Q8R5K2

PR
Gene name
Usp33 (Vdu1)
Protein name
Ubiquitin carboxyl-terminal hydrolase 33
Names
Deubiquitinating enzyme 33, Ubiquitin thioesterase 33, Ubiquitin-specific-processing protease 33, VHL-interacting deubiquitinating enzyme 1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:170822
EC number
3.4.19.12: Omega peptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

363-452 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8R5K2

Entry ID Method Resolution Chain Position Source
AF-Q8R5K2-F1 Predicted AlphaFoldDB

29 variants for Q8R5K2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3393866123 60 H>P No EVA
rs3388659745 67 E>D No EVA
rs3388665923 91 F>S No EVA
rs3388665412 115 S>N No EVA
rs3388662923 134 V>L No EVA
rs3388662859 229 V>E No EVA
rs3388650863 239 Q>* No EVA
rs3388659734 348 E>K No EVA
rs3388665919 356 V>L No EVA
rs3388666981 371 Q>H No EVA
rs3388662920 373 H>Y No EVA
rs31046335 411 L>P No EVA
rs244724348 419 S>P No EVA
rs3388662856 429 S>T No EVA
rs3388668151 440 R>G No EVA
rs3388668177 442 V>D No EVA
rs3388666000 448 D>N No EVA
rs3388665947 453 S>G No EVA
rs31721854 465 I>V No EVA
rs3388670925 470 F>L No EVA
rs3388666904 484 A>G No EVA
rs3388650847 530 W>L No EVA
rs3388674312 562 K>R No EVA
rs3388662872 596 I>F No EVA
rs3393960083 607 L>I No EVA
rs3388662901 821 W>* No EVA
rs3388668216 821 W>* No EVA
rs3388674224 830 K>R No EVA
rs214939882 852 S>N No EVA

No associated diseases with Q8R5K2

7 regional properties for Q8R5K2

Type Name Position InterPro Accession
domain Peptidase C19, ubiquitin carboxyl-terminal hydrolase 154 - 679 IPR001394
domain Zinc finger, UBP-type 6 - 109 IPR001607
domain Peptidase C19, ubiquitin-specific peptidase, DUSP domain 684 - 782 IPR006615-1
domain Peptidase C19, ubiquitin-specific peptidase, DUSP domain 785 - 891 IPR006615-2
conserved_site Ubiquitin specific protease, conserved site 155 - 170 IPR018200-1
conserved_site Ubiquitin specific protease, conserved site 624 - 641 IPR018200-2
domain Ubiquitin specific protease domain 154 - 682 IPR028889

Functions

Description
EC Number 3.4.19.12 Omega peptidases
Subcellular Localization
  • Cytoplasm, perinuclear region
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  • Associates with centrosomes predominantly in S and G2 phases but less in G1 phase (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
focal adhesion A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.

5 GO annotations of molecular function

Name Definition
cysteine-type deubiquitinase activity An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.
cysteine-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
G protein-coupled receptor binding Binding to a G protein-coupled receptor.
small GTPase binding Binding to a small monomeric GTPase.
zinc ion binding Binding to a zinc ion (Zn).

14 GO annotations of biological process

Name Definition
axon guidance The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
cell migration The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
cellular response to starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
centrosome duplication The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.
endocytosis A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
negative regulation of protein binding Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
positive regulation of protein binding Any process that activates or increases the frequency, rate or extent of protein binding.
protein deubiquitination The removal of one or more ubiquitin groups from a protein.
protein K48-linked deubiquitination A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein.
protein K63-linked deubiquitination A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein.
protein stabilization Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
regulation of autophagy Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
regulation of G protein-coupled receptor signaling pathway Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway.
ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P51784 USP11 Ubiquitin carboxyl-terminal hydrolase 11 Homo sapiens (Human) PR
Q9Y2K6 USP20 Ubiquitin carboxyl-terminal hydrolase 20 Homo sapiens (Human) PR
Q8R5H1 Usp15 Ubiquitin carboxyl-terminal hydrolase 15 Mus musculus (Mouse) PR
Q80U87 Usp8 Ubiquitin carboxyl-terminal hydrolase 8 Mus musculus (Mouse) PR
O88623 Usp2 Ubiquitin carboxyl-terminal hydrolase 2 Mus musculus (Mouse) PR
Q8K387 Usp45 Ubiquitin carboxyl-terminal hydrolase 45 Mus musculus (Mouse) PR
Q3TIX9 Usp39 U4/U6.U5 tri-snRNP-associated protein 2 Mus musculus (Mouse) PR
Q9SX68 RPL18 50S ribosomal protein L18, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
F6Z5C0 usp15 Ubiquitin carboxyl-terminal hydrolase 15 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MTTFRNHCPH LDSVGEITKE DLIQKSLGAC QDCKVRGPNL WACLENRCSY VGCGESQVDH
70 80 90 100 110 120
STIHSQETKH YLTVNLTTLR VWCYACSKEV FLDRKLGTPP SLPHVRQPQQ TQENSVQDFK
130 140 150 160 170 180
IPSNPALKTP MVAVSEDLDI EVEEEDELKA RGLTGLKNIG NTCYMNAALQ ALSNCPPLTQ
190 200 210 220 230 240
FFLDCGGLAR TDKKPAICKS YLKLMTELWH KSRPGSVVPA NLFQGIKTVN PTFRGYSQQD
250 260 270 280 290 300
AQEFLRCLMD LLHEELKEQV MEMEEEPQTL TSEETVEEEK SQSDVDFQSC ESCSSSEKAE
310 320 330 340 350 360
NESGSKGFPE DSNETTMLIQ DEDDLEMAKD WQKEKVCNKI NKANADVELD KDRDTVCETV
370 380 390 400 410 420
DLNSQETVKV QIHGRASESI TDVHLNDLAT SQILPSNESV SPRLSASPPK LGSLWPGLSP
430 440 450 460 470 480
PHKKAQSTSA KRKKQHKKYR SVISDIFDGT VISSVQCLTC DRVSITLETF QDLSLPIPGK
490 500 510 520 530 540
EDLAKLHSSS HPTIVKAGSC GEAYAPQGWI AFFMEYVKRF VVSCVPSWFW GPVVTLQDCL
550 560 570 580 590 600
AAFFARDELK GDNMYSCEKC KKLRNGVKFC KVQKFPEILC IHLKRFRHEL MFSTKISTHV
610 620 630 640 650 660
SFPLEGLDLQ PFLAKDSPAQ IVTYDLLSVI CHHGTASSGH YIAYCRNNLN NLWYEFDDQS
670 680 690 700 710 720
VTEVSESTVQ NAEAYVLFYR KSSEEAQKER RRISNLLNIM EPSLLQFYIS RQWLNKFKTF
730 740 750 760 770 780
AEPGPISNND FLCIHGGIPP RKASYIEDLV LMLPQNIWDN LYSRYGGGPA VNHLYICHTC
790 800 810 820 830 840
QIELEKIEKR RKTELEIFIR LNRAFQEEDS PATFYCISMQ WFREWESFVK GKDGDPPGPI
850 860 870 880 890 900
DNTKIAVTKC GSVMLKQGAD SGQISEETWN FLQSIYGGGP EVILRPPVVH VDPDVLQAEE
KIEVETRSL