Q80U87
PR
Gene name |
Usp8 |
Protein name |
Ubiquitin carboxyl-terminal hydrolase 8 |
Names |
Deubiquitinating enzyme 8, Ubiquitin isopeptidase Y, mUBPy, Ubiquitin thioesterase 8, Ubiquitin-specific-processing protease 8 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:84092 |
EC number |
3.4.19.12: Omega peptidases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q80U87
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1UJ0 | X-ray | 170 A | B | 699-709 | PDB |
| AF-Q80U87-F1 | Predicted | AlphaFoldDB |
74 variants for Q80U87
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388592163 | 102 | A>T | No | EVA | |
| rs3388581842 | 108 | S>N | No | EVA | |
| rs3388587556 | 134 | Q>H | No | EVA | |
| rs3388581818 | 135 | Q>* | No | EVA | |
| rs3388583647 | 147 | G>D | No | EVA | |
| rs27467291 | 151 | K>R | No | EVA | |
| rs3388582088 | 161 | K>N | No | EVA | |
| rs27467272 | 167 | I>V | No | EVA | |
| rs27450759 | 182 | A>T | No | EVA | |
| rs3388588700 | 208 | Q>H | No | EVA | |
| rs3410768510 | 209 | D>E | No | EVA | |
| rs218748562 | 252 | S>N | No | EVA | |
| rs27450750 | 265 | A>T | No | EVA | |
| rs3388586243 | 287 | K>R | No | EVA | |
| rs3388581834 | 288 | T>P | No | EVA | |
| rs3388589342 | 313 | T>I | No | EVA | |
| rs3388581399 | 321 | P>L | No | EVA | |
| rs3388588824 | 322 | R>L | No | EVA | |
| rs27450739 | 349 | T>A | No | EVA | |
| rs27450738 | 370 | E>G | No | EVA | |
| rs3392193252 | 380 | L>I | No | EVA | |
| rs3392153277 | 380 | L>R | No | EVA | |
| rs27450710 | 428 | T>I | No | EVA | |
| rs263598242 | 443 | V>I | No | EVA | |
| rs233106515 | 447 | P>S | No | EVA | |
| rs3388591811 | 474 | K>M | No | EVA | |
| rs3388589564 | 495 | R>P | No | EVA | |
| rs3388592150 | 506 | R>G | No | EVA | |
| rs3388589389 | 509 | T>I | No | EVA | |
| rs3392171359 | 529 | T>R | No | EVA | |
| rs3388591758 | 543 | T>R | No | EVA | |
| rs265025382 | 558 | A>V | No | EVA | |
| rs230682125 | 560 | V>I | No | EVA | |
| rs216311740 | 575 | R>K | No | EVA | |
| rs27450704 | 576 | P>L | No | EVA | |
| rs3388591803 | 581 | P>L | No | EVA | |
| rs249181848 | 589 | N>S | No | EVA | |
| rs3388591790 | 645 | M>K | No | EVA | |
| rs3392193854 | 679 | Y>S | No | EVA | |
| rs3388592190 | 715 | E>* | No | EVA | |
| rs3392172148 | 715 | E>L | No | EVA | |
| rs3392201485 | 716 | I>L | No | EVA | |
| rs3392193892 | 717 | S>* | No | EVA | |
| rs3392193849 | 718 | R>G | No | EVA | |
| rs1132962497 | 747 | T>S | No | EVA | |
| rs1131713668 | 750 | M>I | No | EVA | |
| rs3388588911 | 773 | Q>R | No | EVA | |
| rs3391899149 | 828 | Q>K | No | EVA | |
| rs3388586225 | 853 | K>N | No | EVA | |
| rs3388590991 | 863 | L>M | No | EVA | |
| rs3388586287 | 869 | A>T | No | EVA | |
| rs3391899171 | 888 | F>L | No | EVA | |
| rs3392167182 | 888 | F>V | No | EVA | |
| rs3392174947 | 888 | F>Y | No | EVA | |
| rs3392030333 | 912 | M>I | No | EVA | |
| rs3388586301 | 916 | L>* | No | EVA | |
| rs3388591796 | 919 | A>S | No | EVA | |
| rs3392193898 | 923 | K>T | No | EVA | |
| rs3392030345 | 924 | C>* | No | EVA | |
| rs3388575774 | 924 | C>S | No | EVA | |
| rs3388587503 | 930 | L>P | No | EVA | |
| rs3388588718 | 938 | K>R | No | EVA | |
| rs27450623 | 984 | Q>E | No | EVA | |
| rs3392167563 | 998 | D>H | No | EVA | |
| rs3388585167 | 1003 | V>F | No | EVA | |
| rs3410463635 | 1040 | Q>* | No | EVA | |
| rs3388588711 | 1041 | R>H | No | EVA | |
| rs3388591007 | 1043 | F>L | No | EVA | |
| rs3388581424 | 1046 | D>V | No | EVA | |
| rs3388581769 | 1056 | S>Y | No | EVA | |
| rs3388591755 | 1057 | S>Y | No | EVA | |
| rs3388585229 | 1061 | S>L | No | EVA | |
| rs3388592146 | 1063 | A>V | No | EVA | |
| rs3388589538 | 1080 | T>I | No | EVA |
No associated diseases with Q80U87
6 regional properties for Q80U87
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Peptidase C19, ubiquitin carboxyl-terminal hydrolase | 739 - 1068 | IPR001394 |
| domain | Rhodanese-like domain | 184 - 313 | IPR001763 |
| domain | USP8 dimerisation domain | 8 - 115 | IPR015063 |
| conserved_site | Ubiquitin specific protease, conserved site | 740 - 755 | IPR018200-1 |
| conserved_site | Ubiquitin specific protease, conserved site | 1013 - 1030 | IPR018200-2 |
| domain | Ubiquitin specific protease domain | 739 - 1071 | IPR028889 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.4.19.12 | Omega peptidases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
11 GO annotations of cellular component
| Name | Definition |
|---|---|
| acrosomal membrane | The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| dendritic spine | A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. |
| early endosome | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. |
| extrinsic component of endosome membrane | The component of an endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. |
| extrinsic component of plasma membrane | The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| midbody | A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| postsynaptic density | An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| cysteine-type deubiquitinase activity | An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. |
| SH3 domain binding | Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. |
12 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to nerve growth factor stimulus | A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus. |
| endosome organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes. |
| mitotic cytokinesis | A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells. |
| positive regulation of canonical Wnt signaling pathway | Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. |
| protein deubiquitination | The removal of one or more ubiquitin groups from a protein. |
| protein K48-linked deubiquitination | A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein. |
| protein K63-linked deubiquitination | A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein. |
| Ras protein signal transduction | The series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state. |
| regulation of protein catabolic process at postsynapse, modulating synaptic transmission | Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse. |
| regulation of protein localization | Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location. |
| regulation of protein stability | Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation. |
| ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2KHV7 | USP2 | Ubiquitin carboxyl-terminal hydrolase 2 | Bos taurus (Bovine) | PR |
| O75604 | USP2 | Ubiquitin carboxyl-terminal hydrolase 2 | Homo sapiens (Human) | PR |
| P40818 | USP8 | Ubiquitin carboxyl-terminal hydrolase 8 | Homo sapiens (Human) | PR |
| Q8R5K2 | Usp33 | Ubiquitin carboxyl-terminal hydrolase 33 | Mus musculus (Mouse) | PR |
| Q8R5H1 | Usp15 | Ubiquitin carboxyl-terminal hydrolase 15 | Mus musculus (Mouse) | PR |
| O88623 | Usp2 | Ubiquitin carboxyl-terminal hydrolase 2 | Mus musculus (Mouse) | PR |
| Q8K387 | Usp45 | Ubiquitin carboxyl-terminal hydrolase 45 | Mus musculus (Mouse) | PR |
| Q3TIX9 | Usp39 | U4/U6.U5 tri-snRNP-associated protein 2 | Mus musculus (Mouse) | PR |
| Q5U349 | Usp2 | Ubiquitin carboxyl-terminal hydrolase 2 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPAVASVPKE | LYLSSSLKDL | NKKTEVKPEK | TSTKNYIHSA | QKIFKTAEEC | RLDRDEERAY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VLYMKYVAVY | NLIKKRPDFK | QQQDYYLSIL | GPANIKKAIE | EAERLSESLK | LRYEEAEVRK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QLEEKDRREE | EQLQQQKRQE | MGREDSGAAA | KRSVENLLDS | KTKTQRINGE | KSEGAAAAER |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GAITAKELYT | MMMDKNTSLI | IMDARKIQDY | QHSCILDSLS | VPEEAISPGV | TASWIEANLS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DDSKDTWKKR | GSVDYVVLLD | WFSSAKDLLL | GTTLRSLKDA | LFKWESKTVL | RHEPLVLEGG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YENWLLCYPQ | FTTNAKVTPP | PRSRAEEVSV | SLDFTYPSLE | EPVPSKLPTQ | MPPPPIETNE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KALLVTDQDE | KLRLSTQPAL | AGPGAAPRAE | ASPIIQPAPA | TKSVPQVDRT | KKPSVKLPED |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HRIKSENTDQ | SGRVLSDRST | KPVFPSPTTM | LTDEEKARIH | QETALLMEKN | KQEKELWDKQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QKEQKEKLRR | EEQERKAGKT | QDADERDSTE | NQHKAKDGQE | KKDSKQTKTE | DRELSADGAQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EATGTQRQSK | SEHEASDAKV | PVEGKRCPTS | EAQKRPADVS | PASVSGELNA | GKAQREPLTR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ARSEEMGRIV | PGLPLGWAKF | LDPITGTFRY | YHSPTNTVHM | YPPEMAPSSA | PPSTPPTHKV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KPQVPAERDR | EPSKLKRSYS | SPDITQALQE | EEKRRPAVTP | MVNRENKPPC | YPKAEISRLS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ASQIRNLNPV | FGGSGPALTG | LRNLGNTCYM | NSILQCLCNA | PHLADYFNRN | CYQDDINRSN |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LLGHKGEVAE | EFGIIMKALW | TGQYRYISPK | DFKVTIGKIN | DQFAGSSQQD | SQELLLFLMD |
| 850 | 860 | 870 | 880 | 890 | 900 |
| GLHEDLNKAD | NRKRHKEENN | EHLDDLQAAE | HAWQKHKQLN | ESIIVALFQG | QFKSTVQCLT |
| 910 | 920 | 930 | 940 | 950 | 960 |
| CRRRSRTFEA | FMYLSLPLAS | TSKCTLQDCL | RLFSKEEKLT | DNNRFYCSHC | RARRDSLKKI |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| EIWKLPPVLL | VHLKRFSYDG | RWKQKLQTSV | DFPLENLDLS | QYVIGPKNSL | KKYNLFSVSN |
| 1030 | 1040 | 1050 | 1060 | 1070 | |
| HYGGLDGGHY | TAYCKNAARQ | RWFKFDDHEV | SDISVSSVRS | SAAYILFYTS | LGPRITDVAT |