Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for P60039

Entry ID Method Resolution Chain Position Source
AF-P60039-F1 Predicted AlphaFoldDB

6 variants for P60039

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_2_18250320_T_C 28 D>G No 1000Genomes
tmp_2_18250120_G_C 60 N>K No 1000Genomes
tmp_2_18249668_T_C 125 N>S No 1000Genomes
tmp_2_18249664_C_T 126 M>I No 1000Genomes
tmp_2_18249389_C_A 189 M>I No 1000Genomes
tmp_2_18249270_T_C 229 N>S No 1000Genomes

No associated diseases with P60039

4 regional properties for P60039

Type Name Position InterPro Accession
domain Ribosomal protein L30, N-terminal 8 - 79 IPR012988
domain Ribosomal protein L30, ferredoxin-like fold domain 84 - 134 IPR016082
conserved_site Ribosomal protein L30, conserved site 102 - 134 IPR018038
domain Ribosomal protein L7, eukaryotic/archaeal 83 - 242 IPR035808

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosolic large ribosomal subunit The large subunit of a ribosome located in the cytosol.

2 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.
structural constituent of ribosome The action of a molecule that contributes to the structural integrity of the ribosome.

1 GO annotations of biological process

Name Definition
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P05737 RPL7A 60S ribosomal protein L7-A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q58DT1 RPL7 60S ribosomal protein L7 Bos taurus (Bovine) PR
Q6W5P4 NPSR1 Neuropeptide S receptor Homo sapiens (Human) PR
P18124 RPL7 60S ribosomal protein L7 Homo sapiens (Human) PR
Q6DKI1 RPL7L1 60S ribosomal protein L7-like 1 Homo sapiens (Human) PR
Q8BZP8 Npsr1 Neuropeptide S receptor Mus musculus (Mouse) PR
P14148 Rpl7 60S ribosomal protein L7 Mus musculus (Mouse) PR
Q9D8M4 Rpl7l1 60S ribosomal protein L7-like 1 Mus musculus (Mouse) PR
A5GFQ0 RPL7L1 60S ribosomal protein L7-like 1 Sus scrofa (Pig) PR
P05426 Rpl7 60S ribosomal protein L7 Rattus norvegicus (Rat) PR
Q56H79 NPSR1 Neuropeptide S receptor Macaca mulatta (Rhesus macaque) PR
10 20 30 40 50 60
MAESKVVVPE SVLKKIKRQE EWALAKKDEA VAAKKKSVEA RKLIFKRAEQ YAKEYAEKDN
70 80 90 100 110 120
ELIRLKREAK LKGGFYVDPE AKLLFIIRIR GINAIDPKTK KILQLLRLRQ IFNGVFLKVN
130 140 150 160 170 180
KATVNMLRRV EPYVTYGYPN LKSVKELIYK RGYGKLNHQR IALTDNSIVD QALGKHGIIC
190 200 210 220 230 240
VEDLIHEIMT VGPHFKEANN FLWPFQLKAP LGGLKKKRNH YVEGGDAGNR ENFINELVRR
MN