Q8K387
PR
Gene name |
Usp45 |
Protein name |
Ubiquitin carboxyl-terminal hydrolase 45 |
Names |
Deubiquitinating enzyme 45, Ubiquitin thioesterase 45, Ubiquitin-specific-processing protease 45 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:77593 |
EC number |
3.4.19.12: Omega peptidases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8K387
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8K387-F1 | Predicted | AlphaFoldDB |
44 variants for Q8K387
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388669142 | 54 | V>E | No | EVA | |
| rs264305431 | 71 | F>L | No | EVA | |
| rs27731881 | 80 | A>S | No | EVA | |
| rs257568886 | 83 | W>C | No | EVA | |
| rs3393874300 | 112 | E>Q | No | EVA | |
| rs3394152427 | 112 | E>V | No | EVA | |
| rs3393935495 | 130 | C>F | No | EVA | |
| rs258107207 | 175 | A>T | No | EVA | |
| rs216539848 | 176 | G>D | No | EVA | |
| rs243295522 | 186 | T>S | No | EVA | |
| rs3388661376 | 247 | S>L | No | EVA | |
| rs3388674631 | 260 | L>I | No | EVA | |
| rs3394026155 | 284 | A>S | No | EVA | |
| rs3393550384 | 286 | R>L | No | EVA | |
| rs1133225943 | 346 | V>G | No | EVA | |
| rs1134515838 | 346 | V>L | No | EVA | |
| rs1134247529 | 347 | K>Q | No | EVA | |
| rs3388675219 | 352 | D>N | No | EVA | |
| rs3388669131 | 360 | T>I | No | EVA | |
| rs261466679 | 407 | E>D | No | EVA | |
| rs224413318 | 421 | N>S | No | EVA | |
| rs27714922 | 451 | P>S | No | EVA | |
| rs27714921 | 456 | K>N | No | EVA | |
| rs3388667101 | 487 | T>I | No | EVA | |
| rs248468614 | 511 | I>N | No | EVA | |
| rs211778183 | 516 | P>S | No | EVA | |
| rs235248709 | 517 | V>L | No | EVA | |
| rs27714920 | 521 | S>F | No | EVA | |
| rs251890119 | 533 | P>S | No | EVA | |
| rs253238508 | 549 | G>R | No | EVA | |
| rs3388678016 | 564 | S>N | No | EVA | |
| rs3388675232 | 565 | G>D | No | EVA | |
| rs242358454 | 565 | G>S | No | EVA | |
| rs3410424470 | 566 | T>N | No | EVA | |
| rs3388663172 | 582 | V>I | No | EVA | |
| rs3388672129 | 620 | Q>* | No | EVA | |
| rs3388678012 | 627 | T>K | No | EVA | |
| rs3393550465 | 643 | C>W | No | EVA | |
| rs3394022035 | 645 | E>V | No | EVA | |
| rs3388672156 | 652 | K>Q | No | EVA | |
| rs265122634 | 656 | S>P | No | EVA | |
| rs3388655143 | 660 | K>N | No | EVA | |
| rs3388674628 | 764 | T>I | No | EVA | |
| rs245733449 | 771 | G>A | No | EVA |
No associated diseases with Q8K387
Functions
| Description | ||
|---|---|---|
| EC Number | 3.4.19.12 | Omega peptidases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| photoreceptor inner segment | The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| cysteine-type deubiquitinase activity | An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. |
| zinc ion binding | Binding to a zinc ion (Zn). |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| cell migration | The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms. |
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| neural retina development | The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. |
| photoreceptor cell maintenance | Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light. |
| protein deubiquitination | The removal of one or more ubiquitin groups from a protein. |
| ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8R5K2 | Usp33 | Ubiquitin carboxyl-terminal hydrolase 33 | Mus musculus (Mouse) | PR |
| Q8R5H1 | Usp15 | Ubiquitin carboxyl-terminal hydrolase 15 | Mus musculus (Mouse) | PR |
| Q80U87 | Usp8 | Ubiquitin carboxyl-terminal hydrolase 8 | Mus musculus (Mouse) | PR |
| O88623 | Usp2 | Ubiquitin carboxyl-terminal hydrolase 2 | Mus musculus (Mouse) | PR |
| Q3TIX9 | Usp39 | U4/U6.U5 tri-snRNP-associated protein 2 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRVKDPSKDL | PEKGKRNKRP | LLPHDEDSSD | DIAVGLTCQH | VSYAVSVNHV | KKAVAESLWS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VCSECLKERR | FCDGQPVLPA | DVWLCLKCGL | QGCGKNSESQ | HSLRHFKSSG | TESHCVVISL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| STWVIWCYEC | NEKLSTHCNK | KVLAQIVDFL | QKHAFKTQTG | AFSRIIKLCE | EKREAGEIKK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GKKGCTVPSV | KGITNLGNTC | FFNAVIQNLA | QTYILFELMN | EIKEDGTKFK | ISLSSAPQLE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PLVVELSSPG | PLTSALFLFL | HSMKEAEKGP | LSPKVLFNQL | CQKAPRFKGF | QQQDSQELLH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HLLDAVRTEE | TKRIQASILK | AFNNPTTKTA | DDETRKKVKA | YGKEGVKMNF | IDRIFIGELT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| STVMCEECAN | ISTMKDPFID | ISLPIIEERV | SKPVLLGKMS | KCRSLQETDQ | DHNKGTVTVG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NAHQPRASRK | HSSPNDKNQL | SHDRKHLRKW | PSEEEKTVVT | HPKNDNLEAS | PPASTLSTEA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SLNESLTDGS | ERDASLESSV | DADSEASEPE | IASKQPVLLR | SRGDSCGHAE | QHPHLPLASE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LPQAKETHGG | EEEMAEAIAE | LHLSGTVTGN | RDFHREKQPL | NVPNNLCFSE | GKHTRLHSAQ |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NAFQTLSQSY | VTTSKECSVQ | SCLYQFTSME | LLMGNNKLLC | EDCTEKRRKC | HKETSSAEKK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| AGGVYTNARK | QLLISAVPAI | LILHLKRFHQ | AGLSLRKVNR | HVDFPLTLDL | APFCAATCKN |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ISVGEKVLYG | LYGIVEHSGS | MRGGHYTAYV | KVRVPSRKLS | ECITGRKTAA | GLKEPDGELG |
| 790 | 800 | 810 | |||
| GHWVHVSDTY | VQVVPESRAL | SAQAYLLFYE | RIL |