Q5U349

PR
Gene name
Usp2 (Ubp41, Ubp69)
Protein name
Ubiquitin carboxyl-terminal hydrolase 2
Names
41 kDa ubiquitin-specific protease, Deubiquitinating enzyme 2, Ubiquitin thioesterase 2, Ubiquitin-specific-processing protease 2, Ubiquitin-specific-processing protease testis, UBP-t
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:115771
EC number
3.4.19.12: Omega peptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

46-303 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5U349

Entry ID Method Resolution Chain Position Source
AF-Q5U349-F1 Predicted AlphaFoldDB

No variants for Q5U349

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5U349

No associated diseases with Q5U349

4 regional properties for Q5U349

Type Name Position InterPro Accession
domain Peptidase C19, ubiquitin carboxyl-terminal hydrolase 281 - 609 IPR001394
conserved_site Ubiquitin specific protease, conserved site 281 - 296 IPR018200-1
conserved_site Ubiquitin specific protease, conserved site 554 - 571 IPR018200-2
domain Ubiquitin specific protease domain 280 - 612 IPR028889

Functions

Description
EC Number 3.4.19.12 Omega peptidases
Subcellular Localization
  • Cytoplasm
  • ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.

5 GO annotations of molecular function

Name Definition
cyclin binding Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis.
cysteine-type deubiquitinase activity An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.
identical protein binding Binding to an identical protein or proteins.
metal ion binding Binding to a metal ion.
ubiquitin protein ligase binding Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.

14 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
circadian behavior The specific behavior of an organism that recurs with a regularity of approximately 24 hours.
circadian regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
entrainment of circadian clock by photoperiod The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).
locomotor rhythm The rhythm of the locomotor activity of an organism during its 24 hour activity cycle.
muscle organ development The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
negative regulation of calcium ion transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
negative regulation of skeletal muscle tissue development Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
positive regulation of mitotic cell cycle Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.
positive regulation of skeletal muscle tissue development Any process that activates, maintains or increases the rate of skeletal muscle tissue development.
protein deubiquitination The removal of one or more ubiquitin groups from a protein.
protein stabilization Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2KHV7 USP2 Ubiquitin carboxyl-terminal hydrolase 2 Bos taurus (Bovine) PR
P40818 USP8 Ubiquitin carboxyl-terminal hydrolase 8 Homo sapiens (Human) PR
O75604 USP2 Ubiquitin carboxyl-terminal hydrolase 2 Homo sapiens (Human) PR
Q80U87 Usp8 Ubiquitin carboxyl-terminal hydrolase 8 Mus musculus (Mouse) PR
O88623 Usp2 Ubiquitin carboxyl-terminal hydrolase 2 Mus musculus (Mouse) PR
10 20 30 40 50 60
MSQLSSTLKR YTESSRYTDA PYAKSGYGTY TPSSYGANLA ASFLEKEKLG FKPVSPTSFL
70 80 90 100 110 120
PRPRTYGPSS ILDCDRGRPL LRSDITGGSK RSESQTRGNE RPSGSGLNGG SGFPYGVTSN
130 140 150 160 170 180
SLSYLPMNAR DQGVTLGQKK SNSQSDLARD FSSLRTSDSY RTSDGYRASD GFRIDPGNLG
190 200 210 220 230 240
RSPMLARTRK ELCALQGLYQ AASRSEYLTD YLENYGRKGS APQVLTQAPP SRVPEVLSPT
250 260 270 280 290 300
YRPSGRYTLW EKNKGQASGP SRSTSPGRDT MNSKSAQGLA GLRNLGNTCF MNSILQCLSN
310 320 330 340 350 360
TRELRDYCLQ RLYMRDLGHT SSAHTALMEE FAKLIQTIWT SSPNDVVSPS EFKTQIQRYA
370 380 390 400 410 420
PRFVGYNQQD AQEFLRFLLD GLHNEVNRVA ARPKPSPESL DHLPDEEKGR QMWRKYLERE
430 440 450 460 470 480
DSRIGDLFVG QLKSSLTCTD CGYCSTVFDP FWDLSLPIAK RGYPEVTLMD CMRLFTKEDV
490 500 510 520 530 540
LDGDEKPTCC RCRARKRCIK KFSVQRFPKI LVLHLKRFSE SRIRTSKLTT FVNFPLRDLD
550 560 570 580 590 600
LREFASENTN HAVYNLYAVS NHSGTTMGGH YTAYCRSPVT GEWHTFNDSS VTPMSSSQVR
610
TSDAYLLFYE LASPPSRM