O70324
PR
Gene name |
Slc16a2 (Mct8, Xpct) |
Protein name |
Monocarboxylate transporter 8 |
Names |
MCT 8, Solute carrier family 16 member 2, X-linked PEST-containing transporter |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:20502 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O70324
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O70324-F1 | Predicted | AlphaFoldDB |
37 variants for O70324
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3411363342 | 38 | E>V | No | EVA | |
| rs3410984128 | 75 | F>S | No | EVA | |
| rs3411729568 | 95 | A>S | No | EVA | |
| rs3411406852 | 96 | R>G | No | EVA | |
| rs3409944926 | 98 | F>C | No | EVA | |
| rs3411627657 | 98 | F>L | No | EVA | |
| rs3410553045 | 99 | Q>K | No | EVA | |
| rs3411627695 | 100 | P>L | No | EVA | |
| rs3389584281 | 102 | E>K | No | EVA | |
| rs3389573451 | 128 | G>D | No | EVA | |
| rs3389571073 | 154 | A>V | No | EVA | |
| rs3410981513 | 172 | D>Y | No | EVA | |
| rs3411624736 | 188 | F>Y | No | EVA | |
| rs3389568082 | 189 | I>F | No | EVA | |
| rs3389520310 | 224 | V>A | No | EVA | |
| rs3389571086 | 224 | V>F | No | EVA | |
| rs3389551024 | 230 | F>Y | No | EVA | |
| rs3389538839 | 234 | L>I | No | EVA | |
| rs3389538832 | 265 | L>Q | No | EVA | |
| rs3411517837 | 269 | F>C | No | EVA | |
| rs3411624738 | 269 | F>L | No | EVA | |
| rs3411624708 | 270 | Q>K | No | EVA | |
| rs3411569916 | 287 | R>Q | No | EVA | |
| rs3410057285 | 320 | R>C | No | EVA | |
| rs3410550360 | 345 | Y>* | No | EVA | |
| rs3413091443 | 389 | G>R | No | EVA | |
| rs3389571250 | 392 | K>M | No | EVA | |
| rs3408852361 | 472 | A>V | No | EVA | |
| rs3411952713 | 492 | P>Q | No | EVA | |
| rs3389520286 | 509 | R>G | No | EVA | |
| rs3389520323 | 510 | M>I | No | EVA | |
| rs3389538844 | 514 | E>K | No | EVA | |
| rs3389584260 | 515 | Q>H | No | EVA | |
| rs3411404805 | 539 | P>Q | No | EVA | |
| rs3411360542 | 545 | I>T | No | EVA | |
| rs3413128098 | 546 | I>L | No | EVA | |
| rs3410981579 | 546 | I>N | No | EVA |
No associated diseases with O70324
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| amino acid transmembrane transporter activity | Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. |
| identical protein binding | Binding to an identical protein or proteins. |
| symporter activity | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. |
| thyroid hormone transmembrane transporter activity | Enables the transfer of thyroid hormones from one side of a membrane to the other. Thyroid hormone are any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| amino acid import across plasma membrane | The directed movement of an amino acid from outside of a cell, across the plasma membrane and into the cytosol. |
| cellular amino acid metabolic process | The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells. |
| hormone transport | The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| negative regulation of neural precursor cell proliferation | Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation. |
| thyroid hormone generation | The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones. |
| thyroid hormone metabolic process | The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine. |
| thyroid hormone transport | The directed movement of thyroid hormone into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| thyroid-stimulating hormone secretion | The regulated release of thyroid-stimulating hormone, a peptide hormone that stimulates the activity of the thyroid gland, from secretory granules in the anterior pituitary. |
| transport across blood-brain barrier | The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P57788 | SLC16A3 | Monocarboxylate transporter 4 | Gallus gallus (Chicken) | PR |
| Q8TF71 | SLC16A10 | Monocarboxylate transporter 10 | Homo sapiens (Human) | PR |
| P36021 | SLC16A2 | Monocarboxylate transporter 8 | Homo sapiens (Human) | PR |
| O35308 | Slc16a8 | Monocarboxylate transporter 3 | Mus musculus (Mouse) | PR |
| P57787 | Slc16a3 | Monocarboxylate transporter 4 | Mus musculus (Mouse) | PR |
| Q8R0M8 | Slc16a4 | Monocarboxylate transporter 5 | Mus musculus (Mouse) | PR |
| O70461 | Slc16a8 | Monocarboxylate transporter 3 | Rattus norvegicus (Rat) | PR |
| A1L1W9 | slc16a10 | Monocarboxylate transporter 10 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALPSPASEE | AEGPCQEANQ | EYQEPVCSPV | PEPEPEPEPE | PEPDPEPVPV | PPPEPQPEPE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PQPLPDPAPL | PELGFEAEPV | QEPEPTPTVE | TRGTARGFQP | PEGGFGWIVV | FAATWCNGSI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FGIHNSVGIL | YSMLLEEEKE | KNRQVEFQAA | WVGALAMGMI | FFCSPIVSIF | TDRLGCRITA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TTGAAVAFIG | LHTSSFTSSL | SLRYFTYGIL | FGCGCSFAFQ | PSLVILGHYF | QRRLGLANGV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VSAGSSIFSM | SFPFLIKMLG | DKIKLAQTFQ | VLSTFMFVLT | LLSLTYRPLL | PSSQDTPSKR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GAHTLRQRFL | VQFRKYFNMR | VFRQRTYRIW | AFGIAAAALG | YFVPYVHLMK | YVEDKFKEIK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ETWVLLVCIG | ATSGLGRLVS | GHISDSIPGL | KKIYLQVLSF | LLLGLMSMMI | PLCRDFGGLI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VVCLFLGLCD | GFFITIMAPI | AFELVGPMQA | SQAIGYLLGM | MALPMIAGPP | IAGLLRNCFG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DYHVAFYFAG | VPPIIGAVIL | FFVPLMHQRM | FKKEQRDSSK | DKMLSHDPDP | NGELLPGSPT |
| PEEPI |