Q2KHV7

PR
Gene name
USP2 (UBP41)
Protein name
Ubiquitin carboxyl-terminal hydrolase 2
Names
41 kDa ubiquitin-specific protease, Deubiquitinating enzyme 2, Ubiquitin thioesterase 2, Ubiquitin-specific-processing protease 2
Species
Bos taurus (Bovine)
KEGG Pathway
bta:522980
EC number
3.4.19.12: Omega peptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-294 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2KHV7

Entry ID Method Resolution Chain Position Source
AF-Q2KHV7-F1 Predicted AlphaFoldDB

259 variants for Q2KHV7

Variant ID(s) Position Change Description Diseaes Association Provenance
rs465077143 3 Q>* No EVA
rs446596673 3 Q>P No EVA
rs461058248 54 S>R No EVA
rs449130330 54 S>T No EVA
rs463554478 57 T>P No EVA
rs438783868 58 S>I No EVA
rs471838568 61 T>P No EVA
rs441389588 65 T>S No EVA
rs474452634 69 P>H No EVA
rs474452634 69 P>L No EVA
rs456014386 70 S>P No EVA
rs437457892 71 I>S No EVA
rs476920427 72 L>R No EVA
rs431998214 75 D>G No EVA
rs465020498 76 R>L No EVA
rs434560636 78 R>H No EVA
rs434560636 78 R>P No EVA
rs467366087 82 R>G No EVA
rs449015925 82 R>I No EVA
rs481875740 82 R>S No EVA
rs463497170 86 I>F No EVA
rs478297586 86 I>M No EVA
rs445185751 86 I>S No EVA
rs459769207 87 G>W No EVA
rs476889523 93 E>D No EVA
rs452073431 95 Q>* No EVA
rs438359820 95 Q>P No EVA
rs519281654 97 R>L No EVA
rs467302626 106 G>R No EVA
rs455329232 107 L>P No EVA
rs445158124 110 G>A No EVA
rs469909381 110 G>C No EVA
rs478239676 111 S>I No EVA
rs466150636 111 S>R No EVA
rs480667526 114 S>F No EVA
rs483229228 115 Y>F No EVA
rs443838878 115 Y>H No EVA
rs439846619 116 G>A No EVA
rs452823439 117 V>G No EVA
rs472894346 117 V>M No EVA
rs473696724 118 T>P No EVA
rs455322881 119 T>A No EVA
rs436938728 119 T>I No EVA
rs455322881 119 T>P No EVA
rs451411952 121 S>T No EVA
rs433043492 121 S>Y No EVA
rs447609237 122 V>A No EVA
rs480661071 123 S>T No EVA
rs450246467 127 V>A No EVA
rs483134061 134 V>A No EVA
rs483134061 134 V>E No EVA
rs483134061 134 V>G No EVA
rs460840857 137 T>I No EVA
rs473633363 138 Q>R No EVA
rs443252146 139 K>N No EVA
rs476329940 140 K>Q No EVA
rs472530452 142 N>T No EVA
rs432988438 142 N>Y No EVA
rs454050417 143 S>R No EVA
rs435565319 145 S>A No EVA
rs468535479 146 D>A No EVA
rs449561456 148 A>T No EVA
rs450125158 156 T>S No EVA
rs438056460 157 S>T No EVA
rs464632293 158 D>G No EVA
rs464632293 158 D>V No EVA
rs446215184 159 S>R No EVA
rs479301070 160 Y>H No EVA
rs460830972 160 Y>S No EVA
rs448734447 162 L>M No EVA
rs481542078 162 L>R No EVA
rs443188461 163 D>A No EVA
rs476308258 163 D>E No EVA
rs461550975 163 D>Y No EVA
rs439362000 166 N>T No EVA
rs453940199 167 L>P No EVA
rs453940199 167 L>R No EVA
rs474901324 168 G>A No EVA
rs438024696 169 R>P No EVA
rs456485517 169 R>S No EVA
rs464660301 170 S>R No EVA
rs446130891 170 S>T No EVA
rs434158668 172 M>L No EVA
rs467105687 173 L>P No EVA
rs467105687 173 L>R No EVA
rs469518955 174 A>G No EVA
rs481476685 174 A>P No EVA
rs449584288 175 R>G No EVA
rs482734111 175 R>P No EVA
rs439250771 176 T>A No EVA
rs439250771 176 T>P No EVA
rs478775298 177 R>P No EVA
rs441848076 178 K>Q No EVA
rs474889190 178 K>R No EVA
rs444402498 179 E>D No EVA
rs456474941 179 E>G No EVA
rs471009900 180 L>R No EVA
rs452498809 181 C>G No EVA
rs452498809 181 C>R No EVA
rs434046903 181 C>S No EVA
rs466907521 182 A>P No EVA
rs454936385 182 A>V No EVA
rs469506745 183 L>R No EVA
rs451126672 184 Q>K No EVA
rs477754389 184 Q>L No EVA
rs477754389 184 Q>R No EVA
rs464094578 185 G>A No EVA
rs464094578 185 G>V No EVA
rs460273252 186 L>R No EVA
rs478703874 186 L>V No EVA
rs481239353 187 Y>H No EVA
rs481239353 187 Y>N No EVA
rs462839991 187 Y>S No EVA
rs444259972 188 Q>E No EVA
rs444259972 188 Q>K No EVA
rs470933507 188 Q>L No EVA
rs470933507 188 Q>R No EVA
rs473296316 190 A>D No EVA
rs440399986 190 A>P No EVA
rs473296316 190 A>V No EVA
rs436533860 191 S>I No EVA
rs436533860 191 S>T No EVA
rs469372492 192 R>P No EVA
rs457559719 193 S>A No EVA
rs457559719 193 S>P No EVA
rs445576773 195 Y>D No EVA
rs445576773 195 Y>H No EVA
rs433606344 195 Y>S No EVA
rs448225703 198 D>A No EVA
rs477306274 201 E>D No EVA
rs450672351 201 E>G No EVA
rs462721843 201 E>K No EVA
rs458890959 202 N>D No EVA
rs458890959 202 N>H No EVA
rs440392981 202 N>T No EVA
rs461195485 204 G>R No EVA
rs442849678 206 K>Q No EVA
rs475711774 207 A>P No EVA
rs457427961 209 A>S No EVA
rs457427961 209 A>T No EVA
rs472068052 210 P>H No EVA
rs466535423 212 V>A No EVA
rs466535423 212 V>G No EVA
rs433543218 212 V>L No EVA
rs436031906 214 T>P No EVA
rs469116548 215 P>T No EVA
rs450589503 216 T>A No EVA
rs450589503 216 T>P No EVA
rs446735061 221 A>P No EVA
rs446735061 221 A>T No EVA
rs479535187 228 T>A No EVA
rs479535187 228 T>P No EVA
rs442788373 229 Y>S No EVA
rs475697292 230 R>G No EVA
rs438960531 232 S>R No EVA
rs472057138 234 R>L No EVA
rs453457320 235 Y>S No EVA
rs435050126 236 S>G No EVA
rs474502452 237 L>R No EVA
rs454485793 238 W>G No EVA
rs436015998 239 E>G No EVA
rs457053126 240 K>N No EVA
rs469050237 240 K>R No EVA
rs432158389 241 G>A No EVA
rs446601871 243 G>A No EVA
rs465138857 243 G>R No EVA
rs479473725 244 Q>E No EVA
rs467543905 244 Q>H No EVA
rs449191706 245 A>P No EVA
rs482295677 247 V>L No EVA
rs463800311 248 S>P No EVA
rs449618981 250 R>C No EVA
rs478374526 250 R>H No EVA
rs478374526 250 R>L No EVA
rs459891728 253 S>P No EVA
rs474490163 258 T>A No EVA
rs456077449 259 M>L No EVA
rs474103486 261 S>T No EVA
rs455586379 263 S>C No EVA
rs437105009 264 A>S No EVA
rs470143309 268 A>D No EVA
rs438072213 278 F>L No EVA
rs452593559 279 M>I No EVA
rs470979542 279 M>L No EVA
rs434209301 280 N>H No EVA
rs447197291 282 I>S No EVA
rs435204372 283 L>Q No EVA
rs449735402 285 C>F No EVA
rs468233570 285 C>S No EVA
rs457887771 293 R>S No EVA
rs478901043 294 D>A No EVA
rs445899704 294 D>H No EVA
rs460480534 295 Y>C No EVA
rs460480534 295 Y>F No EVA
rs444452683 301 Y>S No EVA
rs470917957 304 D>A No EVA
rs452581094 306 S>I No EVA
rs440612792 307 H>D No EVA
rs473678850 307 H>P No EVA
rs455260730 313 T>P No EVA
rs436697978 317 E>D No EVA
rs468168024 318 E>* No EVA
rs476142207 318 E>A No EVA
rs437617905 329 S>L No EVA
rs452192030 387 N>T No EVA
rs479971275 396 K>E No EVA
rs461543164 398 R>G No EVA
rs443040997 399 Q>P No EVA
rs464088831 400 M>I No EVA
rs476125572 400 M>L No EVA
rs439139096 401 W>G No EVA
rs470552768 411 R>W No EVA
rs479948261 414 D>G No EVA
rs461432118 427 T>N No EVA
rs449450217 437 D>N No EVA
rs482379034 438 P>T No EVA
rs463973285 440 W>* No EVA
rs439075858 441 D>A No EVA
rs439075858 441 D>G No EVA
rs458519507 447 T>S No EVA
rs462197179 510 R>K No EVA
rs448472051 512 R>G No EVA
rs797887851 512 R>P No EVA
rs460027701 538 N>K No EVA
rs478500339 538 N>T No EVA
rs439973503 544 L>V No EVA
rs479419826 545 Y>* No EVA
rs475318886 547 V>G No EVA
rs442432555 547 V>M No EVA
rs438586463 550 H>P No EVA
rs471492293 554 T>A No EVA
rs453095184 554 T>N No EVA
rs434699306 557 G>R No EVA
rs467695980 559 Y>C No EVA
rs455728598 560 T>P No EVA
rs437284133 561 A>S No EVA
rs445436694 562 Y>F No EVA
rs478437062 563 C>G No EVA
rs466401676 564 R>L No EVA
rs447859773 565 S>G No EVA
rs480958102 565 S>R No EVA
rs460865049 571 W>R No EVA
rs442420325 572 H>P No EVA
rs481699671 573 T>A No EVA
rs438474606 575 N>T No EVA
rs463317158 575 N>Y No EVA
rs471543673 576 D>A No EVA
rs453084464 577 S>P No EVA
rs441051140 577 S>Y No EVA
rs474166383 578 S>R No EVA
rs447288426 579 V>G No EVA
rs480394964 580 S>P No EVA
rs468334942 582 M>L No EVA
rs449936977 583 S>A No EVA
rs449936977 583 S>P No EVA
rs482892110 584 S>P No EVA
rs458075827 585 S>T No EVA
rs439576210 588 R>G No EVA
rs479010518 593 Y>S No EVA

No associated diseases with Q2KHV7

4 regional properties for Q2KHV7

Type Name Position InterPro Accession
domain Peptidase C19, ubiquitin carboxyl-terminal hydrolase 269 - 597 IPR001394
conserved_site Ubiquitin specific protease, conserved site 269 - 284 IPR018200-1
conserved_site Ubiquitin specific protease, conserved site 542 - 559 IPR018200-2
domain Ubiquitin specific protease domain 268 - 600 IPR028889

Functions

Description
EC Number 3.4.19.12 Omega peptidases
Subcellular Localization
  • Cytoplasm
  • Cytoplasm, perinuclear region
  • Localizes in the spermatid head in late-elongating spermatids in the thin area between the outer acrosomal membrane and the plasma membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.

2 GO annotations of molecular function

Name Definition
cysteine-type deubiquitinase activity An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.
metal ion binding Binding to a metal ion.

11 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
circadian behavior The specific behavior of an organism that recurs with a regularity of approximately 24 hours.
circadian regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
entrainment of circadian clock by photoperiod The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).
locomotor rhythm The rhythm of the locomotor activity of an organism during its 24 hour activity cycle.
muscle organ development The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
positive regulation of mitotic cell cycle Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.
protein deubiquitination The removal of one or more ubiquitin groups from a protein.
protein stabilization Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P40818 USP8 Ubiquitin carboxyl-terminal hydrolase 8 Homo sapiens (Human) PR
O75604 USP2 Ubiquitin carboxyl-terminal hydrolase 2 Homo sapiens (Human) PR
Q80U87 Usp8 Ubiquitin carboxyl-terminal hydrolase 8 Mus musculus (Mouse) PR
O88623 Usp2 Ubiquitin carboxyl-terminal hydrolase 2 Mus musculus (Mouse) PR
Q5U349 Usp2 Ubiquitin carboxyl-terminal hydrolase 2 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MSQLSSTLKR YTESARFTDA PFTKSSYGTY TPSSYGTNLA ASFLEKEKFG FKPSPPTSYL
70 80 90 100 110 120
TRPRTYGPPS ILDYDRGRPL LRPDVIGGGK RAESQTRGTE RPSGSGLSGG SGFSYGVTTS
130 140 150 160 170 180
SVSYLPVSAR DQGVTLTQKK SNSQSDLARD FSSLQTSDSY RLDSGNLGRS PMLARTRKEL
190 200 210 220 230 240
CALQGLYQAA SRSEYLADYL ENYGRKASAP QVPTPTPPSR APEVLSPTYR PSGRYSLWEK
250 260 270 280 290 300
GKGQALVSSR SSSPGRDTMN SKSAQGLAGL RNLGNTCFMN SILQCLSNTR ELRDYCLQRL
310 320 330 340 350 360
YLRDLSHSSR AHTALMEEFA KLIQTIWTSS PNDVVSPSEF KTQIQRYAPR FVGYNQQDAQ
370 380 390 400 410 420
EFLRFLLDGL HNEVNRVIAR PKSNTENLDH LPDDEKGRQM WRKYLEREDS RIGDLFVGQL
430 440 450 460 470 480
KSSLTCTDCG YCSTVFDPFW DLSLPITKRG YPEVTLMDCM RLFTKEDVLD GDEKPTCCRC
490 500 510 520 530 540
RARKRCIKKF SIQRFPKILV LHLKRFSESR IRTSKLTAFV NFPLRDLDLR EFASENTNHA
550 560 570 580 590 600
VYNLYAVSNH SGTTMGGHYT AYCRSPVTGE WHTFNDSSVS PMSSSQVRTS DAYLLFYELA
SPPSRM