Q3SX14
Gene name |
GSN |
Protein name |
Gelsolin |
Names |
Actin-depolymerizing factor, ADF, Brevin |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:535077 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3SX14
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3SX14-F1 | Predicted | AlphaFoldDB |
No variants for Q3SX14
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q3SX14 | |||||
No associated diseases with Q3SX14
6 regional properties for Q3SX14
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Gelsolin-like domain | 25 - 107 | IPR007123-1 |
| domain | Gelsolin-like domain | 147 - 219 | IPR007123-2 |
| domain | Gelsolin-like domain | 266 - 338 | IPR007123-3 |
| domain | Gelsolin-like domain | 404 - 485 | IPR007123-4 |
| domain | Gelsolin-like domain | 527 - 591 | IPR007123-5 |
| domain | Gelsolin-like domain | 630 - 705 | IPR007123-6 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| actin cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin filament binding | Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. |
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| phosphatidylinositol-4,5-bisphosphate binding | Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| actin filament severing | The process in which an actin filament is broken down into smaller filaments. |
| actin nucleation | The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament. |
| actin polymerization or depolymerization | Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament. |
| barbed-end actin filament capping | The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits. |
| cell projection assembly | Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon. |
| central nervous system development | The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. |
| cilium assembly | The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q24020 | fliI | Protein flightless-1 | Drosophila melanogaster (Fruit fly) | PR |
| O75366 | AVIL | Advillin | Homo sapiens (Human) | PR |
| P06396 | GSN | Gelsolin | Homo sapiens (Human) | PR |
| P13020 | Gsn | Gelsolin | Mus musculus (Mouse) | PR |
| Q68FP1 | Gsn | Gelsolin | Rattus norvegicus (Rat) | PR |
| O65570 | VLN4 | Villin-4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVVEHPEFLK | AGKEPGLQIW | RVEKFDLVPV | PPNLYGDFFT | GDAYVILKTV | QLRNGNLQYD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LHYWLGNECS | QDESGAAAIF | TVQLDDYLNG | RAVQHREVQG | FESATFLGYF | KSGLKYKKGG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VASGFKHVVP | NEVVVQRLFQ | VKGRRVVRAT | EVPVSWESFN | NGDCFILDLG | NDIYQWCGSS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SNRFERLKAT | QVSKGIRDNE | RSGRARVHVS | EEGAEPEAML | EVLGPKPALP | AGTEDTAKED |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AANRKLAKLY | KVSNGAGTMS | VSLVADENPF | AQGALRSEDC | FILDHGKDGK | IFVWKGRQAN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TEERKAALKT | ASDFISKMDY | PRQTQVSVLP | EGGETPLFKQ | FFKNWRDPDQ | TDGPGLSYLS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SHIANVERVP | FDAATLHTST | AMAAQHGMDD | DGRGQKQIWR | IEGSDKVPVD | PATYGQFYGG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DSYIILYNYR | HGGRQGQIIY | NWQGAQSTQD | EVAASAILTA | QLDEELGGTP | VRSRVVQGKE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PAHLMSLFGG | KPMIIYRGGT | SREGGQTAPA | STRLFQVRAS | SSGATRAVEV | MPKAGALNSN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| DAFVLKTPSA | AYLWVGAGAS | EAEKTGALEL | LRVLRAQPVQ | VAEGSEPDSF | WEALGGKAAY |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RTSPRLKDKK | MDAHPPRLFA | CSNKIGRFVI | EEVPGELMQE | DLATDDVMLL | DTWDQVFVWV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| GKDSQEEEKT | EALTSAKRYI | ETDPANRDRR | TPITVVKQGF | EPPSFVGWFL | GWDDNYWSVD |
| 730 | |||||
| PLDRALAELA | A |