AiPD: Autoinhibited Protein Database

Gene name	Slc16a8 (Mct3)
Protein name	Monocarboxylate transporter 3
Names	Osteoclast differentiation factor receptor, ODFR, Receptor activator of NF-KB, MCT 3, Proton-coupled monocarboxylate transporter 3, Solute carrier family 16 member 8
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:57274
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

425-492 (Predicted disordered autoinhibitory region) PR

425-492 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-O35308-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs242959842	6	P>Q	No	EVA
rs227550989	44	R>Q	No	EVA
rs3389293280	64	M>R	No	EVA
rs3389388624	69	Y>N	No	EVA
rs3389293263	173	W>L	No	EVA
rs3389343258	175	G>D	No	EVA
rs3389371152	176	G>D	No	EVA
rs3389367274	241	L>F	No	EVA
rs3406024052	311	L>R	No	EVA
rs3406354911	312	I>M	No	EVA
rs3406278696	312	I>S	No	EVA
rs3406396069	315	R>H	No	EVA
rs3389335551	323	V>I	No	EVA
rs265984912	416	N>D	No	EVA
rs227120197	427	A>T	No	EVA
rs3389335585	458	L>Q	No	EVA
rs3389371213	461	R>G	No	EVA
rs238186053	461	R>Q	No	EVA
rs261784577	468	E>G	No	EVA
rs243921237	471	E>Q	No	EVA
rs3389293338	474	V>M	No	EVA
rs3389335574	475	P>L	No	EVA
rs3389372772	482	I>V	No	EVA
rs3389372773	491	K>E	No	EVA

Type	Name	Position	InterPro Accession
domain	Major facilitator superfamily domain	18 - 411	IPR020846

		Description
EC Number
Subcellular Localization	Basolateral cell membrane ; Multi-pass membrane protein	Basolateral sorting signals (BLSS) in C-terminal cytoplasmic tail ensure its basolateral expression (By similarity) Colocalizes with BSG in basolateral cell membrane of the retinal pigment epithelium (PubMed:18524945)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
apical plasma membrane	The region of the plasma membrane located at the apical end of the cell.
basal plasma membrane	The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
basolateral plasma membrane	The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

Name	Definition
lactate transmembrane transporter activity	Enables the transfer of lactate from one side of a membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices.
monocarboxylic acid transmembrane transporter activity	Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group.
symporter activity	Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.

Name	Definition
monocarboxylic acid transport	The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P57788	SLC16A3	Monocarboxylate transporter 4	Gallus gallus (Chicken)	PR
Q8TF71	SLC16A10	Monocarboxylate transporter 10	Homo sapiens (Human)	PR
P36021	SLC16A2	Monocarboxylate transporter 8	Homo sapiens (Human)	PR
O70324	Slc16a2	Monocarboxylate transporter 8	Mus musculus (Mouse)	PR
P57787	Slc16a3	Monocarboxylate transporter 4	Mus musculus (Mouse)	PR
Q8R0M8	Slc16a4	Monocarboxylate transporter 5	Mus musculus (Mouse)	PR
O70461	Slc16a8	Monocarboxylate transporter 3	Rattus norvegicus (Rat)	PR
A1L1W9	slc16a10	Monocarboxylate transporter 10	Danio rerio (Zebrafish) (Brachydanio rerio)	PR