E1C7T6

PR
Gene name
TYW5
Protein name
tRNA wybutosine-synthesizing protein 5
Names
tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase
Species
Gallus gallus (Chicken)
KEGG Pathway
EC number
1.14.11.42: With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-43 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for E1C7T6

Entry ID Method Resolution Chain Position Source
AF-E1C7T6-F1 Predicted AlphaFoldDB

No variants for E1C7T6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for E1C7T6

No associated diseases with E1C7T6

2 regional properties for E1C7T6

Type Name Position InterPro Accession
domain JmjC domain 126 - 270 IPR003347
domain Cupin-like domain 8 20 - 256 IPR041667

Functions

Description
EC Number 1.14.11.42 With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

5 GO annotations of molecular function

Name Definition
2-oxoglutarate-dependent dioxygenase activity Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor.
iron ion binding Binding to an iron (Fe) ion.
protein homodimerization activity Binding to an identical protein to form a homodimer.
tRNA binding Binding to a transfer RNA.
tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity Catalysis of the reaction: 2-oxoglutarate + O2 + 7-[(3S)-(3-amino-3-carboxypropyl)]-wyosine37 in tRNAPhe = succinate + carbon dioxide + 7-(2-hydroxy-3-amino-3-carboxypropyl)-wyosine37 in tRNAPhe.

1 GO annotations of biological process

Name Definition
wybutosine biosynthetic process The chemical reactions and pathways resulting in the formation of wybutosine, 3H-imidazopurine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q58CU3 HSPBAP1 HSPB1-associated protein 1 Bos taurus (Bovine) PR
Q96EW2 HSPBAP1 HSPB1-associated protein 1 Homo sapiens (Human) PR
Q8BK58 Hspbap1 HSPB1-associated protein 1 Mus musculus (Mouse) PR
Q5BKC6 Hspbap1 HSPB1-associated protein 1 Rattus norvegicus (Rat) PR
Q8RWR1 JMJ30 Lysine-specific demethylase JMJ30 Arabidopsis thaliana (Mouse-ear cress) PR
B2GUS6 kdm8 Lysine-specific demethylase 8 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q6AXL5 hspbap1 HSPB1-associated protein 1 homolog Danio rerio (Zebrafish) (Brachydanio rerio) PR
A8E534 kdm8 Lysine-specific demethylase 8 Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q08BV2 tyw5 tRNA wybutosine-synthesizing protein 5 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MEQREQPAVQ VPSLDGVTRE RFLRDVYPRR EPVVLKGMEL GPCTTKWTVD YLSQAAGSKE
70 80 90 100 110 120
VKIHVSAVPQ MDFLSKNFVY RTLPFDVFVR RAAEVKHKDY FLSEDEKYYL RSVGEDVRKD
130 140 150 160 170 180
IADIRKQFPV LAEDVQIPEY FEKEQFFSSV FRISSAGLQL WTHYDVMDNF LIQVTGRKRV
190 200 210 220 230 240
VLYSPRDVPY LYLSGTKSEV LDVDNPDFEK YPLFAKAKRY QCYLEAGDVL FIPAMWFHNV
250 260 270 280 290 300
ISEEFGVALN VFWKHLPAEC YDKSDTYGNK DPTAASRAIQ ILDRALKTLE ELPEEYRDFY
310
ARRMVLRIQE KAYRNDNG