Q24020
PR
Gene name |
fliI (CG1484) |
Protein name |
Protein flightless-1 |
Names |
Flightless-I |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG1484 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q24020
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q24020-F1 | Predicted | AlphaFoldDB |
1 variants for Q24020
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| 601 | G>S | No |
No associated diseases with Q24020
22 regional properties for Q24020
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Leucine-rich repeat | 30 - 87 | IPR001611-1 |
| repeat | Leucine-rich repeat | 101 - 169 | IPR001611-2 |
| repeat | Leucine-rich repeat | 171 - 191 | IPR001611-3 |
| repeat | Leucine-rich repeat | 220 - 241 | IPR001611-4 |
| repeat | Leucine-rich repeat | 243 - 300 | IPR001611-5 |
| repeat | Leucine-rich repeat | 337 - 358 | IPR001611-6 |
| repeat | Leucine-rich repeat, typical subtype | 28 - 50 | IPR003591-1 |
| repeat | Leucine-rich repeat, typical subtype | 51 - 70 | IPR003591-2 |
| repeat | Leucine-rich repeat, typical subtype | 74 - 98 | IPR003591-3 |
| repeat | Leucine-rich repeat, typical subtype | 99 - 122 | IPR003591-4 |
| repeat | Leucine-rich repeat, typical subtype | 123 - 145 | IPR003591-5 |
| repeat | Leucine-rich repeat, typical subtype | 146 - 168 | IPR003591-6 |
| repeat | Leucine-rich repeat, typical subtype | 169 - 193 | IPR003591-7 |
| repeat | Leucine-rich repeat, typical subtype | 218 - 240 | IPR003591-8 |
| repeat | Leucine-rich repeat, typical subtype | 241 - 264 | IPR003591-9 |
| repeat | Leucine-rich repeat, typical subtype | 265 - 287 | IPR003591-10 |
| repeat | Leucine-rich repeat, typical subtype | 312 - 335 | IPR003591-11 |
| repeat | Leucine-rich repeat, typical subtype | 336 - 358 | IPR003591-12 |
| domain | Gelsolin-like domain | 510 - 589 | IPR007123-1 |
| domain | Gelsolin-like domain | 633 - 703 | IPR007123-2 |
| domain | Gelsolin-like domain | 749 - 822 | IPR007123-3 |
| domain | Gelsolin-like domain | 1168 - 1242 | IPR007123-4 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| actin cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| Z disc | Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin binding | Binding to monomeric or multimeric forms of actin, including actin filaments. |
| actin filament binding | Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. |
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| phosphatidylinositol-4,5-bisphosphate binding | Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| actin filament severing | The process in which an actin filament is broken down into smaller filaments. |
| actin polymerization or depolymerization | Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament. |
| adult somatic muscle development | The process whose specific outcome is the progression of the adult somatic muscle over time, from its formation to the mature structure. |
| barbed-end actin filament capping | The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits. |
| gastrulation involving germ band extension | A complex and coordinated series of cellular movements, including germ band extension, that occurs at the end of cleavage during embryonic development. An example of this process is found in Drosophila melanogaster. |
| myofibril assembly | Formation of myofibrils, the repeating units of striated muscle. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3SX14 | GSN | Gelsolin | Bos taurus (Bovine) | PR |
| O75366 | AVIL | Advillin | Homo sapiens (Human) | PR |
| P06396 | GSN | Gelsolin | Homo sapiens (Human) | PR |
| P13020 | Gsn | Gelsolin | Mus musculus (Mouse) | PR |
| Q68FP1 | Gsn | Gelsolin | Rattus norvegicus (Rat) | PR |
| P34268 | fli-1 | Protein flightless-1 homolog | Caenorhabditis elegans | PR |
| O65570 | VLN4 | Villin-4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSVLPFVRGV | DFTKNDFSAT | FPSSMRQMSR | VQWLTLDRTQ | LAEIPEELGH | LQKLEHLSLN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HNRLEKIFGE | LTELSCLRSL | DLRHNQLKNS | GIPPELFHLE | ELTTLDLSHN | KLKEVPEGLE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RAKNLIVLNL | SNNQIESIPT | PLFIHLTDLL | FLDLSHNRLE | TLPPQTRRLI | NLKTLDLSHN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PLELFQLRQL | PSLQSLEVLK | MSGTQRTLLN | FPTSIDSLAN | LCELDLSHNS | LPKLPDCVYN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VVTLVRLNLS | DNELTELTAG | VELWQRLESL | NLSRNQLVAL | PAALCKLPKL | RRLLVNDNKL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NFEGIPSGIG | KLGALEVFSA | ANNLLEMVPE | GLCRCGALKQ | LNLSCNRLIT | LPDAIHLLEG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LDQLDLRNNP | ELVMPPKPSE | ASKATSLEFY | NIDFSLQTQL | RLAGAAVPPS | MPSSATPKDS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TARKIRLRRG | PRSEGDQDAA | KVLKGMKDVA | KDKDNEAGAV | PEDGKPESLK | PKRWDESLEK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PQLDYSKFFE | KDDGQLPGLT | IWEIENFLPN | KIEEVVHGKF | YEGDCYIVLK | TKFDDLGLLD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| WEIFFWIGNE | ATLDKRACAA | IHAVNLRNFL | GARCRTVREE | QGDESEQFLS | LFETEVIYIE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GGRTATGFYT | IEEMIHITRL | YLVHAYGATI | HLEPVAPAIT | SLDPRHAFVL | DLGTHIYIWM |
| 670 | 680 | 690 | 700 | 710 | 720 |
| GERSKNTLNS | KARLMAEKIS | KTERKNKCEI | QLERQGEESA | EFWQGLGMTS | EEADAAEPPK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| EHVPEDYQPV | QPRLYQVQLG | MGYLELPQVE | LPEQKLCHTL | LNSKHVYILD | CYTDLFVWFG |
| 790 | 800 | 810 | 820 | 830 | 840 |
| KKSTRLVRAA | AVKLSRELFN | MMDRPDYALV | MRVPEGNEMQ | IFRTKFAGWD | EVMAVDFTRT |
| 850 | 860 | 870 | 880 | 890 | 900 |
| AKSVAKTGAN | LTQWARQQET | RTDLAALFMP | RQSAMPLAEA | EQLEEEWNYD | LEMMEAFVLE |
| 910 | 920 | 930 | 940 | 950 | 960 |
| NKKFVRLPEE | ELGRFYTGEC | YVFLCRYCIP | IEEPENGSED | GANPAADVSK | SSANNQPEDE |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| IQCVVYFWQG | RNAGNMGWLT | FTFTLQKKFK | AMFGEELEVV | RIFQQQENLK | FMSHFKRKFI |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| IHTGKRKDKA | HTAKGKSPVE | FFHLRSNGGA | LTTRLIQINP | DAVHLNSTFC | YILHVPFETE |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| DDSQSGIVYV | WIGSKACNEE | AKLVQDIAEQ | MFNSPWVSLQ | ILNEGDEPEN | FFWVALGGRK |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| PYDTDAEYMN | YTRLFRCSNE | RGYYTVAEKC | ADFCQDDLAD | DDIMILDNGE | HVFLWMGPRC |
| 1210 | 1220 | 1230 | 1240 | 1250 | |
| SEVEVKLAYK | SAQVYIQHMR | IKQPERPRKL | FLTMKNKESR | RFTKCFHGWS | AFKVYL |