P57787
PR
Gene name |
Slc16a3 (Mct4) |
Protein name |
Monocarboxylate transporter 4 |
Names |
MCT 4, Solute carrier family 16 member 3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:80879 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P57787
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P57787-F1 | Predicted | AlphaFoldDB |
31 variants for P57787
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389214345 | 76 | P>T | No | EVA | |
| rs3389161104 | 88 | R>P | No | EVA | |
| rs3389236796 | 89 | P>H | No | EVA | |
| rs50633258 | 109 | R>K | No | EVA | |
| rs3389229910 | 134 | L>H | No | EVA | |
| rs864259886 | 155 | G>S | No | EVA | |
| rs3389225379 | 178 | G>D | No | EVA | |
| rs3389161150 | 187 | L>M | No | EVA | |
| rs3389223552 | 188 | L>P | No | EVA | |
| rs3389223567 | 208 | G>R | No | EVA | |
| rs3389223620 | 234 | I>T | No | EVA | |
| rs3389196868 | 248 | V>M | No | EVA | |
| rs3389196909 | 251 | V>A | No | EVA | |
| rs3402886678 | 257 | A>P | No | EVA | |
| rs3403170672 | 258 | K>* | No | EVA | |
| rs3402236273 | 259 | D>H | No | EVA | |
| rs3389189065 | 261 | G>A | No | EVA | |
| rs1133317841 | 291 | L>F | No | EVA | |
| rs3389161110 | 296 | P>A | No | EVA | |
| rs29388476 | 305 | A>S | No | EVA | |
| rs3389214368 | 313 | D>E | No | EVA | |
| rs3389228887 | 318 | T>A | No | EVA | |
| rs3389242537 | 318 | T>I | No | EVA | |
| rs3389161171 | 325 | L>M | No | EVA | |
| rs3389224583 | 327 | V>F | No | EVA | |
| rs3413151088 | 332 | F>Y | No | EVA | |
| rs3389225356 | 344 | F>S | No | EVA | |
| rs3389228119 | 351 | V>M | No | EVA | |
| rs26950837 | 427 | E>K | No | EVA | |
| rs3389225303 | 448 | V>E | No | EVA | |
| rs3389201168 | 459 | N>I | No | EVA |
No associated diseases with P57787
1 regional properties for P57787
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Major facilitator superfamily domain | 21 - 418 | IPR020846 |
Functions
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of postsynaptic density membrane | The component of the postsynaptic density membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| lateral plasma membrane | The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells. |
| nuclear membrane | Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. |
| parallel fiber to Purkinje cell synapse | An excitatory synapse formed by the parallel fibers of granule cells synapsing onto the dendrites of Purkinje cells. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| lactate:proton symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactate (out) + H+ (out) = lactate (in) + H+ (in). |
| monocarboxylic acid transmembrane transporter activity | Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group. |
| pyruvate transmembrane transporter activity | Enables the transfer of pyruvate, 2-oxopropanoate, from one side of a membrane to the other. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| lactate transmembrane transport | The process in which lactate is transported across a membrane. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. |
| monocarboxylic acid transport | The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| plasma membrane lactate transport | The directed movement of lactate across a plasma membrane. |
| pyruvate transmembrane transport | The directed movement of pyruvate across a membrane. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P57788 | SLC16A3 | Monocarboxylate transporter 4 | Gallus gallus (Chicken) | PR |
| Q8TF71 | SLC16A10 | Monocarboxylate transporter 10 | Homo sapiens (Human) | PR |
| P36021 | SLC16A2 | Monocarboxylate transporter 8 | Homo sapiens (Human) | PR |
| O35308 | Slc16a8 | Monocarboxylate transporter 3 | Mus musculus (Mouse) | PR |
| O70324 | Slc16a2 | Monocarboxylate transporter 8 | Mus musculus (Mouse) | PR |
| Q8R0M8 | Slc16a4 | Monocarboxylate transporter 5 | Mus musculus (Mouse) | PR |
| O70461 | Slc16a8 | Monocarboxylate transporter 3 | Rattus norvegicus (Rat) | PR |
| A1L1W9 | slc16a10 | Monocarboxylate transporter 10 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGGAVVDEGP | TGIKAPDGGW | GWAVLFGCFI | ITGFSYAFPK | AVSVFFKELM | HEFGIGYSDT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AWISSILLAM | LYGTGPLCSV | CVNRFGCRPV | MLVGGLFASL | GMVAASFCRS | IIQIYLTTGV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ITGLGLALNF | QPSLIMLNRY | FNKRRPIANG | LAAAGSPVFL | CALSPLGQLL | QDHYGWRGGF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LILGGLLLNC | CVCAALMRPL | VAPQVGGGTE | PRGPQRPPQR | LLDLSVFRDR | GFLIYAVAAS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IMVLGLFVPP | VFVVSYAKDM | GVPDTKAAFL | LTILGFIDIF | ARPTAGFITG | LKKVRPYSVY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LFSFAMFFNG | FTDLTGSTAT | DYGGLVVFCI | FFGISYGMVG | ALQFEVLMAI | VGTQKFSSAI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GLVLLLEAVA | VLIGPPSGGK | LLDATKVYKY | VFILAGAEVL | TSSLVLLLGN | FFCIGKRKRP |
| 430 | 440 | 450 | 460 | ||
| EVTEPEEVAS | EEKLHKPPVD | VGVDSREVEH | FLKAEPEKNG | EVVHTPETSV |