Q58CU3
Gene name |
HSPBAP1 |
Protein name |
HSPB1-associated protein 1 |
Names |
27 kDa heat shock protein-associated protein 1 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:513211 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q58CU3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q58CU3-F1 | Predicted | AlphaFoldDB |
75 variants for Q58CU3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs467688844 | 2 | A>G | No | EVA | |
| rs447821232 | 3 | A>P | No | EVA | |
| rs439093519 | 4 | R>P | No | EVA | |
| rs459110904 | 4 | R>S | No | EVA | |
| rs462571125 | 6 | G>R | No | EVA | |
| rs442435054 | 7 | A>V | No | EVA | |
| rs453806498 | 8 | I>M | No | EVA | |
| rs473929029 | 8 | I>T | No | EVA | |
| rs440106324 | 9 | T>A | No | EVA | |
| rs471592431 | 9 | T>N | No | EVA | |
| rs437931880 | 11 | A>P | No | EVA | |
| rs456406720 | 12 | D>E | No | EVA | |
| rs469292688 | 12 | D>G | No | EVA | |
| rs479114708 | 16 | G>A | No | EVA | |
| rs463236672 | 19 | E>G | No | EVA | |
| rs442473983 | 20 | E>G | No | EVA | |
| rs480236126 | 21 | E>G | No | EVA | |
| rs480236126 | 21 | E>V | No | EVA | |
| rs483138115 | 47 | Y>C | No | EVA | |
| rs452282742 | 85 | P>S | No | EVA | |
| rs449971925 | 86 | Q>H | No | EVA | |
| rs470063845 | 86 | Q>P | No | EVA | |
| rs482237919 | 87 | F>V | No | EVA | |
| rs468550514 | 88 | E>* | No | EVA | |
| rs468550514 | 88 | E>K | No | EVA | |
| rs448496324 | 88 | E>V | No | EVA | |
| rs136377624 | 90 | A>T | No | EVA | |
| rs477540177 | 91 | C>* | No | EVA | |
| rs439738998 | 91 | C>G | No | EVA | |
| rs439738998 | 91 | C>R | No | EVA | |
| rs463906512 | 93 | Y>F | No | EVA | |
| rs443866180 | 94 | V>L | No | EVA | |
| rs474612423 | 95 | E>K | No | EVA | |
| rs454469018 | 96 | A>T | No | EVA | |
| rs472309223 | 99 | E>A | No | EVA | |
| rs440942734 | 99 | E>K | No | EVA | |
| rs452362213 | 100 | E>K | No | EVA | |
| rs432164047 | 105 | N>D | No | EVA | |
| rs481978075 | 112 | S>T | No | EVA | |
| rs469949125 | 118 | Y>F | No | EVA | |
| rs436252429 | 125 | A>G | No | EVA | |
| rs468592259 | 127 | A>D | No | EVA | |
| rs448465039 | 128 | D>Y | No | EVA | |
| rs479991794 | 135 | L>* | No | EVA | |
| rs466268925 | 136 | F>C | No | EVA | |
| rs446071021 | 138 | D>G | No | EVA | |
| rs456853788 | 146 | V>L | No | EVA | |
| rs460494330 | 184 | V>G | No | EVA | |
| rs440581461 | 190 | R>K | No | EVA | |
| rs384831589 | 200 | D>A | No | EVA | |
| rs472373652 | 272 | W>* | No | EVA | |
| rs433019440 | 319 | E>K | No | EVA | |
| rs480577586 | 353 | Y>S | No | EVA | |
| rs460655856 | 359 | L>I | No | EVA | |
| rs440484604 | 360 | N>T | No | EVA | |
| rs465900021 | 365 | V>L | No | EVA | |
| rs458336737 | 367 | V>A | No | EVA | |
| rs521387217 | 368 | E>K | No | EVA | |
| rs444738510 | 376 | S>N | No | EVA | |
| rs516426651 | 397 | P>A | No | EVA | |
| rs479982914 | 416 | D>Y | No | EVA | |
| rs476125834 | 432 | M>R | No | EVA | |
| rs455843468 | 435 | S>G | No | EVA | |
| rs441590676 | 435 | S>T | No | EVA | |
| rs468025704 | 438 | A>T | No | EVA | |
| rs432839105 | 441 | E>A | No | EVA | |
| rs452899187 | 441 | E>Q | No | EVA | |
| rs464374597 | 445 | S>P | No | EVA | |
| rs457106000 | 447 | R>S | No | EVA | |
| rs437111622 | 457 | S>Y | No | EVA | |
| rs468511370 | 460 | D>A | No | EVA | |
| rs448358650 | 475 | A>V | No | EVA | |
| rs447004537 | 480 | Q>H | No | EVA | |
| rs466927809 | 480 | Q>K | No | EVA | |
| rs478346366 | 481 | G>R | No | EVA |
No associated diseases with Q58CU3
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| 2-oxoglutarate-dependent dioxygenase activity | Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| E1C7T6 | TYW5 | tRNA wybutosine-synthesizing protein 5 | Gallus gallus (Chicken) | PR |
| Q96EW2 | HSPBAP1 | HSPB1-associated protein 1 | Homo sapiens (Human) | PR |
| Q8BK58 | Hspbap1 | HSPB1-associated protein 1 | Mus musculus (Mouse) | PR |
| Q5BKC6 | Hspbap1 | HSPB1-associated protein 1 | Rattus norvegicus (Rat) | PR |
| Q8RWR1 | JMJ30 | Lysine-specific demethylase JMJ30 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| B2GUS6 | kdm8 | Lysine-specific demethylase 8 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q08BV2 | tyw5 | tRNA wybutosine-synthesizing protein 5 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| A8E534 | kdm8 | Lysine-specific demethylase 8 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q6AXL5 | hspbap1 | HSPB1-associated protein 1 homolog | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAARPGAITN | ADSASGGGEE | EGKHVKPFTP | EKAKEIIMCL | QQPAVFYNMV | FDWPAQHWTA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KHLSEVLHGK | QIRFRMGTKS | TDTAPQFETA | CNYVEATLEE | FLSWNSDQSS | ISGAFRDYDH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SKFWAYADYK | YFVSLFEDKT | DIFQDVIWSD | FGFPGRNGQE | STLWIGSLGA | HTPCHLDTYG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CNLVFQVQGR | KRWHLFPPED | TPFLYPTRIP | YEESSVFSKI | NVVNPDLKRF | PQFRKARRHM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VTLSPGQVLF | VPRHWWHYVE | SIDPVTVSIN | SWIELEEDHQ | TRVEEAITRM | LVCALKTAEN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PHNTRAWLNP | TELEETSHEI | NCHYLNGAIS | AFFNHYGTSE | VVETQALRTN | REYTIKEELN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| MHSHVGVEQA | GGHNLSSETV | KQEAASPFGL | DLVPVTPSSE | EPSSERGGIF | ENDGEDFVSK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NGKSFGKRQR | MMSESENAVV | EQIASDRTVA | VSQTFVSTDD | LLDCLVNPQV | TRIVAQLLIQ |
| GRST |