Q53GS9
PR
Gene name |
USP39 (CGI-21, HSPC332, PRO2855) |
Protein name |
U4/U6.U5 tri-snRNP-associated protein 2 |
Names |
Inactive ubiquitin-specific peptidase 39, SAD1 homolog, U4/U6.U5 tri-snRNP-associated 65 kDa protein, 65K |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:10713 |
EC number |
3.4.19.12: Omega peptidases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
5 structures for Q53GS9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 3JCR | EM | 700 A | V | 1-565 | PDB |
| 6AH0 | EM | 570 A | W | 1-565 | PDB |
| 6QW6 | EM | 292 A | U | 1-555 | PDB |
| 6QX9 | EM | 328 A | U | 1-555 | PDB |
| AF-Q53GS9-F1 | Predicted | AlphaFoldDB |
393 variants for Q53GS9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs368702825 CA51741513 |
2 | S>F | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs1451038511 CA347494810 |
2 | S>P | No |
ClinGen TOPMed gnomAD |
|
|
CA1743282 rs753021536 |
3 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs753021536 CA1743281 |
3 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1187708357 CA347494818 |
4 | R>G | No |
ClinGen TOPMed |
|
|
CA347494819 rs1187708357 |
4 | R>W | No |
ClinGen TOPMed |
|
|
CA1743284 rs377373923 |
5 | S>C | No |
ClinGen ExAC gnomAD |
|
|
rs764558997 CA1743283 |
5 | S>P | No |
ClinGen ExAC TOPMed |
|
|
rs1194365075 CA347494828 |
6 | K>E | No |
ClinGen gnomAD |
|
|
CA1743285 rs757672604 |
6 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs978887963 CA51741531 |
7 | R>G | No |
ClinGen TOPMed |
|
|
rs781741366 CA1743286 |
8 | E>G | No |
ClinGen ExAC gnomAD |
|
|
CA347494849 rs1285148574 |
9 | S>C | No |
ClinGen gnomAD |
|
|
CA347494850 rs1285148574 |
9 | S>F | No |
ClinGen gnomAD |
|
|
rs1485348665 CA347494852 |
10 | R>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
rs1394422905 CA347494859 |
11 | G>D | No |
ClinGen TOPMed |
|
|
CA1743288 rs755706376 |
11 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA347494868 rs1378525737 |
13 | T>P | No |
ClinGen TOPMed |
|
|
rs779369298 CA1743289 |
14 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs779369298 CA51741538 |
14 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs768255282 CA1743291 |
15 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1743292 rs768255282 |
15 | G>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1743295 rs773271024 |
16 | K>T | No |
ClinGen ExAC gnomAD |
|
|
rs887527600 CA347494891 |
17 | R>P | No |
ClinGen Ensembl |
|
|
rs887527600 CA51741553 |
17 | R>Q | No |
ClinGen Ensembl |
|
|
CA51741582 rs941829473 |
20 | E>G | No |
ClinGen Ensembl |
|
|
rs1432113989 CA347494919 |
21 | S>L | No |
ClinGen gnomAD |
|
|
CA1743297 rs769931462 |
22 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs769931462 CA1743298 |
22 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA347494921 rs1417817111 |
22 | R>W | No |
ClinGen gnomAD |
|
|
rs1454837308 CA347494928 |
23 | G>V | No |
ClinGen gnomAD |
|
|
CA347494930 rs1364524402 |
24 | S>G | No |
ClinGen gnomAD |
|
|
CA51741589 rs1044529615 |
25 | S>C | No |
ClinGen gnomAD |
|
|
rs1044529615 CA347494940 |
25 | S>Y | No |
ClinGen gnomAD |
|
|
CA347494943 rs751798553 |
26 | G>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1743301 rs751798553 |
26 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1371148616 CA347494948 |
27 | R>C | No |
ClinGen gnomAD |
|
|
CA1743302 rs762333361 |
27 | R>H | No |
ClinGen ExAC gnomAD |
|
|
rs867852816 CA51741596 |
28 | V>I | No |
ClinGen Ensembl |
|
|
rs767759506 CA1743303 |
29 | K>* | No |
ClinGen ExAC gnomAD |
|
|
CA347494960 rs1195534786 |
29 | K>R | No |
ClinGen TOPMed |
|
|
rs750952537 CA51741606 |
31 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs750952537 CA1743304 |
31 | E>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1743305 rs183831987 |
33 | D>E | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs552542357 CA1743308 |
34 | R>P | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs552542357 CA1743307 |
34 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs779642637 CA1743306 |
34 | R>W | No |
ClinGen ExAC gnomAD |
|
|
CA51741621 rs1035625944 |
35 | E>K | No |
ClinGen Ensembl |
|
|
rs778580860 CA51741622 |
36 | R>W | No |
ClinGen ExAC gnomAD |
|
|
rs1004362393 CA51741624 |
37 | E>K | No |
ClinGen TOPMed |
|
|
CA1743310 rs371736825 |
37 | E>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs114838872 CA1743311 |
38 | P>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA347495006 rs1420386936 |
38 | P>T | No |
ClinGen gnomAD |
|
|
rs746972484 CA1743313 |
39 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs1165310963 CA347495023 |
40 | A>V | No |
ClinGen gnomAD |
|
|
rs1461245958 CA347495029 |
41 | A>E | No |
ClinGen TOPMed gnomAD |
|
|
rs1390676663 CA347495030 |
42 | S>R | No |
ClinGen TOPMed |
|
|
rs763164583 CA1743316 |
43 | S>F | No |
ClinGen ExAC gnomAD |
|
|
rs768850385 CA1743317 |
44 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs768850385 CA347495043 |
44 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA51741662 rs968952197 |
45 | G>D | No |
ClinGen gnomAD |
|
|
CA347495049 rs1449122669 |
45 | G>S | No |
ClinGen gnomAD |
|
|
rs1382389661 CA347495053 |
46 | S>G | No |
ClinGen gnomAD |
|
|
CA1743318 rs774771518 |
46 | S>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1292216245 CA347495057 |
46 | S>R | No |
ClinGen gnomAD |
|
|
rs774771518 CA347495056 |
46 | S>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs968925369 CA51741671 |
47 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
rs968925369 CA347495062 |
47 | P>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1023203469 CA51741667 |
47 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
rs1023203469 CA347495059 |
47 | P>T | No |
ClinGen TOPMed gnomAD |
|
|
CA1743321 rs767925097 |
48 | V>M | No |
ClinGen ExAC gnomAD |
|
|
CA51741680 rs1000361529 |
49 | R>G | No |
ClinGen TOPMed gnomAD |
|
|
CA1743323 rs367889558 |
50 | V>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA1743322 rs750709837 |
50 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA347495073 rs750709837 |
50 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1253074561 CA347495078 |
51 | K>E | No |
ClinGen TOPMed |
|
|
rs1208305022 CA347495081 |
51 | K>R | No |
ClinGen TOPMed |
|
|
rs754314800 CA347495087 |
52 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs754314800 CA1743325 |
52 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs964702887 CA51741694 |
53 | E>D | No |
ClinGen TOPMed gnomAD |
|
|
rs754552396 CA1743326 |
53 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs754552396 CA1743327 |
53 | E>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA347495101 rs1468161173 |
54 | F>L | No |
ClinGen TOPMed gnomAD |
|
|
CA347495109 rs752363838 |
55 | E>D | No |
ClinGen ExAC gnomAD |
|
|
rs1405452296 CA347495111 |
56 | P>A | No |
ClinGen gnomAD |
|
|
rs1453376967 CA347495115 |
56 | P>L | No |
ClinGen gnomAD |
|
|
CA347495119 rs556991835 |
57 | A>E | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs556991835 CA51741701 |
57 | A>G | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA1743330 rs556991835 |
57 | A>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1384721810 CA347495121 |
58 | S>G | No |
ClinGen TOPMed |
|
|
rs746734029 CA1743331 |
58 | S>I | No |
ClinGen ExAC gnomAD |
|
|
rs757054450 CA347495125 |
58 | S>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs781343856 CA1743333 |
59 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA347495132 rs1202319838 |
60 | R>S | No |
ClinGen gnomAD |
|
|
rs745785307 CA347495150 |
62 | A>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs745785307 CA1743334 |
62 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs575261072 CA1743335 |
63 | P>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA1743336 rs575261072 |
63 | P>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA347495159 rs1365941916 |
64 | A>V | No |
ClinGen TOPMed |
|
|
CA1743337 rs748429498 |
65 | S>A | No |
ClinGen ExAC gnomAD |
|
|
rs772132448 CA1743338 |
65 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA347495178 rs1425486374 |
68 | P>A | No |
ClinGen TOPMed gnomAD |
|
|
rs543189013 CA1743341 |
68 | P>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs543189013 CA1743340 |
68 | P>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs543189013 CA1743342 |
68 | P>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1475678016 CA347495181 |
69 | F>L | No |
ClinGen Ensembl |
|
|
rs1204521116 CA347495192 |
70 | V>G | No |
ClinGen TOPMed |
|
|
CA1743343 rs759983127 |
70 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1470356977 CA347495194 |
71 | R>Q | No |
ClinGen gnomAD |
|
|
CA1743344 rs764731568 |
71 | R>W | No |
ClinGen ExAC gnomAD |
|
|
rs1343692909 CA347495197 |
72 | V>L | No |
ClinGen gnomAD |
|
|
rs752163474 CA1743345 |
74 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA347495212 rs1430271703 |
74 | R>W | No |
ClinGen gnomAD |
|
|
CA1743347 rs763704524 |
75 | E>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA347495215 rs758092721 |
75 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA1743346 rs758092721 |
75 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
rs763704524 CA1743348 |
75 | E>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs370005784 CA51741734 |
76 | R>C | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA347495221 rs370005784 |
76 | R>G | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA347495223 rs1220505044 |
76 | R>P | No |
ClinGen gnomAD |
|
|
CA1743350 rs781076069 |
78 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1743352 rs756071519 |
79 | D>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA1743353 rs779152840 |
80 | E>D | No |
ClinGen ExAC gnomAD |
|
|
CA347495259 rs1419880209 |
81 | D>E | No |
ClinGen gnomAD |
|
|
rs1198360803 CA347495253 |
81 | D>Y | No |
ClinGen gnomAD |
|
|
rs748222143 CA1743354 |
82 | S>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs748222143 CA347495264 |
82 | S>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs773376009 CA1743357 |
84 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1743356 rs773376009 |
84 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs528791760 CA1743359 |
85 | E>D | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs760067189 CA1743360 |
86 | R>G | No |
ClinGen ExAC gnomAD |
|
|
CA347495287 rs1387700726 |
86 | R>L | No |
ClinGen TOPMed |
|
|
CA347495306 rs1403517286 |
89 | R>L | No |
ClinGen gnomAD |
|
|
rs1272232734 CA347495622 |
90 | A>V | No |
ClinGen gnomAD |
|
|
CA1743381 rs144774521 |
91 | K>E | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs775916424 CA347495644 |
94 | R>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs775916424 CA1743383 |
94 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs763457651 CA1743384 |
94 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA347495647 rs1183224300 |
95 | V>M | No |
ClinGen gnomAD |
|
|
CA347495668 rs1473989847 |
98 | E>Q | No |
ClinGen gnomAD |
|
|
CA347495678 rs1206344999 |
99 | D>A | No |
ClinGen TOPMed |
|
|
CA347495679 rs1206344999 |
99 | D>G | No |
ClinGen TOPMed |
|
| TCGA novel | 99 | D>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs151043919 CA1743388 |
100 | R>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs773871254 CA1743386 |
100 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1332859522 CA347495698 |
102 | S>T | No |
ClinGen gnomAD |
|
|
CA1743390 rs760611682 |
103 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 103 | R>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs766266447 CA1743391 |
106 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs987036901 CA51742575 |
109 | D>G | No |
ClinGen Ensembl |
|
|
CA51742577 rs912785369 |
112 | N>S | No |
ClinGen gnomAD |
|
| TCGA novel | 113 | R>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1558851707 CA347496053 |
115 | V>L | No |
ClinGen Ensembl |
|
|
CA347496072 rs1434335249 |
117 | D>Y | No |
ClinGen TOPMed |
|
|
rs776448033 CA1743410 |
126 | I>S | No |
ClinGen ExAC gnomAD |
|
|
rs1450929860 CA347496225 |
126 | I>V | No |
ClinGen gnomAD |
|
|
rs186867317 CA1743412 |
127 | S>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA51743083 rs536447039 |
128 | L>I | No |
ClinGen Ensembl |
|
|
CA1743415 rs767525144 |
141 | K>N | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 143 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 146 | R>W | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1238236248 CA347497330 |
150 | S>A | No |
ClinGen gnomAD |
|
| TCGA novel | 151 | H>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA51743740 rs879083407 |
151 | H>Y | No |
ClinGen Ensembl |
|
|
rs755427548 CA1743443 |
152 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA347497357 rs1384178280 |
152 | A>V | No |
ClinGen gnomAD |
|
|
rs751498808 CA1743444 |
153 | Y>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1166623033 CA347497361 |
153 | Y>H | No |
ClinGen gnomAD |
|
|
rs1461418416 CA347497369 |
154 | I>V | No |
ClinGen gnomAD |
|
| TCGA novel | 155 | H>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1313233722 CA347497457 |
165 | L>P | No |
ClinGen gnomAD |
|
|
rs1276941470 CA347497458 |
166 | N>H | No |
ClinGen TOPMed |
|
| TCGA novel | 171 | K>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA347497501 rs1306324707 |
172 | F>L | No |
ClinGen gnomAD |
|
| TCGA novel | 181 | I>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA347497576 rs1259192513 |
182 | I>V | No |
ClinGen gnomAD |
|
|
CA347497582 rs1558854424 |
183 | D>N | No |
ClinGen Ensembl |
|
| TCGA novel | 185 | S>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA347497621 rs1201179280 |
188 | D>G | No |
ClinGen gnomAD |
|
|
rs377622928 CA1743451 |
189 | I>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA1743452 rs745496090 |
190 | T>A | No |
ClinGen ExAC |
|
|
CA1743453 COSM3840160 rs769633859 |
190 | T>M | breast [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs144485583 CA1743465 |
192 | V>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA347497860 rs1405499060 |
193 | L>S | No |
ClinGen gnomAD |
|
| TCGA novel | 194 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1399835730 CA347497890 |
195 | P>S | No |
ClinGen gnomAD |
|
|
CA347497901 rs1343009761 |
196 | T>S | No |
ClinGen gnomAD |
|
|
CA347497909 rs1274722377 |
197 | F>S | No |
ClinGen gnomAD |
|
|
CA347497918 rs1281736605 |
198 | T>I | No |
ClinGen gnomAD |
|
|
CA1743469 rs756852878 |
198 | T>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1352483134 CA347497944 |
202 | I>V | No |
ClinGen gnomAD |
|
|
rs780512820 CA1743470 |
203 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA347497957 rs1390985790 |
204 | N>D | No |
ClinGen gnomAD |
|
|
CA347497955 rs1390985790 |
204 | N>H | No |
ClinGen gnomAD |
|
|
rs755397048 CA51744826 |
206 | D>E | No |
ClinGen gnomAD |
|
|
CA1743472 rs769278917 |
210 | K>R | No |
ClinGen ExAC |
|
| TCGA novel | 210 | K>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs768435215 CA1743475 |
213 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA347498046 rs1221677819 |
214 | A>T | No |
ClinGen gnomAD |
|
|
CA347498077 rs1378751674 |
216 | D>G | No |
ClinGen gnomAD |
|
|
CA1743478 rs370387517 |
217 | G>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1323500306 CA347498117 |
220 | Y>H | No |
ClinGen gnomAD |
|
|
rs1449140867 CA347498145 |
222 | P>L | No |
ClinGen TOPMed |
|
|
rs1307612184 CA347498211 |
227 | L>P | No |
ClinGen TOPMed gnomAD |
|
|
CA347498280 rs1305725553 |
233 | N>S | No |
ClinGen TOPMed |
|
|
CA347498320 rs1240432141 |
236 | A>V | No |
ClinGen gnomAD |
|
|
rs752122273 CA1743485 |
237 | N>T | No |
ClinGen ExAC gnomAD |
|
|
CA347498344 rs1208978885 |
238 | A>T | No |
ClinGen gnomAD |
|
|
CA1743487 rs372123765 |
239 | V>I | No |
ClinGen ESP ExAC gnomAD |
|
|
rs903103286 CA51747768 |
242 | A>P | No |
ClinGen TOPMed |
|
|
rs1214164236 CA347498642 |
246 | V>A | No |
ClinGen TOPMed |
|
|
CA51747780 rs868268039 |
249 | L>F | No |
ClinGen gnomAD |
|
|
CA347498656 rs868268039 |
249 | L>I | No |
ClinGen gnomAD |
|
|
rs746933002 CA1743516 |
250 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1743515 rs777638540 |
250 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA1743518 rs368012126 |
252 | Y>C | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA51747796 rs1051558799 |
252 | Y>H | No |
ClinGen TOPMed |
|
|
CA1743519 rs749540166 |
253 | F>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA347498681 rs1362602818 |
253 | F>S | No |
ClinGen gnomAD |
|
| TCGA novel | 256 | E>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs769046464 CA1743520 |
259 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
rs769046464 CA347498726 |
259 | Y>S | No |
ClinGen ExAC gnomAD |
|
|
CA347498750 rs1342884527 COSM3840162 |
262 | I>M | Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
CA1743522 rs201584124 |
262 | I>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs762147072 CA1743523 |
263 | K>R | No |
ClinGen ExAC gnomAD |
|
|
rs762147072 CA51747812 |
263 | K>T | No |
ClinGen ExAC gnomAD |
|
|
CA51747823 rs543640825 |
264 | R>C | No |
ClinGen TOPMed |
|
|
CA51747820 rs543640825 |
264 | R>G | No |
ClinGen TOPMed |
|
|
rs767910692 CA1743524 |
264 | R>H | No |
ClinGen ExAC gnomAD |
|
|
rs1017293838 CA51747834 |
265 | P>S | No |
ClinGen TOPMed |
|
|
rs1444525840 CA347498765 |
266 | P>T | No |
ClinGen gnomAD |
|
|
rs1478427561 CA347498782 |
268 | D>E | No |
ClinGen gnomAD |
|
|
CA347498777 rs898859767 |
268 | D>N | No |
ClinGen TOPMed gnomAD |
|
|
rs898859767 CA51747840 |
268 | D>Y | No |
ClinGen TOPMed gnomAD |
|
|
CA347498798 rs1172277229 |
270 | M>I | No |
ClinGen gnomAD |
|
| TCGA novel | 270 | M>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA347498807 rs1344331804 |
271 | F>L | No |
ClinGen TOPMed |
|
|
rs773605164 CA1743525 |
272 | L>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1743526 rs761101414 |
274 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs1573421113 CA347498849 |
278 | G>R | No |
ClinGen Ensembl |
|
|
CA347498859 rs1371747492 |
279 | E>G | No |
ClinGen Ensembl |
|
|
CA347498871 rs1341114649 |
281 | M>T | No |
ClinGen gnomAD |
|
|
rs1297328200 CA347498867 |
281 | M>V | No |
ClinGen gnomAD |
|
|
rs1480469963 CA347498919 |
287 | P>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA1743531 rs748592767 |
288 | R>* | No |
ClinGen ExAC gnomAD |
|
|
CA347498921 COSM3840163 rs1476664894 |
288 | R>Q | Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated Ensembl NCI-TCGA |
|
CA1743532 rs758188312 |
292 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA1743535 rs757223057 |
305 | L>V | No |
ClinGen ExAC gnomAD |
|
|
rs749417185 CA1743537 |
306 | C>F | No |
ClinGen ExAC gnomAD |
|
|
rs374810446 CA1743536 |
306 | C>R | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1432122760 CA347499068 |
309 | K>T | No |
ClinGen gnomAD |
|
|
rs1220746210 CA347499076 |
310 | T>I | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 313 | I>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1558862161 CA347499107 |
315 | K>E | No |
ClinGen Ensembl |
|
|
rs143539117 CA1743539 |
315 | K>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA51751133 rs1045884040 |
317 | G>E | No |
ClinGen gnomAD |
|
|
rs1422924028 CA347499161 |
320 | V>A | No |
ClinGen gnomAD |
|
|
CA1743562 rs747415791 |
324 | S>F | No |
ClinGen ExAC gnomAD |
|
|
rs374381478 CA51751157 |
325 | W>R | No |
ClinGen ESP TOPMed |
|
|
rs771281301 CA1743563 |
327 | L>V | No |
ClinGen ExAC gnomAD |
|
|
CA347499221 rs1311009123 |
329 | A>V | No |
ClinGen gnomAD |
|
|
CA347499230 rs1246165722 |
331 | H>P | No |
ClinGen gnomAD |
|
|
CA51751164 rs998576092 |
331 | H>Q | No |
ClinGen Ensembl |
|
|
rs1375428903 CA347499229 |
331 | H>Y | No |
ClinGen Ensembl |
|
|
rs1197426933 CA347499254 |
335 | G>E | No |
ClinGen gnomAD |
|
|
CA347499260 rs1558867219 |
336 | G>V | No |
ClinGen Ensembl |
|
|
rs200622671 CA1743566 |
338 | K>R | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA1743567 COSM1023389 rs775028076 |
341 | K>N | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
CA1743583 rs141157341 |
344 | I>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1411669550 CA347499343 |
347 | D>H | No |
ClinGen gnomAD |
|
| TCGA novel | 349 | F>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA1743584 rs560266348 |
350 | Q>H | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1358774403 CA347499381 |
352 | S>C | No |
ClinGen gnomAD |
|
|
CA347499384 rs1325941636 |
353 | M>V | No |
ClinGen TOPMed |
|
|
rs369544524 CA1743586 |
355 | I>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA51752008 rs369544524 |
355 | I>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA347499445 rs1244697357 |
361 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
CA347499442 rs1363479648 |
361 | P>S | No |
ClinGen gnomAD |
|
|
rs115043522 CA1743615 |
367 | A>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1402201084 CA347499520 |
371 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
CA1743617 rs750594033 |
374 | L>R | No |
ClinGen ExAC gnomAD |
|
|
CA51753361 rs867992804 |
375 | H>Y | No |
ClinGen Ensembl |
|
|
CA347499567 rs1378655227 |
377 | D>G | No |
ClinGen gnomAD |
|
|
CA347499563 rs1558870030 |
377 | D>N | No |
ClinGen Ensembl |
|
| TCGA novel | 380 | Q>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA51753371 rs372439936 |
380 | Q>R | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA1743618 rs756512545 |
381 | E>* | No |
ClinGen ExAC gnomAD |
|
|
CA1743619 rs756512545 |
381 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
CA1743620 rs200081633 |
382 | T>A | No |
ClinGen ExAC gnomAD |
|
|
CA1743621 rs555765963 |
383 | M>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA1743623 rs747700719 |
386 | S>A | No |
ClinGen ExAC gnomAD |
|
|
rs771705876 CA1743624 |
386 | S>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA347499635 rs1353915240 |
387 | T>S | No |
ClinGen gnomAD |
|
|
rs1290447517 CA347499650 CA347499651 |
389 | M>I | No |
ClinGen gnomAD |
|
|
CA1743625 rs374156240 |
389 | M>K | No |
ClinGen ESP ExAC gnomAD |
|
|
CA1743626 rs374156240 |
389 | M>T | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1573441190 CA347499655 |
390 | Y>S | No |
ClinGen Ensembl |
|
|
rs200865646 CA347499666 |
392 | T>A | No |
ClinGen 1000Genomes TOPMed |
|
|
CA347499669 rs1335584714 |
392 | T>M | No |
ClinGen gnomAD |
|
|
rs200865646 CA51753392 |
392 | T>S | No |
ClinGen 1000Genomes TOPMed |
|
|
CA1743627 rs770765564 |
393 | L>R | No |
ClinGen ExAC gnomAD |
|
|
CA347499684 rs1477416742 |
395 | L>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA347499692 rs1558870182 |
396 | P>L | No |
ClinGen Ensembl |
|
|
rs892119074 CA347499695 |
397 | T>A | No |
ClinGen TOPMed gnomAD |
|
|
CA51753397 rs892119074 |
397 | T>S | No |
ClinGen TOPMed gnomAD |
|
|
CA1743631 rs759494754 |
403 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA51753420 rs1001196152 |
403 | D>V | No |
ClinGen Ensembl |
|
|
rs1462608730 CA347499771 |
408 | L>I | No |
ClinGen gnomAD |
|
|
CA347499772 rs1462608730 |
408 | L>V | No |
ClinGen gnomAD |
|
|
rs1167903660 CA347499811 |
414 | P>S | No |
ClinGen gnomAD |
|
|
CA1743636 rs750660001 |
417 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA347499857 rs1338509718 |
421 | K>E | No |
ClinGen gnomAD |
|
|
CA347499868 rs1276685816 |
422 | F>S | No |
ClinGen TOPMed |
|
|
CA347499878 rs1357262854 |
423 | N>K | No |
ClinGen gnomAD |
|
|
CA1743638 rs533368995 |
423 | N>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1362915202 CA347499882 |
424 | G>D | No |
ClinGen TOPMed |
|
|
CA347499888 rs1296732427 |
425 | I>T | No |
ClinGen TOPMed |
|
|
rs754301836 CA1743639 |
426 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs775677730 CA51753440 |
426 | T>N | No |
ClinGen Ensembl |
|
| TCGA novel | 428 | K>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA347499945 rs1303852696 |
431 | K>N | No |
ClinGen TOPMed |
|
|
CA347500008 rs1385536651 |
440 | R>C | No |
ClinGen gnomAD |
|
|
rs137957308 CA1743666 |
440 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1329352584 CA347500025 |
442 | Q>H | No |
ClinGen TOPMed gnomAD |
|
|
CA347500034 rs1382312988 |
444 | T>A | No |
ClinGen TOPMed |
|
|
rs1233866690 CA347500043 |
445 | K>R | No |
ClinGen gnomAD |
|
|
rs1558872040 CA347500059 |
447 | P>L | No |
ClinGen Ensembl |
|
| TCGA novel | 451 | I>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA347500082 rs1350543708 |
451 | I>N | No |
ClinGen gnomAD |
|
|
CA347500098 rs1285992369 |
453 | C>S | No |
ClinGen gnomAD |
|
|
CA347500097 rs1285992369 |
453 | C>Y | No |
ClinGen gnomAD |
|
|
rs1206444418 CA347500113 |
455 | K>R | No |
ClinGen gnomAD |
|
|
rs1044660 CA51754529 |
456 | R>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
rs1450479837 CA347500155 |
461 | N>Y | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 462 | F>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs779781605 CA51754536 |
464 | V>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs779781605 CA1743671 |
464 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1437634529 CA347500200 |
467 | N>T | No |
ClinGen gnomAD |
|
|
CA347500253 rs1350251931 |
475 | I>V | No |
ClinGen gnomAD |
|
|
rs749242731 CA1743672 |
476 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM1023392 rs1558875194 CA347500287 |
478 | V>A | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated Ensembl NCI-TCGA |
|
CA1743693 rs778773531 |
478 | V>L | No |
ClinGen ExAC gnomAD |
|
|
rs778773531 CA347500284 |
478 | V>M | No |
ClinGen ExAC gnomAD |
|
|
CA347500298 rs1233427114 |
480 | L>V | No |
ClinGen gnomAD |
|
|
rs748061552 CA1743694 |
483 | Y>H | No |
ClinGen ExAC gnomAD |
|
|
CA347500332 rs1315465908 |
485 | S>P | No |
ClinGen gnomAD |
|
|
CA51756386 rs1038050515 |
489 | Q>L | No |
ClinGen Ensembl |
|
|
rs904894205 CA347500392 |
493 | K>N | No |
ClinGen gnomAD |
|
|
CA347500399 rs1251491102 |
494 | N>K | No |
ClinGen gnomAD |
|
|
rs1002276033 CA51756394 |
495 | T>S | No |
ClinGen gnomAD |
|
|
CA51756398 rs374640624 |
497 | Y>C | No |
ClinGen ESP TOPMed |
|
|
rs1179880468 CA347500437 |
500 | I>T | No |
ClinGen gnomAD |
|
|
CA1743695 rs771140022 |
501 | A>G | No |
ClinGen ExAC TOPMed |
|
|
CA347500460 rs1255458174 |
504 | V>M | No |
ClinGen gnomAD |
|
|
CA347500469 rs1475493159 |
505 | H>P | No |
ClinGen gnomAD |
|
|
rs867164533 COSM248250 CA51756401 |
507 | G>D | prostate [Cosmic] | No |
ClinGen cosmic curated TOPMed gnomAD |
|
CA1743697 rs762640231 |
507 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1426823789 CA347500489 |
508 | K>R | No |
ClinGen TOPMed |
|
|
rs770193348 CA1743698 |
509 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs763297712 CA1743700 |
511 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs763297712 CA347500505 |
511 | E>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1408711602 CA347500522 |
513 | S>C | No |
ClinGen TOPMed |
|
|
rs749981625 CA1743706 |
515 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1743705 rs749981625 |
515 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs143344250 CA1743703 COSM288992 |
515 | R>W | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA51756434 rs967436008 |
516 | I>L | No |
ClinGen TOPMed |
|
| TCGA novel | 518 | V>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA347500556 rs1258573634 |
519 | L>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs753514207 CA1743708 |
521 | H>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA347500592 rs1192024388 |
522 | G>V | No |
ClinGen gnomAD |
|
| TCGA novel | 533 | Q>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs372217346 CA1743732 |
535 | T>I | No |
ClinGen ESP ExAC |
|
|
CA347500705 rs372217346 |
535 | T>S | No |
ClinGen ESP ExAC |
|
|
rs1573457302 CA347500733 |
539 | P>L | No |
ClinGen Ensembl |
|
|
CA347500748 rs1405966161 |
541 | M>L | No |
ClinGen gnomAD |
|
|
rs1379076001 CA347500796 |
545 | S>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1305288756 CA347500818 |
547 | A>V | No |
ClinGen gnomAD |
|
|
rs981604053 CA51757781 |
550 | Q>L | No |
ClinGen TOPMed |
|
|
rs755005706 CA1743753 |
555 | R>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA347482078 rs369097755 |
555 | R>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA1743754 rs369097755 |
555 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA347482100 rs1281262749 |
557 | N>D | No |
ClinGen TOPMed gnomAD |
|
|
CA1743756 rs758766897 |
558 | D>E | No |
ClinGen ExAC gnomAD |
|
|
rs1215382435 CA347482139 |
560 | T>N | No |
ClinGen TOPMed |
|
|
CA1743757 rs375627272 |
561 | N>D | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs756086990 CA51743819 |
561 | N>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs747537055 CA1743758 |
561 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA51743824 rs1026564235 |
562 | Q>* | No |
ClinGen Ensembl |
|
|
CA347482156 rs1026564235 |
562 | Q>E | No |
ClinGen Ensembl |
|
|
CA347482158 rs1352324052 |
562 | Q>L | No |
ClinGen TOPMed |
|
|
rs1300704073 CA347482176 |
563 | Q>H | No |
ClinGen TOPMed |
|
|
CA347482182 rs1372414100 |
564 | G>E | No |
ClinGen TOPMed |
|
|
rs371581754 CA1743761 COSM95477 CA1743762 |
564 | G>R | ovary [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
No associated diseases with Q53GS9
Functions
| Description | ||
|---|---|---|
| EC Number | 3.4.19.12 | Omega peptidases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| spliceosomal complex | Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA. |
| U4/U6 x U5 tri-snRNP complex | A ribonucleoprotein complex that is formed by the association of the U4/U6 and U5 snRNPs. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| zinc ion binding | Binding to a zinc ion (Zn). |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| mRNA processing | Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. |
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
| protein deubiquitination | The removal of one or more ubiquitin groups from a protein. |
| RNA splicing | The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. |
| spliceosomal complex assembly | The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9Y2K6 | USP20 | Ubiquitin carboxyl-terminal hydrolase 20 | Homo sapiens (Human) | PR |
| P51784 | USP11 | Ubiquitin carboxyl-terminal hydrolase 11 | Homo sapiens (Human) | PR |
| P40818 | USP8 | Ubiquitin carboxyl-terminal hydrolase 8 | Homo sapiens (Human) | PR |
| O75604 | USP2 | Ubiquitin carboxyl-terminal hydrolase 2 | Homo sapiens (Human) | PR |
| Q3TIX9 | Usp39 | U4/U6.U5 tri-snRNP-associated protein 2 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSGRSKRESR | GSTRGKRESE | SRGSSGRVKR | ERDREREPEA | ASSRGSPVRV | KREFEPASAR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EAPASVVPFV | RVKREREVDE | DSEPEREVRA | KNGRVDSEDR | RSRHCPYLDT | INRSVLDFDF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EKLCSISLSH | INAYACLVCG | KYFQGRGLKS | HAYIHSVQFS | HHVFLNLHTL | KFYCLPDNYE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IIDSSLEDIT | YVLKPTFTKQ | QIANLDKQAK | LSRAYDGTTY | LPGIVGLNNI | KANDYANAVL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QALSNVPPLR | NYFLEEDNYK | NIKRPPGDIM | FLLVQRFGEL | MRKLWNPRNF | KAHVSPHEML |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QAVVLCSKKT | FQITKQGDGV | DFLSWFLNAL | HSALGGTKKK | KKTIVTDVFQ | GSMRIFTKKL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PHPDLPAEEK | EQLLHNDEYQ | ETMVESTFMY | LTLDLPTAPL | YKDEKEQLII | PQVPLFNILA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KFNGITEKEY | KTYKENFLKR | FQLTKLPPYL | IFCIKRFTKN | NFFVEKNPTI | VNFPITNVDL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| REYLSEEVQA | VHKNTTYDLI | ANIVHDGKPS | EGSYRIHVLH | HGTGKWYELQ | DLQVTDILPQ |
| 550 | 560 | ||||
| MITLSEAYIQ | IWKRRDNDET | NQQGA |