AiPD: Autoinhibited Protein Database

P62195

Gene name	PSMC5 (SUG1)
Protein name	26S proteasome regulatory subunit 8
Names	26S proteasome AAA-ATPase subunit RPT6, Proteasome 26S subunit ATPase 5, Proteasome subunit p45, Thyroid hormone receptor-interacting protein 1, TRIP1, p45/SUG
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5705
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-167 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-167 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

59 structures for P62195

Entry ID	Method	Resolution	Chain	Position	Source
2KRK	NMR	-	A	320-395	PDB
3KW6	X-ray	210 A	A	318-395	PDB
5GJQ	EM	450 A	J	1-406	PDB
5GJR	EM	350 A	J/x	1-406	PDB
5L4G	EM	402 A	J	1-406	PDB
5LN3	EM	680 A	J	1-406	PDB
5M32	EM	380 A	h	38-392	PDB
5T0C	EM	380 A	AC/BC	1-406	PDB
5T0G	EM	440 A	C	9-406	PDB
5T0H	EM	680 A	C	9-406	PDB
5T0I	EM	800 A	C	9-406	PDB
5T0J	EM	800 A	C	9-406	PDB
5VFP	EM	420 A	C	11-402	PDB
5VFQ	EM	420 A	C	11-402	PDB
5VFR	EM	490 A	C	11-402	PDB
5VFS	EM	360 A	C	9-397	PDB
5VFT	EM	700 A	C	11-394	PDB
5VFU	EM	580 A	C	11-394	PDB
5VGZ	EM	370 A	C	11-128	PDB
5VHF	EM	570 A	C	11-395	PDB
5VHH	EM	610 A	C	11-395	PDB
5VHI	EM	680 A	C	11-395	PDB
5VHJ	EM	850 A	C	130-395	PDB
5VHM	EM	830 A	C	130-395	PDB
5VHN	EM	730 A	C	130-395	PDB
5VHO	EM	830 A	C	130-395	PDB
5VHP	EM	790 A	C	130-395	PDB
5VHQ	EM	890 A	C	130-395	PDB
5VHR	EM	770 A	C	130-395	PDB
5VHS	EM	880 A	C	11-395	PDB
6MSB	EM	300 A	C	9-406	PDB
6MSD	EM	320 A	C	9-406	PDB
6MSG	EM	350 A	C	9-406	PDB
6MSH	EM	360 A	C	9-406	PDB
6MSJ	EM	330 A	C	9-406	PDB
6MSK	EM	320 A	C	9-406	PDB
6WJD	EM	480 A	C	9-406	PDB
6WJN	EM	570 A	C	11-402	PDB
7QXN	EM	370 A	C	9-406	PDB
7QXP	EM	360 A	C	9-406	PDB
7QXW	EM	410 A	C	9-406	PDB
7QY7	EM	470 A	C	9-402	PDB
7QYA	EM	480 A	C	9-406	PDB
7QYB	EM	410 A	C	9-406	PDB
7W37	EM	300 A	C	9-406	PDB
7W38	EM	310 A	C	9-406	PDB
7W39	EM	320 A	C	9-406	PDB
7W3A	EM	350 A	C	9-406	PDB
7W3B	EM	360 A	C	9-406	PDB
7W3C	EM	340 A	C	9-406	PDB
7W3F	EM	330 A	C	9-406	PDB
7W3G	EM	320 A	C	9-406	PDB
7W3H	EM	320 A	C	9-406	PDB
7W3I	EM	350 A	C	9-406	PDB
7W3J	EM	350 A	C	9-406	PDB
7W3K	EM	360 A	C	9-406	PDB
7W3M	EM	350 A	C	9-406	PDB
8CVT	EM	300 A	C	1-406	PDB
AF-P62195-F1	Predicted				AlphaFoldDB

161 variants for P62195

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs967715869 CA400592604	2	A>E		No	ClinGen TOPMed gnomAD
rs967715869 CA400592606	2	A>G		No	ClinGen TOPMed gnomAD
CA292946147 rs537538880	2	A>P		No	ClinGen 1000Genomes TOPMed
CA292946149 rs967715869	2	A>V		No	ClinGen TOPMed gnomAD
rs1483251327 CA400592614	3	L>V		No	ClinGen TOPMed gnomAD
rs1221743172 CA400592637	5	G>*		No	ClinGen gnomAD
rs926239770 CA292946155	6	P>A		No	ClinGen TOPMed
rs984953757 CA292946158	6	P>L		No	ClinGen Ensembl
CA400592666 rs1223441527	7	E>G		No	ClinGen Ensembl
rs937504689 CA292946161	8	Q>R		No	ClinGen TOPMed gnomAD
rs1391452246 CA400592791	9	M>I		No	ClinGen TOPMed
rs138422324 CA400592866	15	K>E		No	ClinGen ExAC TOPMed gnomAD
rs138422324 CA8705823	15	K>Q		No	ClinGen ExAC TOPMed gnomAD
rs1415435145 CA400592898	17	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
TCGA novel	18	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1374422838 CA400592951	21	R>H		No	ClinGen TOPMed
rs1216127085 CA400593009	25	L>P		No	ClinGen TOPMed
CA8705828 rs200165127	28	I>T		No	ClinGen 1000Genomes ExAC
TCGA novel	31	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1301205613 CA400593231	33	L>M		No	ClinGen gnomAD
CA400593253 rs1426113190	36	N>S		No	ClinGen gnomAD
rs1008437886 CA292947266	38	K>E		No	ClinGen TOPMed
CA400593271 rs1280161518	38	K>N		No	ClinGen gnomAD
CA400593273 rs1375835658	39	S>G		No	ClinGen gnomAD
rs1222245691 CA400593276	39	S>T		No	ClinGen gnomAD
rs1360598038 CA400593285	40	Q>P		No	ClinGen gnomAD
rs1019690643 CA292947270	42	L>F		No	ClinGen TOPMed
CA400593304 rs750251182	43	R>L		No	ClinGen ExAC TOPMed gnomAD
CA8705845 rs750251182	43	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA400593301 rs1231484066	43	R>W		No	ClinGen TOPMed
rs752951324 CA292947301	51	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs567104866 CA8705847	52	L>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1228867189 CA400593407 COSM263142	57	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs758226061 CA8705865	60	R>P		No	ClinGen ExAC TOPMed gnomAD
VAR_035901	60	R>Q	a colorectal cancer sample; somatic mutation [UniProt]	No	UniProt
CA8705867 rs751301920	69	Q>H		No	ClinGen ExAC gnomAD
TCGA novel	70	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA400593570 rs1233105704	71	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
TCGA novel	74	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA400593630 rs374448804	75	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs559656206 CA8705875	77	V>D		No	ClinGen 1000Genomes ExAC gnomAD
CA400593645 rs1471109338	77	V>I		No	ClinGen gnomAD
CA400593682 rs1235842209	80	M>T		No	ClinGen Ensembl
rs1567757313 CA400593769	86	L>*		No	ClinGen Ensembl
CA8705894 rs746291014	91	P>S		No	ClinGen ExAC
rs772459737 CA8705895	92	E>D		No	ClinGen ExAC gnomAD
CA8705896 rs775898082	96	V>L		No	ClinGen ExAC gnomAD
rs1282032143 CA400593959	97	V>I		No	ClinGen gnomAD
CA8705898 rs768992462	99	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs776701733 CA8705899	101	K>R		No	ClinGen ExAC gnomAD
CA400594015 rs1489822994	103	I>T		No	ClinGen gnomAD
rs1293865113 CA400594009	103	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA400594025 rs1199352033	104	D>H		No	ClinGen TOPMed
TCGA novel	104	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1220383102 CA400594041	105	I>V		No	ClinGen gnomAD
CA400594059 rs1485923130	106	N>S		No	ClinGen TOPMed
rs761818702 CA8705902	107	D>Y		No	ClinGen ExAC gnomAD
rs1443382148 CA400594112	108	V>M		No	ClinGen gnomAD
CA292948159 rs759360446	111	N>S		No	ClinGen TOPMed gnomAD
rs747275507 COSM252742 CA8705918	113	R>W	ovary [Cosmic]	No	ClinGen cosmic curated ExAC
TCGA novel	121	Y>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA400594290 rs1249341788	122	T>N		No	ClinGen TOPMed
rs906549571 CA292948209	135	V>M		No	ClinGen TOPMed
TCGA novel	136	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA292948210 rs1802130	138	M>K		No	ClinGen Ensembl
CA292949947 rs201173463	139	M>T		No	ClinGen 1000Genomes
rs146976250 CA8705927	145	D>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs200364182 CA292949973	146	S>L		No	ClinGen 1000Genomes
TCGA novel	146	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	149	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1460260421 CA400594585	151	I>T		No	ClinGen gnomAD
TCGA novel	152	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1228067269 CA400594613	156	K>Q		No	ClinGen TOPMed
rs764184588 CA8705928	157	Q>R		No	ClinGen ExAC gnomAD
rs202169906 CA292949985	159	K>E		No	ClinGen 1000Genomes
COSM982720 CA400594686 rs1422249342	166	E>K	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA400594755 rs1326856075 COSM1385198	176	E>K	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs756629902 CA8705959	189	Y>F		No	ClinGen ExAC TOPMed gnomAD
CA292950356 rs1007714240	192	P>L		No	ClinGen TOPMed
CA8705961 rs749452987	207	T>M		No	ClinGen ExAC gnomAD
TCGA novel	208	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs143717913 CA292950375	213	R>C		No	ClinGen ESP TOPMed gnomAD
rs1248775209 CA400595104	217	S>F		No	ClinGen gnomAD
rs968719 CA400595115	219	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	221	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA400595141 rs1227104699	223	F>I		No	ClinGen TOPMed
rs769914700 CA8705968	225	G>R		No	ClinGen ExAC gnomAD
rs1200029702 CA400595193	229	R>G		No	ClinGen gnomAD
CA400595195 rs1340432915	229	R>K		No	ClinGen gnomAD
CA400595281 rs1435542983	241	H>R		No	ClinGen TOPMed
CA8705996 rs148086513	242	A>V		No	ClinGen ESP ExAC gnomAD
CA400595310 rs1388399745	246	I>V		No	ClinGen TOPMed
CA292950608 rs1802131	249	D>V		No	ClinGen Ensembl
rs1277612217 CA400595370	254	I>V		No	ClinGen gnomAD
rs750595679 CA8706001	257	S>L		No	ClinGen ExAC gnomAD
CA8706004 rs781522827	258	R>L		No	ClinGen ExAC TOPMed gnomAD
CA292950658 rs781522827	258	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA8706003 rs11543211 VAR_048119	258	R>W		No	ClinGen UniProt ExAC dbSNP gnomAD
rs1481519266 CA400595396	259	L>V		No	ClinGen TOPMed gnomAD
rs1171232854 CA400595405	260	E>D		No	ClinGen gnomAD
rs80345213 CA8706006	260	E>G		No	ClinGen ExAC
CA400595400 rs1598355159	260	E>Q		No	ClinGen Ensembl
rs1401921311 CA400595415	262	G>C		No	ClinGen gnomAD
CA400595413 rs1401921311	262	G>S		No	ClinGen gnomAD
CA400595434 rs1359115042	265	G>E		No	ClinGen gnomAD
CA400595440 rs1598355189	266	D>G		No	ClinGen Ensembl
CA292950692 rs1050708	266	D>N		No	ClinGen Ensembl
rs897846834 CA292950702	271	R>C		No	ClinGen TOPMed
CA8706009 rs778907291	272	T>M		No	ClinGen ExAC TOPMed gnomAD
CA400595488 rs1351123653	273	M>T		No	ClinGen gnomAD
rs1283812429 CA400595523	278	N>S		No	ClinGen TOPMed gnomAD
rs1216024518 CA400595534	279	Q>H		No	ClinGen gnomAD
CA400595549 rs1197014415	282	G>S		No	ClinGen gnomAD
CA8706015 rs776860314	288	N>D		No	ClinGen ExAC gnomAD
CA400595676 rs1453376752	291	V>L		No	ClinGen gnomAD
TCGA novel	293	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA400595782 rs1483958329	298	I>M		No	ClinGen TOPMed
TCGA novel	299	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA292950918 rs1050740	300	I>M		No	ClinGen TOPMed
rs1319798057 CA400595813	301	L>V		No	ClinGen gnomAD
CA8706040 COSM982723 rs374419165	303	S>L	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs1340376039 CA400595844	304	A>T		No	ClinGen gnomAD
CA8706042 rs767692177	307	R>H		No	ClinGen ExAC
CA400595961 rs1349754006	320	P>H		No	ClinGen TOPMed
TCGA novel	321	N>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8706045 rs756249254	321	N>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	322	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754834783 CA8706071 COSM1290742	330	K>N	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
TCGA novel	331	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	331	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	333	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1422223376 CA400596064	334	R>Q		No	ClinGen gnomAD
CA400596063 rs1162334738	334	R>W		No	ClinGen TOPMed
CA400596104 rs1213870591	340	R>Q		No	ClinGen gnomAD
rs780778918 CA8706072	340	R>W		No	ClinGen ExAC gnomAD
rs1391574835 CA400596110	341	G>E		No	ClinGen TOPMed
CA400596120 rs1464523684	343	N>H		No	ClinGen gnomAD
CA400596149 rs1446133552	347	I>V		No	ClinGen TOPMed
CA292951147 rs770501716	349	E>D		No	ClinGen Ensembl
rs1267771318 CA400596182	351	M>I		No	ClinGen TOPMed
CA400596185 rs1422535071	352	P>S		No	ClinGen gnomAD
CA8706077 rs543372685	354	A>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1379563051 CA400596302	362	V>M		No	ClinGen TOPMed gnomAD
rs1309185813 CA400596386	368	M>T		No	ClinGen gnomAD
CA400596411 rs1320796271	372	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA400596410 rs1320796271	372	R>G		No	ClinGen TOPMed gnomAD
CA400596416 rs1372995875	373	E>Q		No	ClinGen TOPMed
rs780412308 CA400596425	374	R>L		No	ClinGen ExAC gnomAD
CA8706101 rs780412308	374	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	374	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1259826806 CA400596442	377	H>R		No	ClinGen gnomAD
rs747542979 CA8706122	390	V>I		No	ClinGen ExAC gnomAD
CA8706124 rs781264605	391	M>I		No	ClinGen ExAC gnomAD
CA8706123 rs755426300	391	M>L		No	ClinGen ExAC gnomAD
rs748162252 CA8706125	392	Q>R		No	ClinGen ExAC gnomAD
rs773296559 CA8706127	394	D>N		No	ClinGen ExAC gnomAD
rs146352219 CA8706128	395	S>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	397	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1275288233 CA400596604	398	N>D		No	ClinGen gnomAD
rs771733803 CA8706129	399	M>T		No	ClinGen ExAC gnomAD
CA400596611 rs1404956738	399	M>V		No	ClinGen TOPMed

No associated diseases with P62195

5 regional properties for P62195

Type	Name	Position	InterPro Accession
domain	AAA+ ATPase domain	182 - 321	IPR003593
domain	ATPase, AAA-type, core	186 - 318	IPR003959
conserved_site	ATPase, AAA-type, conserved site	289 - 307	IPR003960
domain	Proteasomal ATPase OB C-terminal domain	73 - 128	IPR032501
domain	AAA ATPase, AAA+ lid domain	342 - 384	IPR041569

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

15 GO annotations of cellular component

Name	Definition
blood microparticle	A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic vesicle	A vesicle found in the cytoplasm of a cell.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
cytosolic proteasome complex	A proteasome complex found in the cytosol of a cell.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
inclusion body	A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nuclear proteasome complex	A proteasome found in the nucleus of a cell.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
postsynapse	The part of a synapse that is part of the post-synaptic cell.
proteasome accessory complex	A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex.
proteasome complex	A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
proteasome regulatory particle, base subcomplex	The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex.

8 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
DNA-binding transcription factor binding	Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription.
general transcription initiation factor binding	Binding to a general transcription initiation factor, a protein that contributes to transcription start site selection and transcription initiation.
proteasome-activating activity	Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome.
TBP-class protein binding	Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).
thyrotropin-releasing hormone receptor binding	Binding to a receptor for thyrotropin-releasing hormone, a tripeptide hormone that is produced by the hypothalamus and stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary.
transcription factor binding	Binding to a transcription factor, a protein required to initiate or regulate transcription.

8 GO annotations of biological process

Name	Definition
modulation of chemical synaptic transmission	Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
negative regulation of DNA-templated transcription	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of programmed cell death	Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
positive regulation of DNA-templated transcription	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of inclusion body assembly	Any process that increases the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body.
positive regulation of proteasomal protein catabolic process	Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process.
proteasome-mediated ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

10 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q01939	RPT6	26S proteasome regulatory subunit 8 homolog	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P62194	PSMC5	26S proteasome regulatory subunit 8	Bos taurus (Bovine)	PR
O18413	Rpt6	26S proteasome regulatory subunit 8	Drosophila melanogaster (Fruit fly)	PR
P62333	PSMC6	26S proteasome regulatory subunit 10B	Homo sapiens (Human)	PR
P43686	PSMC4	26S proteasome regulatory subunit 6B	Homo sapiens (Human)	PR
P17980	PSMC3	26S proteasome regulatory subunit 6A	Homo sapiens (Human)	PR
P35998	PSMC2	26S proteasome regulatory subunit 7	Homo sapiens (Human)	PR
P62196	Psmc5	26S proteasome regulatory subunit 8	Mus musculus (Mouse)	PR
P62197	PSMC5	26S proteasome regulatory subunit 8	Sus scrofa (Pig)	PR
P62198	Psmc5	26S proteasome regulatory subunit 8	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MALDGPEQME	LEEGKAGSGL	RQYYLSKIEE	LQLIVNDKSQ	NLRRLQAQRN	ELNAKVRLLR
70	80	90	100	110	120
EELQLLQEQG	SYVGEVVRAM	DKKKVLVKVH	PEGKFVVDVD	KNIDINDVTP	NCRVALRNDS
130	140	150	160	170	180
YTLHKILPNK	VDPLVSLMMV	EKVPDSTYEM	IGGLDKQIKE	IKEVIELPVK	HPELFEALGI
190	200	210	220	230	240
AQPKGVLLYG	PPGTGKTLLA	RAVAHHTDCT	FIRVSGSELV	QKFIGEGARM	VRELFVMARE
250	260	270	280	290	300
HAPSIIFMDE	IDSIGSSRLE	GGSGGDSEVQ	RTMLELLNQL	DGFEATKNIK	VIMATNRIDI
310	320	330	340	350	360
LDSALLRPGR	IDRKIEFPPP	NEEARLDILK	IHSRKMNLTR	GINLRKIAEL	MPGASGAEVK
370	380	390	400
GVCTEAGMYA	LRERRVHVTQ	EDFEMAVAKV	MQKDSEKNMS	IKKLWK