AiPD: Autoinhibited Protein Database

P51784

Gene name	USP11 (UHX1)
Protein name	Ubiquitin carboxyl-terminal hydrolase 11
Names	Deubiquitinating enzyme 11, Ubiquitin thioesterase 11, Ubiquitin-specific-processing protease 11
Species	Homo sapiens (Human)
KEGG Pathway
EC number	3.4.19.12: Omega peptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

636-707 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

636-707 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for P51784

Entry ID	Method	Resolution	Chain	Position	Source
4MEL	X-ray	290 A	A/B	67-288	PDB
5OK6	X-ray	130 A	A/B	67-288	PDB
8OYP	X-ray	244 A			PDB
AF-P51784-F1	Predicted				AlphaFoldDB

400 variants for P51784

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1368079668 CA412823669	2	A>T		No	ClinGen gnomAD
CA10396701 rs768128867	3	V>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	3	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10396703 rs752840506	4	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs756219949 CA10396704	5	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1220691344 CA412823756	5	P>S		No	ClinGen TOPMed gnomAD
TCGA novel	6	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10396708 rs757466463	9	G>A		No	ClinGen ExAC TOPMed gnomAD
rs757466463 CA412823845	9	G>E		No	ClinGen ExAC TOPMed gnomAD
CA10396707 rs754052339	9	G>W		No	ClinGen ExAC gnomAD
CA329052766 rs954194242	12	C>R		No	ClinGen Ensembl
rs1260064004 CA412824044	18	Q>K		No	ClinGen gnomAD
rs150564617 CA10396710	22	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs745561174 CA10396709	22	V>L		No	ClinGen 1000Genomes ExAC gnomAD
CA10396711 rs139596785	23	A>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA412824147 rs1569233332	23	A>P		No	ClinGen Ensembl
rs779901952 CA10396712	24	V>G		No	ClinGen ExAC
CA412824157 rs1472734723	24	V>I		No	ClinGen gnomAD
rs367543384 CA329052793	25	E>K		No	ClinGen gnomAD
rs746555658 CA10396713	26	G>E		No	ClinGen ExAC TOPMed gnomAD
rs1003392081 CA329052825	31	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA329052827 rs371419131	33	S>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA10396715 rs776184063	33	S>R		No	ClinGen ExAC TOPMed gnomAD
rs371419131 CA10396716	33	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA412824361 rs1354932792	36	G>A		No	ClinGen gnomAD
CA412824359 rs1354932792	36	G>D		No	ClinGen gnomAD
rs149757747 CA10396717	37	C>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA412824412 rs1292654403	39	R>K		No	ClinGen gnomAD
CA10396718 rs774640027	39	R>S		No	ClinGen ExAC gnomAD
rs759925085 CA10396719	40	E>K		No	ClinGen ExAC TOPMed gnomAD
CA10396720 rs772734666	40	E>V		No	ClinGen ExAC gnomAD
CA412824465 rs1489449092	41	R>L		No	ClinGen gnomAD
rs201561406 CA10396721	42	T>M		No	ClinGen 1000Genomes ExAC gnomAD
CA329052881 rs868143684	43	A>E		No	ClinGen TOPMed
rs1413882961 CA412824561	46	T>A		No	ClinGen gnomAD
CA10396724 rs200473032	46	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1169513843 CA412824583	47	V>G		No	ClinGen TOPMed gnomAD
CA10396727 rs750188009	49	A>V		No	ClinGen ExAC
CA329052905 rs985953642	50	N>H		No	ClinGen TOPMed
rs758150431 CA329052916	51	P>A		No	ClinGen ExAC
CA10396729 rs779991733	51	P>L		No	ClinGen ExAC TOPMed gnomAD
rs758150431 CA10396728	51	P>S		No	ClinGen ExAC
TCGA novel	52	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412824702 rs1164807288	52	A>P		No	ClinGen TOPMed
CA412824734 rs1423691689	53	A>V		No	ClinGen TOPMed
CA412824750 rs1188427178	55	A>T		No	ClinGen TOPMed
TCGA novel	55	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412824797 rs1569233400	57	A>V		No	ClinGen Ensembl
rs1413145751 CA412824813	58	V>A		No	ClinGen gnomAD
rs751547246 CA10396733	61	A>V		No	ClinGen ExAC gnomAD
CA10396734 rs754879437	64	V>A		No	ClinGen ExAC gnomAD
CA412824931 rs1280049464	65	T>A		No	ClinGen gnomAD
rs1211759656 CA412824991	68	R>K		No	ClinGen gnomAD
rs747684938 CA10396736	69	E>Q		No	ClinGen ExAC gnomAD
CA412825034 rs1469137375	70	P>L		No	ClinGen gnomAD
rs777419861 CA10396738	73	E>G		No	ClinGen ExAC gnomAD
rs1382020433 CA412825094	73	E>K		No	ClinGen gnomAD
rs201098564 CA10396739	74	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10396740 rs772611974	75	L>V		No	ClinGen ExAC gnomAD
rs1336353225 CA412825198	77	G>S		No	ClinGen gnomAD
rs1359851197 CA412825229	79	D>A		No	ClinGen gnomAD
rs1221437284 CA412825250	80	S>G		No	ClinGen TOPMed
rs1329927293 CA412825320	83	R>C		No	ClinGen gnomAD
rs867773327 CA329052966	83	R>H		No	ClinGen Ensembl
rs867773327 CA412825325	83	R>L		No	ClinGen Ensembl
rs1379839750 CA412825414	88	G>S		No	ClinGen gnomAD
rs1303182693 CA412825437	89	E>Q		No	ClinGen gnomAD
rs749048718 CA10396742	93	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA412825583 rs1278838723	95	P>L		No	ClinGen gnomAD
CA329052975 rs868190084	97	R>W		No	ClinGen gnomAD
CA412825692 rs1201750581	101	S>N		No	ClinGen gnomAD
rs183062376 CA10396750 CA10396749	105	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs751355044 CA10396751	106	E>K		No	ClinGen ExAC gnomAD
CA412828040 rs1292448130	111	K>E		No	ClinGen TOPMed
CA412828173 rs1213029108	119	G>R		No	ClinGen gnomAD
rs754970499 CA10396752	122	Q>R		No	ClinGen ExAC gnomAD
rs1453129074 CA412828272	125	S>C		No	ClinGen gnomAD
CA412828279 rs1199382105	125	S>N		No	ClinGen gnomAD
rs1241304902 CA412828415	133	N>S		No	ClinGen gnomAD
rs752156277 CA10396754	138	Q>K		No	ClinGen ExAC gnomAD
rs372652752 CA10396773	140	E>K		No	ClinGen ESP ExAC gnomAD
CA10396775 rs755971100	144	R>H		No	ClinGen ExAC TOPMed gnomAD
CA412828594 rs1310007314	147	E>K		No	ClinGen gnomAD
CA10396777 rs753381678	153	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA412828669 rs1245460091	155	Y>C		No	ClinGen gnomAD
TCGA novel	166	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1412608043 CA412828893	173	E>Q		No	ClinGen gnomAD
CA10396778 rs756982370	174	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs1218445580 CA412828928	175	G>D		No	ClinGen gnomAD
rs1435416122 CA412828984	179	I>T		No	ClinGen TOPMed
CA10396779 rs778641852	181	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1488776194 CA412829010	181	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1201169481 CA412829129	186	L>M		No	ClinGen gnomAD
CA412829142 rs1456856893	187	P>S		No	ClinGen gnomAD
CA412829284 rs1569235047	193	E>D		No	ClinGen Ensembl
CA412829324 rs1432927940	196	P>S		No	ClinGen gnomAD
rs764064233 CA10396795	203	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA412829408 rs1173522282	203	R>W		No	ClinGen gnomAD
rs1349290091 CA412829441	205	N>S		No	ClinGen TOPMed gnomAD
rs1349290091 CA412829439	205	N>T		No	ClinGen TOPMed gnomAD
CA329059694 rs887899845	206	D>N		No	ClinGen TOPMed
rs1466219251 CA412829489	208	G>S		No	ClinGen TOPMed gnomAD
CA10396796 rs753402265	210	S>F		No	ClinGen ExAC TOPMed gnomAD
rs756785886 CA10396797	212	T>A		No	ClinGen ExAC TOPMed gnomAD
CA10396798 rs376804631	214	Q>E		No	ClinGen ESP ExAC gnomAD
CA10396799 rs750140418	214	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1023999001 CA329059717	217	H>L		No	ClinGen TOPMed
TCGA novel	220	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781669097 CA10396801	220	S>P		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	220	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10396802 rs748448971	221	I>V		No	ClinGen ExAC gnomAD
CA10396819 rs753113285	225	L>S		No	ClinGen ExAC gnomAD
rs756435652 CA10396820	226	R>C		No	ClinGen ExAC gnomAD
rs778278623 CA10396821	226	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs778278623 CA412829755	226	R>L		No	ClinGen ExAC gnomAD
rs1412412114 CA412829780	229	R>L		No	ClinGen TOPMed gnomAD
CA412829779 rs1412412114	229	R>Q		No	ClinGen TOPMed gnomAD
CA412829783 rs1395491251	230	E>K		No	ClinGen gnomAD
CA10396823 rs757753624	231	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs754380001 CA10396822	231	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs779105283 CA10396824	234	V>A		No	ClinGen ExAC
CA10396825 rs745874247	235	E>D		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	236	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	240	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412829887 rs1602710290	240	T>P		No	ClinGen Ensembl
CA10396827 rs780096892	241	R>Q		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	244	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412829976 rs1382798239	249	G>A		No	ClinGen gnomAD
CA412830002 rs1352795597	252	D>Y		No	ClinGen TOPMed
rs1278961980 CA412830037	255	Y>C		No	ClinGen gnomAD
CA412830059 rs1378498421	257	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1378498421 CA412830057	257	T>S		No	ClinGen TOPMed gnomAD
rs776537536 CA10396830	258	H>Y		No	ClinGen ExAC
rs761908448 CA10396831	259	I>T		No	ClinGen ExAC TOPMed gnomAD
rs769843018 CA10396832	260	T>M	Variant assessed as Somatic; 0.0001252 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA412830104 rs1174572088	262	L>V		No	ClinGen TOPMed
rs762306205 CA10396834	263	D>G		No	ClinGen ExAC gnomAD
rs751127253 CA10396836	264	A>T		No	ClinGen ExAC gnomAD
CA10396837 rs759169838	264	A>V		No	ClinGen ExAC gnomAD
CA412830154 rs1319217238	267	E>V		No	ClinGen gnomAD
rs376801006 CA10396839	268	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA412830202 rs1176677668	272	I>V		No	ClinGen gnomAD
rs1440029971 CA412830231	276	T>S		No	ClinGen gnomAD
CA10396853 rs772985298	277	R>C		No	ClinGen ExAC gnomAD
CA329060214 rs896459831	277	R>H		No	ClinGen TOPMed
rs767470264 CA10396856	285	S>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA329060253 COSM267732 rs1001120579	286	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA10396858 rs754333247	288	L>M		No	ClinGen ExAC gnomAD
rs1449474691 CA412830318	289	H>Y		No	ClinGen gnomAD
CA412830361 rs1438198197	293	N>D		No	ClinGen gnomAD
rs773861302 CA10396876	293	N>S		No	ClinGen ExAC gnomAD
CA412830371 rs1602710703	294	N>I		No	ClinGen Ensembl
COSM1121767 rs369208947 CA10396877	296	S>L	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs771741124 CA10396878	299	D>Y		No	ClinGen ExAC gnomAD
rs775072824 CA10396879	303	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1209145748 CA412830439	303	K>R		No	ClinGen gnomAD
CA412830505 rs1292601240	313	N>S		No	ClinGen TOPMed
CA412830528 rs1210928995	317	T>A		No	ClinGen TOPMed
CA412830570 rs1224053620	322	S>*		No	ClinGen gnomAD
TCGA novel	322	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779507275 CA10396896	329	N>S		No	ClinGen ExAC gnomAD
TCGA novel	335	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10396898 rs768342225	342	Y>H		No	ClinGen ExAC gnomAD
TCGA novel	345	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10396900 rs773462135	345	E>D		No	ClinGen ExAC gnomAD
rs1316206055 CA412830768	348	F>L		No	ClinGen TOPMed
CA10396902 rs774953438	349	R>C		No	ClinGen ExAC TOPMed gnomAD
rs760100765 CA10396903	349	R>H		No	ClinGen ExAC gnomAD
CA10396905 rs752824063	353	G>S		No	ClinGen ExAC TOPMed gnomAD
rs760817613 CA10396906	354	M>L		No	ClinGen ExAC TOPMed gnomAD
rs764305951 CA10396908	358	I>M		No	ClinGen ExAC gnomAD
CA329060731 rs867182050	358	I>V		No	ClinGen Ensembl
CA329060756 rs1028586583	360	E>D		No	ClinGen TOPMed gnomAD
TCGA novel	364	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	369	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10396910 rs778654765	375	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA10396911 rs750398962	375	R>H		No	ClinGen ExAC gnomAD
rs1569235559 CA412831014	376	S>C		No	ClinGen Ensembl
rs201567985 CA10396912	380	H>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10396941 rs776013676	386	V>I		No	ClinGen ExAC gnomAD
TCGA novel	400	D>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1169886175 CA412831314	401	S>C		No	ClinGen gnomAD
TCGA novel	408	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs140600622 CA10396946	418	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA10396947 rs772996331	419	V>L		No	ClinGen ExAC gnomAD
TCGA novel	423	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1316643680 CA412831607	426	E>Q		No	ClinGen gnomAD
CA10396948 rs762697251	429	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	430	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10396949 rs202046049	431	A>V		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	435	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10396952 rs767125530	436	Q>P		No	ClinGen ExAC gnomAD
rs1413055463 CA412832424	439	A>T		No	ClinGen gnomAD
TCGA novel CA329061210 rs867366494	443	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs767303942 CA10396972	448	R>W		No	ClinGen ExAC gnomAD
rs752282546 CA10396973	449	R>Q		No	ClinGen ExAC gnomAD
rs6609463 CA329061215 COSM189772	449	R>W	large_intestine [Cosmic]	No	ClinGen cosmic curated Ensembl
rs753582181 CA10396976	463	K>E		No	ClinGen ExAC gnomAD
rs756963826 CA10396977	463	K>R		No	ClinGen ExAC TOPMed gnomAD
CA10396981 rs781511382	473	N>S		No	ClinGen ExAC gnomAD
rs113465400 CA329061245	479	D>N		No	ClinGen Ensembl
CA329061250 rs866378438	487	P>L		No	ClinGen Ensembl
COSM360608 CA10396983 rs368273184	490	I>V	lung [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA412832786 rs1185296821	492	H>L		No	ClinGen gnomAD
TCGA novel	494	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs777801380 CA412832799	494	R>K		No	ClinGen ExAC gnomAD
rs777801380 CA10396984	494	R>T		No	ClinGen ExAC gnomAD
CA412832855 rs1178269512	502	P>S		No	ClinGen gnomAD
TCGA novel	504	D>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412832890 rs1402657679	507	R>C		No	ClinGen gnomAD
rs774213603 CA10396987	507	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs867955965 CA329061341	513	R>Q		No	ClinGen Ensembl
rs1569235913 CA412832943	513	R>W		No	ClinGen Ensembl
rs113846960 CA10397005	515	V>M		No	ClinGen ExAC TOPMed gnomAD
rs775414059 CA10397007	522	I>M		No	ClinGen ExAC gnomAD
rs141092127 CA329061375	523	S>L		No	ClinGen 1000Genomes ESP ExAC gnomAD
rs141092127 CA10397008	523	S>W		No	ClinGen 1000Genomes ESP ExAC gnomAD
TCGA novel	527	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs761179924 CA10397011	533	T>K		No	ClinGen ExAC gnomAD
CA412833148 rs761179924	533	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	534	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM1468123 rs956435731 CA329061418	536	S>L	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs1432032641 CA412833240	540	M>V		No	ClinGen TOPMed
rs1480181127 CA412833346	549	R>C		No	ClinGen TOPMed
TCGA novel	549	R>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412833450 rs1227600364	558	E>K		No	ClinGen gnomAD
rs1278058705 CA412833467	559	P>L		No	ClinGen TOPMed gnomAD
rs769763813 CA10397029	562	S>G		No	ClinGen 1000Genomes ExAC gnomAD
CA329061562 rs994429677	563	I>T		No	ClinGen TOPMed
CA412833529 rs1269738235	566	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA412833553 rs1272037468	568	D>G		No	ClinGen TOPMed
TCGA novel	568	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs761835243	570	F>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA329061852 rs954026696	577	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA10397048 rs781017998	577	R>H		No	ClinGen ExAC gnomAD
TCGA novel	579	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs748093134 CA10397049	580	A>V		No	ClinGen ExAC gnomAD
rs769763897 CA10397050	581	I>V		No	ClinGen ExAC TOPMed gnomAD
CA412833748 rs373083048	583	G>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA10397051 rs373083048	583	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	584	S>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1462182043 CA412833804	588	I>V		No	ClinGen TOPMed
CA329061856 rs909707545	589	V>M		No	ClinGen TOPMed
TCGA novel	595	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1290239581 CA412833934	598	T>N		No	ClinGen gnomAD
CA10397054 rs146934622	601	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs371405317 CA10397055	601	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1239698401 CA412834020	604	N>Y		No	ClinGen TOPMed
rs1569236292 CA412834044	605	N>S		No	ClinGen Ensembl
rs1203588046 CA412834084	607	Y>S		No	ClinGen gnomAD
CA412834103 rs1246386032	608	Y>C		No	ClinGen TOPMed
rs765719583 CA10397061	609	G>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	610	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	623	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA329061920 rs939293473	623	R>W		No	ClinGen TOPMed
CA412834317 rs1416964590	625	R>C		No	ClinGen gnomAD
rs1157335115 CA412834318	625	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1183487137 CA412834326	626	F>V		No	ClinGen gnomAD
TCGA novel	633	N>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1173623159 CA412834410	634	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1470223282 COSM1231954 CA412834456	638	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA10397069 rs756015873	638	R>W		No	ClinGen ExAC
CA10397094 rs779717265	641	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	650	D>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	650	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10397116 rs771583694	659	D>N		No	ClinGen ExAC TOPMed gnomAD
CA10397117 rs774955743	660	D>V		No	ClinGen ExAC gnomAD
CA329062444 rs772183853	661	E>K		No	ClinGen TOPMed gnomAD
TCGA novel	665	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1011717148 CA329062445	666	D>N		No	ClinGen gnomAD
rs1011717148 CA412835323	666	D>Y		No	ClinGen gnomAD
rs369798008 CA10397121	667	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1387390069 CA412835351	668	P>L		No	ClinGen gnomAD
rs1406142716 CA412835354	669	G>R		No	ClinGen gnomAD
rs776434411 CA412835377	672	T>A		No	ClinGen ExAC TOPMed gnomAD
rs1343453814 CA412835380	672	T>N		No	ClinGen gnomAD
CA10397123 rs776434411	672	T>P		No	ClinGen ExAC TOPMed gnomAD
rs761558957 CA10397124	673	G>E		No	ClinGen ExAC gnomAD
CA10397125 rs764986424	675	S>N		No	ClinGen ExAC gnomAD
rs750410978 CA10397126	676	L>F		No	ClinGen ExAC TOPMed gnomAD
CA10397127 rs775998394	677	R>*		No	ClinGen 1000Genomes ExAC gnomAD
CA412835447 rs1396392067	679	P>A		No	ClinGen gnomAD
CA10397128 rs765980035	679	P>L		No	ClinGen ExAC gnomAD
rs1304271469 CA412835516	686	P>S		No	ClinGen gnomAD
TCGA novel	689	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs149631565 RCV000885367 CA10397131	690	V>I		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA10397132 rs551222235	691	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1339755065 CA412835578	691	T>S		No	ClinGen TOPMed
CA10397134 rs779395925	695	P>S		No	ClinGen ExAC
rs373698431 CA10397135	696	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	699	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10397139 rs768899509	708	P>L		No	ClinGen ExAC gnomAD
rs1405887078 CA412835768	708	P>T		No	ClinGen gnomAD
TCGA novel	711	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775646209 CA10397141	712	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA412835825 rs1417404458	713	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1468669616 CA412835827	713	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA412835875 rs1458890129	718	T>N		No	ClinGen TOPMed
TCGA novel	721	T>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412836004 rs1223922759	730	R>H		No	ClinGen gnomAD
rs1186405256 CA412836012	732	T>A		No	ClinGen TOPMed
TCGA novel	732	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1482982454 CA412836020	733	S>C		No	ClinGen Ensembl
CA329062531 rs113679905	733	S>P		No	ClinGen Ensembl
rs113679905 CA329062526	733	S>T		No	ClinGen Ensembl
CA412836024 rs1263996984	734	P>R		No	ClinGen TOPMed
rs150790639 CA329062534	734	P>S		No	ClinGen ESP
TCGA novel	736	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs748434379 CA10397159	741	P>L		No	ClinGen ExAC TOPMed gnomAD
CA412836097 rs1343044760	743	I>V		No	ClinGen gnomAD
TCGA novel	748	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs951524369 CA329062585	750	E>G		No	ClinGen Ensembl
CA412836174 rs1212655922	753	K>R		No	ClinGen gnomAD
rs768809646 CA10397165	754	R>H		No	ClinGen ExAC TOPMed gnomAD
CA412836208 rs1489863607	758	E>Q		No	ClinGen gnomAD
rs377442049 CA10397168	759	V>I		No	ClinGen ESP ExAC gnomAD
rs1183350909 CA412836258	763	G>A		No	ClinGen gnomAD
CA10397184 rs376719457	770	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	771	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs373954740 CA329062757	772	Y>C		No	ClinGen ESP
COSM403895 CA412836324 rs1389270745	773	V>M	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs569469982 CA10397187	775	K>Q		No	ClinGen ExAC gnomAD
rs1380914479 CA412836366	779	V>M		No	ClinGen TOPMed gnomAD
rs377241469 CA10397189	780	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA412836373 rs1247196906	780	R>W		No	ClinGen gnomAD
CA10397191 rs781395709	784	C>*		No	ClinGen 1000Genomes ExAC gnomAD
rs1306664968 CA412836400	784	C>Y		No	ClinGen TOPMed
TCGA novel	795	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1462395391 CA412836495	798	N>D		No	ClinGen TOPMed gnomAD
rs752803321 CA10397194	798	N>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	799	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs780580051 CA10397225	806	K>R		No	ClinGen ExAC gnomAD
rs747642820 CA10397226	807	Q>R		No	ClinGen ExAC gnomAD
TCGA novel	818	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA329063897 rs61760201	819	M>L		No	ClinGen Ensembl
rs1274943699 CA412836672	821	P>L		No	ClinGen TOPMed
COSM462225 rs1371082239 CA412836689	824	L>V	cervix Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA329063924 rs113748630	826	I>S		No	ClinGen Ensembl
rs1371259211 CA412836751	833	Y>S		No	ClinGen gnomAD
CA10397237 rs750732800	834	T>S		No	ClinGen ExAC TOPMed gnomAD
rs758689897 CA412836765	835	K>M		No	ClinGen ExAC TOPMed gnomAD
rs758689897 CA10397238	835	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1171048867 CA412836855	848	P>L		No	ClinGen gnomAD
rs369588851 CA412836856	849	I>L		No	ClinGen ESP ExAC TOPMed
CA10397241 rs369588851	849	I>V		No	ClinGen ESP ExAC TOPMed
TCGA novel	850	R>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412836863 rs781142598	850	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA10397254 rs773359273	853	D>E		No	ClinGen ExAC gnomAD
rs10126669 CA412836906	854	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA412836928 rs1314288453	857	F>L		No	ClinGen gnomAD
rs1602717060 CA412836942	860	Q>K		No	ClinGen Ensembl
rs766658033 CA10397256	862	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs200769176 CA10397258	865	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10397257 rs751339862	865	S>T		No	ClinGen ExAC gnomAD
CA412836993 rs1411702081	867	P>A		No	ClinGen TOPMed
CA10397259 COSM150784 rs140077263	867	P>L	Variant assessed as Somatic; 0.0 impact. stomach [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs140077263 CA329064045	867	P>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA329064059 rs143742824	869	L>M		No	ClinGen ESP TOPMed gnomAD
CA329064086 rs959559374	874	L>I		No	ClinGen TOPMed
rs1158467706 CA412837074	876	A>T		No	ClinGen gnomAD
CA412837120 rs1192004851	880	H>P		No	ClinGen gnomAD
CA412837177 rs1183417765	885	R>C		No	ClinGen TOPMed
CA10397283 rs772171910	894	C>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs778277255 CA10397284	898	S>R		No	ClinGen ExAC TOPMed gnomAD
rs1282624316 CA412837364	899	G>D	Variant assessed as Somatic; 6.247e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA10397285 rs745604815	900	Q>R		No	ClinGen ExAC gnomAD
CA10397287 rs781630707	907	N>I		No	ClinGen ExAC TOPMed gnomAD
rs1320220876 CA412837492	909	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1406651362 CA412837554	914	E>D		No	ClinGen TOPMed
rs886293201 CA329064314	915	N>S		No	ClinGen TOPMed gnomAD
rs1475890818 CA412837590	918	E>G		No	ClinGen TOPMed
rs142646366 CA10397291	918	E>K		No	ClinGen ESP ExAC gnomAD
TCGA novel	921	A>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412837686 rs1469888498	923	Y>H		No	ClinGen TOPMed
rs775741228 CA10397319	928	Q>K		No	ClinGen ExAC TOPMed gnomAD
rs760876517 CA10397320	929	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1446896971 CA412838045	931	D>V		No	ClinGen gnomAD
rs776347977 CA10397322	932	V>M		No	ClinGen ExAC gnomAD
rs1465096594 CA412838065	933	A>V		No	ClinGen gnomAD
CA412838069 rs1366220290	934	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs765036191 CA10397324	934	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA412838076 rs1163328387	935	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
COSM379507 rs749981096 CA10397325	935	R>H	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA412838081 rs749981096	935	R>L		No	ClinGen ExAC TOPMed gnomAD
rs1049090890 CA329064580	938	S>Y		No	ClinGen TOPMed
rs1322333856 CA412838109	939	P>L		No	ClinGen gnomAD
rs1322333856 CA412838105	939	P>Q		No	ClinGen gnomAD
rs377378154 CA10397328	941	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs754673785 CA10397329	943	S>C		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	944	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412838156 rs1448334466	945	A>T		No	ClinGen TOPMed gnomAD
CA412838191 rs1389873275	948	S>F		No	ClinGen TOPMed
rs1602717889 CA412838187	948	S>P		No	ClinGen Ensembl
rs374191188 CA329064620	949	P>S		No	ClinGen ESP gnomAD
rs757802231 CA10397332	952	S>I		No	ClinGen ExAC gnomAD
rs779246297 CA10397333	953	S>F		No	ClinGen ExAC TOPMed gnomAD
rs1167289781 CA412838239	953	S>P		No	ClinGen TOPMed
CA412838267 rs1253725668	956	S>G		No	ClinGen gnomAD
rs1602717966 CA412838295	958	E>A		No	ClinGen Ensembl
rs757577797 CA10397334 CA412838313	959	F>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD

No associated diseases with P51784

3 regional properties for P51784

Type	Name	Position	InterPro Accession
active_site	Aspartic peptidase, active site	86 - 97	IPR001969
domain	Aspartic peptidase, N-terminal	18 - 44	IPR012848
domain	Peptidase family A1 domain	71 - 378	IPR033121

Functions

		Description
EC Number	3.4.19.12	Omega peptidases
Subcellular Localization	Nucleus Cytoplasm Chromosome	Predominantly nuclear (PubMed:12084015, PubMed:15314155) Associates with chromatin (PubMed:20233726, PubMed:20601937)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
chromosome	A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name	Definition
cysteine-type deubiquitinase activity	An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.
cysteine-type endopeptidase activity	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
transcription corepressor binding	Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.

2 GO annotations of biological process

Name	Definition
protein deubiquitination	The removal of one or more ubiquitin groups from a protein.
ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

8 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9Y2K6	USP20	Ubiquitin carboxyl-terminal hydrolase 20	Homo sapiens (Human)	PR
P40818	USP8	Ubiquitin carboxyl-terminal hydrolase 8	Homo sapiens (Human)	PR
O75604	USP2	Ubiquitin carboxyl-terminal hydrolase 2	Homo sapiens (Human)	PR
Q53GS9	USP39	U4/U6.U5 tri-snRNP-associated protein 2	Homo sapiens (Human)	PR
Q8R5K2	Usp33	Ubiquitin carboxyl-terminal hydrolase 33	Mus musculus (Mouse)	PR
Q8R5H1	Usp15	Ubiquitin carboxyl-terminal hydrolase 15	Mus musculus (Mouse)	PR
Q9SX68	RPL18	50S ribosomal protein L18, chloroplastic	Arabidopsis thaliana (Mouse-ear cress)	PR
F6Z5C0	usp15	Ubiquitin carboxyl-terminal hydrolase 15	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR

10	20	30	40	50	60
MAVAPRLFGG	LCFRFRDQNP	EVAVEGRLPI	SHSCVGCRRE	RTAMATVAAN	PAAAAAAVAA
70	80	90	100	110	120
AAAVTEDREP	QHEELPGLDS	QWRQIENGES	GRERPLRAGE	SWFLVEKHWY	KQWEAYVQGG
130	140	150	160	170	180
DQDSSTFPGC	INNATLFQDE	INWRLKEGLV	EGEDYVLLPA	AAWHYLVSWY	GLEHGQPPIE
190	200	210	220	230	240
RKVIELPNIQ	KVEVYPVELL	LVRHNDLGKS	HTVQFSHTDS	IGLVLRTARE	RFLVEPQEDT
250	260	270	280	290	300
RLWAKNSEGS	LDRLYDTHIT	VLDAALETGQ	LIIMETRKKD	GTWPSAQLHV	MNNNMSEEDE
310	320	330	340	350	360
DFKGQPGICG	LTNLGNTCFM	NSALQCLSNV	PQLTEYFLNN	CYLEELNFRN	PLGMKGEIAE
370	380	390	400	410	420
AYADLVKQAW	SGHHRSIVPH	VFKNKVGHFA	SQFLGYQQHD	SQELLSFLLD	GLHEDLNRVK
430	440	450	460	470	480
KKEYVELCDA	AGRPDQEVAQ	EAWQNHKRRN	DSVIVDTFHG	LFKSTLVCPD	CGNVSVTFDP
490	500	510	520	530	540
FCYLSVPLPI	SHKRVLEVFF	IPMDPRRKPE	QHRLVVPKKG	KISDLCVALS	KHTGISPERM
550	560	570	580	590	600
MVADVFSHRF	YKLYQLEEPL	SSILDRDDIF	VYEVSGRIEA	IEGSREDIVV	PVYLRERTPA
610	620	630	640	650	660
RDYNNSYYGL	MLFGHPLLVS	VPRDRFTWEG	LYNVLMYRLS	RYVTKPNSDD	EDDGDEKEDD
670	680	690	700	710	720
EEDKDDVPGP	STGGSLRDPE	PEQAGPSSGV	TNRCPFLLDN	CLGTSQWPPR	RRRKQLFTLQ
730	740	750	760	770	780
TVNSNGTSDR	TTSPEEVHAQ	PYIAIDWEPE	MKKRYYDEVE	AEGYVKHDCV	GYVMKKAPVR
790	800	810	820	830	840
LQECIELFTT	VETLEKENPW	YCPSCKQHQL	ATKKLDLWML	PEILIIHLKR	FSYTKFSREK
850	860	870	880	890	900
LDTLVEFPIR	DLDFSEFVIQ	PQNESNPELY	KYDLIAVSNH	YGGMRDGHYT	TFACNKDSGQ
910	920	930	940	950	960
WHYFDDNSVS	PVNENQIESK	AAYVLFYQRQ	DVARRLLSPA	GSSGAPASPA	CSSPPSSEFM

DVN