Q08BV2

PR
Gene name
tyw5 (zgc:154110)
Protein name
tRNA wybutosine-synthesizing protein 5
Names
tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:557725
EC number
1.14.11.42: With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

82-154 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q08BV2

Entry ID Method Resolution Chain Position Source
AF-Q08BV2-F1 Predicted AlphaFoldDB

No variants for Q08BV2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q08BV2

No associated diseases with Q08BV2

2 regional properties for Q08BV2

Type Name Position InterPro Accession
domain JmjC domain 106 - 268 IPR003347
domain Cupin-like domain 8 18 - 254 IPR041667

Functions

Description
EC Number 1.14.11.42 With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

5 GO annotations of molecular function

Name Definition
2-oxoglutarate-dependent dioxygenase activity Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor.
iron ion binding Binding to an iron (Fe) ion.
protein homodimerization activity Binding to an identical protein to form a homodimer.
tRNA binding Binding to a transfer RNA.
tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity Catalysis of the reaction: 2-oxoglutarate + O2 + 7-[(3S)-(3-amino-3-carboxypropyl)]-wyosine37 in tRNAPhe = succinate + carbon dioxide + 7-(2-hydroxy-3-amino-3-carboxypropyl)-wyosine37 in tRNAPhe.

1 GO annotations of biological process

Name Definition
wybutosine biosynthetic process The chemical reactions and pathways resulting in the formation of wybutosine, 3H-imidazopurine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q58CU3 HSPBAP1 HSPB1-associated protein 1 Bos taurus (Bovine) PR
E1C7T6 TYW5 tRNA wybutosine-synthesizing protein 5 Gallus gallus (Chicken) PR
Q96EW2 HSPBAP1 HSPB1-associated protein 1 Homo sapiens (Human) PR
Q8BK58 Hspbap1 HSPB1-associated protein 1 Mus musculus (Mouse) PR
Q5BKC6 Hspbap1 HSPB1-associated protein 1 Rattus norvegicus (Rat) PR
Q8RWR1 JMJ30 Lysine-specific demethylase JMJ30 Arabidopsis thaliana (Mouse-ear cress) PR
B2GUS6 kdm8 Lysine-specific demethylase 8 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q6AXL5 hspbap1 HSPB1-associated protein 1 homolog Danio rerio (Zebrafish) (Brachydanio rerio) PR
A8E534 kdm8 Lysine-specific demethylase 8 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MDCQEKLEVP VYTDVDKETF LRDIYPQRRP AVLKRVPIGP CVRTWTVCFL AEKGGDREVK
70 80 90 100 110 120
VHVSPEPRMD FLHKNFVYRT LPFDEFIKRA AEAKHPEFFI SEDESYYLRS LGEDARKEPA
130 140 150 160 170 180
DLRKQFPELA EDFHVPQFFE PEQFFSSVFR ISSPGLQLWT HYDVMDNLLA QVTGKKRVVL
190 200 210 220 230 240
YSPEDALHLY LTGDKSEVLD IDSPDLQLYP EFVKARRYEC ILEPGDLLFI PALWFHNTLA
250 260 270 280 290 300
LQFGVGVNVF WRHLPSESYD KKDPYGNKDP VAATRALQSL ERTLGILDEL PPDYRDFYAR
310 320
RMVLRIQSRA YIRKPINAAQ ENSDTT