Q8R5H1
PR
Gene name |
Usp15 (Kiaa0529) |
Protein name |
Ubiquitin carboxyl-terminal hydrolase 15 |
Names |
Deubiquitinating enzyme 15, Ubiquitin thioesterase 15, Ubiquitin-specific-processing protease 15 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:14479 |
EC number |
3.4.19.12: Omega peptidases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8R5H1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8R5H1-F1 | Predicted | AlphaFoldDB |
33 variants for Q8R5H1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389126451 | 40 | Q>L | No | EVA | |
| rs3389140768 | 55 | M>T | No | EVA | |
| rs3389126454 | 58 | Q>P | No | EVA | |
| rs3389131893 | 59 | N>I | No | EVA | |
| rs3389139899 | 115 | R>G | No | EVA | |
| rs1134168249 | 116 | K>R | No | EVA | |
| rs3389102084 | 141 | N>T | No | EVA | |
| rs3389131949 | 142 | G>R | No | EVA | |
| rs3389131980 | 199 | Q>H | No | EVA | |
| rs3389128322 | 263 | Y>F | No | EVA | |
| rs3389122841 | 330 | N>D | No | EVA | |
| rs3389130047 | 342 | Y>* | No | EVA | |
| rs3389126472 | 349 | M>I | No | EVA | |
| rs3389126465 | 448 | C>Y | No | EVA | |
| rs3389107403 | 471 | K>T | No | EVA | |
| rs3389107528 | 474 | R>C | No | EVA | |
| rs3389095119 | 482 | R>* | No | EVA | |
| rs3389132738 | 543 | I>S | No | EVA | |
| rs3389126464 | 553 | E>G | No | EVA | |
| rs3389126464 | 553 | E>V | No | EVA | |
| rs251191698 | 559 | A>T | No | EVA | |
| rs3389135526 | 597 | I>L | No | EVA | |
| rs3389132654 | 634 | C>Y | No | EVA | |
| rs3389071099 | 659 | D>Y | No | EVA | |
| rs3389095037 | 672 | P>H | No | EVA | |
| rs3389126429 | 758 | K>N | No | EVA | |
| rs3389126475 | 810 | P>T | No | EVA | |
| rs3389126462 | 854 | F>I | No | EVA | |
| rs3389135443 | 878 | I>N | No | EVA | |
| rs3389139930 | 903 | K>* | No | EVA | |
| rs3389132733 | 936 | F>L | No | EVA | |
| rs3389128116 | 958 | P>A | No | EVA | |
| rs3389128116 | 958 | P>S | No | EVA |
No associated diseases with Q8R5H1
7 regional properties for Q8R5H1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Peptidase C19, ubiquitin carboxyl-terminal hydrolase | 289 - 930 | IPR001394 |
| domain | Peptidase C19, ubiquitin-specific peptidase, DUSP domain | 7 - 121 | IPR006615 |
| conserved_site | Ubiquitin specific protease, conserved site | 290 - 305 | IPR018200-1 |
| conserved_site | Ubiquitin specific protease, conserved site | 875 - 892 | IPR018200-2 |
| domain | Ubiquitin-like domain, USP-type | 136 - 222 | IPR028135 |
| domain | Ubiquitin specific protease domain | 289 - 933 | IPR028889 |
| domain | Ubiquitin carboxyl-terminal hydrolase, C-terminal | 472 - 600 | IPR029346 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.4.19.12 | Omega peptidases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nuclear body | Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| cysteine-type deubiquitinase activity | An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. |
| cysteine-type endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. |
| identical protein binding | Binding to an identical protein or proteins. |
| Lys48-specific deubiquitinase activity | Hydrolysis of Lys48-linked ubiquitin unit(s) from a ubiquitinated protein. |
| SMAD binding | Binding to a SMAD signaling protein. |
| transforming growth factor beta receptor binding | Binding to a transforming growth factor beta receptor. |
| ubiquitin modification-dependent histone binding | Binding to a histone protein in which a residue has been modified by ubiquitination. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| BMP signaling pathway | The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| histone H2B conserved C-terminal lysine deubiquitination | A histone deubiquitination process in which a ubiquitin monomer is removed from a conserved lysine residue in the C-terminus of histone H2B. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, or K120 in mammals. |
| monoubiquitinated protein deubiquitination | The removal of the ubiquitin group from a monoubiquitinated protein. |
| negative regulation of antifungal innate immune response | Any process that stops, prevents or reduces the frequency, rate or extent of an antifungal innate immune response. |
| pathway-restricted SMAD protein phosphorylation | The process of introducing a phosphate group on to a pathway restricted SMAD protein. A pathway restricted SMAD protein is an effector protein that acts directly downstream of the transforming growth factor family receptor. |
| positive regulation of RIG-I signaling pathway | Any process that activates or increases the frequency, rate or extent of RIG-I signaling pathway. |
| protein deubiquitination | The removal of one or more ubiquitin groups from a protein. |
| protein K27-linked deubiquitination | A protein deubiquitination process in which a K27-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 27 of the ubiquitin monomers, is removed from a protein. |
| transforming growth factor beta receptor signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9Y2K6 | USP20 | Ubiquitin carboxyl-terminal hydrolase 20 | Homo sapiens (Human) | PR |
| P51784 | USP11 | Ubiquitin carboxyl-terminal hydrolase 11 | Homo sapiens (Human) | PR |
| Q8R5K2 | Usp33 | Ubiquitin carboxyl-terminal hydrolase 33 | Mus musculus (Mouse) | PR |
| Q80U87 | Usp8 | Ubiquitin carboxyl-terminal hydrolase 8 | Mus musculus (Mouse) | PR |
| O88623 | Usp2 | Ubiquitin carboxyl-terminal hydrolase 2 | Mus musculus (Mouse) | PR |
| Q8K387 | Usp45 | Ubiquitin carboxyl-terminal hydrolase 45 | Mus musculus (Mouse) | PR |
| Q3TIX9 | Usp39 | U4/U6.U5 tri-snRNP-associated protein 2 | Mus musculus (Mouse) | PR |
| Q9SX68 | RPL18 | 50S ribosomal protein L18, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F6Z5C0 | usp15 | Ubiquitin carboxyl-terminal hydrolase 15 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAEGGAADLD | TQRSDIATLL | KTSLRKGDTW | YLVDSRWFKQ | WKKYVGFDSW | DKYQMGDQNV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YPGPIDNSGL | LKDGDAQSLK | EHLIDELDYI | LLPTEGWNKL | VSWYTLMEGQ | EPIARKVVEQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GMFVKHCKVE | VYLTELKLCE | NGNMNNVVTR | RFSKADTIDT | IEKEIRKIFN | IPDEKEARLW |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NKYMSNTFEP | LNKPDSTIQD | AGLYQGQVLV | IEQKNEDGTW | PRGPSTPKSP | GASNFSTLPK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ISPSSLSNNY | NNINNRNVKN | SNYCLPSYTA | YKNYDYSEPG | RNNEQPGLCG | LSNLGNTCFM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NSAIQCLSNT | PPLTEYFLND | KYQEELNFDN | PLGMRGEIAK | SYAELIKQMW | SGKFSYVTPR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AFKTQVGRFA | PQFSGYQQQD | CQELLAFLLD | GLHEDLNRIR | KKPYIQLKDA | DGRPDKVVAE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EAWENHLKRN | DSIIVDIFHG | LFKSTLVCPE | CAKISVTFDP | FCYLTLPLPM | KKERSLEVYL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VRMDPLAKPM | QYKVIVPKIG | NILDLCTALS | ALSGVPADKM | IVTDIYNHRF | HRIFAVDENL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SSIMERDDIY | VFEININRAE | DTEHVVIPVC | LREKFRHSSY | THHTGSSLFG | QPFLMAIPRN |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NTEDKLYNLL | LLRMCRYVKM | STETEETDGH | LRCCEDQNIN | GNGPNGLHEE | GSPSEMETDE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| PDDESSQDQE | LPSENENSQS | EDSVGGDNDS | ENGLCTEETC | KGQLTGHKKR | LFTFQFNNLG |
| 730 | 740 | 750 | 760 | 770 | 780 |
| NNDINYIKDD | TSHIRFDDRQ | LRLDERSFLA | LDWDPDLKKR | YFDENAAEDF | EKHESVEYKP |
| 790 | 800 | 810 | 820 | 830 | 840 |
| PKRPFVKLKD | CIELFTTKEK | LGAEDPWYCP | NCKEHQQATK | KLDLWSLPPV | LVVHLKRFSY |
| 850 | 860 | 870 | 880 | 890 | 900 |
| SRYMRDKLDT | LVDFPISDLD | MSEFLINPNA | GPCRYNLIAV | SNHYGGMGGG | HYTAFAKNKD |
| 910 | 920 | 930 | 940 | 950 | 960 |
| DGKWYYFDDS | SVSTASEDQI | VSKAAYVLFY | QRQDTFSGTG | FFPLDRETKG | ASAATGIPLE |
| 970 | 980 | ||||
| SDEDSNDNDN | DLENENCMHT | N |