Q22289
Gene name |
tbx-9 (T07C4.6) |
Protein name |
T-box transcription factor tbx-9 |
Names |
|
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_T07C4.6 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q22289
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q22289-F1 | Predicted | AlphaFoldDB |
No variants for Q22289
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q22289 | |||||
No associated diseases with Q22289
3 regional properties for Q22289
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Transcription factor, T-box, conserved site | 15 - 34 | IPR018186-1 |
| conserved_site | Transcription factor, T-box, conserved site | 89 - 107 | IPR018186-2 |
| domain | T-box transcription factor, DNA-binding domain | 5 - 199 | IPR046360 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| transcription regulator complex | A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-binding transcription factor activity | A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. |
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
| RNA polymerase II transcription regulatory region sequence-specific DNA binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cell fate specification | The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. |
| embryonic body morphogenesis | The process in which the anatomical structures of the embryonic soma are generated and organized. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P79779 | TBX6L | T-box-containing protein TBX6L | Gallus gallus (Chicken) | PR |
| Q13207 | TBX2 | T-box transcription factor TBX2 | Homo sapiens (Human) | PR |
| Q16650 | TBR1 | T-box brain protein 1 | Homo sapiens (Human) | PR |
| Q60707 | Tbx2 | T-box transcription factor TBX2 | Mus musculus (Mouse) | PR |
| Q64336 | Tbr1 | T-box brain protein 1 | Mus musculus (Mouse) | PR |
| Q810F8 | Tbx10 | T-box transcription factor TBX10 | Mus musculus (Mouse) | PR |
| Q20257 | tbx-11 | Putative T-box protein 11 | Caenorhabditis elegans | PR |
| Q9N2K7 | tbx-30 | Putative T-box protein 30/42 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSKVKVSIEG | SQETLWKIFH | AEVNEMIVTK | NGRKLFPKLE | YIVEGLDENK | LYAIMLQLQP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VGESRFKFSG | GKWQETGKAE | KQVDAKKMWH | ADGVRKGSDW | MWSSICFDRV | KISNYSESNN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ASMIYLNSMH | KYIPVLTIYE | SPSESPFCVP | QSSNQIVATA | KFPHTEFIAV | TAYQNQKITD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LKIKHNSFAK | GFRDGNLSRK | RRSPSYSDGS | NSQSPSPKSR | SPPEVAPLQS | MPPINPFLFY |
| 250 | 260 | 270 | 280 | 290 | |
| FPHMLSENLP | VQFPFAFPFL | SPLPSTPSSS | SSELSIVKEE | DQEVEEDIDI | VG |