P62194
PR
Gene name |
PSMC5 (SUG1) |
Protein name |
26S proteasome regulatory subunit 8 |
Names |
26S proteasome AAA-ATPase subunit RPT6, Proteasome 26S subunit ATPase 5, Proteasome subunit p45, p45/SUG |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:282015 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P62194
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P62194-F1 | Predicted | AlphaFoldDB |
125 variants for P62194
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs440390865 | 7 | E>K | No | EVA | |
| rs459286864 | 8 | Q>H | No | EVA | |
| rs476791989 | 15 | K>Q | No | EVA | |
| rs469105005 | 30 | E>D | No | EVA | |
| rs451806115 | 36 | N>S | No | EVA | |
| rs470242678 | 38 | K>Q | No | EVA | |
| rs468270429 | 85 | V>E | No | EVA | |
| rs437145958 | 124 | H>Y | No | EVA | |
| rs455552015 | 130 | K>M | No | EVA | |
| rs441332821 | 156 | K>N | No | EVA | |
| rs474099676 | 158 | I>V | No | EVA | |
| rs459659015 | 175 | F>L | No | EVA | |
| rs445187986 | 181 | A>E | No | EVA | |
| rs482300007 | 182 | Q>R | No | EVA | |
| rs477581261 | 186 | V>A | No | EVA | |
| rs477581261 | 186 | V>E | No | EVA | |
| rs459103580 | 186 | V>L | No | EVA | |
| rs469861669 | 187 | L>P | No | EVA | |
| rs481907765 | 188 | L>I | No | EVA | |
| rs467691778 | 193 | G>S | No | EVA | |
| rs434646474 | 193 | G>V | No | EVA | |
| rs453074385 | 194 | T>P | No | EVA | |
| rs453074385 | 194 | T>S | No | EVA | |
| rs465029221 | 197 | T>R | No | EVA | |
| rs432148793 | 202 | A>P | No | EVA | |
| rs457314827 | 203 | V>G | No | EVA | |
| rs475868464 | 205 | H>Q | No | EVA | |
| rs442816554 | 206 | H>R | No | EVA | |
| rs473741481 | 209 | C>G | No | EVA | |
| rs440775882 | 210 | T>P | No | EVA | |
| rs481925750 | 219 | L>* | No | EVA | |
| rs467377406 | 220 | V>G | No | EVA | |
| rs448885610 | 220 | V>I | No | EVA | |
| rs479193817 | 221 | Q>* | No | EVA | |
| rs446749207 | 221 | Q>P | No | EVA | |
| rs446749207 | 221 | Q>R | No | EVA | |
| rs465088803 | 222 | K>E | No | EVA | |
| rs469525386 | 226 | E>* | No | EVA | |
| rs436450112 | 227 | G>R | No | EVA | |
| rs467055095 | 231 | V>L | No | EVA | |
| rs452478650 | 232 | R>G | No | EVA | |
| rs456799182 | 233 | E>D | No | EVA | |
| rs438352623 | 233 | E>Q | No | EVA | |
| rs475258269 | 234 | L>P | No | EVA | |
| rs471523479 | 235 | F>Y | No | EVA | |
| rs461014198 | 236 | V>G | No | EVA | |
| rs438515823 | 237 | M>I | No | EVA | |
| rs472862686 | 237 | M>L | No | EVA | |
| rs458343138 | 238 | A>V | No | EVA | |
| rs450724497 | 243 | P>S | No | EVA | |
| rs462853659 | 253 | S>T | No | EVA | |
| rs481316714 | 253 | S>Y | No | EVA | |
| rs448224233 | 254 | I>F | No | EVA | |
| rs434039019 | 258 | R>S | No | EVA | |
| rs467067252 | 258 | R>T | No | EVA | |
| rs446074944 | 259 | L>R | No | EVA | |
| rs464588523 | 260 | E>G | No | EVA | |
| rs456821266 | 263 | S>A | No | EVA | |
| rs475301129 | 266 | D>G | No | EVA | |
| rs435785427 | 267 | S>R | No | EVA | |
| rs454152222 | 268 | E>G | No | EVA | |
| rs472924506 | 270 | Q>K | No | EVA | |
| rs440096914 | 273 | M>I | No | EVA | |
| rs452066903 | 274 | L>M | No | EVA | |
| rs470455535 | 277 | L>R | No | EVA | |
| rs444007586 | 280 | L>R | No | EVA | |
| rs462818472 | 286 | T>N | No | EVA | |
| rs462818472 | 286 | T>S | No | EVA | |
| rs460298035 | 287 | K>N | No | EVA | |
| rs481311557 | 287 | K>Q | No | EVA | |
| rs441813296 | 287 | K>R | No | EVA | |
| rs478786428 | 288 | N>K | No | EVA | |
| rs446209845 | 290 | K>M | No | EVA | |
| rs478279864 | 291 | V>G | No | EVA | |
| rs445414753 | 293 | M>I | No | EVA | |
| rs437359004 | 295 | T>S | No | EVA | |
| rs468207364 | 296 | N>S | No | EVA | |
| rs435183002 | 298 | I>V | No | EVA | |
| rs453701877 | 299 | D>N | No | EVA | |
| rs472503583 | 300 | I>F | No | EVA | |
| rs472503583 | 300 | I>L | No | EVA | |
| rs433083203 | 302 | D>E | No | EVA | |
| rs451478821 | 304 | A>G | No | EVA | |
| rs476490077 | 305 | L>P | No | EVA | |
| rs462261159 | 307 | R>S | No | EVA | |
| rs474057308 | 310 | R>C | No | EVA | |
| rs441186671 | 311 | I>L | No | EVA | |
| rs459546826 | 312 | D>A | No | EVA | |
| rs462437993 | 312 | D>N | No | EVA | |
| rs477989896 | 313 | R>S | No | EVA | |
| rs445550727 | 314 | K>* | No | EVA | |
| rs464015060 | 315 | I>S | No | EVA | |
| rs482483538 | 316 | E>* | No | EVA | |
| rs435244119 | 319 | P>H | No | EVA | |
| rs468319382 | 319 | P>T | No | EVA | |
| rs480704740 | 320 | P>T | No | EVA | |
| rs465794150 | 322 | E>D | No | EVA | |
| rs432743678 | 323 | E>D | No | EVA | |
| rs464067786 | 324 | A>D | No | EVA | |
| rs482559954 | 325 | R>Q | No | EVA | |
| rs443029872 | 326 | L>M | No | EVA | |
| rs461576613 | 328 | I>L | No | EVA | |
| rs479990259 | 330 | K>E | No | EVA | |
| rs465853714 | 331 | I>S | No | EVA | |
| rs447432653 | 331 | I>V | No | EVA | |
| rs447821575 | 336 | M>I | No | EVA | |
| rs477804545 | 339 | T>S | No | EVA | |
| rs444744830 | 341 | G>E | No | EVA | |
| rs470118613 | 342 | I>V | No | EVA | |
| rs467429243 | 347 | I>M | No | EVA | |
| rs455603792 | 347 | I>V | No | EVA | |
| rs434541230 | 348 | A>G | No | EVA | |
| rs453296120 | 350 | L>V | No | EVA | |
| rs457240299 | 354 | A>E | No | EVA | |
| rs438812285 | 354 | A>S | No | EVA | |
| rs480052239 | 359 | V>A | No | EVA | |
| rs459443613 | 360 | K>E | No | EVA | |
| rs457416592 | 364 | T>N | No | EVA | |
| rs475856425 | 369 | Y>* | No | EVA | |
| rs436385248 | 381 | E>* | No | EVA | |
| rs455239381 | 381 | E>A | No | EVA | |
| rs473644541 | 382 | D>G | No | EVA | |
| rs452806059 | 394 | D>N | No | EVA | |
| rs471219847 | 398 | N>K | No | EVA | |
| rs444616754 | 406 | K>E | No | EVA |
No associated diseases with P62194
2 regional properties for P62194
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Pentatricopeptide repeat | 416 - 440 | IPR002885-1 |
| repeat | Pentatricopeptide repeat | 444 - 478 | IPR002885-2 |
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoplasmic vesicle | A vesicle found in the cytoplasm of a cell. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| organelle membrane | A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle. |
| proteasome accessory complex | A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex. |
| proteasome complex | A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. |
| proteasome regulatory particle, base subcomplex | The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| DNA-binding transcription factor binding | Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. |
| general transcription initiation factor binding | Binding to a general transcription initiation factor, a protein that contributes to transcription start site selection and transcription initiation. |
| proteasome-activating activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome. |
| thyrotropin-releasing hormone receptor binding | Binding to a receptor for thyrotropin-releasing hormone, a tripeptide hormone that is produced by the hypothalamus and stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of DNA-templated transcription | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
| proteasome-mediated ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q01939 | RPT6 | 26S proteasome regulatory subunit 8 homolog | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q5E9F9 | PSMC2 | 26S proteasome regulatory subunit 7 | Bos taurus (Bovine) | PR |
| O18413 | Rpt6 | 26S proteasome regulatory subunit 8 | Drosophila melanogaster (Fruit fly) | PR |
| P62195 | PSMC5 | 26S proteasome regulatory subunit 8 | Homo sapiens (Human) | PR |
| P62196 | Psmc5 | 26S proteasome regulatory subunit 8 | Mus musculus (Mouse) | PR |
| P62197 | PSMC5 | 26S proteasome regulatory subunit 8 | Sus scrofa (Pig) | PR |
| P62198 | Psmc5 | 26S proteasome regulatory subunit 8 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALDGPEQME | LEEGKAGSGL | RQYYLSKIEE | LQLIVNDKSQ | NLRRLQAQRN | ELNAKVRLLR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EELQLLQEQG | SYVGEVVRAM | DKKKVLVKVH | PEGKFVVDVD | KNIDINDVTP | NCRVALRNDS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YTLHKILPNK | VDPLVSLMMV | EKVPDSTYEM | IGGLDKQIKE | IKEVIELPVK | HPELFEALGI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AQPKGVLLYG | PPGTGKTLLA | RAVAHHTDCT | FIRVSGSELV | QKFIGEGARM | VRELFVMARE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HAPSIIFMDE | IDSIGSSRLE | GGSGGDSEVQ | RTMLELLNQL | DGFEATKNIK | VIMATNRIDI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LDSALLRPGR | IDRKIEFPPP | NEEARLDILK | IHSRKMNLTR | GINLRKIAEL | MPGASGAEVK |
| 370 | 380 | 390 | 400 | ||
| GVCTEAGMYA | LRERRVHVTQ | EDFEMAVAKV | MQKDSEKNMS | IKKLWK |