Q8R0M8
Gene name |
Slc16a4 (Mct5) |
Protein name |
Monocarboxylate transporter 5 |
Names |
MCT 5 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:229699 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8R0M8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8R0M8-F1 | Predicted | AlphaFoldDB |
20 variants for Q8R0M8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs235168456 | 4 | K>R | No | EVA | |
| rs3388655248 | 11 | Y>H | No | EVA | |
| rs224696230 | 25 | L>F | No | EVA | |
| rs33760369 | 83 | V>I | No | EVA | |
| rs237620106 | 91 | I>V | No | EVA | |
| rs3388656088 | 102 | V>L | No | EVA | |
| rs33760372 | 110 | I>V | No | EVA | |
| rs3388645742 | 150 | I>T | No | EVA | |
| rs3388655268 | 191 | S>P | No | EVA | |
| rs253042447 | 203 | N>K | No | EVA | |
| rs226865031 | 208 | I>T | No | EVA | |
| rs3388655250 | 222 | A>P | No | EVA | |
| rs3388645171 | 225 | K>R | No | EVA | |
| rs33762803 | 232 | K>N | No | EVA | |
| rs3388656083 | 241 | D>Y | No | EVA | |
| rs33763686 | 248 | E>K | No | EVA | |
| rs33763689 | 273 | P>L | No | EVA | |
| rs241123168 | 279 | G>D | No | EVA | |
| rs226589780 | 411 | Y>* | No | EVA | |
| rs3412535961 | 451 | G>V | No | EVA |
No associated diseases with Q8R0M8
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| monocarboxylic acid transmembrane transporter activity | Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group. |
| symporter activity | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| monocarboxylic acid transport | The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P57788 | SLC16A3 | Monocarboxylate transporter 4 | Gallus gallus (Chicken) | PR |
| Q8TF71 | SLC16A10 | Monocarboxylate transporter 10 | Homo sapiens (Human) | PR |
| P36021 | SLC16A2 | Monocarboxylate transporter 8 | Homo sapiens (Human) | PR |
| P57787 | Slc16a3 | Monocarboxylate transporter 4 | Mus musculus (Mouse) | PR |
| O35308 | Slc16a8 | Monocarboxylate transporter 3 | Mus musculus (Mouse) | PR |
| O70324 | Slc16a2 | Monocarboxylate transporter 8 | Mus musculus (Mouse) | PR |
| O70461 | Slc16a8 | Monocarboxylate transporter 3 | Rattus norvegicus (Rat) | PR |
| A1L1W9 | slc16a10 | Monocarboxylate transporter 10 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVKKEKTPSP | YTKPLDGGWG | WMVVLHFFLV | NVFVMGMTKT | FAIFFVVFQE | EFEGTSEQIG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WIGSIMSSLR | FSAGPLAAII | CDVLGEKATS | ILGTFLVSGG | YVISSWATGI | PFLCVTMGLL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PGLGSAFLYQ | VAAVVITKYF | KKRLGLSTAI | ARSGMGLTFL | LAPFTKFLID | LYDWTGALIL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FGAIILNLVP | SSMLLRPIHS | QSNNNSDIEN | KGSILSATEP | EASYKTETSK | CKETQEPFIK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DSTMKKSEQP | TTTLTVLGNQ | SEEFSNRPHR | NRPLLMSNGK | SHKKKFVSWN | CKQKLLDISL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FRNPFFYIFT | WSFLLSQLAY | FIPTFHLVAR | AKTLGIDVMD | ASYLVSVAGI | TETVSQLISG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| WIADQNWIKK | YQYHKSYLIL | CGVTNLLAPL | ATTFPLLMAY | TILFAIFAGG | YLALILPVLV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DLSKNSRVHK | FLGYASFFAG | IAVLSGPPIA | GWIYDYTQTY | TGSFYFSGTC | YILSSVSLFF |
| 490 | |||||
| VPLAERWKRK | QSDLLRTTIK |