O70461
Gene name |
Slc16a8 (Mct3) |
Protein name |
Monocarboxylate transporter 3 |
Names |
MCT 3, Solute carrier family 16 member 8 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:65200 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O70461
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O70461-F1 | Predicted | AlphaFoldDB |
1 variants for O70461
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs8156377 | 478 | E>K | No | EVA |
No associated diseases with O70461
No regional properties for O70461
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for O70461 | |||
Functions
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| basal plasma membrane | The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| lactate transmembrane transporter activity | Enables the transfer of lactate from one side of a membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. |
| monocarboxylic acid transmembrane transporter activity | Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group. |
| secondary active monocarboxylate transmembrane transporter activity | Catalysis of the movement of a monocarboxylate, any compound containing a single carboxyl group (COOH or COO-), by uniport, symport or antiport across a membrane by a carrier-mediated mechanism. |
| symporter activity | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| monocarboxylic acid transport | The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P57788 | SLC16A3 | Monocarboxylate transporter 4 | Gallus gallus (Chicken) | PR |
| Q8TF71 | SLC16A10 | Monocarboxylate transporter 10 | Homo sapiens (Human) | PR |
| P36021 | SLC16A2 | Monocarboxylate transporter 8 | Homo sapiens (Human) | PR |
| Q8R0M8 | Slc16a4 | Monocarboxylate transporter 5 | Mus musculus (Mouse) | PR |
| O70324 | Slc16a2 | Monocarboxylate transporter 8 | Mus musculus (Mouse) | PR |
| P57787 | Slc16a3 | Monocarboxylate transporter 4 | Mus musculus (Mouse) | PR |
| O35308 | Slc16a8 | Monocarboxylate transporter 3 | Mus musculus (Mouse) | PR |
| A1L1W9 | slc16a10 | Monocarboxylate transporter 10 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGAGGPRRGA | GPPDGGWGWV | VLGACFVITG | FAYGFPKAVS | VFFRELKRDF | GAGYSDTAWV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SSIMLAMLYG | TGPLSSILVT | RFGCRPVMLA | GGLLASAGMI | LASFASRLLE | LYLTAGVLTG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LGLALNFQPS | LIMLGLYFER | RRPLANGLAA | AGSPVFLSTL | SPLGQLLGER | FGWRGGFLLF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GGLLLHCCAC | GAVMRPPPGP | QPRPDPAPPG | GRARHRQLLD | LAVCTDRTFM | VYMVTKFLMA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LGLFVPAILL | VNYAKDAGVP | DAEAAFLLSI | VGFVDIVARP | ACGALAGLGR | LRPHVPYLFS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LALLANGLTD | LISARARSYG | TLVAFCIAFG | LSYGMVGALQ | FEVLMATVGA | PRFPSALGLV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LLVEAVAVLI | GPPSAGRLVD | ALKNYEIIFY | LAGSEVVLAG | VFMAVTTYCC | QRCSKDIPPG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PSAEGGTSDT | EDVEAERDSE | PMPASTEEPG | SLEALEVLSP | RAGSPEPEEE | AVPDLSHESV |
| GGHEAHGQNA |