Q64336
PR
Gene name |
Tbr1 |
Protein name |
T-box brain protein 1 |
Names |
T-brain-1, TBR-1, TES-56 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:21375 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q64336
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q64336-F1 | Predicted | AlphaFoldDB |
25 variants for Q64336
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388557509 | 30 | S>Y | No | EVA | |
| rs3388549057 | 37 | H>R | No | EVA | |
| rs3388558381 | 39 | I>S | No | EVA | |
| rs3388556408 | 41 | S>L | No | EVA | |
| rs3388550688 | 42 | T>A | No | EVA | |
| rs3388556615 | 44 | D>H | No | EVA | |
| rs3388554167 | 48 | R>S | No | EVA | |
| rs3388557493 | 53 | K>T | No | EVA | |
| rs3388554055 | 77 | D>N | No | EVA | |
| rs3388554077 | 86 | V>I | No | EVA | |
| rs3388551748 | 113 | P>S | No | EVA | |
| rs3388549085 | 125 | P>S | No | EVA | |
| rs3388546787 | 127 | P>A | No | EVA | |
| rs28038884 | 128 | S>G | No | EVA | |
| rs3388555153 | 141 | S>N | No | EVA | |
| rs3388557555 | 170 | P>H | No | EVA | |
| rs3388555509 | 204 | A>T | No | EVA | |
| rs3388553576 | 238 | S>R | No | EVA | |
| rs3388549088 | 310 | K>* | No | EVA | |
| rs3388549088 | 310 | K>E | No | EVA | |
| rs3388557546 | 310 | K>R | No | EVA | |
| rs3388558371 | 347 | T>I | No | EVA | |
| rs3391718177 | 377 | I>IFSCVI* | No | EVA | |
| rs3388555520 | 379 | Q>* | No | EVA | |
| rs3388557463 | 597 | A>P | No | EVA |
No associated diseases with Q64336
4 regional properties for Q64336
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Transcription factor, T-box, conserved site | 213 - 232 | IPR018186-1 |
| conserved_site | Transcription factor, T-box, conserved site | 288 - 306 | IPR018186-2 |
| domain | T-box transcription factor-associated | 418 - 679 | IPR032385 |
| domain | T-box transcription factor, DNA-binding domain | 203 - 398 | IPR046360 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin DNA binding | Binding to DNA that is assembled into chromatin. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-binding transcription activator activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. |
| DNA-binding transcription factor activity | A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. |
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
17 GO annotations of biological process
| Name | Definition |
|---|---|
| amygdala development | The progression of the amygdala over time from its initial formation until its mature state. The amygdala is an almond-shaped set of neurons in the medial temporal lobe of the brain that play a key role in processing emotions such as fear and pleasure. |
| cell fate specification | The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. |
| cerebral cortex development | The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon. |
| chromatin remodeling | A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. |
| commitment of neuronal cell to specific neuron type in forebrain | The commitment of neuronal precursor cells to become specialized types of neurons in the forebrain. |
| conditioned taste aversion | A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus. |
| gene expression | The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes. |
| hindbrain development | The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium). |
| histone deacetylation | The modification of histones by removal of acetyl groups. |
| negative regulation of DNA-templated transcription | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
| neuron differentiation | The process in which a relatively unspecialized cell acquires specialized features of a neuron. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| regulation of axon guidance | Any process that modulates the frequency, rate or extent of axon guidance. |
| regulation of gene expression | Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| regulation of neuron projection development | Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| specification of animal organ identity | The regionalization process in which the identity of an animal organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P79779 | TBX6L | T-box-containing protein TBX6L | Gallus gallus (Chicken) | PR |
| Q13207 | TBX2 | T-box transcription factor TBX2 | Homo sapiens (Human) | PR |
| Q16650 | TBR1 | T-box brain protein 1 | Homo sapiens (Human) | PR |
| Q60707 | Tbx2 | T-box transcription factor TBX2 | Mus musculus (Mouse) | PR |
| Q810F8 | Tbx10 | T-box transcription factor TBX10 | Mus musculus (Mouse) | PR |
| Q20257 | tbx-11 | Putative T-box protein 11 | Caenorhabditis elegans | PR |
| Q22289 | tbx-9 | T-box transcription factor tbx-9 | Caenorhabditis elegans | PR |
| Q9N2K7 | tbx-30 | Putative T-box protein 30/42 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQLEHCLSPS | IMLSKKFLNV | SSSYPHSGGS | ELVLHDHPII | STTDNLERSS | PLKKITRGMT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NQSDTDNFPD | SKDSPGDVQR | SKLSPVLDGV | SELRHSFDGS | AADRYLLSQS | SQPQSAATAP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SAMFPYPSQH | GPAHPAFSIG | SPSRYMAHHP | VITNGAYNSL | LSNSSPQGYP | TAGYPYPQQY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GHSYQGAPFY | QFSSTQPGLV | PGKAQVYLCN | RPLWLKFHRH | QTEMIITKQG | RRMFPFLSFN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ISGLDPTAHY | NIFVDVILAD | PNHWRFQGGK | WVPCGKADTN | VQGNRVYMHP | DSPNTGAHWM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RQEISFGKLK | LTNNKGASNN | NGQMVVLQSL | HKYQPRLHVV | EVNEDGTEDT | SQPGRVQTFT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FPETQFIAVT | AYQNTDITQL | KIDHNPFAKG | FRDNYDTIYT | GCDMDRLTPS | PNDSPRSQIV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PGARYAMAGS | FLQDQFVSNY | AKARFHPGAG | AGPGPGTDRS | VPHTNGLLSP | QQAEDPGAPS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PQRWFVTPAN | NRLDFAASAY | DTATDFAGNA | ATLLSYAAAG | VKALPLQAAG | CTGRPLGYYA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| DPSGWGARSP | PQYCGAKSGS | VLPCWPNSAA | AAARMAGANP | YLGEEAEGLA | AERSPLAPAA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EDAKPKDLSD | SSWIETPSSI | KSIDSSDSGI | YEQAKRRRIS | PADTPVSESS | SPLKSEVLAQ |
| 670 | 680 | ||||
| RDCEKNCAKD | IGGYYGFYSH | S |