AiPD: Autoinhibited Protein Database

P18124

Gene name	RPL7
Protein name	60S ribosomal protein L7
Names	Large ribosomal subunit protein uL30
Species	Homo sapiens (Human)
KEGG Pathway	hsa:6129
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-110 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-110 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

95 structures for P18124

Entry ID	Method	Resolution	Chain	Position	Source
4UG0	EM	-	LF	1-248	PDB
4V6X	EM	500 A	CF	1-248	PDB
5AJ0	EM	350 A	AF	1-248	PDB
5LKS	EM	360 A	LF	1-248	PDB
5T2C	EM	360 A	m	1-248	PDB
6IP5	EM	390 A	2A	1-248	PDB
6IP6	EM	450 A	2A	1-248	PDB
6IP8	EM	390 A	2A	1-248	PDB
6LQM	EM	309 A	w	1-248	PDB
6LSR	EM	313 A	w	1-248	PDB
6LSS	EM	323 A	p	1-248	PDB
6LU8	EM	313 A	p	1-248	PDB
6OLE	EM	310 A	H	24-248	PDB
6OLF	EM	390 A	H	24-248	PDB
6OLG	EM	340 A	AF	15-248	PDB
6OLI	EM	350 A	H	24-248	PDB
6OLZ	EM	390 A	AF	15-248	PDB
6OM0	EM	310 A	H	24-248	PDB
6OM7	EM	370 A	H	24-248	PDB
6QZP	EM	290 A	LF	24-248	PDB
6W6L	EM	384 A	H	1-248	PDB
6XA1	EM	280 A	LF	24-248	PDB
6Y0G	EM	320 A	LF	1-248	PDB
6Y2L	EM	300 A	LF	1-248	PDB
6Y57	EM	350 A	LF	1-248	PDB
6Y6X	EM	280 A	LF	24-248	PDB
6Z6L	EM	300 A	LF	1-248	PDB
6Z6M	EM	310 A	LF	1-248	PDB
6Z6N	EM	290 A	LF	1-248	PDB
6ZM7	EM	270 A	LF	1-248	PDB
6ZME	EM	300 A	LF	1-248	PDB
6ZMI	EM	260 A	LF	1-248	PDB
6ZMO	EM	310 A	LF	1-248	PDB
7BHP	EM	330 A	LF	1-248	PDB
7F5S	EM	272 A	LF	1-248	PDB
7OW7	EM	220 A	m	1-248	PDB
7QVP	EM	300 A	LF/MF	1-248	PDB
7XNX	EM	270 A	LF	1-248	PDB
7XNY	EM	250 A	LF	1-248	PDB
8A3D	EM	167 A	m	1-248	PDB
8FKP	EM	285 A	SD	1-248	PDB
8FKQ	EM	276 A	SD	1-248	PDB
8FKR	EM	289 A	SD	1-248	PDB
8FKS	EM	288 A	SD	1-248	PDB
8FKT	EM	281 A	SD	1-248	PDB
8FKU	EM	282 A	SD	1-248	PDB
8FKV	EM	247 A	SD	1-248	PDB
8FKW	EM	250 A	SD	1-248	PDB
8FKX	EM	259 A	SD	1-248	PDB
8FKY	EM	267 A	SD	1-248	PDB
8FKZ	EM	304 A	SD	1-248	PDB
8FL0	EM	291 A	SD	1-248	PDB
8FL2	EM	267 A	SD	1-248	PDB
8FL3	EM	253 A	SD	1-248	PDB
8FL4	EM	289 A	SD	1-248	PDB
8FL6	EM	262 A	SD	1-248	PDB
8FL7	EM	255 A	SD	1-248	PDB
8FL9	EM	275 A	SD	1-248	PDB
8FLA	EM	263 A	SD	1-248	PDB
8FLB	EM	255 A	SD	1-248	PDB
8FLC	EM	276 A	SD	1-248	PDB
8FLD	EM	258 A	SD	1-248	PDB
8FLE	EM	248 A	SD	1-248	PDB
8FLF	EM	265 A	SD	1-248	PDB
8G5Y	EM	229 A	LF	1-248	PDB
8G5Z	EM	264 A	LF	24-248	PDB
8G60	EM	254 A	LF	1-248	PDB
8G61	EM	294 A	LF	1-248	PDB
8G6J	EM	280 A	LF	1-248	PDB
8GLP	EM	167 A	LF	1-248	PDB
8IDT	EM	280 A	p	1-248	PDB
8IDY	EM	300 A	p	1-248	PDB
8IE3	EM	330 A	p	1-248	PDB
8IFD	EM	259 A	2A	1-248	PDB
8IFE	EM	257 A	2A	1-248	PDB
8INE	EM	320 A	p	1-248	PDB
8INF	EM	300 A	p	1-248	PDB
8INK	EM	320 A	p	1-248	PDB
8IPD	EM	320 A	p	1-248	PDB
8IPX	EM	430 A	p	1-248	PDB
8IPY	EM	320 A	p	1-248	PDB
8IR1	EM	330 A	p	1-248	PDB
8IR3	EM	350 A	p	1-248	PDB
8JDJ	EM	250 A	L	1-248	PDB
8JDK	EM	226 A	L	1-248	PDB
8JDL	EM	242 A	L	1-248	PDB
8JDM	EM	267 A	L	1-248	PDB
8OHD	EM	310 A	LF	1-248	PDB
8OJ0	EM	330 A	LF	1-248	PDB
8OJ5	EM	290 A	LF	1-248	PDB
8OJ8	EM	330 A	LF	1-248	PDB
8QFD	EM	220 A	F	1-248	PDB
8Y0W	EM	340 A	LF	1-248	PDB
8Y0X	EM	330 A	LF	1-248	PDB
AF-P18124-F1	Predicted				AlphaFoldDB

171 variants for P18124

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1427284229 CA371487512	2	E>A		No	ClinGen TOPMed
CA179315057 rs374269827	3	G>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs144881278 CA371487507	3	G>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA179315065 rs374269827	3	G>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs144881278 CA4782867	3	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs144881278 CA4782868	3	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4782866 COSM384692 rs374269827	3	G>V	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA179315011 rs1024526474	4	V>A		No	ClinGen TOPMed
rs976896432 CA179315040	4	V>I		No	ClinGen gnomAD
TCGA novel	4	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781513626 CA4782862	5	E>G		No	ClinGen ExAC TOPMed gnomAD
CA371487501 rs1452422554	5	E>Q		No	ClinGen gnomAD
rs781513626 CA179314984	5	E>V		No	ClinGen ExAC TOPMed gnomAD
CA4782828 rs773601416	6	E>G		No	ClinGen ExAC gnomAD
CA179314180 rs949014733	6	E>K		No	ClinGen TOPMed gnomAD
rs949014733 CA179314177	6	E>Q		No	ClinGen TOPMed gnomAD
rs770092622 CA4782827	7	K>E		No	ClinGen ExAC
CA4782824 rs139088283	7	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	8	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768798846 CA4782823	9	K>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA4782822 rs747090327	10	E>K		No	ClinGen ExAC
rs780385214 CA4782820	10	E>V		No	ClinGen ExAC
rs758670175 CA4782819	12	P>S		No	ClinGen ExAC TOPMed gnomAD
rs758670175 CA371487446	12	P>T		No	ClinGen ExAC TOPMed gnomAD
CA371487440 rs1185625920	13	A>T		No	ClinGen gnomAD
CA179314149 rs903389745	13	A>V		No	ClinGen TOPMed gnomAD
CA371487436 rs746127555	14	V>L		No	ClinGen ExAC gnomAD
CA4782818 rs746127555	14	V>M		No	ClinGen ExAC gnomAD
CA4782816 rs755932103	15	P>L		No	ClinGen ExAC TOPMed gnomAD
CA371487414 rs1586182296	17	T>I		No	ClinGen Ensembl
CA179314123 rs754351979	17	T>S		No	ClinGen Ensembl
rs1333558191 CA371487401	19	K>N		No	ClinGen TOPMed
rs11545448 CA179314109	21	K>E		No	ClinGen Ensembl
rs11545448 CA179314114	21	K>Q		No	ClinGen Ensembl
rs971823535 CA179314104	23	R>G		No	ClinGen TOPMed gnomAD
rs944470333 CA179314099	23	R>T		No	ClinGen TOPMed gnomAD
rs751089173 CA4782812	26	A>T		No	ClinGen ExAC TOPMed
rs1240789080 CA371487355	26	A>V		No	ClinGen gnomAD
rs762634079 CA4782810	30	I>F		No	ClinGen ExAC gnomAD
CA4782809 rs772805645	30	I>M		No	ClinGen ExAC TOPMed gnomAD
CA179314069 rs911739540	30	I>S		No	ClinGen TOPMed
rs765621432 CA4782808	32	R>L		No	ClinGen ExAC gnomAD
rs762097799 CA4782807	33	L>M		No	ClinGen ExAC gnomAD
CA179314044 rs985970639	35	K>R		No	ClinGen gnomAD
rs953433195 CA179314041	36	K>N		No	ClinGen gnomAD
rs1390058914 CA371487294	36	K>R		No	ClinGen gnomAD
CA371487289 rs1586182226	37	F>V		No	ClinGen Ensembl
rs1022200885 CA179314028	39	Q>R		No	ClinGen Ensembl
rs747037278 CA4782804	40	K>E		No	ClinGen ExAC TOPMed gnomAD
rs775691726 CA4782803	40	K>N		No	ClinGen ExAC TOPMed gnomAD
CA4782801 rs746101170	41	M>I		No	ClinGen ExAC gnomAD
CA4782802 rs772087127	41	M>R		No	ClinGen ExAC gnomAD
rs778588074 CA4782769	42	L>F		No	ClinGen ExAC gnomAD
COSM1569560 CA371487237 rs1257776173	43	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
TCGA novel	45	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4782767 rs753592188	45	A>V		No	ClinGen ExAC gnomAD
CA4782766 rs764538216	46	R>G		No	ClinGen ExAC gnomAD
CA4782765 rs144358877	46	R>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA179313573 rs776622814	47	R>G		No	ClinGen gnomAD
rs1277708206 CA371487186	51	Y>C		No	ClinGen gnomAD
CA4782764 rs753178602	55	K>E		No	ClinGen ExAC TOPMed gnomAD
rs186048475 CA4782763	55	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs548654516 CA4782760	56	H>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4782762 rs759624682	56	H>Y		No	ClinGen ExAC gnomAD
rs1357171888 CA371487144	57	Y>C		No	ClinGen gnomAD
rs763151745 CA4782759	59	K>Q		No	ClinGen ExAC TOPMed gnomAD
rs773491709 CA4782758	59	K>R		No	ClinGen ExAC TOPMed gnomAD
CA371487096 rs1475864091	63	Q>H		No	ClinGen gnomAD
CA371487090 CA4782754 rs370437154	64	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA4782755 rs779993029	64	M>R		No	ClinGen ExAC TOPMed gnomAD
CA371487087 rs1563543422	65	Y>H		No	ClinGen Ensembl
rs1277869053 CA371487079	66	R>G		No	ClinGen TOPMed
CA179313504 rs977825865	66	R>S		No	ClinGen TOPMed
rs1318867259 CA371487078	66	R>T		No	ClinGen TOPMed
CA371487059 rs1472694595	69	I>V		No	ClinGen gnomAD
CA371487050 rs1236132692	70	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	72	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1186721777 CA371487036	72	A>V		No	ClinGen gnomAD
TCGA novel	73	R>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA179313494 rs958898892	74	M>I		No	ClinGen gnomAD
rs745857989 CA4782753	74	M>V		No	ClinGen ExAC gnomAD
CA371487005 rs1257900312	77	K>E		No	ClinGen gnomAD
TCGA novel	77	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs748941975 CA4782750	82	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA4782747 rs753021081	84	P>L		No	ClinGen ExAC gnomAD
CA371486957 rs756485500	84	P>S		No	ClinGen ExAC gnomAD
CA4782748 rs756485500	84	P>T		No	ClinGen ExAC gnomAD
rs202074117 CA4782746	85	A>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs202074117 CA371486949	85	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs752169201 CA4782744	88	K>R		No	ClinGen ExAC gnomAD
rs1462585666 CA371486917	90	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	91	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4782739 rs760478461	96	R>S		No	ClinGen ExAC gnomAD
CA4782705 rs147209450	98	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA4782704 rs747755328	99	N>S		No	ClinGen ExAC TOPMed gnomAD
rs768845791 CA4782702	100	G>R		No	ClinGen ExAC gnomAD
rs1363399439 CA371486834	101	V>A		No	ClinGen TOPMed gnomAD
rs1421658002 CA371486816	104	K>E		No	ClinGen TOPMed
rs986950223 CA371486795	107	K>R		No	ClinGen TOPMed
CA179313059 rs986950223	107	K>T		No	ClinGen TOPMed
CA4782701 rs79179721	110	Q>E		No	ClinGen 1000Genomes ExAC
rs1482340034 CA371486757	113	R>C		No	ClinGen gnomAD
CA4782698 rs377758132	115	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA371486745 rs1296808555	115	R>H		No	ClinGen TOPMed gnomAD
rs377758132 CA371486747	115	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1436899637 CA371486733	117	I>V		No	ClinGen gnomAD
CA4782696 rs373211060	119	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA371486689 rs1270280398	123	V>A		No	ClinGen TOPMed
CA371486692 rs1431546804	123	V>M		No	ClinGen gnomAD
rs1340792595 CA371486676	125	L>F		No	ClinGen TOPMed
rs764387544 CA4782694	127	K>R		No	ClinGen ExAC TOPMed gnomAD
CA371486646 rs1488121929	129	S>L		No	ClinGen gnomAD
rs766329971 CA4782691	130	I>M		No	ClinGen ExAC TOPMed gnomAD
CA371486644 rs1212766840	130	I>V		No	ClinGen gnomAD
CA371486593 rs1309160345	137	E>G		No	ClinGen gnomAD
CA4782689 rs144230005	140	I>V		No	ClinGen ESP ExAC TOPMed
rs768099547	143	G>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA179312824 rs61754909	144	Y>S		No	ClinGen Ensembl
CA371486518 rs1563543092	146	N>K		No	ClinGen Ensembl
rs1193109535 CA371486520	146	N>S		No	ClinGen TOPMed
rs1253657224 CA371486496	150	V>I		No	ClinGen TOPMed
rs1455968105 CA371486458	155	Y>C		No	ClinGen TOPMed
CA371486444 rs1298543834	157	R>L		No	ClinGen TOPMed gnomAD
rs1465346097 CA371486437	158	G>A		No	ClinGen gnomAD
rs202073759 CA4782665	159	Y>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs772354686 CA4782664	162	I>S		No	ClinGen ExAC gnomAD
rs1160629634 CA371486414	162	I>V		No	ClinGen TOPMed
CA4782663 rs528381376	163	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4782662 rs774669141	164	K>R		No	ClinGen ExAC gnomAD
rs1403195922 CA371486376	167	I>M		No	ClinGen TOPMed
CA179312793 rs973546174	167	I>T		No	ClinGen Ensembl
CA4782659 rs777899375	173	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1310407805 CA371486337	173	A>V		No	ClinGen gnomAD
TCGA novel	176	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781581308 CA179312761	177	R>*		No	ClinGen ExAC gnomAD
rs781581308 CA4782656	177	R>G		No	ClinGen ExAC gnomAD
rs758220252 CA371486315	177	R>P		No	ClinGen ExAC TOPMed gnomAD
rs758220252 CA4782655	177	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	178	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA179312738 rs986834098	179	L>V		No	ClinGen TOPMed
rs1032914485 CA179312370	183	G>D		No	ClinGen TOPMed gnomAD
CA4782626 rs759163467	185	I>M		No	ClinGen ExAC gnomAD
rs1277745185 CA371486238	187	M>T		No	ClinGen gnomAD
rs1397942777 CA371486203	192	H>N		No	ClinGen gnomAD
CA371486177 rs1267585209	195	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	196	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371486162 rs1413893372	197	V>A		No	ClinGen gnomAD
TCGA novel	198	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	199	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1037661081 CA179312358	200	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA371486142 rs1399972665	200	R>L		No	ClinGen gnomAD
CA371486146 rs1037661081	200	R>S		No	ClinGen TOPMed gnomAD
rs1586180994 CA371486076	209	W>*		No	ClinGen Ensembl
rs940796376 CA179312348	210	P>S		No	ClinGen TOPMed
TCGA novel	212	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA179312345 rs889818542	214	S>C		No	ClinGen TOPMed
CA371486034 rs1473557872	216	P>S		No	ClinGen gnomAD
rs773722193 CA4782622	217	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA4782621 rs770456999	218	G>R		No	ClinGen ExAC gnomAD
CA371486013 rs1308102000	220	M>L		No	ClinGen TOPMed
CA4782620 rs762451859	221	K>Q		No	ClinGen ExAC gnomAD
CA4782617 rs747250517	229	E>A		No	ClinGen ExAC gnomAD
CA179312295 rs998553584	233	A>D		No	ClinGen TOPMed
TCGA novel	233	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	236	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs770700008 CA4782615	237	E>D		No	ClinGen ExAC TOPMed gnomAD
CA4782616 rs780143811	237	E>G		No	ClinGen ExAC gnomAD
CA4782613 rs777644144	244	I>L		No	ClinGen ExAC TOPMed gnomAD
CA371485844 rs777644144	244	I>V		No	ClinGen ExAC TOPMed gnomAD
CA4782612 rs756012660	246	R>T		No	ClinGen ExAC gnomAD
CA179312272 rs1037495468	247	M>V		No	ClinGen TOPMed

No associated diseases with P18124

2 regional properties for P18124

Type	Name	Position	InterPro Accession
domain	APO domain	33 - 172	IPR023342-1
domain	APO domain	202 - 318	IPR023342-2

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

10 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
cytosolic large ribosomal subunit	The large subunit of a ribosome located in the cytosol.
cytosolic ribosome	A ribosome located in the cytosol.
focal adhesion	A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
postsynaptic density	An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
ribonucleoprotein complex	A macromolecular complex that contains both RNA and protein molecules.

5 GO annotations of molecular function

Name	Definition
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
identical protein binding	Binding to an identical protein or proteins.
mRNA binding	Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
RNA binding	Binding to an RNA molecule or a portion thereof.
structural constituent of ribosome	The action of a molecule that contributes to the structural integrity of the ribosome.

5 GO annotations of biological process

Name	Definition
cytoplasmic translation	The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
ribosomal large subunit biogenesis	A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.
rRNA processing	Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
translation	The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

11 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P05737	RPL7A	60S ribosomal protein L7-A	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q58DT1	RPL7	60S ribosomal protein L7	Bos taurus (Bovine)	PR
Q6W5P4	NPSR1	Neuropeptide S receptor	Homo sapiens (Human)	PR
Q6DKI1	RPL7L1	60S ribosomal protein L7-like 1	Homo sapiens (Human)	PR
Q8BZP8	Npsr1	Neuropeptide S receptor	Mus musculus (Mouse)	PR
Q9D8M4	Rpl7l1	60S ribosomal protein L7-like 1	Mus musculus (Mouse)	PR
P14148	Rpl7	60S ribosomal protein L7	Mus musculus (Mouse)	PR
A5GFQ0	RPL7L1	60S ribosomal protein L7-like 1	Sus scrofa (Pig)	PR
P05426	Rpl7	60S ribosomal protein L7	Rattus norvegicus (Rat)	PR
Q56H79	NPSR1	Neuropeptide S receptor	Macaca mulatta (Rhesus macaque)	PR
P60039	RPL7C	60S ribosomal protein L7-3	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MEGVEEKKKE	VPAVPETLKK	KRRNFAELKI	KRLRKKFAQK	MLRKARRKLI	YEKAKHYHKE
70	80	90	100	110	120
YRQMYRTEIR	MARMARKAGN	FYVPAEPKLA	FVIRIRGING	VSPKVRKVLQ	LLRLRQIFNG
130	140	150	160	170	180
TFVKLNKASI	NMLRIVEPYI	AWGYPNLKSV	NELIYKRGYG	KINKKRIALT	DNALIARSLG
190	200	210	220	230	240
KYGIICMEDL	IHEIYTVGKR	FKEANNFLWP	FKLSSPRGGM	KKKTTHFVEG	GDAGNREDQI

NRLIRRMN