Q810F8
Gene name |
Tbx10 (Tbx13, Tbx7) |
Protein name |
T-box transcription factor TBX10 |
Names |
T-box protein 10, MmTBX7, T-box protein 13 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:109575 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q810F8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q810F8-F1 | Predicted | AlphaFoldDB |
21 variants for Q810F8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs262465734 | 7 | A>T | No | EVA | |
| rs3407886876 | 22 | E>G | No | EVA | |
| rs3389523618 | 25 | T>I | No | EVA | |
| rs219360884 | 25 | T>P | No | EVA | |
| rs3409078727 | 30 | R>G | No | EVA | |
| rs3408836273 | 34 | R>G | No | EVA | |
| rs3389510815 | 107 | T>K | No | EVA | |
| rs3389518273 | 134 | W>* | No | EVA | |
| rs3409273613 | 144 | T>R | No | EVA | |
| rs3408836278 | 145 | P>R | No | EVA | |
| rs3413012008 | 198 | V>E | No | EVA | |
| rs3389514350 | 205 | K>N | No | EVA | |
| rs3389481254 | 241 | I>V | No | EVA | |
| rs3389507712 | 263 | R>L | No | EVA | |
| rs37553546 | 277 | S>G | No | EVA | |
| rs3389423301 | 290 | D>V | No | EVA | |
| rs242100728 | 307 | N>H | No | EVA | |
| rs3389481221 | 314 | D>H | No | EVA | |
| rs3389507674 | 357 | G>R | No | EVA | |
| rs3389530529 | 373 | T>S | No | EVA | |
| rs3389515692 | 381 | N>K | No | EVA |
1 associated diseases with Q810F8
Without disease ID
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cell fate specification | The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q60707 | Tbx2 | T-box transcription factor TBX2 | Mus musculus (Mouse) | PR |
| Q64336 | Tbr1 | T-box brain protein 1 | Mus musculus (Mouse) | PR |
| Q20257 | tbx-11 | Putative T-box protein 11 | Caenorhabditis elegans | PR |
| Q22289 | tbx-9 | T-box transcription factor tbx-9 | Caenorhabditis elegans | PR |
| Q9N2K7 | tbx-30 | Putative T-box protein 30/42 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAVFLSAGLG | VLAPPETCPH | PETSTSWESR | LGTRFPSGSC | TMSTEAQAMA | EPTGQGPKNP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RVSSVMVQLE | MKPLWEEFNQ | LGTEMIVTKA | GRRMFPTFQV | KILGMDTLAD | YALLMDFIPL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DDKRYRYAFH | SSAWLVAGKA | DPATPGRVHF | HPDSPAKGAQ | WMRQIVSFDK | LKLTNNLMDD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NGHIILNSMH | RYQPRFHVVF | VDPRKDSARY | AQENFKSFVF | TETQFTAVTA | YQNHRITQLK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IASNPFAKGF | READPDSWPV | TPRPLLSIPA | RSRSSLSPCL | LKGSAEREKD | TSKASASSSR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TPTQPHNQLL | PAPDVLLAPA | TYRPLPYQNL | YPGSPSRAGP | PRARLAPYPL | PNISTAGDQE |
| 370 | 380 | ||||
| DPTLAAGLGL | LPTSALCLVS | NQASQ |