Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for P92985

Entry ID Method Resolution Chain Position Source
AF-P92985-F1 Predicted AlphaFoldDB

13 variants for P92985

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH07446007 4 T>S No 1000Genomes
tmp_5_23681672_T_C 15 T>A No 1000Genomes
tmp_5_23681403_T_G 61 E>D No 1000Genomes
tmp_5_23681377_G_A 70 A>V No 1000Genomes
ENSVATH07445995 147 T>I No 1000Genomes
tmp_5_23680494_C_A 162 G>V No 1000Genomes
ENSVATH03448776 167 Q>E No 1000Genomes
ENSVATH03448771 183 N>K No 1000Genomes
ENSVATH03448770 184 I>K No 1000Genomes
ENSVATH03448769 186 E>V No 1000Genomes
ENSVATH00741142 188 K>Q No 1000Genomes
ENSVATH00741141 217 A>S No 1000Genomes
ENSVATH00741141 217 A>T No 1000Genomes

No associated diseases with P92985

2 regional properties for P92985

Type Name Position InterPro Accession
domain Ran binding domain 26 - 155 IPR000156
domain Ran-specific GTPase-activating protein 1, Ran-binding domain 24 - 157 IPR045256

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nuclear pore complex
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear pore A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
mRNA transport The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus.
regulation of catalytic activity Any process that modulates the activity of an enzyme.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3T0M7 RANBP1 Ran-specific GTPase-activating protein Bos taurus (Bovine) PR
Q86VV4 RANBP3L Ran-binding protein 3-like Homo sapiens (Human) PR
P43487 RANBP1 Ran-specific GTPase-activating protein Homo sapiens (Human) PR
P34022 Ranbp1 Ran-specific GTPase-activating protein Mus musculus (Mouse) PR
Q8RWG8 RANBP1B Ran-binding protein 1 homolog b Arabidopsis thaliana (Mouse-ear cress) PR
Q9LMK7 RANBP1A Ran-binding protein 1 homolog a Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MASTEPEREN REDETEVNED EDTGAQVAPI VRLEEVAVTT GEEDEDAVLD LKSKMYRFDK
70 80 90 100 110 120
EGNQWKERGA GTVKLLKHKE TGKVRLVMRQ SKTLKICANH LISSGMSVQE HSGNEKSCLW
130 140 150 160 170 180
HATDFSDGEL KDELFCIRFA SIENCKTFME KFTEIAESQQ VGKESTQGDE AAGLIENLSV
190 200 210
EENISEEKAK EAEEKEPAKE DKETKKEKVE EEKKTEAST