Q8C811
Gene name |
Slc35e2a (Slc35e2) |
Protein name |
Solute carrier family 35 member E2A |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:320541 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8C811
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8C811-F1 | Predicted | AlphaFoldDB |
19 variants for Q8C811
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3395173999 | 36 | R>L* | No | EVA | |
| rs3395096508 | 36 | R>P | No | EVA | |
| rs3395199404 | 37 | S>* | No | EVA | |
| rs3388739132 | 39 | K>R | No | EVA | |
| rs3388724101 | 41 | V>I | No | EVA | |
| rs3388740481 | 60 | E>* | No | EVA | |
| rs3388733200 | 77 | I>N | No | EVA | |
| rs3388740660 | 79 | L>I | No | EVA | |
| rs3388740543 | 175 | V>M | No | EVA | |
| rs3388736681 | 193 | E>D | No | EVA | |
| rs3388740697 | 193 | E>K | No | EVA | |
| rs3388743862 | 209 | G>* | No | EVA | |
| rs3388729603 | 222 | I>V | No | EVA | |
| rs3388739144 | 226 | S>* | No | EVA | |
| rs3388713634 | 228 | A>E | No | EVA | |
| rs3395202818 | 261 | Y>D | No | EVA | |
| rs3388724148 | 348 | K>E | No | EVA | |
| rs3388736668 | 375 | Q>H | No | EVA | |
| rs259248223 | 385 | T>P | No | EVA |
No associated diseases with Q8C811
7 regional properties for Q8C811
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | DNA topoisomerase, type IA, domain 2 | 146 - 242 | IPR003601 |
| domain | DNA topoisomerase, type IA, DNA-binding domain | 289 - 545 | IPR003602 |
| domain | TOPRIM domain | 3 - 155 | IPR006171 |
| domain | DNA topoisomerase, type IA, central | 112 - 125 | IPR013497-1 |
| domain | DNA topoisomerase, type IA, central | 170 - 593 | IPR013497-2 |
| active_site | DNA topoisomerase, type IA, active site | 326 - 340 | IPR023406 |
| domain | DNA topoisomerase 3-like, TOPRIM domain | 3 - 167 | IPR034144 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| antiporter activity | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| blastocyst hatching | The hatching of the cellular blastocyst from the zona pellucida. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q96K37 | SLC35E1 | Solute carrier family 35 member E1 | Homo sapiens (Human) | PR |
| P0CK97 | SLC35E2A | Solute carrier family 35 member E2A | Homo sapiens (Human) | PR |
| P0CK96 | SLC35E2B | Solute carrier family 35 member E2B | Homo sapiens (Human) | PR |
| Q8CD26 | Slc35e1 | Solute carrier family 35 member E1 | Mus musculus (Mouse) | PR |
| Q8RXL8 | UXT3 | UDP-xylose transporter 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SRE4 | URGT1 | UDP-rhamnose/UDP-galactose transporter 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8H0T6 | PPT2 | Phosphoenolpyruvate/phosphate translocator 2, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SS40 | At3g10290 | Probable sugar phosphate/phosphate translocator At3g10290 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSAAAKSQVP | EEAAPGCEEE | PKGKTLLTWG | SLFGHRSEKI | VFTKGDGSPE | ESLLTVTITE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TTVIESDLGV | WSSRALIYLT | LWFFFSFCTL | FLNKYILSLL | EGEPSMLGAV | QMLSTTLIGC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VKIFVPCCLY | QHKTRLSYPP | NFIMTMLFVG | LMRFATVVLG | LVSLKNVAVS | FAETVKSSAP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IFTVIMSRMI | LGEYTGLLVN | LSLIPVMGGL | ALCTATEISF | NILGFSAALS | TNIMDCLQNV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FSKKLLSGDK | YRFSAPELQF | YTSAAAVALL | IPAWTFFMDI | PVIGRSGKSF | SYSQDIVLLL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LTDGALFHLQ | SVTAYALMGK | ISPVTFSVAS | TVKHALSIWL | SIIVFGNKIT | SLSAIGTILV |
| 370 | 380 | 390 | 400 | ||
| TLGVLLYNKA | RQYQQETMQS | LVTATSRNPE | DDTEPLVPQD | SRQHH |