Q3T0M7
Gene name |
RANBP1 |
Protein name |
Ran-specific GTPase-activating protein |
Names |
Ran-binding protein 1, RanBP1 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:533251 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3T0M7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3T0M7-F1 | Predicted | AlphaFoldDB |
74 variants for Q3T0M7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs466199587 | 9 | E>* | No | EVA | |
| rs434751127 | 10 | D>E | No | EVA | |
| rs471853032 | 11 | H>P | No | EVA | |
| rs451827342 | 11 | H>Y | No | EVA | |
| rs483322540 | 12 | D>Y | No | EVA | |
| rs457129023 | 15 | T>N | No | EVA | |
| rs439669984 | 53 | A>G | No | EVA | |
| rs462838712 | 54 | K>Q | No | EVA | |
| rs482907845 | 55 | L>M | No | EVA | |
| rs448254821 | 55 | L>P | No | EVA | |
| rs478953229 | 56 | F>V | No | EVA | |
| rs447327385 | 57 | R>P | No | EVA | |
| rs449826523 | 58 | F>S | No | EVA | |
| rs432698792 | 58 | F>V | No | EVA | |
| rs469864962 | 62 | N>D | No | EVA | |
| rs438220521 | 62 | N>T | No | EVA | |
| rs455096864 | 63 | D>E | No | EVA | |
| rs434263221 | 64 | L>P | No | EVA | |
| rs475352705 | 64 | L>V | No | EVA | |
| rs454233765 | 65 | P>L | No | EVA | |
| rs454233765 | 65 | P>Q | No | EVA | |
| rs439531135 | 66 | E>G | No | EVA | |
| rs462900139 | 67 | W>G | No | EVA | |
| rs476721361 | 70 | R>G | No | EVA | |
| rs476721361 | 70 | R>W | No | EVA | |
| rs461948068 | 74 | D>A | No | EVA | |
| rs478810227 | 74 | D>E | No | EVA | |
| rs461948068 | 74 | D>G | No | EVA | |
| rs447587737 | 79 | K>N | No | EVA | |
| rs477812566 | 83 | K>N | No | EVA | |
| rs458004290 | 83 | K>Q | No | EVA | |
| rs449687799 | 87 | R>L | No | EVA | |
| rs469894620 | 88 | L>P | No | EVA | |
| rs468808015 | 89 | L>P | No | EVA | |
| rs448621859 | 89 | L>V | No | EVA | |
| rs433178125 | 90 | M>I | No | EVA | |
| rs471073083 | 90 | M>K | No | EVA | |
| rs454296242 | 90 | M>V | No | EVA | |
| rs456518586 | 93 | D>A | No | EVA | |
| rs476776057 | 93 | D>E | No | EVA | |
| rs442118301 | 95 | T>P | No | EVA | |
| rs455709148 | 103 | Y>S | No | EVA | |
| rs453850024 | 109 | E>G | No | EVA | |
| rs475103131 | 144 | N>T | No | EVA | |
| rs876309377 | 150 | K>R | No | EVA | |
| rs445657126 | 154 | K>E | No | EVA | |
| rs440308149 | 165 | K>Q | No | EVA | |
| rs465941830 | 170 | S>A | No | EVA | |
| rs465941830 | 170 | S>P | No | EVA | |
| rs459215091 | 175 | S>C | No | EVA | |
| rs455521720 | 178 | K>* | No | EVA | |
| rs455521720 | 178 | K>E | No | EVA | |
| rs435428185 | 179 | V>G | No | EVA | |
| rs470258206 | 180 | V>E | No | EVA | |
| rs470258206 | 180 | V>G | No | EVA | |
| rs450248423 | 182 | K>R | No | EVA | |
| rs478216131 | 183 | L>R | No | EVA | |
| rs464546520 | 188 | V>G | No | EVA | |
| rs447918418 | 191 | G>D | No | EVA | |
| rs462330140 | 192 | E>G | No | EVA | |
| rs448571093 | 193 | Q>P | No | EVA | |
| rs463249353 | 194 | P>A | No | EVA | |
| rs443317150 | 194 | P>L | No | EVA | |
| rs471355880 | 195 | Q>K | No | EVA | |
| rs457675687 | 195 | Q>P | No | EVA | |
| rs440831936 | 196 | D>A | No | EVA | |
| rs440831936 | 196 | D>G | No | EVA | |
| rs455656648 | 197 | A>G | No | EVA | |
| rs472487319 | 197 | A>P | No | EVA | |
| rs435364521 | 199 | P>T | No | EVA | |
| rs476420084 | 200 | A>G | No | EVA | |
| rs433281942 | 202 | V>G | No | EVA | |
| rs464705193 | 207 | Q>G | No | EVA | |
| rs447587146 | 207 | Q>W | No | EVA |
No associated diseases with Q3T0M7
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| centrosome | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nuclear pore | A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| nucleocytoplasmic transport | The directed movement of molecules between the nucleus and the cytoplasm. |
| positive regulation of mitotic centrosome separation | Any process that activates or increases the frequency, rate or extent of centrosome separation. |
| spindle organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3T0M7 | RANBP1 | Ran-specific GTPase-activating protein | Bos taurus (Bovine) | PR |
| P43487 | RANBP1 | Ran-specific GTPase-activating protein | Homo sapiens (Human) | PR |
| P34022 | Ranbp1 | Ran-specific GTPase-activating protein | Mus musculus (Mouse) | PR |
| P92985 | POX1 | Ran-binding protein 1 homolog c | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWG8 | RANBP1B | Ran-binding protein 1 homolog b | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LMK7 | RANBP1A | Ran-binding protein 1 homolog a | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAAKDTHED | HDTSTENADE | SNHDPQFEPI | VSLPEQEIKT | LEEDEEELFK | MRAKLFRFAS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ENDLPEWKER | GTGDVKLLKH | KEKGTIRLLM | RRDKTLKICA | NHYITPMMEL | KPNAGSDRAW |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VWNTHADFAD | ECPKQELLAI | RFLNAENAQK | FKTKFEECRK | EIEEKEKKGS | GKNDSTEKVV |
| 190 | 200 | ||||
| EKLEALSVQE | GEQPQDAAPA | AVEEEQ |