Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q8RWG8

Entry ID Method Resolution Chain Position Source
AF-Q8RWG8-F1 Predicted AlphaFoldDB

19 variants for Q8RWG8

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH01927029 2 A>T No 1000Genomes
tmp_2_12827061_G_C 9 E>D No 1000Genomes
ENSVATH01927031 12 N>H No 1000Genomes
tmp_2_12827153_C_T 40 A>V No 1000Genomes
tmp_2_12827182_A_C 50 T>P No 1000Genomes
tmp_2_12827323_T_G 56 S>A No 1000Genomes
tmp_2_12827393_T_C 79 L>S No 1000Genomes
tmp_2_12827398_C_A 81 H>N No 1000Genomes
ENSVATH13476072 85 G>E No 1000Genomes
tmp_2_12828346_C_T 150 A>V No 1000Genomes
tmp_2_12828367_A_G 157 E>G No 1000Genomes
tmp_2_12828373_C_T 159 A>V No 1000Genomes
ENSVATH05628535 164 E>K No 1000Genomes
tmp_2_12828459_A_T 188 S>C No 1000Genomes
ENSVATH07904936 192 P>L No 1000Genomes
ENSVATH01927071 193 V>E No 1000Genomes
ENSVATH01927072 208 K>N No 1000Genomes
tmp_2_12828526_C_G 210 T>R No 1000Genomes
ENSVATH01927073 213 S>C No 1000Genomes

No associated diseases with Q8RWG8

2 regional properties for Q8RWG8

Type Name Position InterPro Accession
domain Ran binding domain 29 - 164 IPR000156
domain Ran-specific GTPase-activating protein 1, Ran-binding domain 27 - 157 IPR045256

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nuclear pore complex
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear pore A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
peroxisome A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

4 GO annotations of biological process

Name Definition
mRNA transport The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of catalytic activity Any process that modulates the activity of an enzyme.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3T0M7 RANBP1 Ran-specific GTPase-activating protein Bos taurus (Bovine) PR
Q86VV4 RANBP3L Ran-binding protein 3-like Homo sapiens (Human) PR
P43487 RANBP1 Ran-specific GTPase-activating protein Homo sapiens (Human) PR
P34022 Ranbp1 Ran-specific GTPase-activating protein Mus musculus (Mouse) PR
P92985 POX1 Ran-binding protein 1 homolog c Arabidopsis thaliana (Mouse-ear cress) PR
Q9LMK7 RANBP1A Ran-binding protein 1 homolog a Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MASISNEPER ENRDEEETGA NEDEDTGAQV APIVRLEEVA VTTGEEDEDT ILDLKSKLYR
70 80 90 100 110 120
FDKDGSQWKE RGAGTVKFLK HRVSGKIRLV MRQSKTLKIC ANHLVGSGMS VQEHAGNDKS
130 140 150 160 170 180
CVWHARDFSD GELKDELFCI RFASVENCKA FMQKFKEVAE SEEEKEESKD ASDTAGLLEK
190 200 210
LTVEEKESEK KPVEKAEENK KSEAVEEKKT EESVPSA