Q8BK58
Gene name |
Hspbap1 (Pass1) |
Protein name |
HSPB1-associated protein 1 |
Names |
27 kDa heat shock protein-associated protein 1, Protein associated with small stress protein 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:66667 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BK58
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BK58-F1 | Predicted | AlphaFoldDB |
44 variants for Q8BK58
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3406255822 | 6 | E>Q | No | EVA | |
| rs3389430889 | 72 | I>T | No | EVA | |
| rs3389412964 | 73 | R>L | No | EVA | |
| rs3389416769 | 81 | T>I | No | EVA | |
| rs50394991 | 103 | T>I | No | EVA | |
| rs3405168905 | 112 | S>P | No | EVA | |
| rs3389396100 | 121 | S>C | No | EVA | |
| rs3389430894 | 123 | F>Y | No | EVA | |
| rs3389405193 | 140 | T>K | No | EVA | |
| rs214490733 | 141 | D>N | No | EVA | |
| rs3389408568 | 154 | P>H | No | EVA | |
| rs3389413774 | 161 | S>R | No | EVA | |
| rs3389413693 | 165 | I>F | No | EVA | |
| rs46327323 | 181 | C>F | No | EVA | |
| rs3389405160 | 188 | Q>* | No | EVA | |
| rs3389383114 | 206 | P>T | No | EVA | |
| rs3412920680 | 217 | F>I | No | EVA | |
| rs3389425290 | 226 | D>E | No | EVA | |
| rs224095025 | 227 | L>V | No | EVA | |
| rs4173180 | 229 | C>R | No | EVA | |
| rs3389396137 | 232 | Q>R | No | EVA | |
| rs3389430960 | 259 | V>M | No | EVA | |
| rs3389405164 | 289 | R>H | No | EVA | |
| rs254193824 | 316 | T>I | No | EVA | |
| rs3406836235 | 317 | S>R | No | EVA | |
| rs3389425217 | 329 | V>D | No | EVA | |
| rs3389374664 | 339 | A>T | No | EVA | |
| rs31417236 | 344 | L>M | No | EVA | |
| rs31417237 | 346 | V>A | No | EVA | |
| rs31417238 | 348 | S>I | No | EVA | |
| rs265762299 | 349 | A>T | No | EVA | |
| rs3389364015 | 368 | G>A | No | EVA | |
| rs247727366 | 374 | R>G | No | EVA | |
| rs50485304 | 381 | V>A | No | EVA | |
| rs50485304 | 381 | V>E | No | EVA | |
| rs3389374642 | 407 | E>D | No | EVA | |
| rs3389425254 | 409 | S>T | No | EVA | |
| rs3405956901 | 416 | H>P | No | EVA | |
| rs51077684 | 433 | S>N | No | EVA | |
| rs3406901142 | 442 | R>M | No | EVA | |
| rs3389425223 | 447 | H>D | No | EVA | |
| rs3389396107 | 461 | L>P | No | EVA | |
| rs3389396119 | 463 | N>T | No | EVA | |
| rs3389425218 | 466 | V>L | No | EVA |
No associated diseases with Q8BK58
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| 2-oxoglutarate-dependent dioxygenase activity | Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q58CU3 | HSPBAP1 | HSPB1-associated protein 1 | Bos taurus (Bovine) | PR |
| E1C7T6 | TYW5 | tRNA wybutosine-synthesizing protein 5 | Gallus gallus (Chicken) | PR |
| Q96EW2 | HSPBAP1 | HSPB1-associated protein 1 | Homo sapiens (Human) | PR |
| Q5BKC6 | Hspbap1 | HSPB1-associated protein 1 | Rattus norvegicus (Rat) | PR |
| Q8RWR1 | JMJ30 | Lysine-specific demethylase JMJ30 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| B2GUS6 | kdm8 | Lysine-specific demethylase 8 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q08BV2 | tyw5 | tRNA wybutosine-synthesizing protein 5 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| A8E534 | kdm8 | Lysine-specific demethylase 8 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q6AXL5 | hspbap1 | HSPB1-associated protein 1 homolog | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAGCEGIAP | PTLGERTVGE | EGEPVKPFTP | EKAKEIIMSL | QQPAIFCNMV | FDWPSRHWTA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KHLSKVLEGK | QIRFRMGLRG | TGTVPQYETE | CSYVDATLEE | FLTWNCDQSS | ISGPFKDYEH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SKFWAYADYK | YFVTLFEDKT | DVFQEVVWSD | FGFPGRNGQE | STLWIGSFGA | HTPCHLDSYG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CNLVFQVQGR | KRWHLFPPED | TPFLYPTRIP | YEESSVFSKI | NVVNPDLKCF | PQFQKARRHM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VTLSPGQVLF | VPRHWWHYVE | SLDPVTVSIN | SWIELEEDHL | ARVEEAITRM | LVCTLKTAED |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PHHPRTWLNP | TEVEETSHEV | NSCYLNSAVC | AFFDHCEKAK | AVELQVLSAN | GAEPRVQEEH |
| 370 | 380 | 390 | 400 | 410 | 420 |
| MEVEQAQGPS | LTSRAEKQEA | VSLFGPDLIP | VTPASEERGG | ALEGDSEESV | SSNGGHFAEL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PCARRQQTSK | GASALTEPLA | PRGPMAHSRV | FVSTDDLLDC | LVNPQVTRMV | AQLLIQGKSC |
| DTF |