Q11011
PR
Gene name |
Npepps (Psa) |
Protein name |
Puromycin-sensitive aminopeptidase |
Names |
PSA, Cytosol alanyl aminopeptidase, AAP-S |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:19155 |
EC number |
3.4.11.14: Aminopeptidases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q11011
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q11011-F1 | Predicted | AlphaFoldDB |
28 variants for Q11011
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389205231 | 137 | T>I | No | EVA | |
| rs3412537003 | 249 | F>L | No | EVA | |
| rs3389195106 | 250 | V>SDG* | No | EVA | |
| rs3389133398 | 268 | R>P | No | EVA | |
| rs3389195159 | 271 | T>I | No | EVA | |
| rs3389199829 | 272 | P>H | No | EVA | |
| rs3389191349 | 321 | N>K | No | EVA | |
| rs3389159862 | 321 | N>T | No | EVA | |
| rs3389183673 | 370 | T>S | No | EVA | |
| rs3389209873 | 376 | E>G | No | EVA | |
| rs3389195145 | 381 | W>L | No | EVA | |
| rs3389171383 | 430 | V>I | No | EVA | |
| rs3402730261 | 487 | S>C | No | EVA | |
| rs226403724 | 494 | V>M | No | EVA | |
| rs3389205241 | 531 | G>V | No | EVA | |
| rs3389133351 | 533 | Y>* | No | EVA | |
| rs3389209860 | 562 | M>I | No | EVA | |
| rs3402659450 | 614 | V>L | No | EVA | |
| rs3389206804 | 675 | E>A | No | EVA | |
| rs3389183679 | 730 | F>L | No | EVA | |
| rs3389197504 | 781 | E>G | No | EVA | |
| rs3389133384 | 782 | R>K | No | EVA | |
| rs8270304 | 787 | T>I | No | EVA | |
| rs3389205208 | 795 | K>R | No | EVA | |
| rs3389205199 | 828 | A>G | No | EVA | |
| rs3389205228 | 837 | E>K | No | EVA | |
| rs3389191324 | 858 | E>K | No | EVA | |
| rs3389205258 | 865 | M>L | No | EVA |
No associated diseases with Q11011
Functions
| Description | ||
|---|---|---|
| EC Number | 3.4.11.14 | Aminopeptidases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| aminopeptidase activity | Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain. |
| metalloaminopeptidase activity | Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
| peptide binding | Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds. |
| zinc ion binding | Binding to a zinc ion (Zn). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to hypoxia | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. |
| peptide catabolic process | The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. |
| proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
22 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P40462 | TMA108 | Protein TMA108 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P32454 | APE2 | Aminopeptidase 2, mitochondrial | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P79171 | ANPEP | Aminopeptidase N | Felis catus (Cat) (Felis silvestris catus) | PR |
| Q9UIQ6 | LNPEP | Leucyl-cystinyl aminopeptidase | Homo sapiens (Human) | PR |
| Q9UKU6 | TRHDE | Thyrotropin-releasing hormone-degrading ectoenzyme | Homo sapiens (Human) | PR |
| Q9NZ08 | ERAP1 | Endoplasmic reticulum aminopeptidase 1 | Homo sapiens (Human) | PR |
| P15144 | ANPEP | Aminopeptidase N | Homo sapiens (Human) | PR |
| P55786 | NPEPPS | Puromycin-sensitive aminopeptidase | Homo sapiens (Human) | PR |
| P97449 | Anpep | Aminopeptidase N | Mus musculus (Mouse) | PR |
| Q8C129 | Lnpep | Leucyl-cystinyl aminopeptidase | Mus musculus (Mouse) | PR |
| Q8K093 | Trhde | Thyrotropin-releasing hormone-degrading ectoenzyme | Mus musculus (Mouse) | PR |
| Q9EQH2 | Erap1 | Endoplasmic reticulum aminopeptidase 1 | Mus musculus (Mouse) | PR |
| P15145 | ANPEP | Aminopeptidase N | Sus scrofa (Pig) | PR |
| Q10836 | Trhde | Thyrotropin-releasing hormone-degrading ectoenzyme | Rattus norvegicus (Rat) | PR |
| Q9JJ22 | Erap1 | Endoplasmic reticulum aminopeptidase 1 | Rattus norvegicus (Rat) | PR |
| P97629 | Lnpep | Leucyl-cystinyl aminopeptidase | Rattus norvegicus (Rat) | PR |
| P15684 | Anpep | Aminopeptidase N | Rattus norvegicus (Rat) | PR |
| Q0J5V5 | Os08g0398700 | Aminopeptidase M1-B | Oryza sativa subsp japonica (Rice) | PR |
| Q6Z6L4 | Os02g0218200 | Aminopeptidase M1-A | Oryza sativa subsp japonica (Rice) | PR |
| Q6K4E7 | Os09g0362800 | Aminopeptidase M1-D | Oryza sativa subsp japonica (Rice) | PR |
| Q17405 | AC3.5 | Aminopeptidase-like protein AC3.5 | Caenorhabditis elegans | PR |
| Q8VZH2 | APM1 | Aminopeptidase M1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MWLAAAVPSL | ARRLLLLGPP | PPPLLLLLSR | SSRRRRRLHS | LGLAAMPEKR | PFERLPAEVS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PINYSLCLKP | DLLDFTFEGK | LEAAAQVRQA | TNQIVMNCAD | IDIITASYAP | EGDEEIHATG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FNYQNEDEKV | TLSFPSTLQT | GTGTLKIDFV | GELNDKMKGF | YRSRYTTPAG | EVRYAAVTQF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EATDARRAFP | CWDEPAIKAT | FDISLVVPKD | RVALSNMNVI | DRKPYPDDEN | LVEVKFARTP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VMSTYLVAFV | VGEYDFVETR | SKDGVCVRVY | TPVGKAEQGK | FALEVAAKTL | PFYKDYFNVP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YPLPKIDLIA | IADFAAGAME | NWGLVTYRET | ALLIDPKNSC | SSSRQWVALV | VGHELAHQWF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GNLVTMEWWT | HLWLNEGFAS | WIEYLCVDHC | FPEYDIWTQF | VSADYTRAQE | LDALDNSHPI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EVSVGHPSEV | DEIFDAISYS | KGASVIRMLH | DYIGDKDFKK | GMNMYLTKFQ | QKNAATEDLW |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ESLESASGKP | IAAVMNTWTK | QMGFPLIYVE | AEQVEDDRVL | KLSQKKFCAS | GPYGGEDCPQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| WMVPITISTS | EDPNQAKLKI | LMDKPEMSVV | LKNVKPDQWV | KLNLGTVGFY | RTQYSSAMLE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SLLPGIRDLS | LPPVDRLGLQ | NDLFSLARAG | IISTVEVLKV | MEAFVNEPNY | TVWSDLSCNL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| GILSTLLSHT | DFYEEIQEFV | KDVFSPIGER | LGWDPKPGEG | HLDALLRGLV | LGKLGKAGHK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ATLEEARRRF | KEHVEGKQIL | SADLRSPVYL | TVLKHGDGAT | LDIMLKLHKQ | ADMQEEKNRI |
| 790 | 800 | 810 | 820 | 830 | 840 |
| ERVLGATLSP | ELIQKVLTFA | LSEEVRPQDT | VSVIGGVAGG | SKHGRKAAWK | FIKDNWEELH |
| 850 | 860 | 870 | 880 | 890 | 900 |
| NRYQGGFLIS | RLIKLSVEGF | AVDKMAGEVK | AFFESHPAPS | AERTIQQCCE | NILLNAAWLK |
| 910 | |||||
| RDADSIHQYL | LQRKTSPPSV |