AiPD: Autoinhibited Protein Database

Q6DKI1

Gene name	RPL7L1
Protein name	60S ribosomal protein L7-like 1
Names	Large ribosomal subunit protein uL30-like 1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:285855
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

13-97 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

13-97 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

26 structures for Q6DKI1

Entry ID	Method	Resolution	Chain	Position	Source
8FKP	EM	285 A	SI	1-255	PDB
8FKQ	EM	276 A	SI	1-255	PDB
8FKR	EM	289 A	SI	1-255	PDB
8FKS	EM	288 A	SI	1-255	PDB
8FKT	EM	281 A	SI	1-255	PDB
8FKU	EM	282 A	SI	1-255	PDB
8FKV	EM	247 A	SI	1-255	PDB
8FKW	EM	250 A	SI	1-255	PDB
8FKX	EM	259 A	SI	1-255	PDB
8FKY	EM	267 A	SI	1-255	PDB
8FKZ	EM	304 A	SI	1-255	PDB
8FL2	EM	267 A	SI	1-255	PDB
8FL3	EM	253 A	SI	1-255	PDB
8FL4	EM	289 A	SI	1-255	PDB
8FL6	EM	262 A	SI	1-255	PDB
8FL7	EM	255 A	SI	1-255	PDB
8FLA	EM	263 A	SI	1-255	PDB
8FLB	EM	255 A	SI	1-255	PDB
8FLD	EM	258 A	SI	1-255	PDB
8FLE	EM	248 A	SI	1-255	PDB
8INE	EM	320 A	3	1-255	PDB
8INF	EM	300 A	3	1-255	PDB
8IPX	EM	430 A	1	1-255	PDB
8IPY	EM	320 A	1	1-255	PDB
8IR3	EM	350 A	3	1-255	PDB
AF-Q6DKI1-F1	Predicted				AlphaFoldDB

227 variants for Q6DKI1

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs756576258 CA3809647	2	I>L		No	ClinGen ExAC gnomAD
CA566778771 rs1160311894	3	S>G		No	ClinGen gnomAD
CA3809649 rs780765812	3	S>N		No	ClinGen ExAC TOPMed gnomAD
CA3809648 rs780765812	3	S>T		No	ClinGen ExAC TOPMed gnomAD
CA3809650 rs755435206	4	S>C		No	ClinGen ExAC
CA138202428 rs755435206	4	S>G		No	ClinGen ExAC
rs376099875 CA138202448	4	S>N		No	ClinGen ESP TOPMed gnomAD
rs779236578 CA3809651	5	C>Y		No	ClinGen ExAC gnomAD
CA566778772 rs1463035055	6	T>S		No	ClinGen gnomAD
CA566778773 rs1329372420	7	T>P		No	ClinGen gnomAD
rs1376490556 CA566778774	7	T>S		No	ClinGen gnomAD
rs772130843 CA3809653	8	R>G		No	ClinGen ExAC gnomAD
rs1052436423 CA138202458	9	K>N		No	ClinGen Ensembl
CA3809654 rs777718094	11	A>P		No	ClinGen ExAC TOPMed gnomAD
CA364138998 rs777718094	11	A>S		No	ClinGen ExAC TOPMed gnomAD
rs1581653232 CA364139002	11	A>V		No	ClinGen Ensembl
TCGA novel	13	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1472693439 CA364139020	13	Q>R		No	ClinGen TOPMed
rs575325112 CA3809656	14	E>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA364139030 rs1196257898	14	E>K		No	ClinGen gnomAD
rs1215845052 CA364139499	15	Q>P		No	ClinGen gnomAD
CA364139500 rs1215845052	15	Q>R		No	ClinGen gnomAD
rs764189613 CA3809688	18	I>M		No	ClinGen ExAC gnomAD
rs1188397164 CA364139525	19	P>A		No	ClinGen gnomAD
rs1432837021 CA364139533	20	L>S		No	ClinGen gnomAD
rs1174426412 CA364139538	21	V>L		No	ClinGen gnomAD
CA3809689 rs751836177	22	P>L		No	ClinGen ExAC TOPMed gnomAD
CA138203221 rs929593975	22	P>S		No	ClinGen TOPMed gnomAD
rs1009497598 CA138203250	28	K>R		No	ClinGen gnomAD
CA364139595 rs1361784303	29	R>G		No	ClinGen gnomAD
rs1433501528 CA364139635	31	A>G		No	ClinGen gnomAD
rs1463859847 CA364139632	31	A>T		No	ClinGen TOPMed
CA364139636 rs1433501528	31	A>V		No	ClinGen gnomAD
CA138203254 CA364139651 rs888342970	32	Y>*		No	ClinGen TOPMed gnomAD
rs1291342711 CA364139653	33	Q>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1366216165 CA364139656	33	Q>R		No	ClinGen gnomAD
rs1021265662 CA138203258	34	A>S		No	ClinGen TOPMed
rs1386996249 CA364139681	35	L>R		No	ClinGen gnomAD
CA3809690 rs147359090	36	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA364139690 rs147359090	36	K>T		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	37	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751534485 CA138203267	38	T>I		No	ClinGen Ensembl
rs781256226 CA364139764	40	A>S		No	ClinGen ExAC TOPMed gnomAD
rs781256226 CA3809691	40	A>T		No	ClinGen ExAC TOPMed gnomAD
CA3809692 rs746017852	41	K>T		No	ClinGen ExAC TOPMed gnomAD
CA364139806 rs1362809580	42	Q>H		No	ClinGen TOPMed
TCGA novel	43	A>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs756035386 CA3809693	43	A>V		No	ClinGen ExAC gnomAD
CA3809695 rs780089884	44	L>F		No	ClinGen ExAC gnomAD
CA3809694 rs780089884	44	L>V		No	ClinGen ExAC gnomAD
CA3809696 rs768528425	45	L>V		No	ClinGen ExAC
CA364139867 rs773827748	46	A>G		No	ClinGen ExAC gnomAD
CA138203306 rs557873667	46	A>P		No	ClinGen 1000Genomes
CA3809697 rs773827748	46	A>V		No	ClinGen ExAC gnomAD
rs771638910 CA3809699	48	K>N		No	ClinGen ExAC gnomAD
CA3809698 rs757126662	48	K>Q		No	ClinGen ExAC TOPMed gnomAD
CA3809700 rs772843247	49	E>A		No	ClinGen ExAC gnomAD
rs760315570 CA3809701	49	E>D		No	ClinGen ExAC gnomAD
rs139475580 CA3809724	52	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA364140963 rs1329072753	53	G>R		No	ClinGen gnomAD
rs201486705 CA138205074	54	K>E		No	ClinGen 1000Genomes
CA364141021 rs1360012060	55	G>V		No	ClinGen TOPMed
rs898995786 CA138205085	57	R>G		No	ClinGen TOPMed
CA364141044 rs1283351214	57	R>K		No	ClinGen gnomAD
CA364141103 rs1235048977	60	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA3809727 rs774768542	60	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA138205092 rs1051550372	61	L>V		No	ClinGen Ensembl
rs41274880 CA3809729	62	E>A		No	ClinGen 1000Genomes ExAC gnomAD
CA364141159 rs1273917912	63	S>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA3809731 rs760698808	64	F>L		No	ClinGen ExAC
rs750675802 CA3809730	64	F>L		No	ClinGen ExAC
rs368559463 CA3809733	66	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs375871884 CA3809732	66	H>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA364141206 rs1237256058	66	H>Y		No	ClinGen gnomAD
CA3809734 rs754937108	68	S>A		No	ClinGen ExAC gnomAD
CA3809735 rs778773742	68	S>F		No	ClinGen ExAC TOPMed gnomAD
rs148678082 CA3809736	69	W>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3809738 rs767183272	70	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA3809737 rs758304165	70	R>W		No	ClinGen ExAC TOPMed gnomAD
rs141495140 CA3809739	73	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA364141362 rs1375775806	73	R>H		No	ClinGen TOPMed gnomAD
CA3809740 rs770282712	74	D>G		No	ClinGen ExAC TOPMed gnomAD
rs1342997949 CA364141375	74	D>H		No	ClinGen TOPMed
rs142190825 CA3809741	75	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1338547834 CA364141412	75	K>T		No	ClinGen TOPMed gnomAD
rs745431151 CA3809743	77	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs745431151 CA3809742	77	R>G		No	ClinGen ExAC TOPMed gnomAD
rs774880247 CA3809744	77	R>H		No	ClinGen ExAC gnomAD
rs1460608925 CA364141513	79	R>K		No	ClinGen TOPMed
CA3809745 rs146721546	80	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA364141536 rs772450159	80	R>L		No	ClinGen ExAC TOPMed gnomAD
CA3809746 rs772450159	80	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs992876541 CA138205178	83	V>L		No	ClinGen Ensembl
CA138205183 rs574281629	85	P>H		No	ClinGen 1000Genomes gnomAD
CA3809749 rs766575068	86	H>R		No	ClinGen ExAC TOPMed gnomAD
CA364141675 rs1488234189	87	A>T		No	ClinGen TOPMed gnomAD
CA364141706 rs1193362905	88	L>S		No	ClinGen gnomAD
CA364141747 rs1476845934	90	L>S		No	ClinGen gnomAD
rs1395489243 CA364141851	94	H>Q		No	ClinGen TOPMed gnomAD
CA3809750 rs776758407	94	H>R		No	ClinGen ExAC TOPMed gnomAD
rs1581657548 CA364141904	96	L>F		No	ClinGen Ensembl
CA3809752 rs371976454	97	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs752709495 CA3809753	99	V>I		No	ClinGen ExAC TOPMed gnomAD
CA364141965 rs1342769153	100	V>L		No	ClinGen gnomAD
CA3809754 rs191520270	101	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA3809755 rs369318268	101	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs867618823 CA138205202	102	I>V		No	ClinGen TOPMed gnomAD
CA3809758 rs780761819	103	E>K		No	ClinGen ExAC TOPMed gnomAD
rs745355927 CA3809759	104	R>M		No	ClinGen ExAC TOPMed gnomAD
rs745355927 CA364142015	104	R>T		No	ClinGen ExAC TOPMed gnomAD
CA364142692 rs1183697024	107	G>S		No	ClinGen gnomAD
CA3809778 rs779545995	108	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs374234947 CA138205775	109	S>R		No	ClinGen ESP TOPMed gnomAD
rs1164379995 CA364142729	110	L>I		No	ClinGen TOPMed gnomAD
CA364142767 rs1395236481	113	Q>*		No	ClinGen gnomAD
rs1463215831 CA364142777	114	R>G		No	ClinGen gnomAD
rs1056757372 CA138205780	115	T>I		No	ClinGen TOPMed
rs1581658540 CA364142808	116	I>T		No	ClinGen Ensembl
CA364142805 rs1329515677	116	I>V		No	ClinGen gnomAD
rs201422156 CA3809779	117	A>T		No	ClinGen ExAC gnomAD
CA3809780 rs199719364	120	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA3809781 rs778300981	120	R>H		No	ClinGen ExAC TOPMed gnomAD
CA3809782 rs778300981	120	R>L		No	ClinGen ExAC TOPMed gnomAD
CA138205822 rs187563119	122	K>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs187563119 CA3809785	122	K>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA364142892 rs1396706695	123	K>N		No	ClinGen gnomAD
rs11558570 CA138205824	124	I>T		No	ClinGen Ensembl
rs769924963 CA3809786	126	S>N		No	ClinGen ExAC TOPMed gnomAD
CA3809789 rs768686813	128	V>I		No	ClinGen ExAC gnomAD
rs774191392 CA3809790	131	K>R		No	ClinGen ExAC gnomAD
CA364143017 rs1253806264	132	V>F		No	ClinGen gnomAD
rs767230269 CA3809792	133	T>I		No	ClinGen ExAC gnomAD
CA3809793 rs750026125	135	Q>E		No	ClinGen ExAC gnomAD
CA138205863 rs941397514	135	Q>H		No	ClinGen gnomAD
rs750026125 CA364143061	135	Q>K		No	ClinGen ExAC gnomAD
rs1188486343	135	Q>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1291684228 CA364143144	139	M>I		No	ClinGen TOPMed
CA3809795 rs146567370	139	M>T		No	ClinGen ESP ExAC
CA138205877 rs887539882	139	M>V		No	ClinGen TOPMed gnomAD
rs753322811 CA3809796	141	R>C		No	ClinGen ExAC gnomAD
rs377107940 CA3809797	141	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA364143168 rs377107940	141	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA138205886 rs755413267	142	I>T		No	ClinGen Ensembl
rs1313975097 CA364143172	142	I>V		No	ClinGen gnomAD
rs1356837096 CA364143191	143	V>G		No	ClinGen gnomAD
TCGA novel	145	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778213006 CA3809798	145	P>S		No	ClinGen ExAC gnomAD
CA364143268 rs1581658715	148	T>A		No	ClinGen Ensembl
rs140942522 CA3809799	148	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs372171526 CA3809820	151	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA3809822 rs749535685	153	N>T		No	ClinGen ExAC TOPMed gnomAD
CA3809821 rs780379225	153	N>Y		No	ClinGen ExAC gnomAD
CA3809823 rs755042877	156	S>C		No	ClinGen ExAC TOPMed gnomAD
CA364143647 rs1174168714	157	V>L		No	ClinGen TOPMed gnomAD
rs748319350 CA3809825	158	R>*		No	ClinGen ExAC TOPMed gnomAD
rs771880708 CA3809826	158	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA364143725 rs1273533575	161	I>M		No	ClinGen TOPMed
CA364143714 rs1345298162	161	I>V		No	ClinGen gnomAD
rs150181635 CA3809827	164	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1393358517 CA364143826 CA364143828	168	K>N		No	ClinGen gnomAD
CA3809829 rs770735484	175	P>A		No	ClinGen ExAC gnomAD
rs1223178349 CA364143990	175	P>R		No	ClinGen gnomAD
CA364144031 rs1318630814	177	T>I		No	ClinGen gnomAD
CA364144066 rs1468216519	178	D>E		No	ClinGen gnomAD
rs1271339004 CA364144058	178	D>G		No	ClinGen gnomAD
rs368319057 CA3809832	179	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA3809834 rs569000174	180	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3809835 rs569000174	180	T>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3809837 rs756489549	184	E>A		No	ClinGen ExAC gnomAD
rs376499758 CA3809862	191	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA3809863 rs370025817	193	C>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs149005023 CA138206895	197	L>H		No	ClinGen ESP
rs573377311 CA364144979	198	I>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs573377311 CA3809865	198	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA364144992 rs1237667545	199	H>D		No	ClinGen gnomAD
rs777831758 CA3809866	199	H>R		No	ClinGen ExAC TOPMed gnomAD
rs17854962 CA138206902	200	E>G		No	ClinGen Ensembl
rs1355752479 CA364145025	201	I>T		No	ClinGen TOPMed gnomAD
rs757171081 CA3809868	202	A>S		No	ClinGen ExAC gnomAD
CA3809869 rs781149553	202	A>V		No	ClinGen ExAC gnomAD
rs192054853 CA3809870	204	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs374453299 CA3809871	206	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA364145102 rs1324690574	207	H>L		No	ClinGen gnomAD
rs748979299 CA3809873	208	F>L		No	ClinGen ExAC gnomAD
CA364145154 rs1367593294	210	E>G		No	ClinGen gnomAD
CA3809874 rs377679031	211	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs773988735 CA3809875	212	S>P		No	ClinGen ExAC TOPMed gnomAD
rs771530529 CA3809877	213	W>R		No	ClinGen ExAC gnomAD
rs1281564818 CA364145205	214	F>L		No	ClinGen gnomAD
CA364145208 rs1445868424	214	F>Y		No	ClinGen gnomAD
rs1249410996 CA364145234	216	C>G		No	ClinGen TOPMed
rs777306121 CA3809878	218	F>C		No	ClinGen ExAC gnomAD
rs759767510 CA3809879	219	H>R		No	ClinGen ExAC TOPMed gnomAD
CA364145309 rs1395391914	221	S>L		No	ClinGen gnomAD
CA138206954 rs912950267	221	S>T		No	ClinGen TOPMed
CA138206955 rs561827581	222	V>A		No	ClinGen 1000Genomes
CA3809880 rs765644044	223	A>V		No	ClinGen ExAC gnomAD
CA3809881 rs201862271	224	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs369621205 CA364145339	224	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA3809882 rs369621205	224	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA364145340 rs369621205	224	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA364145350 rs1319029580	225	H>R		No	ClinGen gnomAD
rs760670367 CA3809883	228	K>R		No	ClinGen ExAC TOPMed gnomAD
rs751615019 CA3809884	229	N>S		No	ClinGen ExAC gnomAD
CA3809886 rs781059579	231	V>M		No	ClinGen ExAC TOPMed gnomAD
rs750389497 CA3809887	234	L>F		No	ClinGen ExAC TOPMed gnomAD
CA138206976 rs201178717	239	T>K		No	ClinGen 1000Genomes gnomAD
CA364145518 rs1205280293	239	T>S		No	ClinGen gnomAD
CA3809889 rs779898947	240	P>L		No	ClinGen ExAC gnomAD
CA138206986 rs370265415	242	Y>C		No	ClinGen ESP TOPMed gnomAD
rs764070104 CA138206982	242	Y>H		No	ClinGen Ensembl
rs370265415 CA364145548	242	Y>S		No	ClinGen ESP TOPMed gnomAD
rs564479434 CA364145559	243	R>L		No	ClinGen 1000Genomes ExAC gnomAD
rs564479434 CA3809891	243	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs749099772 CA3809890	243	R>W		No	ClinGen ExAC TOPMed gnomAD
rs747619440 CA3809893	244	G>A		No	ClinGen ExAC TOPMed gnomAD
CA3809894 rs747619440	244	G>D		No	ClinGen ExAC TOPMed gnomAD
CA3809892 rs778750418	244	G>S		No	ClinGen ExAC TOPMed gnomAD
CA364145582 CA3809895 rs777216441	245	E>D		No	ClinGen ExAC TOPMed gnomAD
rs143781630 CA3809897	246	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs143781630 CA3809898	246	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs372984948 CA3809899	246	R>H		No	ClinGen ESP ExAC gnomAD
CA364145591 rs372984948	246	R>P		No	ClinGen ESP ExAC gnomAD
CA3809901 rs751803316	248	N>S		No	ClinGen ExAC gnomAD
rs377736942 CA3809903	252	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs750539100 CA3809904	252	R>H		No	ClinGen ExAC TOPMed gnomAD
CA3809905 rs756068684	253	Q>R		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with Q6DKI1

1 regional properties for Q6DKI1

Type	Name	Position	InterPro Accession
domain	GPCR, rhodopsin-like, 7TM	82 - 577	IPR017452

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
cytosolic large ribosomal subunit	The large subunit of a ribosome located in the cytosol.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

2 GO annotations of molecular function

Name	Definition
RNA binding	Binding to an RNA molecule or a portion thereof.
structural constituent of ribosome	The action of a molecule that contributes to the structural integrity of the ribosome.

2 GO annotations of biological process

Name	Definition
blastocyst formation	The initial formation of a blastocyst from a solid ball of cells known as a morula.
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.

11 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P05737	RPL7A	60S ribosomal protein L7-A	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q58DT1	RPL7	60S ribosomal protein L7	Bos taurus (Bovine)	PR
Q6W5P4	NPSR1	Neuropeptide S receptor	Homo sapiens (Human)	PR
P18124	RPL7	60S ribosomal protein L7	Homo sapiens (Human)	PR
Q8BZP8	Npsr1	Neuropeptide S receptor	Mus musculus (Mouse)	PR
P14148	Rpl7	60S ribosomal protein L7	Mus musculus (Mouse)	PR
Q9D8M4	Rpl7l1	60S ribosomal protein L7-like 1	Mus musculus (Mouse)	PR
A5GFQ0	RPL7L1	60S ribosomal protein L7-like 1	Sus scrofa (Pig)	PR
P05426	Rpl7	60S ribosomal protein L7	Rattus norvegicus (Rat)	PR
Q56H79	NPSR1	Neuropeptide S receptor	Macaca mulatta (Rhesus macaque)	PR
P60039	RPL7C	60S ribosomal protein L7-3	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MISSCTTRKM	AEQEQRKIPL	VPENLLKKRK	AYQALKATQA	KQALLAKKEQ	KKGKGLRFKR
70	80	90	100	110	120
LESFLHDSWR	QKRDKVRLRR	LEVKPHALEL	PDKHSLAFVV	RIERIDGVSL	LVQRTIARLR
130	140	150	160	170	180
LKKIFSGVFV	KVTPQNLKML	RIVEPYVTWG	FPNLKSVREL	ILKRGQAKVK	NKTIPLTDNT
190	200	210	220	230	240
VIEEHLGKFG	VICLEDLIHE	IAFPGKHFQE	ISWFLCPFHL	SVARHATKNR	VGFLKEMGTP
250
GYRGERINQL	IRQLN