPSHYELR | LEIDPKQSSP | NFKGSAIIHL | KFNPNSTTLA | SIEDSFTQFK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LHSKDLIVLS | AHATIGSTKF | DLKISQDTGK | HLSIFNSESP | IQLSNDCPLI | LSVQYVGKIR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DIKTHHDKTF | GIFKTNFMDR | KTGTANNHVV | ATHCQPFSAS | NIFPCIDEPS | NKSTFQLNIA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TDAQYKAVSN | TPVEMVEALD | SSQKHLVKFA | KTPLMTTSVF | GFSIGDLEFL | KTEIKLEGDR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TIPVSIYAPW | DIANAAFTLD | TVQKYLPLLE | SYFKCPYPLP | KLDFVLLPYL | SDMAMENFGM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ITIQLNHLLI | PPNALANETV | REQAQQLIVH | ELVHQWMGNY | ISFDSWESLW | FNESFATWLA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| CHILEQNGDL | SHYWTSEPYL | LQQVEPTMCR | DAADVNGRSI | FQIAQRNTGI | DSQTSDIFDP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EAYTKGIIML | RSLQLATGES | HLQKGLESVF | EDTKTFHARS | VKPMDIWNHI | GKFLKSQNIT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NFVSSWTRTP | GLPVVKVEVE | EKDGKTQTKL | TQHRFINQLS | TEEKDQLEDV | PYQVPLFGVL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PDGKMDTKNV | LLTDRTLKFD | YPILVINHLA | QGYYRVSYES | EECYALINDK | ITEETLSEID |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LRKIFLDLSQ | FIGDEGFQNS | IHLHGLFKIL | NHIASPSTKI | ASKYWDPLSK | GLEVLQTIDR |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ASLTSSKLQS | FLKKKIVIPL | FNKIDWPHGE | FDKSTNPHEL | KVMSQVLFLN | KNSAKCAELC |
| 730 | 740 | 750 | 760 | 770 | 780 |
| QIYFKHLLQG | PRSSVPLELV | NSILVVVSQH | CANIKQWKKI | FDLVKRSSCT | GITNHVINMY |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DQNSSETAML | IQNGAIESLG | FCLDSDIVKK | TLNFITSNIE | SEGMELALFG | FNYNFKKRLN |
| 850 | 860 | 870 | 880 | 890 | 900 |
| KNEKPQDQVV | RETIWEWYMG | NFDQWARKAT | RKGTTTGDHL | HKALRSISLI | IFQMFVADEP |
| 910 | 920 | 930 | 940 | ||
| QKIEKFINLE | KEKLGQSLLS | LDDIWASVQQ | DEESRKTIRR | DLASLV |