AiPD: Autoinhibited Protein Database

Gene name	Usp39
Protein name	U4/U6.U5 tri-snRNP-associated protein 2
Names	Inactive ubiquitin-specific peptidase 39
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:28035
EC number	3.4.19.12: Omega peptidases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-123 (Predicted disordered autoinhibitory region) PR

1-123 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q3TIX9-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388836957	117	F>Y	No	EVA
rs3388839085	129	H>L	No	EVA
rs3388832250	163	F>S	No	EVA
rs3388839091	166	L>I	No	EVA
rs3388839814	171	F>S	No	EVA
rs3388830495	179	E>D	No	EVA
rs3388834401	190	Y>C	No	EVA
rs3388836984	199	Q>H	No	EVA
rs3388843221	209	K>*	No	EVA
rs3388837050	221	P>S	No	EVA
rs3388839094	236	N>Y	No	EVA
rs3396477791	251	Y>*	No	EVA
rs3396956417	254	E>Q	No	EVA
rs3396916999	261	I>M	No	EVA
rs3396888771	262	K>M	No	EVA
rs3396647133	268	I>M	No	EVA
rs3396963558	268	I>V	No	EVA
rs3388830512	289	F>L	No	EVA
rs3397070101	291	A>V	No	EVA
rs3396966693	292	H>L	No	EVA
rs3388832259	323	S>Y	No	EVA
rs3388836054	335	G>S	No	EVA
rs3388834412	345	N>S	No	EVA
rs3388822748	347	V>I	No	EVA
rs3388839161	359	L>I	No	EVA
rs3412994222	461	F>L	No	EVA
rs3388835700	490	V>I	No	EVA
rs3413069254	538	P>S	No	EVA
rs3388834387	539	Q>L	No	EVA

Type	Name	Position	InterPro Accession
domain	Globin	16 - 156	IPR000971
domain	Myoglobin-like, M family globin domain	26 - 156	IPR044399

		Description
EC Number	3.4.19.12	Omega peptidases
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
spliceosomal complex	Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.
U4/U6 x U5 tri-snRNP complex	A ribonucleoprotein complex that is formed by the association of the U4/U6 and U5 snRNPs.

Name	Definition
cysteine-type deubiquitinase activity	An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.
zinc ion binding	Binding to a zinc ion (Zn).

Name	Definition
cell cycle	The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
mRNA splicing, via spliceosome	The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
protein deubiquitination	The removal of one or more ubiquitin groups from a protein.
spliceosomal complex assembly	The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q53GS9	USP39	U4/U6.U5 tri-snRNP-associated protein 2	Homo sapiens (Human)	PR
Q8R5K2	Usp33	Ubiquitin carboxyl-terminal hydrolase 33	Mus musculus (Mouse)	PR
Q8R5H1	Usp15	Ubiquitin carboxyl-terminal hydrolase 15	Mus musculus (Mouse)	PR
Q80U87	Usp8	Ubiquitin carboxyl-terminal hydrolase 8	Mus musculus (Mouse)	PR
O88623	Usp2	Ubiquitin carboxyl-terminal hydrolase 2	Mus musculus (Mouse)	PR
Q8K387	Usp45	Ubiquitin carboxyl-terminal hydrolase 45	Mus musculus (Mouse)	PR