O65570
PR
Gene name |
VLN4 |
Protein name |
Villin-4 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G30160 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for O65570
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5VNT | NMR | - | A | 912-974 | PDB |
| AF-O65570-F1 | Predicted | AlphaFoldDB |
43 variants for O65570
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_4_14754691_G_C | 22 | E>Q | No | 1000Genomes | |
| tmp_4_14754749_A_G | 41 | K>R | No | 1000Genomes | |
| ENSVATH02943138 | 45 | G>A | No | 1000Genomes | |
| ENSVATH06801929 | 85 | T>I | No | 1000Genomes | |
| ENSVATH00545112 | 168 | Y>F | No | 1000Genomes | |
| tmp_4_14755387_A_G | 169 | I>V | No | 1000Genomes | |
| ENSVATH06801933 | 248 | T>P | No | 1000Genomes | |
| tmp_4_14755862_T_A | 272 | L>M | No | 1000Genomes | |
| ENSVATH12311778 | 278 | D>E | No | 1000Genomes | |
| ENSVATH02943140 | 278 | D>N | No | 1000Genomes | |
| tmp_4_14755976_G_A | 310 | A>T | No | 1000Genomes | |
| ENSVATH12311779 | 312 | E>D | No | 1000Genomes | |
| ENSVATH00545114 | 313 | E>K | No | 1000Genomes | |
| ENSVATH12311780 | 314 | M>I | No | 1000Genomes | |
| ENSVATH12311781 | 316 | R>C | No | 1000Genomes | |
| ENSVATH06801939 | 379 | P>S | No | 1000Genomes | |
| ENSVATH06801939 | 379 | P>T | No | 1000Genomes | |
| ENSVATH12311782 | 398 | R>L | No | 1000Genomes | |
| tmp_4_14756561_A_T,G | 444 | Q>L | No | 1000Genomes | |
| tmp_4_14756561_A_T,G | 444 | Q>R | No | 1000Genomes | |
| ENSVATH12311806 | 451 | G>C | No | 1000Genomes | |
| tmp_4_14756704_C_T | 455 | S>F | No | 1000Genomes | |
| tmp_4_14757087_G_T | 510 | D>Y | No | 1000Genomes | |
| tmp_4_14757171_G_A | 538 | D>N | No | 1000Genomes | |
| tmp_4_14757319_T_A | 559 | F>Y | No | 1000Genomes | |
| ENSVATH12311809 | 610 | S>L | No | 1000Genomes | |
| ENSVATH14314157 | 620 | R>C | No | 1000Genomes | |
| ENSVATH12311810 | 620 | R>H | No | 1000Genomes | |
| ENSVATH12311811 | 626 | S>A | No | 1000Genomes | |
| ENSVATH06801946 | 628 | T>S | No | 1000Genomes | |
| tmp_4_14758202_C_T | 695 | S>F | No | 1000Genomes | |
| tmp_4_14758242_G_C | 708 | E>D | No | 1000Genomes | |
| ENSVATH00545118 | 725 | A>T | No | 1000Genomes | |
| tmp_4_14758617_T_G | 767 | S>A | No | 1000Genomes | |
| tmp_4_14758690_A_G | 791 | N>S | No | 1000Genomes | |
| ENSVATH14314161 | 837 | A>T | No | 1000Genomes | |
| tmp_4_14758893_G_A | 859 | A>T | No | 1000Genomes | |
| tmp_4_14759083_C_T | 863 | T>I | No | 1000Genomes | |
| ENSVATH12311827 | 879 | K>E | No | 1000Genomes | |
| ENSVATH14314163 | 880 | K>R | No | 1000Genomes | |
| tmp_4_14759248_A_G | 918 | D>G | No | 1000Genomes | |
| tmp_4_14759417_A_G | 944 | E>G | No | 1000Genomes | |
| ENSVATH00545120 | 947 | E>D | No | 1000Genomes |
No associated diseases with O65570
5 regional properties for O65570
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Villin headpiece | 909 - 974 | IPR003128 |
| domain | Gelsolin-like domain | 29 - 111 | IPR007123-1 |
| domain | Gelsolin-like domain | 150 - 217 | IPR007123-2 |
| domain | Gelsolin-like domain | 267 - 333 | IPR007123-3 |
| domain | Gelsolin-like domain | 638 - 711 | IPR007123-4 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin filament binding | Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. |
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| actin crosslink formation | The process in which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes. |
| actin filament capping | The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits. |
| actin filament depolymerization | Disassembly of actin filaments by the removal of actin monomers from a filament. |
| actin filament organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. |
| actin filament severing | The process in which an actin filament is broken down into smaller filaments. |
| cytoplasmic streaming | The directed flow of cytosol (the liquid component of the cytoplasm) and the organelles it contains. |
| root hair elongation | The process in which the root hair grows longer. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3SX14 | GSN | Gelsolin | Bos taurus (Bovine) | PR |
| Q24020 | fliI | Protein flightless-1 | Drosophila melanogaster (Fruit fly) | PR |
| O75366 | AVIL | Advillin | Homo sapiens (Human) | PR |
| P06396 | GSN | Gelsolin | Homo sapiens (Human) | PR |
| P13020 | Gsn | Gelsolin | Mus musculus (Mouse) | PR |
| Q68FP1 | Gsn | Gelsolin | Rattus norvegicus (Rat) | PR |
| P34268 | fli-1 | Protein flightless-1 homolog | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSVSMRDLDP | AFQGAGQKAG | IEIWRIENFI | PTPIPKSSIG | KFFTGDSYIV | LKTTALKTGA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LRHDIHYWLG | KDTSQDEAGT | AAVKTVELDA | ALGGRAVQYR | EVQGHETEKF | LSYFKPCIIP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QEGGVASGFK | HVVAEEHITR | LFVCRGKHVV | HVKEVPFARS | SLNHDDIYIL | DTKSKIFQFN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GSNSSIQERA | KALEVVQYIK | DTYHDGTCEV | ATVEDGKLMA | DADSGEFWGF | FGGFAPLPRK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TANDEDKTYN | SDITRLFCVE | KGQANPVEGD | TLKREMLDTN | KCYILDCGIE | VFVWMGRTTS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LDDRKIASKA | AEEMIRSSER | PKSQMIRIIE | GFETVPFRSK | FESWTQETNT | TVSEDGRGRV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AALLQRQGVN | VRGLMKAAPP | KEEPQVFIDC | TGNLQVWRVN | GQAKTLLQAA | DHSKFYSGDC |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YVFQYSYPGE | EKEEVLIGTW | FGKQSVEEER | GSAVSMASKM | VESMKFVPAQ | ARIYEGKEPI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QFFVIMQSFI | VFKGGISSGY | KKYIAEKEVD | DDTYNENGVA | LFRIQGSGPE | NMQAIQVDPV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AASLNSSYYY | ILHNDSSVFT | WAGNLSTATD | QELAERQLDL | IKPNQQSRAQ | KEGSESEQFW |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ELLGGKAEYS | SQKLTKEPER | DPHLFSCTFT | KEVLKVTEIY | NFTQDDLMTE | DIFIIDCHSE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| IFVWVGQEVV | PKNKLLALTI | GEKFIEKDSL | LEKLSPEAPI | YVIMEGGEPS | FFTRFFTSWD |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SSKSAMHGNS | FQRKLKIVKN | GGTPVADKPK | RRTPASYGGR | ASVPDKSQQR | SRSMSFSPDR |
| 790 | 800 | 810 | 820 | 830 | 840 |
| VRVRGRSPAF | NALAATFESQ | NARNLSTPPP | VVRKLYPRSV | TPDSSKFAPA | PKSSAIASRS |
| 850 | 860 | 870 | 880 | 890 | 900 |
| ALFEKIPPQE | PSIPKPVKAS | PKTPESPAPE | SNSKEQEEKK | ENDKEEGSMS | SRIESLTIQE |
| 910 | 920 | 930 | 940 | 950 | 960 |
| DAKEGVEDEE | DLPAHPYDRL | KTTSTDPVSD | IDVTRREAYL | SSEEFKEKFG | MTKEAFYKLP |
| 970 | |||||
| KWKQNKFKMA | VQLF |