Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P05426
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 7QGG | EM | 286 A | H | 1-260 | PDB |
| AF-P05426-F1 | Predicted | AlphaFoldDB |
No variants for P05426
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P05426 | |||||
No associated diseases with P05426
4 regional properties for P05426
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Ribosomal protein L30, N-terminal | 26 - 97 | IPR012988 |
| domain | Ribosomal protein L30, ferredoxin-like fold domain | 102 - 152 | IPR016082 |
| conserved_site | Ribosomal protein L30, conserved site | 120 - 152 | IPR018038 |
| domain | Ribosomal protein L7, eukaryotic/archaeal | 101 - 260 | IPR035808 |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| A band | The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line. |
| cytosolic large ribosomal subunit | The large subunit of a ribosome located in the cytosol. |
| cytosolic ribosome | A ribosome located in the cytosol. |
| polysome | A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro. |
| postsynaptic density | An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. |
| ribonucleoprotein complex | A macromolecular complex that contains both RNA and protein molecules. |
| ribosome | An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| 5S rRNA binding | Binding to a 5S ribosomal RNA, the smallest RNA constituent of a ribosome. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| identical protein binding | Binding to an identical protein or proteins. |
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| structural constituent of ribosome | The action of a molecule that contributes to the structural integrity of the ribosome. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| liver regeneration | The regrowth of lost or destroyed liver. |
| maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. |
| ribosomal large subunit biogenesis | A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis. |
| rRNA processing | Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P05737 | RPL7A | 60S ribosomal protein L7-A | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q58DT1 | RPL7 | 60S ribosomal protein L7 | Bos taurus (Bovine) | PR |
| Q6W5P4 | NPSR1 | Neuropeptide S receptor | Homo sapiens (Human) | PR |
| Q6DKI1 | RPL7L1 | 60S ribosomal protein L7-like 1 | Homo sapiens (Human) | PR |
| P18124 | RPL7 | 60S ribosomal protein L7 | Homo sapiens (Human) | PR |
| Q8BZP8 | Npsr1 | Neuropeptide S receptor | Mus musculus (Mouse) | PR |
| Q9D8M4 | Rpl7l1 | 60S ribosomal protein L7-like 1 | Mus musculus (Mouse) | PR |
| P14148 | Rpl7 | 60S ribosomal protein L7 | Mus musculus (Mouse) | PR |
| A5GFQ0 | RPL7L1 | 60S ribosomal protein L7-like 1 | Sus scrofa (Pig) | PR |
| Q56H79 | NPSR1 | Neuropeptide S receptor | Macaca mulatta (Rhesus macaque) | PR |
| P60039 | RPL7C | 60S ribosomal protein L7-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEAVPEKKKK | VAAALGTLKK | KKVPAVPETL | KKKRRNFAEL | KVKRLRKKFA | LKTLRKARRK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LIYEKAKHYH | KEYRQMYRTE | IRMARMARKA | GNFYVPAEPK | LAFVIRIRGI | NGVSPKVRKV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LQLLRLRQIF | NGTFVKLNKA | SVNMLRIVEP | YIAWGYPNLK | SVNELIYKRG | YGKINKKRIA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LTDNSLVARS | LGKFGIICME | DLIHEIYTVG | KRFKEANNFL | WPFKLSSPRG | GMKKKTTHFV |
| 250 | |||||
| EGGDAGNRED | QINRLIRRMN |