AiPD: Autoinhibited Protein Database

P43487

Gene name	RANBP1
Protein name	Ran-specific GTPase-activating protein
Names	SCFR, Proto-oncogene c-Kit, Tyrosine-protein kinase Kit, Ran-binding protein 1, RanBP1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5902
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-62 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-62 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for P43487

Entry ID	Method	Resolution	Chain	Position	Source
1K5D	X-ray	270 A	B/E/H/K	1-201	PDB
1K5G	X-ray	310 A	B/E/H/K	1-201	PDB
AF-P43487-F1	Predicted				AlphaFoldDB

108 variants for P43487

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs888265731 CA322188054	2	A>E		No	ClinGen TOPMed gnomAD
rs1315900817 CA410722534	3	A>T		No	ClinGen gnomAD
rs1235039441 CA410722546	4	A>T		No	ClinGen gnomAD
rs202049598 CA322189333	7	T>A		No	ClinGen Ensembl
CA322189334 rs1002133449	7	T>S		No	ClinGen TOPMed gnomAD
CA10108137 rs772778926	8	H>Q		No	ClinGen ExAC gnomAD
CA10108138 rs141200787	10	D>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA10108140 rs776990071	11	H>R		No	ClinGen ExAC TOPMed gnomAD
rs1393208667 CA410722748	12	D>H		No	ClinGen TOPMed
rs759846029 CA10108141	14	S>F		No	ClinGen ExAC gnomAD
VAR_036567	16	E>D	a breast cancer sample; somatic mutation [UniProt]	No	UniProt
CA410722781 rs1244075667	17	N>D		No	ClinGen gnomAD
CA322189359 rs753737885	18	T>I		No	ClinGen Ensembl
rs1460303594 CA410722807	20	E>D		No	ClinGen TOPMed
CA410722813 rs1205917225	21	S>C		No	ClinGen gnomAD
CA10108144 rs763303315	21	S>P		No	ClinGen ExAC TOPMed gnomAD
CA410722819 rs1166080494	22	N>I		No	ClinGen TOPMed
CA322189402 rs765529450	23	H>D		No	ClinGen Ensembl
rs557893626 CA10108146	25	P>S		No	ClinGen 1000Genomes ExAC gnomAD
rs756055432 CA10108147	26	Q>E		No	ClinGen ExAC gnomAD
rs112943865 CA322189437	27	F>S		No	ClinGen Ensembl
rs1362862198 CA410722890	32	S>C		No	ClinGen TOPMed
rs753621407 CA410722924	35	E>D		No	ClinGen ExAC gnomAD
CA410722953 rs1365008477	37	E>D		No	ClinGen TOPMed gnomAD
rs1358259872 CA410723046	44	D>E		No	ClinGen gnomAD
CA410723034 rs1331723716	44	D>Y		No	ClinGen gnomAD
CA10108153 rs370443280	46	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs759336871 CA10108185	51	M>I		No	ClinGen ExAC gnomAD
CA410723139 rs1381755023	51	M>V		No	ClinGen gnomAD
TCGA novel	53	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10108188 rs758215616	57	R>*		No	ClinGen ExAC gnomAD
CA10108189 rs763921981	59	A>V		No	ClinGen ExAC gnomAD
rs756998095 CA10108191	61	E>D		No	ClinGen ExAC TOPMed gnomAD
CA10108194 rs745394823	63	D>H		No	ClinGen ExAC gnomAD
CA10108193 rs745394823	63	D>N		No	ClinGen ExAC gnomAD
rs202103269 CA322192335	64	L>I		No	ClinGen TOPMed gnomAD
rs996606991 CA322192337	65	P>R		No	ClinGen TOPMed
CA10108195 rs144901362	75	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	76	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs772355561 CA322192368	82	E>G		No	ClinGen ExAC TOPMed gnomAD
rs772355561 CA10108200	82	E>V		No	ClinGen ExAC TOPMed gnomAD
rs1191368966 CA410724558	84	G>R		No	ClinGen gnomAD
rs1165405324 CA410724571	85	A>V		No	ClinGen TOPMed
TCGA novel	86	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10108202 rs375393752	87	R>S		No	ClinGen ESP ExAC gnomAD
CA410724612 rs1456575617	89	L>V		No	ClinGen gnomAD
rs1290899632 CA410724626	90	M>T		No	ClinGen gnomAD
rs1038888637 CA322192403	91	R>Q		No	ClinGen TOPMed
CA410724682 rs1602542121	95	T>P		No	ClinGen Ensembl
rs368169084 CA10108206	104	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs764502102 CA10108266	105	T>M		No	ClinGen ExAC gnomAD
rs745898188 CA10108270	107	M>I		No	ClinGen ExAC gnomAD
CA10108269 rs188352527	107	M>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs756164171 CA10108271	109	E>D		No	ClinGen ExAC TOPMed gnomAD
CA10108274 COSM1414935 rs771917916	114	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1161055011 CA410725183	116	S>N		No	ClinGen gnomAD
rs917545001 CA322197575	117	D>N		No	ClinGen Ensembl
CA10108276 rs746834606	118	R>C		No	ClinGen ExAC gnomAD
TCGA novel	118	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA410725241 rs1221805287	119	A>V		No	ClinGen TOPMed
rs1602551584 CA410725322	124	T>P		No	ClinGen Ensembl
TCGA novel	128	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	129	A>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA410725544 rs1392358264	134	K>T		No	ClinGen TOPMed
rs1285741088 CA410725586	136	E>G		No	ClinGen gnomAD
TCGA novel	139	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1192557874 CA410725684	141	R>H		No	ClinGen gnomAD
CA10108287 rs767917893	144	N>S		No	ClinGen ExAC gnomAD
rs902976093 CA322197613	145	A>T		No	ClinGen TOPMed
VAR_053629 CA322197619 rs5746863	145	A>V		No	ClinGen UniProt Ensembl dbSNP
CA322197623 rs934382136	146	E>D		No	ClinGen TOPMed gnomAD
CA10108328 rs765398844	147	N>S		No	ClinGen ExAC gnomAD
rs1487861854 CA410727793	149	Q>R		No	ClinGen TOPMed gnomAD
CA410727861 rs1440147846	152	K>*		No	ClinGen gnomAD
CA10108330 rs757190321	152	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1244875569 CA410727894	153	T>I		No	ClinGen TOPMed
TCGA novel	153	T>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10108333 rs769969249	162	I>M		No	ClinGen ExAC TOPMed gnomAD
CA410728078 rs1182521407	162	I>T		No	ClinGen TOPMed gnomAD
rs1443000381 CA410728092	163	E>G		No	ClinGen gnomAD
TCGA novel	163	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA410728095 rs1383356063	164	E>K		No	ClinGen TOPMed gnomAD
CA10108334 rs536923215	165	R>K		No	ClinGen 1000Genomes ExAC gnomAD
CA410728139 rs1407136376	167	K>E		No	ClinGen TOPMed gnomAD
CA410729422 rs1241939206	169	A>G		No	ClinGen TOPMed
rs759533670 CA10108393	170	G>E		No	ClinGen ExAC gnomAD
rs1273658174 CA410729446	171	S>L		No	ClinGen TOPMed
rs150530613 CA322198652	172	G>S		No	ClinGen ESP TOPMed
CA10108395 rs752498683	173	K>E		No	ClinGen ExAC gnomAD
CA10108396 rs372174173	174	N>S		No	ClinGen ESP ExAC gnomAD
rs756772977 CA10108399	178	E>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1324165575 CA410729543	178	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA410729558 rs1480115101	179	K>E		No	ClinGen gnomAD
rs780610564 CA10108400	181	A>V		No	ClinGen ExAC TOPMed gnomAD
CA410729643 rs1568986565	185	E>D		No	ClinGen Ensembl
CA410729651 rs1297863457	186	A>G		No	ClinGen gnomAD
rs971346070 CA322198680	186	A>S		No	ClinGen Ensembl
rs768710680 CA10108405	188	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA322198693 rs891175953	190	K>M		No	ClinGen TOPMed
rs368678998 CA10108407	191	E>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA322198720 rs919494336	192	E>A		No	ClinGen gnomAD
CA410729710 rs1602556833	192	E>D		No	ClinGen Ensembl
rs372271212 CA10108408	194	K>R		No	ClinGen ESP ExAC gnomAD
CA10108409 rs772185902	195	E>D		No	ClinGen ExAC gnomAD
CA10108410 rs773220129	196	D>G		No	ClinGen ExAC gnomAD
rs930941473 CA322198729	197	A>T		No	ClinGen TOPMed gnomAD
CA410729777 rs1210222155	199	E>K		No	ClinGen gnomAD
rs376753468 CA10108411	201	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD

No associated diseases with P43487

2 regional properties for P43487

Type	Name	Position	InterPro Accession
domain	Ran binding domain	26 - 164	IPR000156
domain	Ran-specific GTPase-activating protein 1, Ran-binding domain	24 - 160	IPR045256

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
centrosome	A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear envelope	The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
nuclear pore	A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name	Definition
cadherin binding	Binding to cadherin, a type I membrane protein involved in cell adhesion.
GDP-dissociation inhibitor activity	Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding.
GTPase activator activity	Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
small GTPase binding	Binding to a small monomeric GTPase.

3 GO annotations of biological process

Name	Definition
nucleocytoplasmic transport	The directed movement of molecules between the nucleus and the cytoplasm.
positive regulation of mitotic centrosome separation	Any process that activates or increases the frequency, rate or extent of centrosome separation.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

6 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q3T0M7	RANBP1	Ran-specific GTPase-activating protein	Bos taurus (Bovine)	PR
Q86VV4	RANBP3L	Ran-binding protein 3-like	Homo sapiens (Human)	PR
P34022	Ranbp1	Ran-specific GTPase-activating protein	Mus musculus (Mouse)	PR
Q9LMK7	RANBP1A	Ran-binding protein 1 homolog a	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8RWG8	RANBP1B	Ran-binding protein 1 homolog b	Arabidopsis thaliana (Mouse-ear cress)	PR
P92985	POX1	Ran-binding protein 1 homolog c	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MAAAKDTHED	HDTSTENTDE	SNHDPQFEPI	VSLPEQEIKT	LEEDEEELFK	MRAKLFRFAS
70	80	90	100	110	120
ENDLPEWKER	GTGDVKLLKH	KEKGAIRLLM	RRDKTLKICA	NHYITPMMEL	KPNAGSDRAW
130	140	150	160	170	180
VWNTHADFAD	ECPKPELLAI	RFLNAENAQK	FKTKFEECRK	EIEEREKKAG	SGKNDHAEKV
190	200
AEKLEALSVK	EETKEDAEEK	Q