Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P79779
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P79779-F1 | Predicted | AlphaFoldDB |
No variants for P79779
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P79779 | |||||
No associated diseases with P79779
3 regional properties for P79779
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Transcription factor, T-box, conserved site | 36 - 55 | IPR018186-1 |
| conserved_site | Transcription factor, T-box, conserved site | 110 - 128 | IPR018186-2 |
| domain | T-box transcription factor, DNA-binding domain | 26 - 214 | IPR046360 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| cardiac chamber development | The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart. |
| cell fate specification | The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. |
| central nervous system development | The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. |
| heart looping | The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation. |
| positive regulation of cell population proliferation | Any process that activates or increases the rate or extent of cell proliferation. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q13207 | TBX2 | T-box transcription factor TBX2 | Homo sapiens (Human) | PR |
| Q16650 | TBR1 | T-box brain protein 1 | Homo sapiens (Human) | PR |
| Q60707 | Tbx2 | T-box transcription factor TBX2 | Mus musculus (Mouse) | PR |
| Q64336 | Tbr1 | T-box brain protein 1 | Mus musculus (Mouse) | PR |
| Q20257 | tbx-11 | Putative T-box protein 11 | Caenorhabditis elegans | PR |
| Q22289 | tbx-9 | T-box transcription factor tbx-9 | Caenorhabditis elegans | PR |
| Q9N2K7 | tbx-30 | Putative T-box protein 30/42 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQVLPDIKAP | CDALASPSLE | PYPQSSITVT | LEDMGLWMKF | HQIGTEMIIT | KSGRRMFPQC |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KIKVSGLIPY | AKYLMLVDFV | PVDNFRYKWN | KDQWEVAGKA | EPQLPCRTYV | HPDSPAPGSH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| WMKEPVSFQK | LKLTNNTLDQ | HGHIILHSMH | RYKPRFHIVQ | ADDLFSVRWS | IFQVFSFPET |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VFTSVTAYQN | EQITKLKIDN | NPFAKGFREH | GKNTRREGRA | KSQKPSPAKG | QKRKLPEEKE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SGAEERDFEK | DENVDVKEES | NPIVVSSGYP | FWISEQNSSH | AFPAASPAPA | EQREGPAREQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QVPTPSYQTY | RFHEAGDSQQ | LPSRDVAALN | DFRGRCHPLD | LATVPEHDSK | QLPEGFTNLP |
| P |