P57788

PR
Gene name
SLC16A3 (MCT4)
Protein name
Monocarboxylate transporter 4
Names
MCT 4, Solute carrier family 16 member 3
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:395383
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

390-473 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P57788

Entry ID Method Resolution Chain Position Source
AF-P57788-F1 Predicted AlphaFoldDB

5 variants for P57788

Variant ID(s) Position Change Description Diseaes Association Provenance
rs732951444 13 V>I No Ensembl
rs733249543 87 C>W No Ensembl
rs736315959 92 L>R No Ensembl
rs731362458 206 S>Y No Ensembl
rs734307268 424 K>R No Ensembl

No associated diseases with P57788

1 regional properties for P57788

Type Name Position InterPro Accession
domain Major facilitator superfamily domain 320 - 539 IPR020846

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Basolateral cell membrane ; Multi-pass membrane protein
  • Plasma membrane localization is dependent upon the BSG/MCT4 interaction
  • Basolateral sorting signals (BLSS) in C-terminal cytoplasmic tail ensure its basolateral expression in polarised epithelial cells
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
basolateral plasma membrane The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
lactate:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactate (out) + H+ (out) = lactate (in) + H+ (in).
pyruvate transmembrane transporter activity Enables the transfer of pyruvate, 2-oxopropanoate, from one side of a membrane to the other.

2 GO annotations of biological process

Name Definition
lactate transmembrane transport The process in which lactate is transported across a membrane. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices.
pyruvate transmembrane transport The directed movement of pyruvate across a membrane.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8TF71 SLC16A10 Monocarboxylate transporter 10 Homo sapiens (Human) PR
P36021 SLC16A2 Monocarboxylate transporter 8 Homo sapiens (Human) PR
Q8R0M8 Slc16a4 Monocarboxylate transporter 5 Mus musculus (Mouse) PR
O70324 Slc16a2 Monocarboxylate transporter 8 Mus musculus (Mouse) PR
O35308 Slc16a8 Monocarboxylate transporter 3 Mus musculus (Mouse) PR
P57787 Slc16a3 Monocarboxylate transporter 4 Mus musculus (Mouse) PR
O70461 Slc16a8 Monocarboxylate transporter 3 Rattus norvegicus (Rat) PR
A1L1W9 slc16a10 Monocarboxylate transporter 10 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MGAVVVDDGP SGVKAPDGGW GWAVLFGCFI ITGFSYAFPK AVSVFFKELI REFGVGYSDT
70 80 90 100 110 120
AWISSILLAM LYGTGPLCSV CVNRFGCRPV MLVGGLFASM GMVIASFCTS IVQIYLTAGV
130 140 150 160 170 180
ITGLGLALNF QPSLIMLNRY FDKRRPLANG LSAAGSPVFL CALSPLGQIL QHEYGWRGGF
190 200 210 220 230 240
LILGGMLLNC CVCGALMRPL EPPKKSEATK EPAEKKAKKK LLDFSVFKDG GFVIYTLAAS
250 260 270 280 290 300
IMVLGLFVPP VFVVSYAKDL GYQDTKAAFL LTILGFIDIF ARPICGMVAG LKWVRPRCVY
310 320 330 340 350 360
LFSFAMIFNG FTDLMGSMSV DYGGLVVFCI FFGISYGMVG ALQFEVLMAI VGTQKFSSAI
370 380 390 400 410 420
GLVLLAEAMA VLIGPPSAGK LLDLTRRYMF VFIIAGIEVT TSALVLALGN FFCIKKKPAE
430 440 450 460 470
PHTKEAAAER EELNKSEDKT PEDAKVDSIE VEQFLKDEPE KNGEVVTNPE TCV