Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A6NEC2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A6NEC2-F1 | Predicted | AlphaFoldDB |
No variants for A6NEC2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A6NEC2 | |||||
No associated diseases with A6NEC2
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| extracellular exosome | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| metalloaminopeptidase activity | Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
| peptide binding | Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds. |
| zinc ion binding | Binding to a zinc ion (Zn). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| peptide catabolic process | The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. |
| proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0J5V5 | Os08g0398700 | Aminopeptidase M1-B | Oryza sativa subsp japonica (Rice) | PR |
| Q6Z6L4 | Os02g0218200 | Aminopeptidase M1-A | Oryza sativa subsp japonica (Rice) | PR |
| Q6K4E7 | Os09g0362800 | Aminopeptidase M1-D | Oryza sativa subsp japonica (Rice) | PR |
| Q8VZH2 | APM1 | Aminopeptidase M1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MWLAAAAPSL | ARRLLFLGPP | PPPLLLLVFS | RSSRRRLHSL | GLAAMPEKRP | FERLPADVSP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| INCSLCLKPD | LLDFTFEGKL | EAAAQVRQAT | NQIVMNCADI | DIITASYAPE | GDEEIHATGF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NYQNEDEKVT | LSFPSTLQTG | TGTLKIDFVG | ELNDKMKGFY | RSKYTTPSGE | VRYAAVTQFE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ATDARRAFPC | WDERAIKATF | DISLVVPKDR | VALSNMNVID | RKPYPDDENL | VEVKFARTPV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TSTYLVAFVV | GEYDFVETRS | KDGVCVCVYT | PVGKAEQGKF | ALEVAAKTLP | FYKDYFNVPY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PLPKIDLIAI | ADFAAGAMEN | WDLVTYRETA | LLIDPKNSCS | SSRQWVALVV | GHELAHQWFG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NLVTMEWWTH | LRLNEGFASW | IEYLCVDHCF | PEYDIWTQFV | SADYTRAQEL | DALDNSHPIE |
| 430 | 440 | 450 | 460 | 470 | |
| VSVGHPSEVD | EIFDAISYSK | GASVIRMLHD | YIGDKDFKKG | MNMYLTKFQQ | KNAAAGNL |